Home Top Picks Metabolic Health
Metabolic Health

Best metabolic health
supplements.

Support blood sugar regulation, insulin sensitivity, lipid balance, and cellular energy metabolism — critical for managing metabolic syndrome and related conditions.

85
Ingredients
262
Clinical trials
4
Trending now
🏆 Evidence Ranked
Top Metabolic Health Supplements
Ranked by evidence level, then number of clinical trials.
#1 Pick
Cognitive
Vitamin B12
Vitamin B12, also known as cobalamin, is a water-soluble vitamin commonly supplemented as cyanocobalamin or me…
Very Strong
10 trials
#2 Pick
Muscle & Recovery
Magnesium
Magnesium supplements, typically containing magnesium in forms like magnesium citrate, oxide, glycinate, or ma…
Very Strong
9 trials
#3 Pick
Metabolic Health
Folate
Folate, also known as vitamin B9, is a water-soluble vitamin commonly supplemented as folic acid or its bioact…
Very Strong
8 trials
#4 Pick
Bone Health
Vitamin D
Vitamin D, often supplied in supplements as cholecalciferol (D3) or ergocalciferol (D2), is a fat-soluble vita…
Very Strong
7 trials
#5 Pick
Cardiovascular
Niacin
Niacin, or vitamin B3, is a vital nutrient that supports energy production by serving as a precursor to coenzy…
Very Strong
5 trials
📈 Trending Now
Fastest Growing Metabolic Health Ingredients
Ingredients seeing rapid growth in research interest and formulator adoption in 2024–2025.
Trending
Metabolic Health
Akkermansia muciniphila
Akkermansia muciniphila is a gram-negative, anaerobic bacterium in the human gut, thriving in the mucus layer.…
Limited
5 trials
Trending
Metabolic Health
Berberine
Berberine is a bioactive compound extracted from plants like barberry and goldenseal, known for its antimicrob…
Strong
6 trials
Trending
Weight Management
Slendesta® (Potato Protein Extract)
Slendesta® (Kemin Industries) is a standardized extract of protease inhibitor II (PI2) from potato (Solanum tu…
Moderate
2 trials
Trending
Athletic Performance
Betaine / TMG (Trimethylglycine)
Betaine (trimethylglycine, TMG) is a naturally occurring compound found in beets, spinach, and whole grains th…
Moderate
2 trials
🔬 Emerging Research
Future Metabolic Health Ingredients to Watch
Lower evidence now but active research underway — these may become top picks within 2–3 years.
Emerging
Metabolic Health
Akkermansia muciniphila
Akkermansia muciniphila is a gram-negative, anaerobic bacterium in the human gut, thriving in the mucus layer.…
Limited
5 trials
Emerging
Metabolic Health
Arabinoxylan (Arrabina®)
Arabinoxylan is a hemicellulose fiber derived from the bran layer of wheat (Triticum aestivum) or other cereal…
Moderate
2 trials
Emerging
Metabolic Health
Eriocitrin / Eriomin® (Lemon Flavonoid)
Eriocitrin is the primary flavanone glycoside found in lemon (Citrus limon) peel and juice, accounting for muc…
Moderate
2 trials
All Ingredients
All 85 Metabolic Health Supplements
Complete list, sorted by evidence strength.
Cognitive
Vitamin B12
Vitamin B12, also known as cobalamin, is a water-soluble vitamin commonly supplemented as cyanocobalamin or me…
Very Strong
10 trials
Muscle & Recovery
Magnesium
Magnesium supplements, typically containing magnesium in forms like magnesium citrate, oxide, glycinate, or ma…
Very Strong
9 trials
Metabolic Health
Folate
Folate, also known as vitamin B9, is a water-soluble vitamin commonly supplemented as folic acid or its bioact…
Very Strong
8 trials
Bone Health
Vitamin D
Vitamin D, often supplied in supplements as cholecalciferol (D3) or ergocalciferol (D2), is a fat-soluble vita…
Very Strong
7 trials
Cardiovascular
Niacin
Niacin, or vitamin B3, is a vital nutrient that supports energy production by serving as a precursor to coenzy…
Very Strong
5 trials
Immune Support
Zinc
Zinc, an essential trace mineral, is commonly supplemented in forms like zinc gluconate, acetate, or citrate,…
Very Strong
4 trials
Metabolic Health
Copper
Copper is an essential trace mineral and cofactor for over 30 enzymatic reactions, including those governing e…
Very Strong
2 trials
Energy
Iron
Iron is an essential trace mineral and a central component of hemoglobin, enabling red blood cells to carry ox…
Very Strong
2 trials
Metabolic Health
Psyllium Husk (Plantago ovata)
Psyllium husk is the soluble fiber derived from the seed husks of Plantago ovata — the most widely sold dietar…
Very Strong
2 trials
Athletic Performance
Sodium / Electrolyte Sodium
Sodium is the primary extracellular cation in the human body — essential for maintaining fluid balance, nerve…
Very Strong
2 trials
Metabolic Health
Iodine
Iodine is an essential trace mineral and the primary raw material for thyroid hormone synthesis. Adequate iodi…
Very Strong
1 trial
Cardiovascular
Potassium
Potassium is the most abundant intracellular cation in the human body, critical for maintaining membrane poten…
Very Strong
1 trial
Energy
Riboflavin
Riboflavin, or vitamin B2, is a water-soluble vitamin essential for energy production and maintaining healthy…
Strong
8 trials
Cognitive
Ashwagandha
Ashwagandha is an adaptogenic herb that may reduce stress, enhance mood, and support overall vitality by modul…
Strong
7 trials
Cognitive
KSM-66®
KSM-66 Ashwagandha, a standardized root extract, promotes stress relief and cognitive clarity by balancing cor…
Strong
7 trials
Metabolic Health
Berberine
Berberine is a bioactive compound extracted from plants like barberry and goldenseal, known for its antimicrob…
Strong
6 trials
Energy
Thiamine
Thiamine, also known as vitamin B1, is a water-soluble vitamin essential for converting carbohydrates into ene…
Strong
5 trials
Cognitive
Vitamin B6 (Pyridoxine)
Vitamin B6 (pyridoxine) is a water-soluble vitamin essential for amino acid metabolism, neurotransmitter synth…
Strong
5 trials
Energy
Nicotinamide Riboside (Niagen®)
Nicotinamide Riboside (NR) is a form of vitamin B3 and a direct precursor to NAD+, the coenzyme central to cel…
Strong
4 trials
Energy
Pantothenic Acid
Pantothenic acid, or vitamin B5, is a water-soluble vitamin essential for synthesizing coenzyme A, which suppo…
Strong
4 trials
Cardiovascular
Bergamot Polyphenol Extract (Bergamonte®)
Bergamot (Citrus bergamia) is a citrus fruit grown almost exclusively in the Calabria region of southern Italy…
Strong
3 trials
Immune Support
Black Seed Oil / Thymoquinone (ThymoQuin®)
Nigella sativa (black seed, black cumin, kalonji) is an annual flowering plant whose seeds have been used medi…
Strong
3 trials
Weight Management
Capsaicin / Capsicum Extract (Capsimax®)
Capsaicin is the primary bioactive compound in hot peppers, responsible for their heat and their powerful ther…
Strong
3 trials
Metabolic Health
Ginger (Zingiber officinale)
Ginger is one of the most widely consumed spices and medicinal plants globally, with over 5,000 years of docum…
Strong
3 trials
Cognitive
Saffron Extract (Saffretine®)
Saffron is the dried stigma of Crocus sativus, the most expensive spice in the world by weight, with a rich hi…
Strong
3 trials
Antioxidant
Sulforaphane / Glucoraphanin (Truebroc®)
Sulforaphane is an isothiocyanate compound produced when glucoraphanin — found in broccoli seeds and sprouts —…
Strong
3 trials
Athletic Performance
Tongkat Ali (LJ100®)
Tongkat Ali (Longjack) is a flowering plant native to Southeast Asia whose root has been used for centuries in…
Strong
3 trials
Antioxidant
Alpha Lipoic Acid
Alpha lipoic acid (ALA) is a naturally occurring organosulfur compound and universal antioxidant active in bot…
Strong
2 trials
Cardiovascular
Beta-Glucans (Oat & Yeast-Derived)
Beta-glucans are a family of soluble polysaccharide fibers consisting of glucose units linked by beta-1,3 and…
Strong
2 trials
Metabolic Health
Black Cohosh (Actaea racemosa)
Black cohosh is a flowering plant native to eastern North America whose root extract has been used by Native A…
Strong
2 trials
Metabolic Health
Black Pepper Extract (BioPerine®)
Black pepper extract standardized for piperine (BioPerine®) is the most widely used bioavailability enhancer i…
Strong
2 trials
Metabolic Health
Chasteberry / Vitex (Vitex agnus-castus)
Chasteberry (Vitex agnus-castus) fruit extract is the most clinically studied herbal medicine for premenstrual…
Strong
2 trials
Cognitive
Choline
Choline is an essential nutrient and precursor to acetylcholine (the primary learning and memory neurotransmit…
Strong
2 trials
Cardiovascular
Flaxseed / Flaxseed Oil (Linum usitatissimum)
Flaxseed (linseed) is one of the richest plant sources of alpha-linolenic acid (ALA, omega-3), lignans (phytoe…
Strong
2 trials
Weight Management
Glucomannan (Konjac Root Fiber)
Glucomannan is a water-soluble dietary fiber derived from the root of the konjac plant (Amorphophallus konjac)…
Strong
2 trials
Metabolic Health
Inositol (Myo-Inositol)
Inositol is a naturally occurring sugar alcohol acting as a secondary messenger in insulin signaling and criti…
Strong
2 trials
Athletic Performance
L-Carnitine (Carnipure®)
L-Carnitine is a naturally occurring amino acid derivative essential for transporting long-chain fatty acids i…
Strong
2 trials
Bone Health
Manganese
Manganese is an essential trace mineral and cofactor for over 300 enzymes — most notably manganese superoxide…
Strong
2 trials
Cardiovascular
Olive Leaf Extract (Witholytin®)
Olive leaf extract contains oleuropein — the bitter polyphenol responsible for many of the health benefits ass…
Strong
2 trials
Metabolic Health
Peppermint (Mentha × piperita)
Peppermint is a hybrid mint (Mentha aquatica × Mentha spicata) whose leaves and extracted essential oil provid…
Strong
2 trials
Immune Support
Probiotics (Lactobacillus / Bifidobacterium)
Probiotics are live microorganisms that, when administered in adequate amounts, confer a health benefit to the…
Strong
2 trials
Antioxidant
Selenium
Selenium is an essential trace mineral that functions as a critical component of selenoproteins, including glu…
Strong
2 trials
Metabolic Health
Soy Isoflavones (Glycine max)
Soy isoflavones — primarily genistein, daidzein, and glycitein — are phytoestrogens found in soybeans that bin…
Strong
2 trials
Metabolic Health
Biotin
Biotin, also known as vitamin B7, is a water-soluble vitamin that supports healthy hair, skin, and nails while…
Moderate
7 trials
Metabolic Health
DHEA
Dehydroepiandrosterone (DHEA) is a steroid hormone naturally produced by the adrenal glands, serving as a prec…
Moderate
7 trials
Metabolic Health
Saw Palmetto
Saw palmetto (Serenoa repens) is a small palm native to the southeastern United States, with its berries used…
Moderate
6 trials
Metabolic Health
Chromium
Chromium is an essential trace mineral that plays a key role in regulating blood sugar by enhancing the effect…
Moderate
5 trials
Metabolic Health
Inulin
Chicory root inulin is a soluble fiber and prebiotic that supports gut health by promoting beneficial bacteria…
Moderate
5 trials
Energy
Shilajit / Fulvic Acid (PrimaVie®)
Shilajit is a mineral-rich resinous exudate formed over millennia from the decomposition of plant matter compr…
Moderate
3 trials
Metabolic Health
Acacia Fiber (inavea™ Pure Acacia)
Acacia fiber (gum arabic) is a natural soluble dietary fiber harvested from the sap of Acacia senegal and Acac…
Moderate
2 trials
Antioxidant
Amla / Indian Gooseberry (Capros®)
Amla (Indian gooseberry) is one of the richest natural sources of vitamin C and polyphenols on earth — contain…
Moderate
2 trials
Bone Health
Aquamin® (Marine Minerals)
Aquamin® (Marigot Ltd.) is a unique multi-mineral complex harvested from the red marine algae Lithothamnion ca…
Moderate
2 trials
Metabolic Health
Arabinoxylan (Arrabina®)
Arabinoxylan is a hemicellulose fiber derived from the bran layer of wheat (Triticum aestivum) or other cereal…
Moderate
2 trials
Immune Support
Astragalus (Astragalus membranaceus)
Astragalus (Huang Qi) is one of the most important tonic herbs in Traditional Chinese Medicine, used for over…
Moderate
2 trials
Athletic Performance
Betaine / TMG (Trimethylglycine)
Betaine (trimethylglycine, TMG) is a naturally occurring compound found in beets, spinach, and whole grains th…
Moderate
2 trials
Bone Health
Boron
Boron is a trace mineral found naturally in fruits, vegetables, and nuts that plays underappreciated roles in…
Moderate
2 trials
Metabolic Health
Digestive Enzymes (DigeZyme®)
DigeZyme® (Sabinsa Corporation) is a broad-spectrum multi-enzyme complex containing five key digestive enzymes…
Moderate
2 trials
Metabolic Health
Eriocitrin / Eriomin® (Lemon Flavonoid)
Eriocitrin is the primary flavanone glycoside found in lemon (Citrus limon) peel and juice, accounting for muc…
Moderate
2 trials
Metabolic Health
Evening Primrose Oil (Oenothera biennis)
Evening primrose oil (EPO) is cold-pressed from the seeds of Oenothera biennis and is one of the richest plant…
Moderate
2 trials
Metabolic Health
Fenugreek
Fenugreek is an annual plant native to the Mediterranean and South Asia, used for millennia in Ayurvedic and t…
Moderate
2 trials
Metabolic Health
GlucoVantage® (Dihydroberberine)
GlucoVantage® is NNB Nutrition's patented dihydroberberine (DHB) — the active reduced metabolite of berberine…
Moderate
2 trials
Cognitive
Holy Basil (Tulsi)
Holy basil (Tulsi) is a sacred plant in Ayurvedic medicine and one of the most revered adaptogens in Indian tr…
Moderate
2 trials
Liver Support
Licorice Root (Glycyrrhiza glabra)
Licorice root is one of the most widely used herbs in both Eastern and Western herbal medicine traditions — th…
Moderate
2 trials
Weight Management
Metabolaid® (Hibiscus + Lemon Verbena)
Metabolaid® (Monteloeder/SuanNutra) is a patented combination of Hibiscus sabdariffa and Lemon verbena (Lippia…
Moderate
2 trials
Weight Management
MitoBurn® (L-BAIBA)
MitoBurn® is NNB Nutrition's patented stabilized form of L-β-aminoisobutyric acid (L-BAIBA) — a myokine natura…
Moderate
2 trials
Antioxidant
Moringa
Moringa oleifera, the 'miracle tree,' is native to South Asia and one of the most nutrient-dense plants known.…
Moderate
2 trials
Energy
NMN (Nicotinamide Mononucleotide)
NMN is a direct precursor to NAD+, a coenzyme essential for cellular energy production, DNA repair, and sirtui…
Moderate
2 trials
Cardiovascular
Pantethine (Pantesin®)
Pantethine is the biologically active, reduced disulfide form of pantothenic acid (vitamin B5) and the direct…
Moderate
2 trials
Metabolic Health
Red Clover (Trifolium pratense)
Red clover flowers contain four isoflavones — formononetin, biochanin A, daidzein, and genistein — with red cl…
Moderate
2 trials
Cardiovascular
Resveratrol
Resveratrol is a polyphenolic stilbene found in red wine, grapes, and Japanese knotweed root. It activates sir…
Moderate
2 trials
Energy
RiaGev® (NR + D-Ribose NAD+ Complex)
RiaGev® (Bioenergy Life Science) is a patented combination of nicotinamide riboside (NR) and D-ribose — two co…
Moderate
2 trials
Weight Management
Slendesta® (Potato Protein Extract)
Slendesta® (Kemin Industries) is a standardized extract of protease inhibitor II (PI2) from potato (Solanum tu…
Moderate
2 trials
Cognitive
Spearmint Extract (Neumentix®)
Neumentix® (Kemin Industries) is a patented spearmint extract standardized for rosmarinic acid and other polyp…
Moderate
2 trials
Antioxidant
Terminalia Chebula (Rejuna®)
Terminalia chebula (Haritaki, Black myrobalan) is the most revered herb in Tibetan and Ayurvedic medicine — ca…
Moderate
2 trials
Immune Support
Tinospora Cordifolia (Tinofend®)
Tinospora cordifolia (Guduchi or Giloy) is a climbing shrub central to Ayurvedic medicine for over 3,000 years…
Moderate
2 trials
Liver Support
L-Methionine
L-Methionine is an essential sulfur-containing amino acid and the universal methyl group donor in one-carbon m…
Moderate
1 trial
Metabolic Health
Molybdenum
Molybdenum is an essential ultratrace mineral required as a cofactor for four known human metalloenzymes: sulf…
Moderate
1 trial
Metabolic Health
Maca
Maca (Lepidium meyenii), a Peruvian root vegetable from the Andes, is traditionally used to enhance fertility,…
Limited
8 trials
Metabolic Health
Akkermansia muciniphila
Akkermansia muciniphila is a gram-negative, anaerobic bacterium in the human gut, thriving in the mucus layer.…
Limited
5 trials
Metabolic Health
Coconut Oil
Coconut oil is a dietary supplement derived from the meat of mature coconuts, rich in medium-chain triglycerid…
Limited
4 trials
Antioxidant
Chlorella
Chlorella is a single-celled freshwater green algae packed with chlorophyll, complete protein (60% by weight),…
Limited
2 trials
Metabolic Health
Aloe Vera (Aloe barbadensis miller)
Aloe vera is a succulent plant whose gel (from the inner leaf) and latex (from the leaf skin) have been used m…
Limited
1 trial
Liver Support
Dandelion Root
Dandelion root is one of the most widely used hepatic and diuretic herbs in Western botanical medicine. Rich i…
Limited
1 trial
Weight Management
Fucoxanthin
Fucoxanthin is a marine carotenoid found abundantly in edible brown seaweeds (wakame, hijiki, kombu) that has…
Limited
1 trial
Metabolic Health
Vanadium (Vanadyl Sulfate)
Vanadium is a trace element with no established essential function in humans — though insulin-mimetic properti…
Limited
1 trial