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Top Picks — Immune Support

🛡️ Best Immune Support Supplements

Beta-glucans, vitamins, and immunomodulatory ingredients clinically studied for cold/flu prevention, immune resilience, and host defense.

163 ingredients reviewed Ranked by clinical evidence

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Top 5 — Ranked by Evidence

Common Cold Duration and Severity Reduction

75–90 mg/day (RDA); immune/antioxidant: 200–500 mg/day; upper limit 2,000 mg/day; lip

Bifidobacterium animalis subsp. lactis (BB-12 / HN019)

Immune function and respiratory infection reduction

1–10 billion CFU/day (BB-12); 17.2 billion CFU/day (HN019 in constipation studies)

BLIS K12® (Streptococcus salivarius for ENT — Stratum Nutrition)

Upper Respiratory Infection Prevention

1 billion CFU/day BLIS K12 (research-validated)

EpiCor® (Postbiotic Yeast Fermentate — Cargill)

Gut-immune axis support

500 mg/day EpiCor (research-validated)

Respiratory infections

RDA: 600-800 IU/day. Optimal serum 25(OH)D: 30-50 ng/mL (typically 1,000-2,000 IU/day

📈 Fastest Growing Immune Support Ingredients

Branded ingredients seeing rapid growth in formulator adoption and clinical research in 2024–2026.

EpiCor® (Postbiotic Yeast Fermentate — Cargill)

Gut-immune axis support

500 mg/day EpiCor (research-validated)

BLIS K12® (Streptococcus salivarius for ENT — Stratum Nutrition)

Upper Respiratory Infection Prevention

1 billion CFU/day (1 lozenge or slow-release tablet) across published trials. Best taken…

Anti-inflammatory and immunomodulatory effects

Standard cardiometabolic dose: 500-2,000 mg/day cold-pressed black seed oil. Higher-dose…

🔬 Future Immune Support Ingredients to Watch

Lower current evidence but active research underway — these may become top picks within 2–3 years.

ResistAid® (Larch Arabinogalactan — Lonza)

Antibody Response Enhancement

1.5-4.5 g/day ResistAid (research-validated)

PEA — Palmitoylethanolamide

Neuropathic pain relief (substantial evidence)

Standard dose: 300-1,200 mg/day PEA. Most clinical trials use 600 mg twice daily (1,200 mg…

Bifidobacterium breve

Atopic dermatitis and food allergy management in infants

INFANT AD (M-16V Morinaga): 1×10⁹ CFU/day × 1 mo. PRETERM (M-16V): 1×10⁹ CFU/day NICU. ADULT…

Recommended Immune Support Products

Heads up: NutraSmarts may earn a commission from purchases made through these links, at no extra cost to you. We curate these picks based on the same evidence we cite throughout the page. Full disclosure.

Real products featuring the best-evidenced immune support ingredients ranked above — chosen for clinically-studied forms and doses, third-party testing, and value. Match the supplement to your specific need.

Best foundation — fix Vitamin D deficiency first Amazon →

Sports Research Vitamin D3 5000 IU + Coconut MCT Oil

Vitamin D3 (cholecalciferol) — 5000 IU + MCT

Vitamin D deficiency directly impairs immune function and affects 40%+ of U.S. adults. The 5000 IU (125 mcg) dose corrects deficiency reliably — typical 1000-2000 IU products often don't move serum levels enough. Coconut MCT oil pairing improves fat-soluble vitamin absorption. Year-round daily prevention. Test serum 25-hydroxyvitamin D after 8-12 weeks; target 40-60 ng/mL. Best foundational immune supplement before anything else.

Best beta-glucan immune modulator (Wellmune®) Amazon →

Immune Health Basics Ultra Strength Immunity (Wellmune®)

Wellmune® beta-1,3/1,6-glucan — 250 mg

Wellmune® is the most-studied branded beta-glucan with 13+ peer-reviewed clinical trials. 250 mg matches the clinical RCT dose — Talbott 2013 showed a 10% URI rate in stressed adults vs. 29% on placebo. Different mechanism than vitamin D: primes innate immune cells (macrophages and neutrophils) via gut Peyer's patches. Best for daily prevention during high-stress periods (work, travel, training).

Best postbiotic for URI prevention (gut-immune axis) Amazon →

Doctor's Best EpiCor Immune Support

EpiCor® dried yeast fermentate — 500 mg

EpiCor® is a dried yeast fermentate (postbiotic) with the strongest evidence among postbiotics for upper respiratory infection prevention. 500 mg matches the clinical dose and activates NK (natural killer) cells within 2 hours. Different mechanism than Wellmune — works via gut-immune axis with postbiotic metabolites rather than direct immune cell priming. Doctor's Best provides genuine EpiCor at a reasonable price.

Best botanical for active illness (take at first symptoms) Amazon →

Double Wood Andrographis with AP-Bio®

Andrographis paniculata — AP-Bio® standardized

Andrographis has the strongest clinical evidence for reducing cold duration and severity when started at first symptoms. AP-Bio® is the patented standardized extract used in the RCTs — different from generic andrographis powder, which is less potent. Take for 3-5 days at first symptoms, not as daily prophylaxis. Distinct use case from the other three products: this one is for active illness, not prevention.

All Immune Support Ingredients (163)

Common Cold Duration and Severity Reduction

75–90 mg/day (RDA); immune/antioxidant: 200–500 mg/day; upper limit 2,000 mg/day; lip

Bifidobacterium animalis subsp. lactis (BB-12 / HN019)

Immune function and respiratory infection reduction

1–10 billion CFU/day (BB-12); 17.2 billion CFU/day (HN019 in constipation studies)

BLIS K12® (Streptococcus salivarius for ENT — Stratum Nutrition)

Upper Respiratory Infection Prevention

1 billion CFU/day BLIS K12 (research-validated)

EpiCor® (Postbiotic Yeast Fermentate — Cargill)

Gut-immune axis support

500 mg/day EpiCor (research-validated)

Respiratory infections

RDA: 600-800 IU/day. Optimal serum 25(OH)D: 30-50 ng/mL (typically 1,000-2,000 IU/day

Immune System Support

8–11 mg/day (RDA); therapeutic: 25–40 mg/day elemental zinc; upper limit 40 mg/day; a

Aqua-D3® (Water-Dispersible Vitamin D3)

Commonly 1000 to 4000 IU per day.

Kyolic® (Aged Garlic Extract — Wakunaga)

Immune system support

Standard cardiovascular protocol: 1,200-2,400 mg/day Kyolic® in divided doses. Differ

Common Cold Symptom Reduction

15–50 mg elemental zinc/day for general supplementation; for cold treatment 13.3–23 m

Immune Function and Mucosal Barrier Integrity

700–900 mcg RAE/day (adults); upper limit 3,000 mcg RAE/day

Spectramune® (Immune Defense Complex)

23% fewer respiratory infections (12-week trial)

Per Spectramune® clinical dosing; PLT Health Solutions product specifications

Lactobacillus rhamnosus GG (LGG)

Upper Respiratory Tract Infection Reduction

10–20 billion CFU/day; 5–10 billion CFU/day commonly used in pediatric protocols

PROMUNEL® (Propolis Immune Extract)

Immune modulation and inflammatory regulation

400–800 mg/day propolis extract; PROMUNEL® clinical dose per PLT specifications; immu

ResistAid® (Larch Arabinogalactan — Lonza)

Antibody Response Enhancement

1.5-4.5 g/day ResistAid (research-validated)

Bovine Colostrum

Upper respiratory illness in athletes

Athletic gut/immune: 20-60 g/day × 4-12 weeks. Pediatric diarrhea: 7-14 g/day. Choose

AlvioLife® (Respiratory Health & Performance)

Immune biomarker modulation (IFN-γ up, IL-4 down)

Per AlvioLife® clinical dosing; PLT Health Solutions product specifications

Upper respiratory tract infections

Standard URI dose: 200-1,200 mg/day andrographis extract standardized to ≥10% androgr

Beta-Glucans (Oat & Yeast-Derived)

Innate immune activation (mechanism)

Cholesterol (FDA claim): 3 g/day oat β-glucan. Immune (Wellmune®): 250-500 mg/day yea

BetaVia™ (Euglena gracilis Algae Beta-1,3-Glucan — Kemin)

Fewer URTI sick days (90-day RCT)

Pivotal trial: 367 mg/day BetaVia Complete for 90 days. Kemin recommended dosing: 375

Bioferrin® (Lactoferrin — Glanbia)

100-1000 mg/day lactoferrin (varies by application; immune support typical 100-300 mg

C-Fence® (Sustained-Release Vitamin C — Nutriventia)

Commonly providing a standard daily vitamin C dose in one sustained-release serving.

Garlic (Allium sativum)

Antimicrobial and immune activity

600–1,200 mg/day aged garlic extract (AGE); raw garlic equivalent: 2–4 cloves/day; al

L-OptiZinc® (Zinc Mono-L-Methionine — Lonza)

Immune System Support

10-30 mg elemental zinc/day (per L-OptiZinc product specification)

Immune function

55 mcg/day (RDA); therapeutic studies: 100–200 mcg/day; upper limit 400 mcg/day

SelenoForce® (Selenium-Enriched Yeast — Sabinsa)

Immune function support

100-200 mcg/day elemental selenium from SelenoForce. RDA: 55 mcg/day; tolerable upper

Shiitake Mushroom (Lentinula edodes)

Immune Modulation

1,000-3,000 mg/day mushroom extract; lentinan is typically given INJECTABLY (1-2 mg/w

Immune modulation

15 mg/day (RDA); therapeutic studies use 400–1,000 IU/day

Common Cold Treatment (Cold-Eeze)

13–23 mg elemental zinc per lozenge for cold use (75–100 mg/day total); 50 mg three t

Bacillus subtilis

Immune system training and infection resistance

1–10 billion CFU/day; DE111 commonly dosed at 1 billion CFU/day

Bacillus clausii (Enterogermina® / Erceflora)

Recurrent respiratory infections in children

Standard dose: 2 billion spores (2×10⁹ CFU) 2-3 times daily as oral suspension. AAD p

Bifidobacterium bifidum

Immune modulation and balanced inflammation

IBS (live MIMBb75): 1×10⁹ CFU/day for 4+ weeks; IBS (heat-inactivated MIMBb75 / SYN-H

Anti-inflammatory and immunomodulatory effects

Standard cardiometabolic dose: 500-2,000 mg/day cold-pressed black seed oil. Higher-d

Lactobacillus fermentum CECT5716 (Lc40 / Hereditum®)

Infant respiratory and GI infection reduction

Mastitis prevention/treatment: 3×10⁹ CFU/day for 21 days minimum, ideally throughout

LactoSpore® (Heat-Stable Bacillus coagulans Probiotic)

Immune system support

1–4 billion CFU/day LactoSpore® Bacillus coagulans; IBS and gut health: 2 billion CFU

Morinaga BB536 (Bifidobacterium longum BB536)

Often 1 to 5 billion CFU or more per day.

ParActin® (Andrographis Extract — HP Ingredients)

Immune system modulation

Standard formulation use: 100-300 mg ParActin® once or twice daily. Take with food to

PeakO2® (Adaptogenic Mushroom Blend)

Immune support and adaptogenic stress resilience

1–4g/day for ongoing use; 4g/day for clinical performance benefits (21-day loading);

Probiotics (Multi-strain Blends)

Immune modulation

1–10 billion CFU/day maintenance; up to 50 billion CFU/day therapeutic

Ester-C® (Buffered Calcium Ascorbate Vitamin C — American Health)

500 to 1000 mg of vitamin C per day.

Lactobacillus acidophilus

Vaginal microbiome restoration and BV/yeast infection prevention

1–10 billion CFU/day for general use; up to 50 billion CFU/day in IBS or vaginal heal

Lactobacillus casei

Common cold reduction in elderly and athletes

10^9–10^10 CFU/day (Yakult provides 10^10 CFU/65mL bottle); 10–100 billion CFU/day in

Immune System Support

300–500 mg three times daily (900–1,500 mg/day) during illness; prevention: 300 mg/da

FucoMax® (Fucoidan from Brown Seaweed — BGG)

Antiviral and antibacterial activity

Per BGG FucoMax product specification

Phellinus linteus (Meshimakobu / Sanghuang)

Immune improvement RCT (, LDH cytotoxicity)

: PL mycelium extract 1,000 mg/day × 8 weeks (n=98, KCTC0399BP strain). IMMUNITY RCT:

Agaricus blazei Murill (AbM / Himematsutake / Royal Sun Mushroom)

Multiple myeloma chemotherapy immunomodulation

ANDOSAN™ ORAL: 60 mL/day liquid extract × 7 weeks (multiple myeloma protocol). NSCLC

Astragalus (Astragalus membranaceus)

Immune system modulation and enhancement

ROOT: 2-6 g/day dried OR 250-500 mg/day standardized extract. IMMUNE: 500 mg BID. TA-

Immune stimulation

600–900 mg extract/day during illness; 150–300 mg/day for prevention

Immune System Support

200–400 mg/day standardized extract (ginsenosides ≥4–7%); American ginseng: 100–200 m

Isenolic® (Olive Polyphenols for Cold/Flu)

Neuraminidase inhibition (anti-influenza mechanism)

Per Pharmactive product specification

Reishi Mushroom

Immune modulation

1.5–9 g/day whole mushroom powder; 1–1.5 g/day standardized extract

Tinofend® (Tinospora cordifolia for Immune — Verdure)

Macrophage activation and immune cell function

Per Verdure Tinofend product specification

AHCC (Active Hexose Correlated Compound)

Immune Cell Activation

1-3 g/day; 3 g/day used in HPV clearance trials (Smith 2019 — 6 months); 1-3 g/day fo

DE111® (Bacillus subtilis Probiotic — ADM Deerland)

Commonly 1 billion CFU per day.

GliSODin® (Vegetal SOD with Gliadin — Isocell)

Immune and airway balance

Around 250 mg per day.

Maitake Mushroom (Grifola frondosa)

Immune Activation (D-Fraction)

1-3 mg D-fraction/kg body weight (50-300 mg D-fraction/day for typical adults); whole

Prodiet® Lactoferrin (Native Bovine Lactoferrin — Ingredia)

Commonly 100 to 200 mg per day.

500–1,000 mg/day; absorption enhanced significantly with vitamin C or bromelain; quer

SoWell™ (Postbiotic Heat-Killed Lactobacillus)

Shelf-stable immune modulation

Per SoWell™ product specifications; typical postbiotic dose 10–100 billion CFU equiva

StaiMune® (Inactivated Bacillus coagulans GBI-30 — Kerry)

Around 0.5 to 1 billion inactivated cells per day.

Streptococcus thermophilus (Specific Strains)

ST36 immune + intestinal function support

ST81: 3 billion CFU/day. ST36: similar consumer dose. AAD prevention combination with

Zinmax® (Premium Zinc Picolinate - Nutrition 21)

8-15 mg elemental zinc daily (typical zinc supplementation; therapeutic doses higher)

Beef Spleen (Desiccated)

Immune-related peptides (mechanistically interesting, clinically uncharacterized)

Typical supplementation: 1.5-3 g/day (2-4 capsules at 750 mg each) desiccated beef sp

Arabinoxylan (Arrabina®)

Immune system modulation

4–15 g/day; blood sugar management: 8–15 g/day with meals; immune studies: 4–10 g/day

Immune modulation

1,000–3,000 mg/day mycelium powder; 400–800 mg/day standardized extract

Earthlight® (Whole Food Mushroom Vitamin D2)

Immune function support

250–1000 IU Vitamin D2 equivalent per serving as Earthlight®; dosing equivalent to 25

effera® (Human-Identical Lactoferrin)

Superior immune activation vs. bovine lactoferrin

Per effera® product specifications; Helaina clinical dosing; typical lactoferrin dose

Eleuthero / Siberian Ginseng (Eleutherococcus senticosus)

Immune Function Modulation

300-1,200 mg/day standardized extract; root powder 1-3 g/day

iXOS® (Xylooligosaccharides Prebiotic)

Metabolic and immune health benefits

1–2g/day iXOS® for prebiotic bifidogenic effects (much lower than other prebiotics at

Lactobacillus plantarum

Immune function in athletes and stressed populations

10–50 billion CFU/day; 299v strain typically 20 billion CFU/day; weight management st

Lactobacillus salivarius (Multi-Strain)

CECT5713 immune support (Sierra et al.)

ORAL HEALTH (WB21): 2.0×10⁹ CFU/day × 2 weeks (caries). PERIODONTAL (heat-killed CP33

Lion's Mane Mushroom

500–3,000 mg/day dried mushroom powder; extract: 250–500 mg/day (standardized to >30%

Polypodium Leucotomos

Immune Modulation

Typically dosed at 240–480 mg/day

Setria® Glutathione

Immune system enhancement

250–500 mg/day; 250 mg shown effective for increasing blood glutathione levels

Immune enhancement

1–8 g/day; most clinical trials use 2–4 g/day

Turkey Tail Mushroom

Immune system activation

1–3 g/day PSK extract; 2–9 g/day whole mushroom powder

Zinc Bisglycinate (Zinc Glycinate)

15–30 mg elemental zinc/day for general supplementation; up to 50 mg for short-term t

15–50 mg elemental zinc/day; toothpaste/mouthwash use 0.1–0.3% concentration

Immunell™ (Nucleotides + Prebiotic Acacia)

Immune Response Reinforcement

Nexira specifies recommended dose; clinical research uses varying nucleotide intake l

Chaga Mushroom (Inonotus obliquus)

Immune Modulation

500-2,000 mg/day extract; standardized to beta-glucan content (typically 30%+); tradi

CM-Glucan™ Nu

Immune 'training' and resilience

Hōlistiq™ (Adaptogen + Mushroom Wellness Blend)

Immune modulation and defense

Per product label; typical adaptogen blend 300–800mg/day; mushroom component 500mg–2g

Attenutin® (Scutellaria and Acacia for Respiratory Health — Unigen)

Immune and inflammatory balance

Per the product specification.

Berriqi® (Boysenberry and Apple Polyphenols — Anagenix)

Immune recovery

A daily serving of the standardized polyphenol concentrate.

Eyebright (Euphrasia officinalis)

Upper respiratory mucosal support

Oral: 400–800 mg/day dried herb or standardized extract; ophthalmic solution: 1–2 dro

GS15-4® (Enzyme-Fermented Ginseng — Ilhwa)

Around 165 mg of fermented ginseng extract per day.

Nutramunity® Beta-Glucan (Yeast Beta-Glucan)

Commonly around 75 to 250 mg per day.

Prodiet® Colostrum (Bovine Colostrum — Ingredia)

Commonly a few grams of colostrum per day.

Progestive® (Bacillus coagulans Probiotic — Nutraceuticals International Group)

Immune and strain-dependent note

Commonly billions of CFU per day.

Sparassis crispa (Cauliflower Mushroom / Hanabiratake)

Dectin-1 / GM-CSF immunomodulation pathway

β-GLUCAN content: >40% of dry weight (highest among medicinal mushrooms). MOUSE Sarco

Spirumune® (Spirulina for Immunity)

Commonly 1 to 2 grams of spirulina per day.

SynBalance® (Probiotic Strains — ROELMI)

Commonly billions of CFU per day, depending on the strain.

Thymocid® (Black Cumin Seed Extract — Natural Remedies)

A standardized daily dose providing a defined amount of thymoquinone.

Olivactive® (Olive Leaf Extract for Immune Support)

Reduced sick days in athletes

Per Pharmactive product specification

Goldenseal (Hydrastis canadensis)

Antimicrobial and immune support

500–1,000 mg/day dried root powder; standardized extract: 250–500 mg/day; typically u

Kutki (Picrorhiza kurroa)

Immunomodulation

TRADITIONAL AYURVEDIC: 250-500 mg dried rhizome 2-3×/day OR 1-3 g/day decoction. STAN

Lactobacillus paracasei (Multi-Strain Specialist)

Upper respiratory symptom duration

L. CASEI 431® RESPIRATORY: ≥1×10⁹ CFU/day × 42 days. KW3110 POLLEN ALLERGY: 4×10¹⁰ CF

Immune function — preliminary evidence

General use: 3-6 g/day. NAFLD studies: 1.2-1.5 g/day × 3 months. Metabolic syndrome:

Antiviral activity (preclinical)

Traditional/clinical doses: 100-500 mg/day humic acid extract. No FDA-recognized stan

Shatavari (Asparagus racemosus / Xeya®)

Immune support — modest evidence

500-1,000 mg/day standardized root extract. Lactation: 300 mg twice daily. PCOS (CL22

Tinospora Cordifolia (Tinofend®)

Immune system modulation

300 mg/day Tinofend® (standardized extract); traditional Ayurvedic dose: 1–3 g/day wh

Cat's Claw (Uncaria tomentosa)

Immune system modulation

250–500 mg/day standardized POA extract; rheumatoid arthritis trials: 60 mg freeze-dr

Uva ursi (Bearberry)

Traditional use for acute urinary tract infection symptoms

ATAFUTI 2019: 3600 mg extract = 720 mg arbutin/day × 5 d. REGATTA: 6 caps × 105 mg =

Biootic® (Probiotic Cultures)

Commonly billions of CFU per day, depending on the strain.

Brewster Probiotics™ (Probiotic Cultures)

Varies by strain and product; commonly billions of CFU per day.

Noni (Morinda citrifolia)

Immune modulation

30–750 mL/day noni juice; most studies use 29–118 mL (1–4 oz) daily; freeze-dried pow

Ferrous Sulfate

Established Standard for Iron Deficiency

60-200 mg elemental iron/day for adult IDA treatment (often 325 mg ferrous sulfate =

Aged Garlic Extract

Blood pressure reduction in hypertension

Standard cardiovascular dose: 600-2,400 mg/day AGE standardized to S-allyl cysteine c

Bifidobacterium breve

Atopic dermatitis and food allergy management in infants

INFANT AD (M-16V Morinaga): 1×10⁹ CFU/day × 1 mo. PRETERM (M-16V): 1×10⁹ CFU/day NICU

BLIS M18® (Streptococcus salivarius for Oral Health — Stratum Nutrition)

Dental Health Support

1 billion CFU/day BLIS M18 (research-validated)

Calendula (Pot Marigold)

Prevention of acute radiation-induced dermatitis (Pivotal RCT)

RADIATION DERMATITIS: Boiron Pommade au Calendula 2×/day during radiotherapy. WOUND/S

Clostridium butyricum MIYAIRI 588 (CBM588 / MIYA-BM® / Butirrisan®)

Butyrate production in the gut

Standard dose: 20-80 mg/day of MIYA-BM® powder providing 1-4×10⁸ CFU. Adult AAD preve

Escherichia coli Nissle 1917 (Mutaflor®)

Ulcerative colitis maintenance

Ulcerative colitis maintenance: 100 mg twice daily (5×10⁹ CFU/capsule × 2/day) per Mu

Ferrous Bisglycinate

Superior GI Tolerability

25-60 mg elemental iron/day; pregnancy: 25-30 mg/day often sufficient

Ferrous Fumarate

Higher Elemental Iron Content

60-200 mg elemental iron/day for adult IDA (often 200 mg ferrous fumarate = 65 mg ele

Gingever® (High-Potency Ginger Extract — OmniActive)

Occasional constipation (Eraiah 2024)

280 mg/day Gingever (Eraiah 2024 constipation trial, taken nightly after dinner for 8

Limosilactobacillus reuteri DSM 17938 (BioGaia Protectis®)

Infant colic crying time reduction

Infants: 100 million CFU (1×10⁸) once daily as drops (BioGaia Protectis® dosing). Chi

PEA — Palmitoylethanolamide

Neuropathic pain relief (substantial evidence)

Standard dose: 300-1,200 mg/day PEA. Most clinical trials use 600 mg twice daily (1,2

Saccharomyces boulardii

Antibiotic-associated diarrhea prevention

250–500 mg twice daily (5–10 billion CFU/day); 250 mg three times daily for C. diffic

Selenium Yeast (High-Selenium Yeast)

Used in Major Cancer Trials

100-200 µg elemental selenium/day; SELECT used 200 µg/day; NPC trial used 200 µg/day

Selenomethionine

Hashimoto's Thyroiditis Adjunct

100-200 µg elemental selenium/day; Hashimoto's trials typically 200 µg/day

Mild-to-moderate acne treatment

TOPICAL ACNE: 5% TTO gel 1-2×/day. DANDRUFF: 5% shampoo daily. ORAL/PERIODONTITIS: 0.

Aged Black Garlic ABG10+® (Pharmactive)

Blood pressure reduction in hypertensive adults

Standard dose: 250-500 mg/day ABG10+® standardized aged black garlic extract. Cardiov

Bifidobacterium longum

Stress reduction and emotional regulation (psychobiotic effects)

1–10 billion CFU/day; 1714 strain studies use 1 billion CFU/day for psychobiotic effe

Anti-inflammatory and pain relief

200–400 mg/day (500–2,000 GDU) for anti-inflammatory; 400–800 mg/day with meals for d

Butterbur (Petasites hybridus)

Migraine prevention

50–75 mg twice daily PA-free Petadolex® (75–150 mg/day) for migraine prevention; alle

Codonopsis lanceolata (Deodeok / Korean Bonnet Bellflower)

Sarcopenia 12-week RCT protocol (Kyung Hee)

TCM TYPICAL: 9-15 g/day root decoction. SARCOPENIA RCT (Park 2022 protocol): 750 mg w

Codonopsis pilosula (Dang Shen / Poor Man's Ginseng)

Chronic fatigue 8-week pilot RCT (Frontiers in Pharmacology 2021)

TCM TYPICAL: 9-15 g/day root decoction. oncology adjunct: oral liquid (approved Chine

Cran-d'Or® (Cranberry Extract)

Urinary tract health

Commonly around 500 mg of cranberry concentrate per day.

Cran-Gyn PRO® (Cranberry for Urinary and Feminine Health)

Urinary tract health

Commonly around 500 mg of cranberry concentrate per day.

Urinary Tract Health

400–500 mg/day standardized extract (PAC 36 mg); for UTI prevention: daily long-term;

Cranbey® (Cranberry Extract)

Urinary tract health

Commonly around 500 mg of cranberry concentrate per day.

Cranmax® (Whole Cranberry Concentrate — Decas)

Urinary tract health

Commonly 500 mg of cranberry concentrate per day.

Ferrous Gluconate

Better GI Tolerability

50-300 mg elemental iron/day; often 325 mg ferrous gluconate = ~38 mg elemental Fe pe

Heme Iron Polypeptide (HIP)

Distinct Absorption Pathway (HCP1)

10-22 mg elemental heme iron/day; Proferrin Forte = 11 mg elemental iron per tablet

ImmuseLC-Plasma (Lactococcus lactis strain Plasma)

Plasmacytoid dendritic cell activation

100 billion (10¹¹) heat-killed L. lactis strain Plasma/day standard RCT dose. Kirin i

IBS-D and post-infectious IBS — strongest gut evidence

Gut barrier: 15 g/day (3x5g). Permeability (2024 meta): >30 g/day, <2 weeks. Sickle c

Herpes simplex virus (HSV) suppression

500–3,000 mg/day; herpes suppression: 1,000–3,000 mg/day during outbreaks, 500–1,500

Lactobacillus johnsonii La1 (NCC533 / CNCM I-1225)

H. pylori suppression supernatant trial

MICHETTI 1999 H. PYLORI: La1 whey-based culture supernatant ~10⁹ CFU/mL adults. FERME

Multivitamin / Multimineral

Reduced total cancer incidence in older men (PHS II)

STANDARD: 1 tablet/day MVMM ~100% DV most vitamins, 25-100% DV minerals. PHS II + COS

Neem (Azadirachta indica)

Plaque and Gingivitis Reduction (RCT-Confirmed)

PINGALI 2020 T2DM: 125/250/500 mg standardized neem BID = 250-1000 mg/day × 12 wk + m

Optibiome® BS50 (Bacillus subtilis MB40 — BIO-CAT Microbials)

Decreased gastrointestinal symptoms in healthy adults

Per BIO-CAT Optibiome BS50 product specification

Rosmarinic Acid

Reduced seasonal allergic rhinitis symptoms

ALLERGIC RHINITIS: 50-200 mg/day Perilla × 21 d. AD COGNITION (Noguchi-Shinohara): 50

Cholesterol reduction in elderly hypercholesterolemia

CV: 860 mg/day × 20 wk hypercholesterolemia. STRANDBERG 1990: 900 mg/day. PK: 500 mg

Streptococcus salivarius

Recurrent strep throat and tonsillitis prevention (K12)

1 billion CFU/day (K12 lozenge); 1 billion CFU/day (M18 lozenge)

Thyme (Thymus vulgaris)

Acute Bronchitis Cough Reduction (RCT-Confirmed)

BRONCHIPRET® THYME-IVY: 5.4 mL × 3/day × 11 d. BRONCHIPRET® TP: 1 tablet × 3/day × 11

Verilla® (Perilla Extract for Seasonal Allergy)

Seasonal allergy comfort

Around 50 to 200 mg of rosmarinic acid per day.

Zinc Picolinate

Bioavailability

15–50 mg elemental zinc/day; for short-term immune/skin: up to 50 mg/day for 4–8 week

Enhanced vitamin C bioavailability vs isolated ascorbic acid

UCHIDA 2011 BIOAVAILABILITY: 50 mg vit C from acerola juice. COMMERCIAL: 100-500 mg p

Akkermansia muciniphila

GLP-1 secretion via P9 protein (mechanistic)

Depommier 2019: 10¹⁰ CFU/day pasteurized × 3 months. Most products: 10⁸-10⁹ CFU/day.

Beef Kidney (Desiccated)

Exceptional selenium concentration

Typical supplementation: 1.5-3 g/day (2-4 capsules at 750 mg each) desiccated beef ki

Beef Liver (Desiccated)

Highest natural source of preformed vitamin A (retinol)

Typical supplementation: 3-6 g/day (4-8 capsules at 750 mg each) desiccated beef live

BioEcolians® (Alpha-Glucan Oligosaccharide — Solabia)

Prebiotic microbiome support

Typically a few grams per day for digestive use; lower amounts in topical application

Superior antioxidant effect vs isolated vitamin C

RCT: 70 mL 100% camu juice daily (~1050 mg vit C) × 7 d. POWDER SUPPLEMENTS: 100-500

CaroCare® (Natural Beta-Carotene — DSM)

Vitamin A support

Commonly providing a few milligrams of beta-carotene per day.

Carotex® (Natural Beta-Carotene and Carotenoids — Zeus Hygia)

Vitamin A and antioxidant support

Commonly providing a few milligrams of carotenoids per day.

CompleteGreens™ (Comprehensive Greens Base)

Ready-to-use turnkey superfood base

3–8g/day comprehensive greens blend; specific CompleteGreens™ dosing per NNB product

Faecalibacterium prausnitzii (Next-Generation Probiotic)

Anti-inflammatory effects in IBD

Clinical trial doses: typically 1-10 billion CFU/day in oxygen-protected formulations

Iron Polysaccharide Complex (Niferex®)

Better GI Tolerability

150-300 mg elemental iron/day (Niferex® Forte = 150 mg elemental iron per capsule)

Myrrh (Commiphora molmol)

Anti-inflammatory Activity (Mechanistic / Preclinical)

MIRAZID® antiparasitic: 600 mg (2 × 300 mg) daily empty stomach × 3-6 d. Soliman 2004

Oregano Oil (Origanum vulgare)

Enteric Parasite Activity (Limited Human Evidence)

FORCE 2000 ENTERIC PARASITES: 600 mg emulsified oregano oil daily × 6 wk. CONSUMER: 1

BiAloe® (Aloe Vera Polysaccharides)

Digestive support

Commonly a few hundred milligrams per day.

NaturSYN® Defense (Anti-Inflammatory Botanical Blend)

Balanced inflammatory response

Per the product specification.