Home Ingredients DE111® (Bacillus subtilis Probiotic — ADM Deerland)
Gut HealthImmune Support

DE111® (Bacillus subtilis Probiotic — ADM Deerland)

Bacillus subtilis
Evidence Level
Moderate
1 Clinical Trial
3 Documented Benefits
3/5 Evidence Score

DE111® is a spore-forming Bacillus subtilis probiotic from ADM Deerland, prized for surviving heat, acid, and shelf storage that destroy many probiotics. Studied for digestive regularity and immune balance, the hardy spores germinate in the gut after being swallowed.

Studied Dose Commonly 1 billion CFU per day.
Active Compound Bacillus subtilis DE111, a spore-forming probiotic strain.

Benefits

Digestive regularity

In clinical research, Bacillus subtilis DE111 supported a more normal, regular bowel pattern in healthy people.

Supported by Trial 1

Gut microbiome balance

The spores germinate in the intestine and support a healthier balance of gut bacteria.

Immune support

Research on DE111 observed favorable shifts in immune-cell activity, reflecting the gut-immune connection.

Supported by Trial 1

Mechanism of action

1

Spore survival and germination

As spores, DE111 survives stomach acid and heat, then germinates into active bacteria in the small intestine within hours of being swallowed.

2

Microbiome and gut-barrier support

DE111 supports a balanced microbiome and the gut environment, which underpins both digestion and immune function.

Clinical trials

1
Bacillus subtilis DE111 and Gut/Immune — Study
PubMed

Study examining the gastrointestinal and immunomodulatory effects of Bacillus subtilis DE111. (Freedman et al. 2021, International Journal of Molecular Sciences)

Healthy adults.

DE111 supported digestive regularity and favorable immune-cell measures versus placebo.

Side effects and drug interactions

Common Potential side effects

GENERALLY WELL-TOLERATED — spore probiotics are well tolerated.
Mild gas or bloating can occur at first.
Those who are immunocompromised should consult a doctor.

Important Drug interactions

No major drug interactions are established for this ingredient.
Tell your doctor about all supplements if you take prescription medication.
Use caution if pregnant, breastfeeding, or managing a health condition.

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Frequently asked questions about DE111® (Bacillus subtilis Probiotic — ADM Deerland)

What is DE111® (Bacillus subtilis Probiotic — ADM Deerland)?

DE111® is a spore-forming Bacillus subtilis probiotic from ADM Deerland, prized for surviving heat, acid, and shelf storage that destroy many probiotics. Studied for digestive regularity and immune balance, the hardy spores germinate in the gut after being swallowed.

What is the recommended dosage of DE111® (Bacillus subtilis Probiotic — ADM Deerland)?

The clinically studied dose for DE111® (Bacillus subtilis Probiotic — ADM Deerland) is Commonly 1 billion CFU per day.. Always follow product labeling and consult a healthcare provider for personalized dosing recommendations.

What is DE111® (Bacillus subtilis Probiotic — ADM Deerland) used for?

DE111® (Bacillus subtilis Probiotic — ADM Deerland) is studied for digestive regularity, gut microbiome balance, immune support. In clinical research, Bacillus subtilis DE111 supported a more normal, regular bowel pattern in healthy people.

Are there side effects from taking DE111® (Bacillus subtilis Probiotic — ADM Deerland)?

Reported potential side effects may include: GENERALLY WELL-TOLERATED — spore probiotics are well tolerated. Mild gas or bloating can occur at first. Always consult a healthcare provider before starting any new supplement, especially if you have underlying conditions or take medications.

Is DE111® (Bacillus subtilis Probiotic — ADM Deerland) safe to take?

Whether DE111® (Bacillus subtilis Probiotic — ADM Deerland) is safe depends on the dose, your overall health, and any medications you take. At studied doses, reported side effects can include: GENERALLY WELL-TOLERATED — spore probiotics are well tolerated. It may also interact with certain medications. DE111® (Bacillus subtilis Probiotic — ADM Deerland) is not suitable for everyone — consult a healthcare provider before use if you are pregnant or breastfeeding, have a medical condition, or take prescription medications.

References(1 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Freedman KE, Hill JL, Wei Y, et al. Examining the Gastrointestinal and Immunomodulatory Effects of the Novel Probiotic Bacillus subtilis DE111. Int J Mol Sci. 2021;22(5)..PubMedUsed to support: Study supporting gut and immune benefit of Bacillus subtilis DE111.