DE111® (Bacillus subtilis Probiotic — ADM Deerland)

DE111® is a spore-forming Bacillus subtilis probiotic from ADM Deerland, prized for surviving heat, acid, and shelf storage that destroy many probiotics. Studied for digestive regularity and immune balance, the hardy spores germinate in the gut after being swallowed.

DE111 is researched primarily for Gut Health and Immune Support. In clinical research, Bacillus subtilis DE111 supported a more normal, regular bowel pattern in healthy people.

The clinically studied dose is Commonly 1 billion CFU per day. Always follow the product label and check with a healthcare provider for personal advice.

For most healthy adults, DE111 is well tolerated at studied doses. Reported effects can include: Generally well-tolerated — spore probiotics are well tolerated. Mild gas or bloating can occur at first. It may also interact with some medications. DE111 is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Possible interactions include: No major drug interactions are established for this ingredient. Tell your doctor about all supplements if you take prescription medication. If you take prescription medication, check with a pharmacist or doctor before using it.

NutraSmarts rates the evidence for DE111 as Moderate (3 out of 5). It is backed by 1 clinical trial and 1 cited reference summarized on this page. A higher rating reflects more, larger, and better-designed human studies.