Home Ingredients GyngerLean® (Three-Ginger Thermogenic Blend)
Weight ManagementMetabolic Health

GyngerLean® (Three-Ginger Thermogenic Blend)

Alpinia galanga, Kaempferia parviflora, Zingiber officinale
Evidence Level
Preliminary
1 Clinical Trial
5 Documented Benefits
1/5 Evidence Score

GyngerLean® (Cepham Inc.) is a blend of three plants from the ginger family, not a single ginger extract: Alpinia galanga (red ginger), Kaempferia parviflora (black ginger) and Zingiber officinale (yellow ginger). Cepham's product sheet says the black ginger is standardized for the methoxyflavones DMF, TMF and PMF, the red ginger for alpha and beta pinenes and the yellow ginger for gingerols and shogaols, but gives no amounts. A supplier listing gives a 100 to 200 mg dose range and markets it as a thermogenic ingredient without caffeine. One small study of the blend itself has been published: in ten healthy men, single doses of 100 mg and 200 mg did not change resting energy expenditure, while the respiratory exchange ratio fell after 200 mg, a shift toward burning fat. That study had no placebo group and lasted three hours. Other evidence here comes from trials of black ginger extract or ordinary ginger on their own.

Studied Dose Not established for the blend. Its one published study gave single doses of 100 mg and 200 mg, and a supplier listing gives the same 100 to 200 mg range. Component trials used 90 to 180 mg of black ginger extract, and 600 mg of ginger extract to 2 g of ginger powder a day.
Active Compound GyngerLean® by Cepham Inc., a blend of three ginger-family plants. According to Cepham's product sheet, Alpinia galanga (red ginger) is standardized for alpha and beta pinenes; Kaempferia parviflora (black ginger) for the methoxyflavones 5,7-dimethoxyflavone (DMF), 5,7,4'-trimethoxyflavone (TMF) and 3,5,7,3',4'-pentamethoxyflavone (PMF); and Zingiber officinale (yellow ginger) for gingerols and shogaols. The amount of each plant and of each marker compound is not public.

Benefits

Resting energy use and fat oxidation after one GyngerLean dose in ten men

In the one published study of the blend, ten healthy men with a body mass index of 25 to 30 took single doses of 100 mg and 200 mg on separate days, with no placebo. Resting energy expenditure, the main outcome, did not change at either dose. After 200 mg the respiratory exchange ratio was lower at two and three hours than before the dose, which points to more fat burned relative to carbohydrate; 100 mg changed nothing.

Supported by Trial 1

Abdominal body fat in a trial of black ginger (Kaempferia parviflora) extract

Black ginger is one of the three plants in the blend. In a 12-week placebo-controlled trial in 76 overweight Japanese adults, 150 mg of black ginger extract a day reduced visceral, subcutaneous and total abdominal fat area and triglycerides compared with placebo; the extract maker sponsored the study and employed half of the authors. This tested black ginger alone, not GyngerLean, whose black ginger content is not public.

Supported by Trial 1

Insulin and blood sugar markers in trials of ginger or black ginger alone

In a 12-week placebo-controlled trial in 80 women with obesity, 2 g of ordinary ginger powder a day lowered fasting insulin and an insulin resistance score compared with placebo; glucose fell in both groups with no difference between them. In healthy volunteers, 90 or 180 mg of black ginger extract a day for 28 days did not change glucose tolerance. Neither study used GyngerLean.

Supported by Trial 1

Energy expenditure, appetite and body weight in trials of ordinary ginger

In ten men with overweight, 2 g of ginger powder in a hot drink with breakfast raised the thermic effect of food by about 43 kcal a day and lowered hunger ratings, with appetite hormones unchanged. In 66 women, 600 mg of ginger extract a day for three months did not change resting energy expenditure or body composition. A pooled analysis of 14 trials found lower body weight with ginger. None used GyngerLean.

Supported by Trial 1

Blood inflammation markers in trials of ordinary ginger

In a 12-week placebo-controlled trial in 70 adults with type 2 diabetes, 1600 mg of ginger a day lowered CRP and prostaglandin E2 but not TNF-alpha. In ten men with overweight, ginger with breakfast did not change CRP, interleukin 6 or TNF-alpha. Results in a patient group may not apply to healthy people, and neither study used GyngerLean.

Supported by Trial 1

Mechanism of action

1

Proposed brown adipose tissue pathway

In 20 young men, a single 100 mg dose of black ginger extract raised resting energy expenditure compared with placebo, with a larger rise in men whose brown adipose tissue was more active on cold-exposure scans; the extract contained methoxyflavones but no detectable 6-gingerol or 6-shogaol, and respiratory quotient did not change. The GyngerLean study found the reverse pattern: no change in energy expenditure but a lower respiratory exchange ratio after 200 mg. How the blend might act is therefore unknown. A ghrelin route is often proposed, but the one ginger study that measured appetite hormones found active ghrelin unchanged.

Clinical trials

1
GyngerLean 100 mg and 200 mg Single Doses in Ten Men (No Placebo Arm)
PubMed

Randomized, double-blind crossover study comparing two single doses of GyngerLean with no placebo; each dose was compared with that visit's own baseline over three hours after a 4-hour fast. The primary outcome, resting energy expenditure, did not change, and a single visit cannot show any effect on body weight. Cepham supplied the product and the authors report no funding. Registered as NCT06805201 after the study ended. (Evans et al. 2025, Cureus)

Ten healthy men, average age 27, average body mass index 27.8.

Resting energy expenditure did not change after either dose. After 200 mg the respiratory exchange ratio fell from 0.81 before the dose to 0.77 at two hours and 0.75 at three hours; after 100 mg it did not change.

Side effects and drug interactions

Common Potential side effects

Ginger can cause stomach upset, belching, indigestion, heartburn and nausea, which EU assessors list as common; hypersensitivity reactions have also been reported.
In a 12-week trial of black ginger extract alone at 150 mg a day, no adverse events linked to the extract were reported. No tolerability data have been published for the three-plant blend; its one published study, of single doses, did not report on side effects.
EU assessors advise avoiding ginger during pregnancy as a precaution and do not recommend it while breastfeeding, because safety has not been established; they also do not recommend it under 18 because of insufficient data.

Important Drug interactions

Warfarin: in an open-label study of 12 healthy men, ginger at recommended doses, taken for 7 days before and 7 days after a warfarin dose, did not change INR, platelet aggregation or warfarin levels. Higher doses and the blend were not tested, so people on blood thinners should check with a clinician.
Drugs broken down by CYP3A enzymes: in mice, 10 days of 5,7-dimethoxyflavone, a main compound of black ginger, lowered liver CYP3A levels and raised blood exposure to midazolam by 130%. This has not been tested in people; ask a clinician before combining GyngerLean with such medicines.
EU assessors list no known drug interactions for ginger root itself.

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Frequently asked questions about GyngerLean® (Three-Ginger Thermogenic Blend)

Is GyngerLean the same as ordinary ginger?

No. It blends three plants from the ginger family: kitchen ginger (Zingiber officinale), black ginger (Kaempferia parviflora) and red ginger (Alpinia galanga). It is sold at 100 to 200 mg, while ginger powder trials used about 2 g a day. Cepham has not published how much of each plant the blend contains, so results from ginger or black ginger trials cannot be assumed to apply to it.

Does GyngerLean contain caffeine?

Cepham's product sheet and a supplier listing both describe it as stimulant and caffeine free, and list only the three ginger-family plants. Finished products that contain GyngerLean may add caffeine or other stimulants, so check the full label of the product you buy.

Has GyngerLean been tested against a placebo?

Not in any published study found for this review. The one published study compared single 100 mg and 200 mg doses in ten men over three hours, without a placebo. Resting energy expenditure did not change, and the respiratory exchange ratio fell after 200 mg. Cepham's product sheet mentions an open-label human study of the blend, but no data from it have been published. No trial of body weight or body fat with the blend has been published.

What is GyngerLean?

GyngerLean® (Cepham Inc.) is a blend of three plants from the ginger family, not a single ginger extract: Alpinia galanga (red ginger), Kaempferia parviflora (black ginger) and Zingiber officinale (yellow ginger).

What is GyngerLean used for?

GyngerLean is researched primarily for Weight Management and Metabolic Health. In the one published study of the blend, ten healthy men with a body mass index of 25 to 30 took single doses of 100 mg and 200 mg on separate days, with no placebo.

What is the recommended dosage of GyngerLean?

Not established for the blend. Its one published study gave single doses of 100 mg and 200 mg, and a supplier listing gives the same 100 to 200 mg range. Always follow the product label and check with a healthcare provider for personal advice.

Is GyngerLean safe, and does it have side effects?

Side effects and cautions reported for GyngerLean include: Ginger can cause stomach upset, belching, indigestion, heartburn and nausea, which EU assessors list as common; hypersensitivity reactions have also been reported. It may also interact with some medications. GyngerLean is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does GyngerLean interact with any medications?

Possible interactions include: Warfarin: in an open-label study of 12 healthy men, ginger at recommended doses, taken for 7 days before and 7 days after a warfarin dose, did not change INR, platelet aggregation or warfarin levels. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for GyngerLean?

NutraSmarts rates the evidence for GyngerLean as Preliminary (1 out of 5). It is backed by 1 study summary and 14 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(14 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Maharlouei N, Tabrizi R, Lankarani KB, Rezaianzadeh A, Akbari M, Kolahdooz F, Rahimi M, Keneshlou F, Asemi Z. The effects of ginger intake on weight loss and metabolic profiles among overweight and obese subjects: A systematic review and meta-analysis of randomized controlled trials. Crit Rev Food Sci Nutr. 2019;59(11):1753-1766. doi: 10.1080/10408398.2018.1427044.PubMedUsed to support: Systematic review and pooled analysis of 14 randomized trials (473 people with overweight or obesity): ginger lowered body weight, waist-to-hip ratio, fasting glucose and HOMA-IR and raised HDL cholesterol, but did not change BMI, insulin, triglycerides, or total or LDL cholesterol. It did not measure energy expenditure. Ordinary ginger, not the GyngerLean blend.
  2. Mansour MS, Ni YM, Roberts AL, Kelleman M, Roychoudhury A, St-Onge MP. Ginger consumption enhances the thermic effect of food and promotes feelings of satiety without affecting metabolic and hormonal parameters in overweight men: a pilot study. Metabolism. 2012;61(10):1347-52. doi: 10.1016/j.metabol.2012.03.016.PubMedUsed to support: Randomized crossover study in ten men with overweight (average BMI 27.2): 2 g of ginger powder in a hot drink with breakfast raised the thermic effect of food by about 43 kcal a day and lowered hunger and prospective food intake ratings; fullness did not reach significance. Resting energy expenditure, respiratory quotient, glucose, insulin, lipids, CRP, interleukin 6, TNF-alpha, leptin, adiponectin, GLP-1, peptide YY and active ghrelin did not change. Ordinary ginger powder, not GyngerLean.
  3. Arablou T, Aryaeian N, Valizadeh M, Sharifi F, Hosseini A, Djalali M. The effect of ginger consumption on glycemic status, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus. Int J Food Sci Nutr. 2014;65(4):515-20. doi: 10.3109/09637486.2014.880671.PubMedUsed to support: Double-blind placebo-controlled trial in 70 adults with type 2 diabetes: 1600 mg of ginger a day for 12 weeks lowered fasting glucose, HbA1c, insulin, HOMA, triglycerides, total cholesterol, CRP and prostaglandin E2 compared with placebo; HDL, LDL and TNF-alpha did not differ. A patient group taking ordinary ginger, not GyngerLean.
  4. Evans C, Kalman D, Jiannine L, Ricci T, Byers P, Pereira F, Miriyala V, Antonio J. The Acute Metabolic Impacts of Kampferia parviflora Extract in Healthy Men: A Randomized, Double-Blind, Proof-of-Concept Study. Cureus. 2025;17(4):e81561. doi: 10.7759/cureus.81561.PubMedUsed to support: The one published study of GyngerLean itself (the title names black ginger extract, but the product tested was the three-plant blend). Ten healthy men (average age 27, BMI 27.8) took single 100 mg and 200 mg doses in a double-blind crossover with no placebo arm. Resting energy expenditure, the primary outcome, did not change at either dose; after 200 mg the respiratory exchange ratio fell from 0.81 to 0.77 at two hours and 0.75 at three hours compared with that visit's baseline, and 100 mg changed nothing. Cepham supplied the product; the authors report no funding. Registered as NCT06805201 after the study ended.
  5. Matsushita M, Yoneshiro T, Aita S, Kamiya T, Kusaba N, Yamaguchi K, Takagaki K, Kameya T, Sugie H, Saito M. Kaempferia parviflora extract increases whole-body energy expenditure in humans: roles of brown adipose tissue. J Nutr Sci Vitaminol (Tokyo). 2015;61(1):79-83. doi: 10.3177/jnsv.61.79.PubMedUsed to support: Single-blind randomized crossover study in 20 healthy young men: one 100 mg capsule of black ginger extract raised resting energy expenditure by up to 229 kJ a day at 60 minutes compared with no change after placebo, with a larger rise in men with more active brown adipose tissue and no significant rise in the others. Respiratory quotient did not change. The extract was made by a company that employed four of the authors. Black ginger alone, not GyngerLean.
  6. Yoshino S, Awa R, Miyake Y, Fukuhara I, Sato H, Ashino T, Tomita S, Kuwahara H. Daily intake of Kaempferia parviflora extract decreases abdominal fat in overweight and preobese subjects: a randomized, double-blind, placebo-controlled clinical study. Diabetes Metab Syndr Obes. 2018;11:447-458. doi: 10.2147/DMSO.S169925.PubMedUsed to support: Randomized, double-blind, placebo-controlled 12-week trial in 76 Japanese adults with a BMI of 24 to 30: 150 mg of black ginger extract once daily reduced visceral, subcutaneous and total abdominal fat area and triglycerides compared with placebo, with no extract-related adverse events. The extract maker, Maruzen Pharmaceuticals, sponsored the study, and four of the eight authors were its employees. Black ginger alone, not GyngerLean.
  7. Sripanidkulchai B, Mekjaruskul C, Areemit R, Cheawchanwattana A, Sithithaworn J. Glucose Tolerance Test and Pharmacokinetic Study of Kaempferia parviflora Extract in Healthy Subjects. Nutrients. 2019;11(5):1176. doi: 10.3390/nu11051176.PubMedUsed to support: Placebo-controlled study in healthy volunteers: black ginger extract at 90 or 180 mg a day for 28 days did not change oral glucose tolerance. Methoxyflavones PMF and TMF were detected in blood with half-lives of 2 to 3 hours. A null result for blood sugar with black ginger alone, not GyngerLean.
  8. Braga Tibaes JR, Martins LB, Rodrigues AMDS, Amaral MHA, Teixeira AL, Ferreira AVM. Ginger supplementation does not increase energy expenditure in female adults. Nutrition. 2022;103-104:111803. doi: 10.1016/j.nut.2022.111803.PubMedUsed to support: Secondary analysis of a randomized, double-blind, placebo-controlled trial in 66 women with high body fat: 600 mg of dry ginger extract a day for three months did not change resting energy expenditure, body measurements, body composition or blood pressure compared with placebo. A null result for ordinary ginger extract, not GyngerLean.
  9. Ebrahimzadeh Attari V, Ostadrahimi A, Asghari Jafarabadi M, Mehralizadeh S, Mahluji S. Changes of serum adipocytokines and body weight following Zingiber officinale supplementation in obese women: a RCT. Eur J Nutr. 2016;55(6):2129-36. doi: 10.1007/s00394-015-1027-6.PubMedUsed to support: Randomized, double-blind, placebo-controlled trial in 80 women with obesity: 2 g of ginger powder a day for 12 weeks lowered BMI, serum insulin and HOMA-IR and raised QUICKI compared with placebo. Leptin, resistin and glucose fell in both groups without a difference between them, and body composition and adiponectin did not change. The authors call the effect minor. Ordinary ginger powder, not GyngerLean.
  10. Jiang X, Williams KM, Liauw WS, Ammit AJ, Roufogalis BD, Duke CC, Day RO, McLachlan AJ. Effect of ginkgo and ginger on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects. Br J Clin Pharmacol. 2005;59(4):425-32. doi: 10.1111/j.1365-2125.2005.02322.x.PubMedUsed to support: Open-label randomized crossover study in 12 healthy men: ginger at recommended doses, taken for 7 days before and 7 days after a single 25 mg warfarin dose, did not change INR, platelet aggregation, warfarin clearance or protein binding. Single warfarin dose in healthy men; does not cover people on long-term warfarin or high ginger doses.
  11. Ochiai W, Kobayashi H, Kitaoka S, Kashiwada M, Koyama Y, Nakaishi S, Nagai T, Aburada M, Sugiyama K. Effect of the active ingredient of Kaempferia parviflora, 5,7-dimethoxyflavone, on the pharmacokinetics of midazolam. J Nat Med. 2018;72(3):607-614. doi: 10.1007/s11418-018-1184-z.PubMedUsed to support: Mouse study: 10 days of 5,7-dimethoxyflavone, a main compound of black ginger, lowered liver CYP3A expression, raised the area under the curve of oral midazolam by 130% and lengthened its half-life by about 100 minutes. Animal data only; supports a precaution with drugs cleared by CYP3A, not a demonstrated human interaction.
  12. NXT Ingredients. GyngerLean™ by Cepham NXT Ingredients website. 2026;Accessed 2026-10-22..SourceUsed to support: Not PubMed-indexed; a third-party ingredient directory listing Cepham Inc. as the supplier. Lists the three ingredients (Alpinia galanga, Kaempferia parviflora, Zingiber officinale), says the blend is standardized for gingerols, shogaols, methoxyflavones and pinenes without percentages, gives a 100 to 200 mg dose range, and markets it for fat oxidation 'without caffeine stimulation'. Its research library is listed as coming soon; marketing claims, not evidence.
  13. European Medicines Agency, Committee on Herbal Medicinal Products. European Union herbal monograph on Zingiber officinale Roscoe, rhizoma (Final, Revision 1) EMA/HMPC/885789/2022. 2025;Adopted 7 May 2025..SourceUsed to support: Not PubMed-indexed; official EU monograph. Lists stomach upset, belching, indigestion, heartburn and nausea as common undesirable effects and hypersensitivity at unknown frequency; no known drug interactions; avoid in pregnancy as a precaution; use during breastfeeding not recommended; use under 18 not recommended or not established for lack of data.
  14. Cepham Inc. GyngerLean (product information sheet) Cepham Inc. website. 2023;Two-page PDF, uploaded March 2023 per its URL path; accessed 2026-10-22..SourceUsed to support: Not PubMed-indexed; the maker's own marketing sheet for professionals. Names the three plants and says the black ginger is standardized for DMF, TMF and PMF, the red ginger for alpha and beta pinenes and the yellow ginger for gingerols and shogaols, without amounts, and calls the blend stimulant and caffeine free. It says initial findings come from an open-arm human study of GyngerLean and lists six effects with no data; its references are animal studies and reviews. It also said animal safety studies were underway, to be followed by a double-blind, placebo-controlled human study; none was found on PubMed as of 2026-10-22.