Fenugreek

Trigonella foenum-graecum
Evidence Level
Moderate
4 Clinical Trials
4 Documented Benefits
3/5 Evidence Score

Fenugreek (Trigonella foenum-graecum) is a seed used as a cooking spice and as a supplement. Its best known supplement use is a standardized seed extract for testosterone and sexual function in men: in a 12-week placebo-controlled trial of 120 healthy men aged 43 to 70, 600 mg a day of the extract Testofen® raised total and free testosterone and improved sexual function. Pooled analyses of several extracts point to at most a small rise in total testosterone, no reliable rise in free testosterone, and very uncertain evidence. In pooled trials of adults with type 2 diabetes, fenugreek seed lowered fasting blood sugar and HbA1c, and it is a traditional aid for breast milk supply with conflicting evidence. Fenugreek can cause digestive upset and a maple-syrup body odor, may lower blood sugar, and is not considered safe in pregnancy above food amounts.

Studied Dose Testosterone trials used 600 mg a day of a standardized extract for 12 weeks; another trial tested 600 to 1,800 mg a day of a different extract. For breast milk, 1 to 6 g of seed a day is typical; blood sugar effects are described at about 25 g or more a day.
Active Compound Seed compounds include 4-hydroxyisoleucine, saponins and mucilage (a soluble fiber); testosterone trials used branded standardized seed extracts such as Testofen.

Benefits

Testosterone levels in men

In a 12-week trial of 120 healthy men aged 43 to 70, 600 mg a day of the branded extract Testofen raised total and free testosterone more than placebo. A 12-week trial of a different extract found no significant rise in blood testosterone versus placebo. Pooled analyses found a small rise in total testosterone but no reliable rise in free testosterone, and the most recent rated the evidence very uncertain.

Blood sugar levels

Pooled analyses of randomized trials found that fenugreek seed lowered fasting blood sugar, HbA1c and after-meal blood sugar compared with control in adults with type 2 diabetes, mainly at medium or high seed doses. Most trials were of low methodological quality, the participants were under medical care, and fenugreek does not replace diabetes medicine.

Breast milk supply

Fenugreek is widely used to increase breast milk. The NIH LactMed review notes that one pooled analysis found a mild effect, another found no good evidence, and the effect may be mainly psychological. Safety data in nursing mothers and infants are thin, so talk with a doctor or lactation consultant first.

Sexual function in men

In a 12-week trial of 120 healthy men aged 43 to 70, 600 mg a day of the branded extract Testofen improved sexual function, including morning erections and frequency of sexual activity, versus placebo. A 12-week trial of a different extract in 95 men aged 40 to 80 found no significant change in libido questionnaire answers versus placebo. No study cited here tested women.

Mechanism of action

1

Hormone signaling (proposed)

The NIH LactMed review notes that some studies suggest fenugreek may increase insulin, prolactin and oxytocin secretion, one proposed explanation for its effects on milk supply and blood sugar. LactMed also notes the milk effect may be mainly psychological.

2

Soluble fiber at gram doses

The seed contains mucilage, a soluble fiber. LactMed describes cholesterol and blood sugar lowering at about 25 g or more of seed a day, amounts where fiber could contribute; the 600 mg extract doses used in testosterone trials supply very little fiber.

Clinical trials

1
Testofen Fenugreek Extract in Men Aged 43 to 70
PubMed

Double-blind, randomized, placebo-controlled trial of a standardized fenugreek seed extract (Testofen), 600 mg a day for 12 weeks. Primary outcome: Aging Male Symptom score. Funding is listed as Gencor Pacific (industry) in a later systematic review (Rao et al. 2016, Aging Male).

120 healthy men aged 43 to 70.

Aging male symptom scores fell more than with placebo. Sexual function improved, including morning erections and frequency of sexual activity, and total and free testosterone rose versus placebo. It is one branded extract tested by one research group.

2
TrigozimR Fenugreek Extract in Men Aged 40 to 80
PubMed

Double-blind, randomized, placebo-controlled trial of a fenugreek extract (TrigozimR) at 600, 1,200 or 1,800 mg a day for 12 weeks; all groups, including placebo, also received vitamins and minerals. Primary outcome: testosterone in blood and saliva. Plasma total testosterone and free testosterone index rose from baseline but not significantly versus placebo; saliva testosterone rose versus placebo; libido questionnaire answers did not differ from placebo. Financed by PurOmega Ltd.; the authors also declared funding from the contract laboratory Vitas, in which two authors hold stock (Lee-Ødegård et al. 2024, PLoS One).

95 men aged 40 to 80 who completed the trial.

The blood hormone result did not differ significantly from placebo, although a saliva measure rose versus placebo. Self-reported questionnaire answers did not change versus placebo, and no side effects were observed.

3
Fenugreek and Testosterone: Pooled Analysis of Trials in Men
PubMed

Systematic review and meta-analysis of randomized placebo-controlled trials of oral fenugreek preparations, with GRADE certainty ratings. Industry funding or company involvement was common across the included studies (Yang et al. 2026, Frontiers in Nutrition).

Adult men in 13 included studies; 6 contributed to the total testosterone analysis and 5 to free testosterone.

Fenugreek was linked to a small rise in total testosterone (SMD 0.25) but no significant change in free testosterone. No study was at low risk of bias, certainty was very low, and the authors concluded the evidence does not support testosterone-boosting claims.

4
Fenugreek Seed and Blood Sugar: Pooled Analysis of 10 Trials
PubMed

Meta-analysis of clinical trials of at least 1 week comparing fenugreek seed with a control intervention. Significant effects on fasting and 2-hour glucose were found only in trials giving medium or high doses to people with diabetes, and most trials were of low methodological quality (Neelakantan et al. 2014, Nutrition Journal).

10 trials in people with and without diabetes; the effects came from trials in people with diabetes.

Compared with control, fenugreek lowered fasting blood glucose by 0.96 mmol/l (10 trials), 2-hour post-load glucose by 2.19 mmol/l (7 trials) and HbA1c by 0.85% (3 trials), with considerable differences between studies.

Side effects and drug interactions

Common Potential side effects

Digestive upset such as diarrhea, gas and nausea is the most commonly reported side effect.
A maple-syrup-like smell in urine, sweat or skin, reported in adults and in breastfed infants.
Large doses may cause a harmful drop in blood sugar; a drop in blood potassium has also been reported.
Allergic reactions, including serious ones, can occur; cross-reaction with chickpeas, peanuts and other legumes is possible.
Liver toxicity has been reported, both alone and in herbal combinations.
Not considered safe in pregnancy in amounts greater than those found in food.

Important Drug interactions

Diabetes medicines: fenugreek may add to their blood-sugar-lowering effect, so monitor blood sugar.
Warfarin: fenugreek can interact with warfarin and cause bleeding; a case report linked fenugreek taken with boldo to a raised INR.
Testosterone or other hormone therapy: a standardized extract raised testosterone in one trial, so ask your prescriber before combining them.

Frequently asked questions about Fenugreek

What is the recommended dosage of Fenugreek?

There is no established recommended dose. The main testosterone trial used 600 mg a day of a standardized seed extract for 12 weeks in men aged 43 to 70. For breast milk, 1 to 6 g of seed a day is typical. Blood sugar effects are described at much larger amounts, about 25 g or more of seed a day, and the diabetes trials were done under medical care.

What is Fenugreek used for?

Fenugreek is a cooking spice and a supplement. As a standardized extract it has been studied for testosterone and sexual function in men, and seed powder has been studied for blood sugar in people with type 2 diabetes. It is also a traditional aid for breast milk supply, where the evidence is conflicting.

Does fenugreek boost testosterone?

Not reliably. One industry-funded trial of 120 men aged 43 to 70 taking 600 mg a day of a standardized extract found higher total and free testosterone than placebo, but a later trial of a different extract found no significant difference in blood testosterone versus placebo. Pooled analyses show at most a small rise in total testosterone, and the most recent rated the evidence very uncertain and said it does not support testosterone-boosting claims. Fenugreek used in cooking is not the same as these extracts.

Is Fenugreek safe, and does it have side effects?

The NIH LactMed review says that when used as a medicinal, fenugreek "is generally well tolerated in adults," but digestive side effects such as diarrhea, gas and nausea may occur, and it can cause a maple-syrup-like body odor. It may lower blood sugar (use caution with diabetes medicine), can interact with warfarin, and can cause allergic reactions, with possible cross-reaction with peanuts, chickpeas and other legumes. NCCIH says it is not safe in pregnancy in amounts greater than those found in food.

What is Fenugreek?

Fenugreek (Trigonella foenum-graecum) is a seed used as a cooking spice and as a supplement. Its best known supplement use is a standardized seed extract for testosterone and sexual function in men: in a 12-week placebo-controlled trial of 120 healthy men aged 43 to 70, 600 mg a day of the extract Testofen® raised tota…

Does Fenugreek interact with any medications?

Possible interactions include: Diabetes medicines: fenugreek may add to their blood-sugar-lowering effect, so monitor blood sugar. Warfarin: fenugreek can interact with warfarin and cause bleeding; a case report linked fenugreek taken with boldo to a raised INR. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for Fenugreek?

NutraSmarts rates the evidence for Fenugreek as Moderate (3 out of 5). It is backed by 4 study summaries and 12 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(12 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Rao A, Steels E, Inder WJ, Abraham S, Vitetta L. Testofen, a specialised Trigonella foenum-graecum seed extract reduces age-related symptoms of androgen decrease, increases testosterone levels and improves sexual function in healthy aging males in a double-blind randomised clinical study. Aging Male. 2016;19(2):134-42. doi: 10.3109/13685538.2015.1135323.PubMedUsed to support: Double-blind, randomized, placebo-controlled trial: 120 healthy men aged 43 to 70 took 600 mg a day of the standardized extract Testofen or placebo for 12 weeks. Aging Male Symptom scores (the primary outcome) improved, total and free testosterone rose, and sexual function (morning erections, frequency of sexual activity) improved versus placebo. The result applies to this one extract, not to fenugreek seed in general.
  2. Lee-Ødegård S, Gundersen TE, Drevon CA. Effect of a plant extract of fenugreek (Trigonella foenum-graecum) on testosterone in blood plasma and saliva in a double blind randomized controlled intervention study. PLoS One. 2024;19(9):e0310170. doi: 10.1371/journal.pone.0310170.PubMedUsed to support: Double-blind randomized trial in 95 men aged 40 to 80 (TrigozimR 0, 600, 1,200 or 1,800 mg a day for 12 weeks; every group, including placebo, also took vitamins and minerals): plasma total testosterone and free testosterone index rose from baseline but not significantly versus placebo, saliva testosterone rose versus placebo, and no subjective effects (including on libido questions) or side effects were seen. The study was financed by PurOmega Ltd.; the authors also declared funding from the contract laboratory Vitas, in which two authors hold stock.
  3. Shakil S, Akhtar SE, Ali A, Antony M, Antony I, Mansour E, Khawar Farooqui S, Akbar A, Alazazzi H, Alsufyani R, Alsufyani M, Alawadhi R, Ramtohul RK, Hadeed S, Tabassi A, Tabassi A, Almas T. Enhancing glycaemic control and promoting cardiovascular health: the therapeutic potential of Trigonella foenumgraecum in diabetic patients - a systematic review and meta-analysis. Ann Med Surg (Lond). 2024;86(6):3460-3467. doi: 10.1097/MS9.0000000000001750.PubMedUsed to support: Systematic review and meta-analysis of randomized controlled trials in people with type 2 diabetes: fenugreek seed powder reduced fasting blood sugar, HbA1c and postprandial glucose compared with control. This is a population under medical care, not healthy adults.
  4. Yang P, Niu Z, Guo J, Huang T, Chang D, Huang X. Effects of oral fenugreek-derived preparations on testosterone-related outcomes in adult men: a systematic review and meta-analysis of randomized placebo-controlled trials. Front Nutr. 2026;13:1903508. doi: 10.3389/fnut.2026.1903508.PubMedUsed to support: Meta-analysis of randomized placebo-controlled trials in adult men (13 studies): a small favorable effect on total testosterone (SMD 0.25, 95% CI 0.02 to 0.48) but no significant effect on free testosterone (SMD 0.08). No trial was at low risk of bias and certainty was very low; the authors concluded current evidence does not support testosterone-boosting claims.
  5. Isenmann E, Alisauskas P, Flenker U, Schalla J, Diel P. The Anabolic Effect of Fenugreek: A Systematic Review with Meta-analysis. Int J Sports Med. 2023;44(10):692-703. doi: 10.1055/a-2048-5925.PubMedUsed to support: Meta-analysis of seven studies (449 participants, mostly men): a small effect on total testosterone (SMD 0.32, 95% CI 0.09 to 0.55); free testosterone, lean mass, fat mass and leg press changes did not reach significance. No conclusions could be drawn for women.
  6. Drugs and Lactation Database (LactMed), National Institute of Child Health and Human Development. Fenugreek. Drugs and Lactation Database (LactMed). 2006;Bethesda (MD): National Institute of Child Health and Human Development; 2006-. Updated 2026 Oct 15..PubMedUsed to support: NIH LactMed fenugreek monograph: used as a galactogogue at 1 to 6 g a day; one meta-analysis found a mild effect and another found no good evidence, and the effect may be mainly psychological. Side effects include digestive upset, allergic reactions, a 14% drop in serum potassium, and reported liver toxicity; cross-reaction with legumes is possible; at about 25 g or more a day it may lower blood sugar and cholesterol; it can interact with warfarin to cause bleeding.
  7. Amiri Ardekani E, Parvizi MM, Zare R, Mosaffa Jahromi M, Rampp T, Pasalar M. Exploring the Adverse Effects of Fenugreek in Humans: A Scoping Review. Iran J Med Sci. 2026;51(1):4-18. doi: 10.30476/ijms.2025.106073.4017.PubMedUsed to support: Scoping review of 60 articles on fenugreek adverse effects: mild digestive discomfort was most common; hypoglycemia, possible low potassium, allergic reactions, maple-syrup odor of urine, sweat or skin in infants and mothers, and some drug interactions were also reported. No deaths have been attributed to fenugreek.
  8. Lambert JP, Cormier J. Potential interaction between warfarin and boldo-fenugreek. Pharmacotherapy. 2001;21(4):509-12. doi: 10.1592/phco.21.5.509.34492.PubMedUsed to support: Case report: a woman on warfarin had a raised INR while taking boldo and fenugreek, which returned to normal after stopping them and rose again when they were restarted.
  9. National Center for Complementary and Integrative Health. Fenugreek. NCCIH (National Institutes of Health). 2025;Web page, last updated February 2025; accessed 2026..SourceUsed to support: NIH NCCIH fenugreek fact sheet (not PubMed-indexed): digestive side effects such as diarrhea and nausea; large doses may cause a harmful drop in blood sugar; allergic reactions, including serious ones, can occur; not safe in pregnancy in amounts greater than those found in food. It says there is not enough high-quality evidence to determine whether fenugreek is useful for diabetes, and that it is uncertain whether it increases milk supply.
  10. Neelakantan N, Narayanan M, de Souza RJ, van Dam RM. Effect of fenugreek (Trigonella foenum-graecum L.) intake on glycemia: a meta-analysis of clinical trials. Nutr J. 2014;13:7. doi: 10.1186/1475-2891-13-7.PubMedUsed to support: Meta-analysis of 10 clinical trials comparing fenugreek seed with a control: fasting blood glucose fell by 0.96 mmol/l, 2-hour post-load glucose by 2.19 mmol/l and HbA1c by 0.85% versus control. Significant glucose effects were found only for medium or high doses in people with diabetes, heterogeneity was considerable, and most trials were of low methodological quality.
  11. Mansoori A, Hosseini S, Zilaee M, Hormoznejad R, Fathi M. Effect of fenugreek extract supplement on testosterone levels in male: A meta-analysis of clinical trials. Phytother Res. 2020;34(7):1550-1555. doi: 10.1002/ptr.6627.PubMedUsed to support: Meta-analysis of four randomized trials comparing fenugreek extract with control in men: fenugreek extract had a significant effect on serum total testosterone. Free testosterone was not analyzed.
  12. Steels E, Rao A, Vitetta L. Physiological aspects of male libido enhanced by standardized Trigonella foenum-graecum extract and mineral formulation. Phytother Res. 2011;25(9):1294-300. doi: 10.1002/ptr.3360.PubMedUsed to support: Double-blind randomized placebo-controlled trial in 60 healthy men aged 25 to 52 without erectile dysfunction, 600 mg a day of Testofen in a mineral formulation for 6 weeks. The authors reported a positive effect on libido, with significant increases in the sexual arousal and orgasm subdomains; serum testosterone and prolactin stayed within the reference range. A later systematic review lists the product as an extract combined with magnesium, zinc and pyridoxine, so effects cannot be credited to fenugreek alone. The abstract does not report the size of the difference versus placebo.