Benefits
Fasting blood sugar and blood lipids in a 40-person capsule trial
Forty adults with type 2 diabetes who stayed on their usual tablets took 1, 2 or 3 g a day of ground bay leaf or a corn flour placebo for 30 days, 10 per group. Fasting glucose fell 21 to 26% and LDL cholesterol 32 to 40% within the bay leaf groups, with no significant change on placebo. Higher doses did no better, blinding is not described, and no larger trial has followed.
Blood glucose after a carbohydrate meal with bay leaf baked in
In a randomized crossover test, 20 healthy adults ate cookies with 50 g of carbohydrate containing 0%, 3% or 6% bay leaf powder. Blood glucose was lower with the 6% cookie at 30 and 45 minutes, but the overall 2-hour glucose response did not differ between cookies. Appetite did not change and no digestive discomfort was reported.
HDL cholesterol in healthy adults drinking bay leaf tea
Thirty healthy adults aged 20 to 57 drank a tea made from 5 g of dried bay leaves in 100 ml of water once a day for 10 days. HDL cholesterol rose slightly from the start, while LDL cholesterol and triglycerides did not change significantly. There was no control group, so the change cannot be firmly credited to the tea.
Self-rated stress and blood cortisol in a 10-day tea study
Using the same tea and schedule in 30 healthy adults, the same research group reported lower plasma cortisol and lower scores on standard stress (PSS) and anxiety (STAI) questionnaires after 10 days. With no placebo or control group, expectation and repeat testing could explain much of the change.
Insulin-like activity of leaf extracts in laboratory tests
In a US Department of Agriculture screen of 49 herbs, spices and medicinal plants, bay leaf extract increased insulin-dependent glucose use in rat fat cells, and the effect disappeared when phenolic compounds were removed. Cinnamon was the most active plant in the same screen. These are cell results and do not show an effect in people.
Mechanism of action
Leaf chemistry: aroma oil and sesquiterpene lactones
The leaf's essential oil is dominated by 1,8-cineole. The leaf also contains sesquiterpene lactones such as costunolide, which in rats reduced the rise in blood alcohol after an alcohol dose without affecting glucose absorption, and which is also a strong skin allergen. Phenolic compounds appear to carry the insulin-like activity seen in cell tests.
Insulin signaling in liver cells under high glucose
In human liver cells (HepG2) exposed to high glucose and high insulin, pretreatment with an ethanol extract of the leaf lowered reactive oxygen species and markers of cell death and inflammation, and raised the expression of insulin-signaling genes (IRS1, IRS2, INSR). This is a single cell-culture model, not a clinical outcome.
Inflammasome signaling in immune cells
In mouse immune cells, a leaf extract and its main oil component 1,8-cineole suppressed activation of the NLRP3 inflammasome and the release of interleukin-1 beta, and the extract lowered inflammatory cytokines in a mouse lung injury model. These findings have not been tested in people taking bay leaf by mouth.
Clinical trials
Randomized, placebo-controlled trial of 1, 2 or 3 g a day of ground bay leaf in 500 mg capsules, or corn flour placebo, for 30 days followed by a 10-day washout; blinding is not described, and the placebo group took 2 capsules a day while the 2 g and 3 g groups took 4 and 6. (Khan et al. 2009, J Clin Biochem Nutr)
40 adults aged 40 or older with type 2 diabetes in Peshawar, Pakistan (18 men, 22 women), 10 per group, not on insulin and continuing their sulfonylurea and metformin tablets.
After 30 days, fasting glucose was 21 to 26% lower than at the start in all three bay leaf groups, total cholesterol 20 to 24% lower and LDL cholesterol 32 to 40% lower; HDL rose and triglycerides fell in the 1 g and 2 g groups. The placebo group showed no significant change. There was no dose response from 1 to 3 g, significance was reported within groups, the 3 g group started with higher HDL, and HbA1c was not measured.
Randomized crossover study comparing plain wheat cookies with cookies containing 3% or 6% bay leaf powder by weight, each providing 50 g of available carbohydrate, eaten at breakfast 1 to 2 weeks apart. (Khan et al. 2017, J Am Coll Nutr)
20 healthy adults.
Blood glucose was significantly lower after the 6% bay leaf cookie than the plain cookie at 30 and 45 minutes, but the incremental area under the 2-hour glucose curve did not differ among the three cookies (p = 0.411). Appetite ratings did not differ, all cookies were rated acceptable, and no digestive discomfort was reported.
Single-group before-and-after study, with no control group, of a tea made from 5 g of dried bay leaves in 100 ml of boiled water once a day for 10 days. (Chbili et al. 2020, J Am Coll Nutr)
30 healthy Tunisian volunteers aged 20 to 57.
HDL cholesterol rose significantly between day 0 and day 11 (p = 0.01). LDL cholesterol and triglycerides fell slightly, a change the authors describe as not statistically significant. With no control group and only 10 days of use, the HDL change cannot be firmly attributed to the tea; the authors call for larger and longer studies.
Single-group before-and-after study, with no control group, using the same tea (5 g of dried leaves in 100 ml of boiled water once a day for 10 days). (Chbili et al. 2022, Arch Ital Biol)
30 healthy Tunisian volunteers aged 20 to 57.
Plasma cortisol fell between day 0 and day 11 (p = 0.001), and scores on the PSS stress and STAI anxiety questionnaires also fell (p = 0.006 and p = 0.002). With no placebo or control group, expectation and repeat testing may account for part of these changes; the authors call for larger and longer studies.