Fig (Ficus carica)

Ficus carica
Evidence Level
Limited
8 Clinical Trials
7 Documented Benefits
2/5 Evidence Score

Fig (Ficus carica) is a Mediterranean fruit eaten fresh or dried, and its leaves are also brewed as a tea. This record treats two separate materials: the fruit (fresh, dried, as a paste or syrup, or as a standardized extract) and the leaf. Dried figs are dense in sugar but also supply fiber, potassium, calcium and magnesium. Human research is small. Three controlled trials of fig fruit, given as a paste, as whole fruit and as a syrup to people with hard or infrequent stools, found better stool form, transit time or bowel movement counts than the control group, while adding 120 g a day of dried figs did not lower LDL cholesterol. Single small studies tested a fig fruit extract and a fig leaf decoction on blood sugar after a meal. Fig sap and leaves can cause burn-like skin reactions in sunlight, and figs can trigger allergy in people sensitized to weeping fig or birch pollen.

Studied Dose Fruit: paste 300 g/day for 8 weeks; about 90 g/day for 4 months; dried figs 120 g/day for 5 weeks; syrup 15 mL nightly (about 1.2 g fig) for 2 weeks; extract 100 to 1,200 mg in one drink. Leaf: tea 500 mL/day for 8 weeks; decoction with breakfast for 1 month.
Active Compound Fig fruit (fresh, dried, paste, syrup or extract): sugars, dietary fiber, potassium, calcium, magnesium and polyphenols; some extracts are standardized to abscisic acid. Fig leaf (tea, decoction or extract) is a separate material; the leaves and milky sap of many varieties contain furanocoumarins such as psoralen and bergapten.

Benefits

Bowel transit time and stool form with daily fig paste

In an 8-week double-blind trial in 80 Korean adults with functional constipation, 300 g a day of fig paste shortened colon transit time more than a matched placebo paste (by 24.5 vs 15.0 hours) and improved stool form and abdominal discomfort. Stool frequency, straining and overall relief did not differ. The paste maker co-funded the trial.

Bowel habits with whole figs or a fig fruit syrup

In a three-arm trial of 150 adults with constipation-predominant IBS (fig, flixweed seed or usual diet), about 90 g a day of fig for 4 months improved pain frequency, bloating, stool frequency and hard stools versus a usual-diet control with no placebo, but not pain severity. In 90 pregnant women with constipation, a nightly fig fruit syrup gave more bowel movements than a placebo syrup over 2 weeks.

Post-meal blood sugar and insulin with a fig fruit extract

In a crossover study of 10 healthy adults, a fig fruit extract standardized to abscisic acid, added to a 50 g glucose drink, lowered the glycemic index by about 25% and the insulin response by about 24% at the higher dose; the lower doses did not significantly lower glucose. The extract maker funded the study, which tested single drinks, not daily use.

Post-meal blood sugar with a fig leaf decoction at breakfast

In a crossover study of 10 adults with type 1 diabetes on insulin, a month of fig leaf decoction with breakfast gave lower post-meal glucose than a month of plain commercial tea, and insulin doses were 12% lower. A later review of plant trials in this group found no difference in HbA1c or fasting glucose and noted unclear randomization, a comparison drink that was easy to tell apart and no washout period.

Fiber and mineral intake from dried figs

USDA lists 9.8 g of fiber, 680 mg of potassium, 162 mg of calcium and 68 mg of magnesium per 100 g of dried figs. In a 10-week crossover trial, adding about 120 g a day raised reported calcium, magnesium and potassium intake, but blood mineral levels did not change and LDL cholesterol did not fall.

Skin symptom scores with daily fig leaf tea

In an 8-week double-blind trial in 30 Japanese adults with mild atopic dermatitis, 500 mL a day of tea from a fig cultivar without furanocoumarins lowered a dermatologist-rated eczema score more than a colored-water placebo. A patient-rated eczema score did not differ between groups, and the difference faded within 4 weeks of stopping.

Menstrual discomfort scores with dried figs

In Turkish midwifery students with painful periods, eating 6 dried figs a day (about 150 g) on the first 3 days of each period for 3 cycles gave lower pain, distress and stress scores than empty placebo capsules or cinnamon. Participants could tell figs from capsules, scores were self-reported, and group sizes differ between sections of the paper.

Mechanism of action

1

Fiber, water and sugars in the fruit

Dried figs supply about 9.8 g of fiber and 48 g of sugars per 100 g. The paste used in the transit trial was 89% water and 1.7% fiber, so 300 g gave about 5 g of fiber. In rat studies by the same group, fig paste raised stool water content. Fiber is the usual explanation offered, but the human trials did not test how the fruit works.

2

Abscisic acid and the LANCL2 receptor (lab and animal work)

Abscisic acid is a plant hormone found in figs. In obese and diabetic mouse models, an abscisic acid-enriched fig extract improved glucose tolerance and insulin sensitivity, and the effect was lost in mice lacking the LANCL2 receptor in muscle. These are mouse and cell findings; the senior author is a shareholder of BioTherapeutics, Inc.

3

Furanocoumarins in leaves and sap

The leaves and milky sap of many fig varieties contain furanocoumarins such as psoralen and bergapten. On skin that is then exposed to sunlight, these compounds cause phototoxic burns. The fig leaf tea trial used a cultivar without furanocoumarins, so its results do not cover other leaf teas or extracts.

Clinical trials

1
Fig Paste and Colon Transit Time: 8-Week Placebo-Controlled RCT
PubMed

Randomized, double-blind, placebo-controlled trial at Chonbuk National University Hospital, Korea (registered NCT02138851), of fig paste supplied by Yeongam Green Fig Agriculture, which co-funded the study with Korean government research bodies. (Baek et al. 2016, Asia Pac J Clin Nutr)

80 adults aged 19 to 39 with functional constipation (Rome III) and colon transit time of at least 36 hours; 74 completed. Three packs a day (300 g/day, standardized to 1.7% fiber) of fig paste or a matched water, sugar and starch placebo before meals for 8 weeks.

Colon transit time fell by 24.5 hours on fig paste and by 15.0 hours on placebo, a significant between-group difference (p = 0.030). Stool form on the Bristol scale (p = 0.024) and abdominal discomfort (p = 0.012) also improved more than on placebo. Frequency of bowel movements, straining, sense of incomplete evacuation and overall relief did not differ. No serious adverse events were reported.

2
Fig or Flixweed vs Usual Diet in Constipation-Predominant IBS: 4-Month RCT (no placebo)
PubMed

Randomized trial at Isfahan University of Medical Sciences, Iran, with only the investigators masked, comparing fig or flixweed seed with a usual-diet control; the trial registration (NCT02559245) gives the fig dose as 45 g before breakfast and before lunch (90 g/day). (Pourmasoumi et al. 2019, Explore (NY))

150 adults with constipation-predominant irritable bowel syndrome assigned to fig, flixweed or control for 4 months.

Compared with control, fig improved pain frequency, bloating, stool frequency and hard stools, along with quality of life and satisfaction with bowel habits. Abdominal pain severity and C-reactive protein did not change. The control group ate no placebo food, and the abstract does not say whether the figs were fresh or dried.

3
Fig Syrup and Fig-Walnut Syrup vs Placebo Syrup in Pregnancy: 2-Week RCT
PubMed

Double-blind randomized trial at Tabriz University of Medical Sciences, Iran (registered with the Iranian Registry of Clinical Trials), funded by the university, with syrups made by Sina Noandish Tabiat Company. The fig syrup was a hot-water extract of fig fruit with about 400 mg of fig per 5 mL. (Valizadeh et al. 2025, Nutr Metab (Lond))

90 pregnant women with functional constipation (30 per group); 15 mL of fig syrup, fig-walnut syrup or a matched placebo syrup nightly for 14 days, with 2 weeks of follow-up. 84 completed.

Both fig syrups gave more bowel movements per week than placebo, with no difference between the two fig syrups. Stool amount, consistency, straining and the sense of incomplete evacuation improved versus placebo, while the sense of blockage and need for manual maneuvers did not. Quality of life improved more than with placebo (on the questionnaire used, a lower score means better quality of life). One woman in each fig group had diarrhea.

4
Dried Figs 120 g/day and LDL Cholesterol: 10-Week Crossover RCT (no fall)
PubMed

Randomized crossover trial at Loma Linda University, California, partly funded by the California Fig Advisory Board, which supplied the figs, and by an NIH grant. A second paper from the same trial reported mineral intake and blood mineral levels. (Peterson et al. 2011, Ann Nutr Metab)

102 adults aged 30 to 75 with raised LDL cholesterol (100 to 189 mg/dL) randomized; 83 had final blood tests. About 120 g/day of dried California Mission figs added to the usual diet for 5 weeks versus the usual diet for 5 weeks.

LDL and HDL cholesterol did not differ between the fig and usual-diet periods. Total cholesterol tended to be higher with figs (230 vs 224 mg/dL, p = 0.021, not significant after the paper's correction for multiple tests), driven by one sequence group. Sugar intake rose from 23.4% to 32.2% of calories, and body weight did not change significantly. In the companion paper, reported calcium, magnesium and potassium intake rose, but blood iron, magnesium, potassium and zinc did not change.

5
Abscisic Acid-Standardized Fig Fruit Extract and Glycemic Index: Crossover RCT
PubMed

Randomized, double-blind crossover glycemic index study run by the University of Sydney testing service and funded by extract maker Euromed (ABAlife), four of whose employees are co-authors. (Atkinson et al. 2019, Nutrients)

10 healthy adults; each tested a 50 g glucose drink alone (three times) and with 100 or 200 mg of one fig fruit extract or 600 or 1,200 mg of another, supplying 40 or 80 micrograms of abscisic acid.

At the 80 microgram dose, both extracts lowered the glycemic index by about 25% (p = 0.001 and p = 0.002) and the insulin index by about 24% versus the glucose drink alone. The 40 microgram doses lowered the glycemic index by about 14%, not significantly, though they did lower the insulin index. No adverse events were reported. These were single test drinks; daily use was not studied.

6
Fig Leaf Decoction with Breakfast in Type 1 Diabetes: 2-Month Crossover
PubMed

Randomized crossover study by researchers from the Badajoz medical faculty and University Hospital 12 Octubre, Madrid, Spain, of a fig leaf (Ficus carica) decoction versus a non-sweet commercial tea, each for one month alongside the usual diet and twice-daily insulin. (Serraclara et al. 1998, Diabetes Res Clin Pract)

10 adults with type 1 diabetes aged 22 to 38 (6 men, 4 women); 2 dropped out because of intolerance.

Post-breakfast glucose was lower during the fig leaf month than the tea month (156.6 vs 293.7 mg/dL, p < 0.001), with no difference before the meal, and the average insulin dose was 12% lower. The comparison drink was an ordinary tea rather than a matched placebo, and the abstract does not give the amount of leaf used.

7
Fig Leaf Tea vs Placebo in Mild Atopic Dermatitis: 8-Week RCT
PubMed

Double-blind, randomized, placebo-controlled trial by the Toyo Institute of Food Technology with volunteers from a clinic in Osaka, Japan; the paper reports no external funding. The tea was made from Grise de Tarascon, a fig cultivar without furanocoumarins. (Abe et al. 2022, Nutrients)

30 adults aged 20 to 59 with mild atopic dermatitis (EASI 2 to 15), 15 per group; 500 mL a day of fig leaf tea or colored water for 8 weeks, then 4 weeks without.

The dermatologist-rated EASI score fell by 3.13 points on fig leaf tea versus 0.19 on placebo at week 8 (p = 0.036). The patient-rated POEM score and the TARC blood marker did not differ between groups. Four weeks after stopping, the difference was no longer significant. Routine blood tests showed no harmful changes.

8
Dried Figs vs Cinnamon or Placebo Capsules for Menstrual Pain: 3-Cycle RCT
PubMed

Randomized, placebo-controlled trial among midwifery students at Adnan Menderes University, Turkey; the placebo was empty capsules, so the fig group was not blinded. Single author, no conflicts declared; an erratum was later published. (Amanak 2020, P R Health Sci J)

Women students with primary dysmenorrhea; group sizes differ between sections of the paper (about 31 to 36 per group). The fig group ate 6 dried figs a day (about 150 g) on days 1 to 3 of 3 cycles; the cinnamon group took 1,260 mg a day.

Over 3 cycles, the dried fig group had lower pain severity, pain duration, menstrual distress and perceived stress scores, and higher quality of life scores, than both the cinnamon and placebo groups. The fig amount was set to match the calories of the cinnamon dose by a calculation that overstates cinnamon's calories, and all outcomes were self-reported.

Side effects and drug interactions

Common Potential side effects

Dried figs are sugar-dense: USDA lists 249 kcal, 64 g of carbohydrate and 48 g of sugars per 100 g. Adding 120 g a day raised sugar intake from about 23% to 32% of calories in one trial, so count dried figs like other dried fruit if you watch sugar or calories.
Loose stools are possible: one woman in each fig syrup group had diarrhea, and in the dried fig crossover trial one participant in the figs-first group left with persistent diarrhea and one in the other sequence group left with diarrhea.
Figs can cause allergic reactions. In an Austrian allergy clinic, people sensitized to weeping fig (Ficus benjamina, a common houseplant) often had positive skin tests to fresh fig (83%) and dried fig (37%), and some had whole-body reactions such as hives, swelling or asthma after eating figs and related fruits; most were not allergic to rubber latex.
People with birch pollen allergy may react to fresh figs: in one clinic, 78% of birch-allergic patients had a positive skin test to fresh fig and two-thirds of those reported symptoms after eating it, while dried figs were mostly tolerated. Mulberry and jackfruit carry the same allergen family.
The leaves and milky sap (latex) of many fig varieties contain furanocoumarins. Sap on the skin followed by sunlight can cause phytophotodermatitis, a burn-like reaction with redness and swelling; one man who handled a fig tree needed care in a burn unit. Wear gloves and cover skin when pruning or picking, and do not apply fig sap or leaves to the skin.
Fig leaf products: the leaves of many varieties contain furanocoumarins. The fig leaf tea trial used a cultivar without them, and its authors advise choosing furanocoumarin-free leaf tea; other leaf teas and extracts have not been tested for safety in trials. In the fig leaf decoction study, 2 of 10 participants dropped out because of intolerance.

Important Drug interactions

Insulin and other glucose-lowering medicines: in a small crossover study, a fig leaf decoction with breakfast lowered post-meal glucose and insulin doses were 12% lower, so monitor blood sugar if adding fig leaf products; dried figs also add sugar.
Fig leaf products that contain furanocoumarins: the authors of the fig leaf tea trial caution that, like the furanocoumarins in grapefruit, those in fig leaves could affect the drug-metabolizing enzyme CYP3A4. This has not been tested in people.
Warfarin: dried figs supply some vitamin K (USDA lists about 16 micrograms per 100 g), so keep fig intake steady rather than changing it suddenly.
No formal drug interaction studies of fig fruit or fig leaf in people were found.

Frequently asked questions about Fig (Ficus carica)

Is fig leaf tea the same as eating figs?

No. The fruit and the leaf are different materials with different research. The bowel studies used the fruit, as a paste, whole fruit or a fruit syrup. The leaf was tested as a tea in one 30-person skin trial and as a decoction in one 10-person blood sugar study. The leaves and sap of many varieties also contain furanocoumarins, compounds that make skin react to sunlight.

How many figs did the bowel studies use?

The amounts were large: 300 g a day of fig paste (about 5 g of fiber) for 8 weeks, and about 90 g a day of fig for 4 months. A cholesterol trial added 120 g a day of dried figs, roughly 12 to 15 figs. The fig syrup trial used only about 1.2 g of fig per nightly dose, so syrups and extracts do not translate to whole fruit.

Why can fig sap burn the skin?

The leaves and milky sap of many fig varieties contain furanocoumarins such as psoralen and bergapten. When sap gets on the skin and the skin is then exposed to sunlight, these compounds can cause a burn-like reaction with redness and swelling, sometimes severe enough to need burn-unit care. Gloves and long sleeves help when pruning or picking figs. Eating the fruit is not the concern here.

Can people sensitive to birch pollen or weeping fig eat figs?

They may react. In Austrian allergy clinic studies, most people sensitized to weeping fig or allergic to birch pollen had positive skin tests to fresh fig, and many reported symptoms after eating it. Birch-allergic patients mostly tolerated dried figs, but people sensitized to weeping fig often reacted to dried figs too. Ask an allergist before trying figs.

Are dried figs high in sugar?

Yes. USDA lists about 48 g of sugars and 249 kcal per 100 g of dried figs, compared with about 16 g of sugars in 100 g of fresh figs. In one trial, adding 120 g of dried figs a day raised sugar intake from about 23% to 32% of calories, though body weight did not change significantly over 5 weeks.

What is Fig?

Fig (Ficus carica) is a Mediterranean fruit eaten fresh or dried, and its leaves are also brewed as a tea. This record treats two separate materials: the fruit (fresh, dried, as a paste or syrup, or as a standardized extract) and the leaf.

What is Fig used for?

Fig is researched primarily for Gut Health and Metabolic Health. In an 8-week double-blind trial in 80 Korean adults with functional constipation, 300 g a day of fig paste shortened colon transit time more than a matched placebo paste (by 24.5 vs 15.

What is the recommended dosage of Fig?

The clinically studied dose is Fruit: paste 300 g/day for 8 weeks; about 90 g/day for 4 months; dried figs 120 g/day for 5 weeks; syrup 15 mL nightly (about 1.2 g fig) for 2 weeks; extract 100 to 1,200 mg in one drink. Leaf: tea 500 mL/day for 8 weeks; decoction with breakfast for 1 month. Always follow the product label and check with a healthcare provider for personal advice.

Is Fig safe, and does it have side effects?

Side effects and cautions reported for Fig include: Dried figs are sugar-dense: USDA lists 249 kcal, 64 g of carbohydrate and 48 g of sugars per 100 g. Adding 120 g a day raised sugar intake from about 23% to 32% of calories in one trial, so count dried figs like other dried fruit if you watch sugar or calories. It may also interact with some medications. Fig is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does Fig interact with any medications?

Possible interactions include: Insulin and other glucose-lowering medicines: in a small crossover study, a fig leaf decoction with breakfast lowered post-meal glucose and insulin doses were 12% lower, so monitor blood sugar if adding fig leaf products; dried figs also add sugar. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for Fig?

NutraSmarts rates the evidence for Fig as Limited (2 out of 5). It is backed by 8 study summaries and 16 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(16 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Baek HI, Ha KC, Kim HM, Choi EK, Park EO, Park BH, Yang HJ, Kim MJ, Kang HJ, Chae SW. Randomized, double-blind, placebo-controlled trial of Ficus carica paste for the management of functional constipation. Asia Pac J Clin Nutr. 2016;25(3):487-96. doi: 10.6133/apjcn.092015.06.PubMedUsed to support: Randomized, double-blind, placebo-controlled trial in 80 Korean adults with functional constipation (74 completed): 300 g a day of fig paste (1.7% fiber) for 8 weeks shortened colon transit time more than placebo (24.5 vs 15.0 hours, p = 0.030) and improved Bristol stool form and abdominal discomfort; stool frequency, straining and overall relief did not differ. Co-funded by the paste maker, Yeongam Green Fig Agriculture, and Korean government research bodies.
  2. Pourmasoumi M, Ghiasvand R, Darvishi L, Hadi A, Bahreini N, Keshavarzpour Z. Comparison and Assessment of Flixweed and Fig Effects on Irritable Bowel Syndrome with Predominant Constipation: A Single-Blind Randomized Clinical Trial. Explore (NY). 2019;15(3):198-205. doi: 10.1016/j.explore.2018.09.003.PubMedUsed to support: Randomized trial with only investigators masked in 150 adults with constipation-predominant irritable bowel syndrome: fig or flixweed for 4 months improved pain frequency, distention, stool frequency, hard stools, quality of life and satisfaction with bowel habits versus a control group, but not abdominal pain severity or C-reactive protein. The control group received no placebo.
  3. Valizadeh R, Mohammad-Alizadeh-Charandabi S, Hajizadeh K, Araj-Khodaei M, Mirghafourvand M. The effect of combined fig-Walnut syrup on functional constipation in pregnant women: a randomized controlled trial. Nutr Metab (Lond). 2025;22(1):3. doi: 10.1186/s12986-025-00895-3.PubMedUsed to support: Double-blind randomized trial in 90 pregnant women with functional constipation: 15 mL nightly of a fig fruit syrup or fig-walnut syrup for 14 days gave more bowel movements and better stool consistency, straining and quality of life scores than a placebo syrup, with no difference between the two fig syrups. Funded by Tabriz University of Medical Sciences; one case of diarrhea in each fig group.
  4. Peterson JM, Montgomery S, Haddad E, Kearney L, Tonstad S. Effect of consumption of dried California mission figs on lipid concentrations. Ann Nutr Metab. 2011;58(3):232-8. doi: 10.1159/000330112.PubMedUsed to support: Randomized crossover trial in adults with raised LDL cholesterol (102 randomized, 83 analyzed): adding 120 g a day of dried California Mission figs for 5 weeks did not lower LDL cholesterol; HDL cholesterol and triglycerides did not change, total cholesterol rose slightly, and sugar intake rose from 23.4% to 32.2% of calories. Partly funded by the California Fig Advisory Board, which supplied the figs.
  5. Alshaeri HK, Natto ZS, Tonstad S, Haddad E, Jaceldo-Siegl K. Effect of dried California Mission figs on mineral status and food replacement. Public Health Nutr. 2015;18(6):1135-40. doi: 10.1017/S1368980014001566.PubMedUsed to support: Second report from the same Loma Linda crossover trial (88 completers, 120 g a day of dried figs for 5 weeks), funded by the California Fig Advisory Board: reported dietary calcium, magnesium and potassium intake rose with figs, but blood iron, magnesium, potassium and zinc did not change.
  6. Atkinson FS, Villar A, Mulà A, Zangara A, Risco E, Smidt CR, Hontecillas R, Leber A, Bassaganya-Riera J. Abscisic Acid Standardized Fig (Ficus carica) Extracts Ameliorate Postprandial Glycemic and Insulinemic Responses in Healthy Adults. Nutrients. 2019;11(8):1757. doi: 10.3390/nu11081757.PubMedUsed to support: Randomized, double-blind crossover glycemic index study in 10 healthy adults funded by extract maker Euromed: fig fruit extracts supplying 80 micrograms of abscisic acid lowered the glycemic index of a 50 g glucose drink by about 25% and the insulin index by about 24%; 40 microgram doses lowered the glycemic index by about 14%, not significantly.
  7. Serraclara A, Hawkins F, Pérez C, Domínguez E, Campillo JE, Torres MD. Hypoglycemic action of an oral fig-leaf decoction in type-I diabetic patients. Diabetes Res Clin Pract. 1998;39(1):19-22. doi: 10.1016/s0168-8227(97)00112-5.PubMedUsed to support: Randomized crossover study in 10 adults with type 1 diabetes: a month of fig leaf decoction with breakfast gave lower post-breakfast glucose than a month of commercial tea (156.6 vs 293.7 mg/dL), with no difference in pre-meal glucose and a 12% lower average insulin dose. Two participants dropped out because of intolerance.
  8. Barzkar F, Baradaran HR, Khamseh ME, Vesal Azad R, Koohpayehzadeh J, Moradi Y. Medicinal plants in the adjunctive treatment of patients with type-1 diabetes: a systematic review of randomized clinical trials. J Diabetes Metab Disord. 2020;19(2):1917-1929. doi: 10.1007/s40200-020-00633-x.PubMedUsed to support: Systematic review of 4 randomized trials of medicinal plants in type 1 diabetes, all very small: it reported no significant effect of the fig leaf decoction on HbA1c or fasting glucose, judged blinding at high risk of bias, and noted the crossover had no washout period. The authors concluded no recommendations can be made.
  9. Abe T, Koyama Y, Nishimura K, Okiura A, Takahashi T. Efficacy and Safety of Fig (Ficus carica L.) Leaf Tea in Adults with Mild Atopic Dermatitis: A Double-Blind, Randomized, Placebo-Controlled Preliminary Trial. Nutrients. 2022;14(21):4470. doi: 10.3390/nu14214470.PubMedUsed to support: Double-blind, randomized, placebo-controlled trial in 30 adults with mild atopic dermatitis: 500 mL a day of tea from a furanocoumarin-free fig cultivar for 8 weeks lowered the dermatologist-rated EASI score more than colored water (p = 0.036 at week 8), while the patient-rated POEM score did not differ and the effect faded after stopping. The authors note that many fig varieties contain the phototoxic furanocoumarins psoralen and bergapten and caution about possible CYP3A4 drug interactions.
  10. Amanak K. Effects of Dry Figs on Primary Dysmenorrhea Symptoms, perceived Stress Levels and the Quality of Life. P R Health Sci J. 2020;39(4):319-326..PubMedUsed to support: Randomized trial in midwifery students with primary dysmenorrhea: 6 dried figs a day (about 150 g) on days 1 to 3 of 3 menstrual cycles gave lower self-rated pain severity and duration, menstrual distress and perceived stress, and higher quality of life, than cinnamon (1,260 mg a day) or empty placebo capsules. The placebo did not mask the figs, group sizes differ between sections of the paper, and an erratum was published.
  11. Hemmer W, Focke M, Götz M, Jarisch R. Sensitization to Ficus benjamina: relationship to natural rubber latex allergy and identification of foods implicated in the Ficus-fruit syndrome. Clin Exp Allergy. 2004;34(8):1251-8. doi: 10.1111/j.1365-2222.2004.02046.x.PubMedUsed to support: Of 2,662 patients with a positive skin test to any airborne allergen at a Vienna clinic, 66 (2.5%) reacted to weeping fig (Ficus benjamina) latex. Among those tested, 83% were positive to fresh fig and 37% to dried fig, with clinical reactions mainly to fresh and dried fig and kiwi, including some whole-body reactions; nearly 90% were negative for rubber latex.
  12. Hemmer W, Focke M, Marzban G, Swoboda I, Jarisch R, Laimer M. Identification of Bet v 1-related allergens in fig and other Moraceae fruits. Clin Exp Allergy. 2010;40(4):679-87. doi: 10.1111/j.1365-2222.2010.03486.x.PubMedUsed to support: Skin testing of 188 patients at a Vienna clinic: 78% of those with isolated birch pollen allergy reacted to fresh fig and 10% to dried fig, and two-thirds of fig-positive birch-allergic patients reported symptoms after eating fresh figs while dried figs were mostly tolerated. Fig, mulberry and jackfruit contain allergens related to the birch allergen Bet v 1.
  13. Mansilla-Polo M, Martín-Torregrosa D, Abril-Pérez C, Botella-Estrada R. Phytophotodermatitis as a clinical problem and as a therapeutic option: Case report and review of the literature. Photodiagnosis Photodyn Ther. 2023;41:103304. doi: 10.1016/j.pdpdt.2023.103304.PubMedUsed to support: Case report and literature review: a 28-year-old man developed severe phytophotodermatitis needing burn-unit care after handling a fig tree with widespread sun exposure. Phytophotodermatitis is caused by plant furanocoumarins (psoralens), notably from citrus and fig trees; fig latex is also used traditionally on warts without scientific evaluation.
  14. Leber A, Hontecillas R, Tubau-Juni N, Zoccoli-Rodriguez V, Goodpaster B, Bassaganya-Riera J. Abscisic acid enriched fig extract promotes insulin sensitivity by decreasing systemic inflammation and activating LANCL2 in skeletal muscle. Sci Rep. 2020;10(1):10463. doi: 10.1038/s41598-020-67300-2.PubMedUsed to support: Mouse and cell study: an abscisic acid-enriched fig fruit extract improved glucose tolerance, insulin sensitivity and fasting blood glucose in obese and db/db mice, and the effect was lost in mice lacking the LANCL2 receptor in skeletal muscle. The senior author is a shareholder of BioTherapeutics, Inc. Laboratory and animal work, not human outcomes.
  15. U.S. Department of Agriculture, Agricultural Research Service. FoodData Central, SR Legacy: Figs, dried, uncooked (FDC ID 174665) and Figs, raw (FDC ID 173021). USDA FoodData Central. 2019;SR Legacy, published April 2019; accessed 2026..SourceUsed to support: Not PubMed-indexed; official USDA nutrient database. Per 100 g, dried figs: 249 kcal, 63.87 g carbohydrate, 47.92 g total sugars, 9.8 g dietary fiber, 680 mg potassium, 162 mg calcium, 68 mg magnesium, 2.03 mg iron, 15.6 micrograms vitamin K. Raw figs: 74 kcal, 19.18 g carbohydrate, 16.26 g sugars, 2.9 g fiber.
  16. Pourmasoumi M; Isfahan University of Medical Sciences. Effect of Flixweed and Fig on Irritable Bowel Syndrome With Predominant Constipation: a Single Blind Randomized Clinical Trial. ClinicalTrials.gov NCT02559245. ClinicalTrials.gov. 2015;NCT02559245; first posted September 2015, last updated May 2018; accessed 2026..SourceUsed to support: Not PubMed-indexed; trial registration for the Isfahan fig and flixweed trial. Fig arm: 45 g before breakfast and before lunch (90 g/day); control arm: usual diet with no intervention; masking of investigators only; 150 enrolled.