Home Ingredients Prodiet® Lactoferrin (Native Bovine Lactoferrin — Ingredia)
Immune SupportGut Health

Prodiet® Lactoferrin (Native Bovine Lactoferrin — Ingredia)

Evidence Level
Moderate
1 Clinical Trial
3 Documented Benefits
3/5 Evidence Score

Prodiet® Lactoferrin is a native (non-denatured) bovine lactoferrin from Ingredia, produced from fresh French milk. Lactoferrin is an iron-binding glycoprotein that is part of the body's natural defenses, studied as a class for immune, gut, and iron support; the evidence here reflects bovine lactoferrin generally rather than Prodiet-brand-specific human trials.

Studied Dose Commonly 100 to 200 mg per day.
Active Compound Native bovine lactoferrin, an iron-binding glycoprotein from milk.

Benefits

Immune defense

Bovine lactoferrin has been studied as an immune-supporting glycoprotein. The clearest infection-reduction trial cited here (Manzoni 2014) was in high-risk preterm infants for prevention of necrotizing enterocolitis, so infection-related benefits in adults are extrapolated from the broader lactoferrin research base rather than from a Prodiet-brand adult trial.

Supported by Trial 1

Iron balance

Lactoferrin binds and helps regulate iron, supporting healthy iron status and limiting iron available to harmful microbes.

Supported by Trial 1

Gut health

By binding iron and acting on microbes, lactoferrin supports a healthier balance of gut bacteria and a strong intestinal barrier.

Supported by Trial 1

Mechanism of action

1

Iron sequestration

Lactoferrin binds free iron, starving harmful bacteria of the iron they need to grow while supporting the body's own iron handling.

2

Immunomodulation

Lactoferrin interacts with immune cells and microbial surfaces, providing antimicrobial, antiviral, and immune-supporting activity.

Clinical trials

1
Bovine Lactoferrin and Infection — RCT
PubMed

Randomized clinical trial of bovine lactoferrin for prevention of necrotizing enterocolitis and infection in very-low-birth-weight (preterm) neonates. (Manzoni et al. 2014, Early Human Development)

Very-low-birth-weight preterm neonates (a NEC-prevention setting, not adults).

Bovine lactoferrin reduced late-onset sepsis and NEC versus placebo in preterm infants; this supports lactoferrin's immune activity but was observed in neonates, so it does not directly demonstrate adult immune benefit.

Side effects and drug interactions

Common Potential side effects

Generally well-tolerated — derived from milk.
Mild digestive upset is occasionally reported.
Avoid if you have a milk-protein allergy.

Important Drug interactions

No major drug interactions are established for this ingredient.
Tell your doctor about all supplements if you take prescription medication.
Use caution if pregnant, breastfeeding, or managing a health condition.

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Frequently asked questions about Prodiet® Lactoferrin (Native Bovine Lactoferrin — Ingredia)

What is Prodiet Lactoferrin?

Prodiet® Lactoferrin is a native (non-denatured) bovine lactoferrin from Ingredia, produced from fresh French milk. Lactoferrin is an iron-binding glycoprotein that is part of the body's natural defenses, studied as a class for immune, gut, and iron support; the evidence here reflects bovine lactoferrin generally rathe…

What is Prodiet Lactoferrin used for?

Prodiet Lactoferrin is researched primarily for Immune Support and Gut Health. Bovine lactoferrin has been studied as an immune-supporting glycoprotein. The clearest infection-reduction trial cited here (Manzoni 2014) was in high-risk preterm infants for prevention of necrotizing enterocolitis, so infection-related be…

What is the recommended dosage of Prodiet Lactoferrin?

The clinically studied dose is Commonly 100 to 200 mg per day. Always follow the product label and check with a healthcare provider for personal advice.

Is Prodiet Lactoferrin safe, and does it have side effects?

For most healthy adults, Prodiet Lactoferrin is well tolerated at studied doses. Reported effects can include: Generally well-tolerated — derived from milk. Mild digestive upset is occasionally reported. It may also interact with some medications. Prodiet Lactoferrin is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does Prodiet Lactoferrin interact with any medications?

Possible interactions include: No major drug interactions are established for this ingredient. Tell your doctor about all supplements if you take prescription medication. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for Prodiet Lactoferrin?

NutraSmarts rates the evidence for Prodiet Lactoferrin as Moderate (3 out of 5). It is backed by 1 clinical trial and 1 cited reference summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(1 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Manzoni P, Meyer M, Stolfi I, et al. Bovine lactoferrin supplementation for prevention of necrotizing enterocolitis in very-low-birth-weight neonates: a randomized clinical trial. Early Hum Dev. 2014;90 Suppl 1:S60-5..PubMedUsed to support: RCT in very-low-birth-weight preterm neonates showing reduced late-onset sepsis and necrotizing enterocolitis; supports lactoferrin's immune activity but is not an adult general-immunity trial.