Home Ingredients Bergacyn® (Bergamot and Cardoon Extract — Bionap)
CardiovascularMetabolic Health

Bergacyn® (Bergamot and Cardoon Extract — Bionap)

Citrus bergamia
Evidence Level
Moderate
1 Clinical Trial
3 Documented Benefits
3/5 Evidence Score

Bergacyn® is a branded combination from Bionap that pairs bergamot (Citrus bergamia) polyphenols with cardoon (Cynara cardunculus) extract. The two plants are combined with the aim of complementary effects on lipids, liver fat, and vascular measures. Most of the human lipid evidence is for bergamot on its own, while the specific Bergacyn® combination has so far been evaluated in a single published trial (Musolino 2020).

Studied Dose Around 600 mg per day of the combined extract.
Active Compound A standardized combination of bergamot (Citrus bergamia) flavonoid polyphenols and cardoon (Cynara cardunculus) extract rich in chlorogenic acids and luteolin.

Benefits

Lipids and metabolic support

The bergamot and cardoon combination is studied for improving cholesterol and triglyceride profiles and supporting metabolic health. The clearest lipid evidence is for bergamot on its own, while any added benefit from pairing it with cardoon rests on a single combination trial.

Supported by Trial 1

Liver fat support

In a single trial of the bergamot-cardoon combination (Musolino 2020), the blend was evaluated for effects on liver-fat and related metabolic measures in adults with fatty liver. This reflects one trial rather than an established outcome, and the combination is not intended to diagnose, treat, or prevent fatty liver disease.

Supported by Trial 1

Vascular health

The polyphenol blend supports endothelial function and vascular health through antioxidant and lipid-modulating actions.

Supported by Trial 1

Mechanism of action

1

Synergistic polyphenols

Bergamot flavonoids and cardoon chlorogenic acids act on complementary pathways in lipid metabolism and oxidative stress, with the proposed combined effect so far tested in a single human trial that compared the blend against each extract alone.

2

Lipid and antioxidant modulation

The extracts reduce oxidative modification of lipids and support healthier cholesterol handling in the liver and blood vessels.

Clinical trials

1
Bergamot and Cardoon Combination — Study
PubMed

Study of the synergistic effect of Citrus bergamia and Cynara cardunculus extracts on vascular and metabolic outcomes. (Musolino et al. 2020, Journal of Traditional and Complementary Medicine)

Adults.

The combination improved vascular and lipid-related measures, supporting the rationale for pairing bergamot with cardoon.

Side effects and drug interactions

Common Potential side effects

Generally well-tolerated — mild digestive upset is occasionally reported.
Cardoon may stimulate bile flow; those with bile-duct obstruction should avoid it.
Citrus-sensitive individuals should start at a low dose.

Important Drug interactions

Statins and lipid drugs — possible additive effect; monitor with your doctor.
Bile or gallbladder conditions — cardoon stimulates bile; use caution.
Drugs metabolized by CYP enzymes — citrus polyphenols may interact.

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Frequently asked questions about Bergacyn® (Bergamot and Cardoon Extract — Bionap)

What is Bergacyn?

Bergacyn® is a branded combination from Bionap that pairs bergamot (Citrus bergamia) polyphenols with cardoon (Cynara cardunculus) extract. The two plants are combined with the aim of complementary effects on lipids, liver fat, and vascular measures.

What is Bergacyn used for?

Bergacyn is researched primarily for Cardiovascular and Metabolic Health. The bergamot and cardoon combination is studied for improving cholesterol and triglyceride profiles and supporting metabolic health.

What is the recommended dosage of Bergacyn?

The clinically studied dose is Around 600 mg per day of the combined extract. Always follow the product label and check with a healthcare provider for personal advice.

Is Bergacyn safe, and does it have side effects?

For most healthy adults, Bergacyn is well tolerated at studied doses. Reported effects can include: Generally well-tolerated — mild digestive upset is occasionally reported. Cardoon may stimulate bile flow; those with bile-duct obstruction should avoid it. It may also interact with some medications. Bergacyn is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does Bergacyn interact with any medications?

Possible interactions include: Statins and lipid drugs — possible additive effect; monitor with your doctor. Bile or gallbladder conditions — cardoon stimulates bile; use caution. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for Bergacyn?

NutraSmarts rates the evidence for Bergacyn as Moderate (3 out of 5). It is backed by 1 clinical trial and 1 cited reference summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(1 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Musolino V, Gliozzi M, Bombardelli E, et al. The synergistic effect of Citrus bergamia and Cynara cardunculus extracts on vascular inflammation and oxidative stress. J Tradit Complement Med. 2020;10(3):268-274..PubMedUsed to support: Study supporting the bergamot-cardoon combination.