Home Ingredients C-Fence® (Sustained-Release Vitamin C — Nutriventia)
Immune Support

C-Fence® (Sustained-Release Vitamin C — Nutriventia)

Evidence Level
Limited
1 Clinical Trial
3 Documented Benefits
2/5 Evidence Score

C-Fence® is a sustained-release vitamin C from Nutriventia, designed to release gradually over about 12 hours. In one small single-dose study funded by the maker, a 500 mg tablet kept blood vitamin C above baseline for 24 hours in 18 healthy adults. That study compared the tablet with placebo, not with ordinary vitamin C, so better uptake and gentler digestion than plain vitamin C are design goals rather than measured results.

Studied Dose The only dose tested in a published study of this branded form is a single 500 mg sustained-release tablet, in one small pharmacokinetic study of blood levels. No daily dose of C-Fence has been tested for immune or antioxidant outcomes.
Active Compound Sustained-release (gastro-retentive) vitamin C (ascorbic acid) granules.

Benefits

Immune support

Vitamin C supports normal immune function. In the Cochrane review, taking it every day shortened colds by 8% in adults and 14% in children and eased severity, but it did not reduce how often people in the general community caught colds, and starting it after symptoms began showed no consistent benefit. That evidence is for vitamin C in general, not for C-Fence.

Supported by Trial 1

Antioxidant protection

Vitamin C is a key water-soluble antioxidant in the body and helps regenerate other antioxidants. That is established nutrient biochemistry; no study cited on this page measured an antioxidant outcome for C-Fence or for vitamin C.

Supported by Trial 1

Better tolerance and steadier levels

C-Fence's sustained release is designed to maintain vitamin C levels through the day, and one small single-dose study did show levels held above baseline for 24 hours. Gut comfort was never compared against plain vitamin C, so easier digestion remains a design goal rather than a measured result.

Supported by Trial 1

Mechanism of action

1

Sustained absorption

Gradual release is intended to keep blood vitamin C steadier and to limit the spillover and gut irritation that large immediate-release doses can cause. One small study measured longer-lasting blood levels against placebo rather than against ordinary vitamin C, and it did not measure gut comfort at all.

2

Antioxidant and immune roles

Vitamin C donates electrons to neutralize free radicals and supports the function of immune cells and collagen formation.

Clinical trials

1
Vitamin C and the Common Cold: Cochrane Review
PubMed

Cochrane systematic review of vitamin C for preventing and treating the common cold. (Hemila and Chalker 2013, Cochrane Database of Systematic Reviews)

Adults and children across many trials: 29 comparisons and 11,306 participants for cold incidence, 31 comparisons and 9,745 cold episodes for duration, plus 7 therapeutic comparisons covering 3,249 episodes.

Taking vitamin C every day shortened colds by 8% in adults and 14% in children and reduced severity. It did not reduce how often people caught colds in the general community, pooled risk ratio 0.97 across 10,708 participants, and the authors conclude that routine vitamin C supplementation is not justified on that basis. Starting vitamin C after symptoms appear, which is what most people do, showed no consistent effect on duration or severity. A clear reduction in colds appeared only in marathon runners, skiers and soldiers on subarctic exercises, risk ratio 0.48. This review is about vitamin C in general; no trial in it used C-Fence.

Side effects and drug interactions

Common Potential side effects

Generally well-tolerated.
Very high doses can cause digestive upset or loose stools.
People prone to kidney stones should not take high doses long-term.

Important Drug interactions

Generally compatible with medications.
High-dose vitamin C can affect some lab tests; tell your doctor.
Ask your doctor if you have kidney disease or take chemotherapy.

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Frequently asked questions about C-Fence® (Sustained-Release Vitamin C — Nutriventia)

What is C-Fence?

C-Fence® is a sustained-release vitamin C from Nutriventia, designed to release gradually over about 12 hours. In one small single-dose study funded by the maker, a 500 mg tablet kept blood vitamin C above baseline for 24 hours in 18 healthy adults.

What is C-Fence used for?

C-Fence is researched primarily for Immune Support. Vitamin C supports normal immune function. In the Cochrane review, taking it every day shortened colds by 8% in adults and 14% in children and eased severity, but it did not reduce how often people in the general community caught colds, and…

What is the recommended dosage of C-Fence?

The clinically studied dose is The only dose tested in a published study of this branded form is a single 500 mg sustained-release tablet, in one small pharmacokinetic study of blood levels. No daily dose of C-Fence has been tested for immune or antioxidant outcomes. Always follow the product label and check with a healthcare provider for personal advice.

Is C-Fence safe, and does it have side effects?

For most healthy adults, C-Fence is well tolerated at studied doses. Reported effects can include: Generally well-tolerated. Very high doses can cause digestive upset or loose stools. It may also interact with some medications. C-Fence is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does C-Fence interact with any medications?

Possible interactions include: Generally compatible with medications. High-dose vitamin C can affect some lab tests; tell your doctor. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for C-Fence?

NutraSmarts rates the evidence for C-Fence as Limited (2 out of 5). It is backed by 1 clinical trial and 1 cited reference summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(1 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Hemila H, Chalker E. Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev. 2013;2013(1):CD000980..PubMedUsed to support: Cochrane review of vitamin C for the common cold. Regular daily use shortened colds by 8% in adults and 14% in children and reduced severity, but it did not reduce cold incidence in the general community and showed no consistent effect when started after symptoms appeared. No trial in this review used C-Fence.