Home Ingredients Bergacyn® (Bergamot and Cardoon Extract — Bionap)
CardiovascularMetabolic Health

Bergacyn® (Bergamot and Cardoon Extract — Bionap)

Citrus bergamia
Evidence Level
Moderate
1 Clinical Trial
3 Documented Benefits
3/5 Evidence Score

Bergacyn® is a branded combination from Bionap that pairs bergamot (Citrus bergamia) polyphenols with cardoon (Cynara cardunculus) extract. The two plants are combined for a synergistic effect on lipids, liver fat, and vascular health, and the blend has been studied for metabolic and cardiovascular outcomes.

Studied Dose Around 600 mg per day of the combined extract.
Active Compound A standardized combination of bergamot (Citrus bergamia) flavonoid polyphenols and cardoon (Cynara cardunculus) extract rich in chlorogenic acids and luteolin.

Benefits

Lipids and metabolic support

The bergamot and cardoon combination is studied for improving cholesterol and triglyceride profiles and supporting metabolic health beyond either plant alone.

Supported by Trial 1

Liver fat support

Both bergamot and cardoon are researched for supporting healthy liver fat levels, relevant to fatty-liver-prone metabolic profiles.

Supported by Trial 1

Vascular health

The polyphenol blend supports endothelial function and vascular health through antioxidant and lipid-modulating actions.

Supported by Trial 1

Mechanism of action

1

Synergistic polyphenols

Bergamot flavonoids and cardoon chlorogenic acids act on complementary pathways in lipid metabolism and oxidative stress, producing a combined effect.

2

Lipid and antioxidant modulation

The extracts reduce oxidative modification of lipids and support healthier cholesterol handling in the liver and blood vessels.

Clinical trials

1
Bergamot and Cardoon Combination — Study
PubMed

Study of the synergistic effect of Citrus bergamia and Cynara cardunculus extracts on vascular and metabolic outcomes. (Musolino et al. 2020, Journal of Traditional and Complementary Medicine)

Adults.

The combination improved vascular and lipid-related measures, supporting the rationale for pairing bergamot with cardoon.

Side effects and drug interactions

Common Potential side effects

GENERALLY WELL-TOLERATED — mild digestive upset is occasionally reported.
Cardoon may stimulate bile flow; those with bile-duct obstruction should avoid it.
Citrus-sensitive individuals should start at a low dose.

Important Drug interactions

Statins and lipid drugs — possible additive effect; monitor with your doctor.
Bile or gallbladder conditions — cardoon stimulates bile; use caution.
Drugs metabolized by CYP enzymes — citrus polyphenols may interact.

More Cardiovascular Ingredients

Cardiovascular
Niacin
Niacin, or vitamin B3, is a vital nutrient that supports energy production by serving as a…
Cardiovascular
Omega-3 Fatty Acids
Omega-3 fatty acids, primarily eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), an…
Cardiovascular
Potassium
Potassium is the most abundant intracellular cation in the human body and an essential min…
Cardiovascular
Pycnogenol® (French Maritime Pine Bark)
Pycnogenol® (Horphag Research) is a standardized extract from the bark of French maritime…

Explore Other Ingredients

Antioxidant
Dandelion Root
Dandelion root is one of the most widely used hepatic and diuretic herbs in Western botani…
Antioxidant
Milk Thistle
Milk thistle, derived from the Silybum marianum plant, contains silymarin, a compound know…
Antioxidant
Setria® Glutathione
Setria® is Kyowa Hakko's patented reduced L-glutathione (GSH) produced via fermentation —…

Frequently asked questions about Bergacyn® (Bergamot and Cardoon Extract — Bionap)

What is Bergacyn® (Bergamot and Cardoon Extract — Bionap)?

Bergacyn® is a branded combination from Bionap that pairs bergamot (Citrus bergamia) polyphenols with cardoon (Cynara cardunculus) extract. The two plants are combined for a synergistic effect on lipids, liver fat, and vascular health, and the blend has been studied for metabolic and cardiovascular outcomes.

What is the recommended dosage of Bergacyn® (Bergamot and Cardoon Extract — Bionap)?

The clinically studied dose for Bergacyn® (Bergamot and Cardoon Extract — Bionap) is Around 600 mg per day of the combined extract.. Always follow product labeling and consult a healthcare provider for personalized dosing recommendations.

What is Bergacyn® (Bergamot and Cardoon Extract — Bionap) used for?

Bergacyn® (Bergamot and Cardoon Extract — Bionap) is studied for lipids and metabolic support, liver fat support, vascular health. The bergamot and cardoon combination is studied for improving cholesterol and triglyceride profiles and supporting metabolic health beyond either plant alone.

Are there side effects from taking Bergacyn® (Bergamot and Cardoon Extract — Bionap)?

Reported potential side effects may include: GENERALLY WELL-TOLERATED — mild digestive upset is occasionally reported. Cardoon may stimulate bile flow; those with bile-duct obstruction should avoid it. Always consult a healthcare provider before starting any new supplement, especially if you have underlying conditions or take medications.

Is Bergacyn® (Bergamot and Cardoon Extract — Bionap) safe to take?

Whether Bergacyn® (Bergamot and Cardoon Extract — Bionap) is safe depends on the dose, your overall health, and any medications you take. At studied doses, reported side effects can include: GENERALLY WELL-TOLERATED — mild digestive upset is occasionally reported. It may also interact with certain medications. Bergacyn® (Bergamot and Cardoon Extract — Bionap) is not suitable for everyone — consult a healthcare provider before use if you are pregnant or breastfeeding, have a medical condition, or take prescription medications.

References(1 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Musolino V, Gliozzi M, Bombardelli E, et al. The synergistic effect of Citrus bergamia and Cynara cardunculus extracts on vascular inflammation and oxidative stress. J Tradit Complement Med. 2020;10(3):268-274..PubMedUsed to support: Study supporting the bergamot-cardoon combination.