Blackcurrant Extract (Ribes nigrum Fruit)

Ribes nigrum
Evidence Level
Moderate
8 Clinical Trials
6 Documented Benefits
3/5 Evidence Score

Blackcurrant extract is a concentrated powder made from the fruit of the blackcurrant bush (Ribes nigrum) and standardized for anthocyanins, the dark purple pigments of the berry. Four anthocyanins make up nearly all of them: the rutinoside and glucoside forms of delphinidin and cyanidin. Most human research used New Zealand blackcurrant extract, usually 300 to 600 mg a day of a powder that is about 35% anthocyanins. Small trials in active adults have tested endurance and sprint performance, fat use during exercise and muscle recovery; pooled results show a small performance benefit, but several trials found no effect. Other small, short studies looked at blood sugar after meals, blood flow, artery stiffness and eye fatigue after screen work. This page covers the fruit extract only. Black currant seed oil, a source of the fatty acid GLA, is a separate ingredient.

Studied Dose Sports trials: 300 to 600 mg/day of New Zealand blackcurrant extract (about 105 to 210 mg anthocyanins), usually for 7 days before exercise. Blood sugar: 600 mg/day extract for 8 days. Products differ in strength, so compare mg of anthocyanins, not grams of powder.
Active Compound Anthocyanins, mainly delphinidin-3-rutinoside and cyanidin-3-rutinoside with smaller amounts of their glucosides; New Zealand extract powders used in trials supply about 35% anthocyanins.

Benefits

Endurance and repeated-sprint exercise performance

A meta-analysis of 9 small placebo-controlled trials found a small average performance gain of about 0.45% with 105 to 210 mg of anthocyanins taken before exercise. A newer review of 21 crossover trials rated the certainty as low: effects were clearest in repeated sprints and smaller and variable in endurance cycling, and one trial in 16 trained cyclists found no effect.

Fat use during moderate exercise

Pooling 15 controlled studies in 226 active adults, blackcurrant extract raised fat burning during exercise by about 0.04 g per minute on average and lowered carbohydrate use. The reviewers noted that responses differed by person, sex, training status, dose and length of use. This is a shift in fuel use during exercise, not evidence of weight or fat loss.

Muscle soreness and recovery after hard exercise

In a trial of 27 adults not used to resistance training, 3 g a day of extract for 8 days before and 4 days after a hard arm workout gave faster return of strength, about half the soreness at 24 and 48 hours, and lower creatine kinase (a muscle damage marker) at 96 hours. In 20 recreational runners, 600 mg a day made no difference to recovery after a half-marathon.

Blood sugar and insulin response after meals

In a crossover trial in 23 adults, a drink with extract supplying 600 mg of anthocyanins lowered the early rise in blood sugar and insulin after a high-carbohydrate meal, while 150 and 300 mg did not. In 13 adults with overweight or obesity, 600 mg a day of extract for 8 days improved insulin sensitivity and trimmed post-meal glucose, but a single dose did not. Both studies were small and short.

Blood flow and artery stiffness

In 14 adults in their early 70s, 600 mg a day of extract for 7 days lowered pulse-wave velocity (a measure of artery stiffness) and central blood pressure more than placebo. A blackcurrant drink taken with a high-fat meal improved blood vessel dilation in 23 healthy adults. These were short studies of markers, not of heart health outcomes.

Eye fatigue after screen work

In one small crossover study in healthy adults, the shift in eye focus after a screen task was smaller with 50 mg of blackcurrant anthocyanins than with placebo, but only borderline and not statistically significant; eye-strain symptom scores did improve. Dark adaptation improved after 50 mg in 12 people versus their own pre-dose values. It is a single, older study.

Mechanism of action

1

Delphinidin and cyanidin anthocyanins and their breakdown products

Delphinidin-3-rutinoside, cyanidin-3-rutinoside and their glucoside forms typically make up about 97 to 98% of the berry's anthocyanins. In a human beverage trial, blood levels of breakdown products such as hippuric acid and isovanillic acid predicted the change in blood vessel dilation, which suggests these metabolites, not only the intact pigments, may be active.

2

Relaxation of blood vessel walls

In a rat hind-limb model, blackcurrant concentrate lowered resistance to blood flow through the vessel lining, using nitric oxide, hydrogen peroxide and potassium channels, with two delphinidin anthocyanins doing most of the work. In a small human study, a single dose kept forearm blood flow up during prolonged sitting, with no difference from placebo in blood nitrite, nitrate or endothelin-1, so the pathway in people is unclear.

3

Shift in fuel use during exercise

Pooled exercise studies show more fat and less carbohydrate burned at moderate intensity after several days of extract. One proposed explanation is that better blood flow to working muscle changes the delivery of fuel, but this has not been confirmed in people.

4

Blunted early sugar and gut hormone response

With a high-carbohydrate meal, the 600 mg anthocyanin drink lowered early blood sugar and insulin along with GIP, a gut hormone released as sugar is absorbed. This pattern fits slower sugar uptake from the gut, but the trial did not measure absorption directly.

Clinical trials

1
New Zealand Blackcurrant and Sport Performance: Meta-Analysis of 9 Trials
PubMed

Systematic review of 16 randomized placebo-controlled trials of New Zealand blackcurrant products, 9 of which were pooled in a meta-analysis of sport performance; searches ran to August 2019 (Braakhuis et al. 2020, J Int Soc Sports Nutr).

Healthy human participants in small randomized placebo-controlled trials, mostly exercise performance tests.

Performance improved by a pooled 0.45% (95% CI 0.09 to 0.81, p = 0.01), with an apparent effective dose of 105 to 210 mg of anthocyanins before exercise. Too few studies reported oxidative markers, cognition or side effects to draw conclusions. A published correction disclosed that one author holds roles with organizations that could benefit from blackcurrant sports products, and that adding an excluded low-oxygen trial gives 0.41%.

2
7 Days of Extract and a 16.1 km Cycling Time Trial (crossover RCT)
PubMed

Randomized, double-blind, placebo-controlled crossover trial of New Zealand blackcurrant extract (CurraNZ, 300 mg/day providing 105 mg anthocyanins) for 7 days with a 14-day washout (Cook et al. 2015, Eur J Appl Physiol).

14 trained male cyclists, mean age 38.

The 16.1 km time trial was 2.4% faster with extract (1678 vs 1722 seconds, P < 0.05), and fat oxidation at 65% of VO2max was 27% higher. Blood lactate was higher right after the time trial. One small study in men only.

3
Single Dose or 7 Days of Extract in Trained Cyclists: No Effect (crossover RCT)
PubMed

Placebo-controlled, double-blind, randomized crossover trial testing a single dose and 7 days of blackcurrant extract at 4.3 mg anthocyanins per kg body weight a day (about 315 mg on average), registered as ACTRN12622001277730 (Morton et al. 2025, Eur J Sport Sci).

16 trained cyclists (10 men, 6 women), mean age 37, each completing a maximal incremental test and a 4 km time trial.

Neither the single dose nor 7 days of extract changed cycling performance or the measured physiological and metabolic responses (p > 0.05); any differences were trivial to small. This null result came from a group that included the lead author of the earlier positive meta-analysis.

4
Extract and Recovery from Muscle-Damaging Arm Exercise (parallel RCT)
PubMed

Double-blind, randomized, placebo-controlled parallel trial of New Zealand blackcurrant extract 3 g/day for 8 days before and 4 days after exercise; the manufacturer supplied the capsules but, per the authors, had no role in design, analysis or writing (Hunt et al. 2021, Nutrients).

27 healthy men and women not used to resistance training (14 extract, 13 placebo), doing 60 strenuous biceps contractions.

Strength returned to baseline faster (p = 0.04), soreness was lower at 24 hours (21 vs 40 mm) and 48 hours (22 vs 44 mm), and creatine kinase was lower at 96 hours (p = 0.04). A small trial with a wide spread in the creatine kinase values.

5
Extract and Recovery After a Half-Marathon: No Effect (RCT)
PubMed

Randomized, double-blind, placebo-controlled independent-groups trial of New Zealand blackcurrant extract (CurraNZ) 600 mg/day for 7 days before and 2 days after a half-marathon (Costello et al. 2020, Int J Sport Nutr Exerc Metab).

20 recreational runners (8 women), mean age 30.

No effect on recovery of jump performance or on perceived muscle soreness and fatigue over 48 hours. Urine interleukin-6, an inflammation marker, rose at 48 hours in the extract group only.

6
Insulin Sensitivity and Post-Meal Glucose in Adults with Overweight (two small RCTs)
PubMed

Two double-blind randomized placebo-controlled trials of New Zealand blackcurrant extract 600 mg: a single dose before a high-carbohydrate, high-fat liquid meal, and 8 days of daily intake with continuous glucose monitoring (Nolan et al. 2021, Eur J Nutr).

25 sedentary adults with overweight or obesity (12 in the single-dose trial, 13 in the 8-day trial).

A single dose had no effect on 3-hour glucose, insulin or triglyceride responses. After 8 days, insulin sensitivity was 22% better than with placebo (P = 0.011), C-reactive protein was lower, and free-living glucose rises after breakfast and lunch were 9% and 8% smaller. Very small groups over about a week.

7
Blackcurrant Extract Drinks and Post-Meal Blood Sugar: Dose Comparison (crossover RCT)
PubMed

Randomized, double-blind crossover trial of low-sugar fruit drinks with blackcurrant extract providing 150, 300 or 600 mg anthocyanins, or no extract, taken just before a high-carbohydrate meal; three co-authors worked for GlaxoSmithKline (one) and Suntory Beverage and Food (two) (Castro-Acosta et al. 2016, J Nutr Biochem).

23 men and postmenopausal women, mean age 46.

Only the 600 mg drink lowered the early (first 30 minutes) rise in blood glucose and insulin and reduced GIP; the 150 and 300 mg drinks did not differ from control. No effect on an oxidative stress marker or on vascular function. This tested a drink with extract, roughly equal to 100 g of blackcurrants, not capsules.

8
7 Days of Extract and Artery Stiffness in Older Adults (crossover RCT)
PubMed

Randomized, double-blind, placebo-controlled crossover trial with a 28-day washout; two 300 mg capsules a day of New Zealand blackcurrant extract for 7 days (Okamoto et al. 2020, Clin Exp Hypertens).

14 older adults, mean age 73.

Carotid-femoral pulse-wave velocity (central artery stiffness) and central blood pressure fell more with extract than with placebo (P = .04 and P = .001). Blood lipids did not change. One small, one-week study of markers.

Side effects and drug interactions

Common Potential side effects

No serious harmful effects were reported in the short trials (mostly 1 to 2 weeks); a 2020 review noted minor stomach upset in 2 of 24 people in one drink study and found too few studies reported side effects to judge safety properly. Long-term safety of concentrated extracts has not been studied.
There is no safety research in pregnancy or breastfeeding; avoid concentrated extracts then unless a doctor agrees.
Some blackcurrant drinks and purees contain added sugar; check the label if you are watching sugar intake.

Important Drug interactions

Diabetes medicines (including insulin and sulfonylureas): blackcurrant extract lowered post-meal glucose and insulin in small trials, so an additive effect on blood sugar is possible; check your levels and talk to your doctor.
Blood pressure medicines: one small trial in older adults found lower central blood pressure after 7 days; tell your doctor if you take blood pressure drugs.
Blood thinners and antiplatelet drugs (such as warfarin, aspirin or clopidogrel): a blackcurrant drink showed a non-significant trend toward reduced platelet clumping in one trial; no interaction studies exist, so ask your doctor before combining.
No formal drug interaction studies have been done for blackcurrant extract.

Frequently asked questions about Blackcurrant Extract (Ribes nigrum Fruit)

Is blackcurrant extract the same as black currant seed oil?

No. The fruit extract supplies anthocyanins, the purple pigments studied for exercise, blood sugar and blood flow. Black currant seed oil comes from the seeds and supplies fatty acids such as GLA. They are separate ingredients with separate research, so check which one a product contains.

How much did the studies use?

Most exercise trials used 300 to 600 mg a day of New Zealand blackcurrant extract, which supplies roughly 105 to 210 mg of anthocyanins, often taken daily for about a week before testing. The blood sugar study used 600 mg a day for 8 days. Extracts vary in strength, so compare the mg of anthocyanins on the label rather than the weight of powder.

Does a single dose before exercise work?

The evidence is mixed. Several positive trials, such as the cycling time-trial study, gave the extract daily for 7 days. One trial in trained cyclists found no effect from either a single dose or 7 days, and in adults with overweight a single dose did not change blood sugar after a meal while 8 days of use did.

Can I get the same effect from blackcurrants or blackcurrant juice?

Possibly in part. The 600 mg anthocyanin drink that lowered post-meal blood sugar was estimated to equal about 100 g of blackcurrants, and 75 g of blackcurrant puree eaten with added sugars gave a smaller early blood sugar rise than the same sugars in water. Many commercial blackcurrant drinks contain added sugar, so check the label and the anthocyanin content.

How does this relate to VitaCurrant?

VitaCurrant is a branded blackcurrant fruit extract standardized for anthocyanins, so it is one form of this ingredient. The trials on this page used other blackcurrant extracts, mostly New Zealand extract powders, not VitaCurrant itself.

What is Blackcurrant Extract?

Blackcurrant extract is a concentrated powder made from the fruit of the blackcurrant bush (Ribes nigrum) and standardized for anthocyanins, the dark purple pigments of the berry. Four anthocyanins make up nearly all of them: the rutinoside and glucoside forms of delphinidin and cyanidin.

What is Blackcurrant Extract used for?

Blackcurrant Extract is researched primarily for Athletic Performance, Muscle & Recovery, and Metabolic Health. A meta-analysis of 9 small placebo-controlled trials found a small average performance gain of about 0.45% with 105 to 210 mg of anthocyanins taken before exercise.

What is the recommended dosage of Blackcurrant Extract?

The clinically studied dose is Sports trials: 300 to 600 mg/day of New Zealand blackcurrant extract (about 105 to 210 mg anthocyanins), usually for 7 days before exercise. Blood sugar: 600 mg/day extract for 8 days. Always follow the product label and check with a healthcare provider for personal advice.

Is Blackcurrant Extract safe, and does it have side effects?

For most healthy adults, Blackcurrant Extract is well tolerated at studied doses. Reported effects can include: No serious harmful effects were reported in the short trials (mostly 1 to 2 weeks); a 2020 review noted minor stomach upset in 2 of 24 people in one drink study and found too few studies reported side effects to judge safety properly. It may also interact with some medications. Blackcurrant Extract is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does Blackcurrant Extract interact with any medications?

Possible interactions include: Diabetes medicines (including insulin and sulfonylureas): blackcurrant extract lowered post-meal glucose and insulin in small trials, so an additive effect on blood sugar is possible; check your levels and talk to your doctor. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for Blackcurrant Extract?

NutraSmarts rates the evidence for Blackcurrant Extract as Moderate (3 out of 5). It is backed by 8 clinical trials and 16 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(16 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Braakhuis AJ, Somerville VX, Hurst RD. The effect of New Zealand blackcurrant on sport performance and related biomarkers: a systematic review and meta-analysis. J Int Soc Sports Nutr. 2020;17(1):25. doi: 10.1186/s12970-020-00354-9.PubMedUsed to support: Systematic review of 16 placebo-controlled trials of New Zealand blackcurrant, 9 pooled: a small improvement in sport performance (0.45%, 95% CI 0.09 to 0.81), apparent effective dose 105 to 210 mg anthocyanins before exercise; too few studies reported side effects. A 2021 correction (PMID 33430883) disclosed one author's ties to organizations that could benefit from blackcurrant sports products.
  2. Gholamian S, Ebrahimi S, Razmdideh A, Shariatzadeh M, Moeini ER. Effect of New Zealand Blackcurrant Supplementation on Sports Performance: A Systematic Review. Curr Dev Nutr. 2026;10(7):109388. doi: 10.1016/j.cdnut.2026.109388.PubMedUsed to support: Systematic review of 21 randomized crossover trials: small-to-moderate average effect on sport performance (d = 0.44), largest in repeated high-intensity efforts, smaller and variable in cycling and absent in low oxygen; certainty was low for performance and moderate for metabolic outcomes such as fat oxidation.
  3. Cook MD, Bateman JJ, Willems MET. Blackcurrant Anthocyanin Supplementation Alters Exercise-Induced Substrate Utilization - A Systematic Review and Meta-Analysis. J Diet Suppl. 2026;23(2):290-305. doi: 10.1080/19390211.2026.2624114.PubMedUsed to support: Meta-analysis of 15 controlled studies in 226 active adults: blackcurrant extract increased fat oxidation (0.042 g per minute) and decreased carbohydrate oxidation during exercise, with responses varying by training status, sex, dose and duration.
  4. Cook MD, Myers SD, Blacker SD, Willems ME. New Zealand blackcurrant extract improves cycling performance and fat oxidation in cyclists. Eur J Appl Physiol. 2015;115(11):2357-65. doi: 10.1007/s00421-015-3215-8.PubMedUsed to support: Crossover RCT in 14 trained male cyclists: 300 mg/day CurraNZ (105 mg anthocyanins) for 7 days improved 16.1 km time-trial performance by 2.4% and raised fat oxidation at 65% VO2max by 27%.
  5. Morton LC, Paton CD, Aberkane R, Braakhuis AJ. No Effect of Acute or Chronic New Zealand Blackcurrant Extract on Cycling Performance or Physiological Responses in Trained Cyclists. Eur J Sport Sci. 2025;25(3):e12267. doi: 10.1002/ejsc.12267.PubMedUsed to support: Registered crossover RCT in 16 trained cyclists: neither a single dose nor 7 days of blackcurrant extract changed 4 km time-trial performance or physiological responses.
  6. Hunt JEA, Coelho MOC, Buxton S, Butcher R, Foran D, Rowland D, Gurton W, Macrae H, Jones L, Gapper KS, Manders RJF, King DG. Consumption of New Zealand Blackcurrant Extract Improves Recovery from Exercise-Induced Muscle Damage in Non-Resistance Trained Men and Women: A Double-Blind Randomised Trial. Nutrients. 2021;13(8):2875. doi: 10.3390/nu13082875.PubMedUsed to support: Parallel RCT in 27 untrained adults: 3 g/day New Zealand blackcurrant extract for 8 days before and 4 days after damaging arm exercise sped strength recovery and lowered soreness at 24 and 48 hours and creatine kinase at 96 hours. Capsules supplied by the manufacturer.
  7. Costello R, Willems MET, Myers SD, Myers F, Lewis NA, Lee BJ, Blacker SD. No Effect of New Zealand Blackcurrant Extract on Recovery of Muscle Damage Following Running a Half-Marathon. Int J Sport Nutr Exerc Metab. 2020;30(4):287-294. doi: 10.1123/ijsnem.2019-0312.PubMedUsed to support: RCT in 20 recreational runners: 600 mg/day New Zealand blackcurrant extract around a half-marathon did not change recovery of jump performance, soreness or fatigue.
  8. Nolan A, Brett R, Strauss JA, Stewart CE, Shepherd SO. Short-term, but not acute, intake of New Zealand blackcurrant extract improves insulin sensitivity and free-living postprandial glucose excursions in individuals with overweight or obesity. Eur J Nutr. 2021;60(3):1253-1262. doi: 10.1007/s00394-020-02329-7.PubMedUsed to support: Two small RCTs in adults with overweight or obesity: a single 600 mg dose did not change post-meal glucose, but 8 days of 600 mg/day improved insulin sensitivity by 22% and reduced free-living post-meal glucose rises by 8 to 9%.
  9. Castro-Acosta ML, Smith L, Miller RJ, McCarthy DI, Farrimond JA, Hall WL. Drinks containing anthocyanin-rich blackcurrant extract decrease postprandial blood glucose, insulin and incretin concentrations. J Nutr Biochem. 2016;38:154-161. doi: 10.1016/j.jnutbio.2016.09.002.PubMedUsed to support: Crossover RCT in 23 adults: a drink with blackcurrant extract supplying 600 mg anthocyanins, but not 150 or 300 mg, lowered early post-meal glucose, insulin and GIP; no effect on vascular function. Three co-authors were from GlaxoSmithKline (one) and Suntory (two).
  10. Lappi J, Raninen K, Väkeväinen K, Kårlund A, Törrönen R, Kolehmainen M. Blackcurrant (Ribes nigrum) lowers sugar-induced postprandial glycaemia independently and in a product with fermented quinoa: a randomised crossover trial. Br J Nutr. 2021;126(5):708-717. doi: 10.1017/S0007114520004468.PubMedUsed to support: Crossover trial in 26 healthy adults: 75 g of blackcurrant puree with added sugars, alone or in a fermented quinoa product, lowered early blood glucose and insulin compared with sugar water. A whole-fruit food study, not an extract.
  11. Okamoto T, Hashimoto Y, Kobayashi R, Nakazato K, Willems MET. Effects of blackcurrant extract on arterial functions in older adults: A randomized, double-blind, placebo-controlled, crossover trial. Clin Exp Hypertens. 2020;42(7):640-647. doi: 10.1080/10641963.2020.1764015.PubMedUsed to support: Crossover RCT in 14 adults with mean age 73: 7 days of New Zealand blackcurrant extract (two 300 mg capsules a day) reduced carotid-femoral pulse-wave velocity and central blood pressure compared with placebo; no change in blood lipids.
  12. Amini AM, Zhou R, Austermann K, Králová D, Serra G, Ibrahim IS, Corona G, Bergillos-Meca T, Aboufarrag H, Kroon PA, Spencer JP, Yaqoob P. Acute Effects of an Anthocyanin-Rich Blackcurrant Beverage on Markers of Cardiovascular Disease Risk in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial. J Nutr. 2025;155(7):2275-2289. doi: 10.1016/j.tjnut.2025.05.017.PubMedUsed to support: Crossover RCT in 23 healthy adults: a 200 mL blackcurrant drink with 711 mg anthocyanins, taken with high-fat meals, improved flow-mediated dilation over 6 hours versus placebo; platelet effects were only a trend, and blood pressure findings were exploratory. Plasma phenolic metabolites predicted the response. One author reported employment with GlaxoSmithKline Consumer Health and Haleon, and the senior author reported GlaxoSmithKline funding.
  13. Barnes MJ, Perry BG, Hurst RD, Lomiwes D. Anthocyanin-Rich New Zealand Blackcurrant Extract Supports the Maintenance of Forearm Blood-Flow During Prolonged Sedentary Sitting. Front Nutr. 2020;7:74. doi: 10.3389/fnut.2020.00074.PubMedUsed to support: Crossover study in 10 healthy men: a single dose of New Zealand blackcurrant extract (1.87 mg anthocyanins per kg) maintained forearm blood flow during 2 hours of sitting, with no difference from placebo in blood pressure, plasma nitrite, nitrate or endothelin-1, and did not improve handgrip exercise.
  14. Nakaishi H, Matsumoto H, Tominaga S, Hirayama M. Effects of black current anthocyanoside intake on dark adaptation and VDT work-induced transient refractive alteration in healthy humans. Altern Med Rev. 2000;5(6):553-62..PubMedUsed to support: Small double-blind, placebo-controlled crossover study in healthy adults: 50 mg blackcurrant anthocyanins lowered the dark-adaptation threshold versus pre-dose values (n = 12); after screen work the focusing shift was smaller than with placebo but only borderline (p = 0.064, n = 21); eye-strain questionnaire scores improved. An erratum was published (Altern Med Rev 2001;6(1):60).
  15. Šimerdová B, Bobríková M, Lhotská I, Kaplan J, Křenová A, Šatínský D. Evaluation of Anthocyanin Profiles in Various Blackcurrant Cultivars over a Three-Year Period Using a Fast HPLC-DAD Method. Foods. 2021;10(8):1745. doi: 10.3390/foods10081745.PubMedUsed to support: Lab analysis of 14 blackcurrant cultivars and one gooseberry hybrid: delphinidin-3-rutinoside (36.7 to 63.6%) and cyanidin-3-rutinoside (26.4 to 40.6%) were the main anthocyanins, with smaller shares of their glucosides; the paper notes these four usually make up about 97 to 98% of blackcurrant anthocyanins.
  16. Iwasaki-Kurashige K, Loyaga-Rendon RY, Matsumoto H, Tokunaga T, Azuma H. Possible mediators involved in decreasing peripheral vascular resistance with blackcurrant concentrate (BC) in hind-limb perfusion model of the rat. Vascul Pharmacol. 2006;44(4):215-23. doi: 10.1016/j.vph.2005.12.001.PubMedUsed to support: Rat hind-limb experiment (animal and lab work only): blackcurrant concentrate lowered vascular resistance through endothelial nitric oxide, hydrogen peroxide and potassium channels, with two delphinidin anthocyanins as the main active components.