Home Top Picks Energy
Energy

Best energy
supplements.

Support ATP production, mitochondrial function, and cellular bioenergetics — from NAD+ precursors and adaptogenic herbs to direct mitochondrial cofactors.

36
Ingredients
123
Clinical trials
4
Trending now
🏆 Evidence Ranked
Top Energy Supplements
Ranked by evidence level, then number of clinical trials.
#1 Pick
Cognitive
Vitamin B12
Vitamin B12, also known as cobalamin, is a water-soluble vitamin commonly supplemented as cyanocobalamin or me…
Very Strong
10 trials
#2 Pick
Energy
Caffeine
Caffeine, a natural stimulant found in coffee, tea, and other plants, is commonly supplemented in forms like c…
Very Strong
8 trials
#3 Pick
Cardiovascular
Niacin
Niacin, or vitamin B3, is a vital nutrient that supports energy production by serving as a precursor to coenzy…
Very Strong
5 trials
#4 Pick
Energy
Iron
Iron is an essential trace mineral and a central component of hemoglobin, enabling red blood cells to carry ox…
Very Strong
2 trials
#5 Pick
Metabolic Health
Iodine
Iodine is an essential trace mineral and the primary raw material for thyroid hormone synthesis. Adequate iodi…
Very Strong
1 trial
📈 Trending Now
Fastest Growing Energy Ingredients
Ingredients seeing rapid growth in research interest and formulator adoption in 2024–2025.
Trending
Energy
NMN (Nicotinamide Mononucleotide)
NMN is a direct precursor to NAD+, a coenzyme essential for cellular energy production, DNA repair, and sirtui…
Moderate
2 trials
Trending
Cognitive
Rhodiola Rosea
Rhodiola rosea is an adaptogenic herb from arctic and mountainous regions of Europe and Asia, used for centuri…
Strong
2 trials
Trending
Energy
Shilajit / Fulvic Acid (PrimaVie®)
Shilajit is a mineral-rich resinous exudate formed over millennia from the decomposition of plant matter compr…
Moderate
3 trials
Trending
Energy
MCT Oil (Medium-Chain Triglycerides)
Medium-chain triglycerides (MCTs) are saturated fatty acids with 6–12 carbon chains (caprylic C8, capric C10,…
Moderate
2 trials
🔬 Emerging Research
Future Energy Ingredients to Watch
Lower evidence now but active research underway — these may become top picks within 2–3 years.
Emerging
Energy
D-Ribose (Bioenergy Ribose®)
D-ribose is a naturally occurring pentose sugar that serves as the structural backbone of ATP, ADP, AMP, RNA,…
Moderate
2 trials
Emerging
Energy
RiaGev® (NR + D-Ribose NAD+ Complex)
RiaGev® (Bioenergy Life Science) is a patented combination of nicotinamide riboside (NR) and D-ribose — two co…
Moderate
2 trials
Emerging
Energy
Robuvit® (French Oak Wood Extract)
Robuvit® (Horphag Research) is a standardized extract from the heartwood of French oak (Quercus robur) trees g…
Moderate
2 trials
All Ingredients
All 36 Energy Supplements
Complete list, sorted by evidence strength.
Cognitive
Vitamin B12
Vitamin B12, also known as cobalamin, is a water-soluble vitamin commonly supplemented as cyanocobalamin or me…
Very Strong
10 trials
Energy
Caffeine
Caffeine, a natural stimulant found in coffee, tea, and other plants, is commonly supplemented in forms like c…
Very Strong
8 trials
Cardiovascular
Niacin
Niacin, or vitamin B3, is a vital nutrient that supports energy production by serving as a precursor to coenzy…
Very Strong
5 trials
Energy
Iron
Iron is an essential trace mineral and a central component of hemoglobin, enabling red blood cells to carry ox…
Very Strong
2 trials
Metabolic Health
Iodine
Iodine is an essential trace mineral and the primary raw material for thyroid hormone synthesis. Adequate iodi…
Very Strong
1 trial
Cardiovascular
CoEnzyme Q10
Coenzyme Q10 (CoQ10), also known as ubiquinone, is a naturally occurring compound found in cell mitochondria,…
Strong
8 trials
Energy
Riboflavin
Riboflavin, or vitamin B2, is a water-soluble vitamin essential for energy production and maintaining healthy…
Strong
8 trials
Energy
Thiamine
Thiamine, also known as vitamin B1, is a water-soluble vitamin essential for converting carbohydrates into ene…
Strong
5 trials
Cognitive
Vitamin B6 (Pyridoxine)
Vitamin B6 (pyridoxine) is a water-soluble vitamin essential for amino acid metabolism, neurotransmitter synth…
Strong
5 trials
Energy
Nicotinamide Riboside (Niagen®)
Nicotinamide Riboside (NR) is a form of vitamin B3 and a direct precursor to NAD+, the coenzyme central to cel…
Strong
4 trials
Energy
Pantothenic Acid
Pantothenic acid, or vitamin B5, is a water-soluble vitamin essential for synthesizing coenzyme A, which suppo…
Strong
4 trials
Cognitive
Acetyl-L-Carnitine (ALCAR)
Acetyl-L-carnitine (ALCAR) is the acetylated form of L-carnitine — a naturally occurring amino acid derivative…
Strong
2 trials
Bone Health
Phosphorus / Phosphate
Phosphorus is the second most abundant mineral in the human body after calcium — comprising approximately 1% o…
Strong
2 trials
Cognitive
Rhodiola Rosea
Rhodiola rosea is an adaptogenic herb from arctic and mountainous regions of Europe and Asia, used for centuri…
Strong
2 trials
Cognitive
Suntheanine®
Suntheanine® is a patented, 100% pure L-isomer theanine produced via an enzymatic process that mimics biosynth…
Strong
2 trials
Metabolic Health
Biotin
Biotin, also known as vitamin B7, is a water-soluble vitamin that supports healthy hair, skin, and nails while…
Moderate
7 trials
Energy
Ginseng
Ginseng, derived from the roots of plants like Panax ginseng, contains ginsenosides, active compounds known fo…
Moderate
6 trials
Antioxidant
Ergothioneine (ErgoActive®)
Ergothioneine (EGT) is a naturally occurring amino acid and potent antioxidant synthesized exclusively by cert…
Moderate
3 trials
Energy
Shilajit / Fulvic Acid (PrimaVie®)
Shilajit is a mineral-rich resinous exudate formed over millennia from the decomposition of plant matter compr…
Moderate
3 trials
Cognitive
Alpinia Galanga (enXtra®)
enXtra® (OmniActive Health Technologies) is a patented, caffeine-free standardized extract of Alpinia galanga…
Moderate
2 trials
Cognitive
Coffee Fruit Extract (CoffeeFruit Pure™)
Coffee fruit extract (CFE) is derived from the pulp of the coffee cherry — the red fruit surrounding the coffe…
Moderate
2 trials
Athletic Performance
Cordyceps
Cordyceps is a medicinal fungus traditionally used in Tibetan and Chinese medicine for energy, stamina, and lo…
Moderate
2 trials
Energy
D-Ribose (Bioenergy Ribose®)
D-ribose is a naturally occurring pentose sugar that serves as the structural backbone of ATP, ADP, AMP, RNA,…
Moderate
2 trials
Cognitive
L-Tyrosine
L-Tyrosine is a conditionally essential amino acid and the direct precursor to the catecholamine neurotransmit…
Moderate
2 trials
Energy
MCT Oil (Medium-Chain Triglycerides)
Medium-chain triglycerides (MCTs) are saturated fatty acids with 6–12 carbon chains (caprylic C8, capric C10,…
Moderate
2 trials
Antioxidant
Moringa
Moringa oleifera, the 'miracle tree,' is native to South Asia and one of the most nutrient-dense plants known.…
Moderate
2 trials
Energy
NMN (Nicotinamide Mononucleotide)
NMN is a direct precursor to NAD+, a coenzyme essential for cellular energy production, DNA repair, and sirtui…
Moderate
2 trials
Cognitive
PQQ (Pyrroloquinoline Quinone)
Pyrroloquinoline quinone (PQQ) is a redox-active coenzyme and potent antioxidant naturally present in human br…
Moderate
2 trials
Cardiovascular
Pantethine (Pantesin®)
Pantethine is the biologically active, reduced disulfide form of pantothenic acid (vitamin B5) and the direct…
Moderate
2 trials
Energy
RiaGev® (NR + D-Ribose NAD+ Complex)
RiaGev® (Bioenergy Life Science) is a patented combination of nicotinamide riboside (NR) and D-ribose — two co…
Moderate
2 trials
Energy
Robuvit® (French Oak Wood Extract)
Robuvit® (Horphag Research) is a standardized extract from the heartwood of French oak (Quercus robur) trees g…
Moderate
2 trials
Cognitive
SalidroPure™ (Pure Salidroside)
SalidroPure™ is NNB Nutrition's precision-fermented pure salidroside — the primary bioactive compound in Rhodi…
Moderate
2 trials
Immune Support
Spirulina
Spirulina is a blue-green microalgae and one of the most nutrient-dense foods on earth, containing 60–70% prot…
Moderate
2 trials
Energy
TeaCrine® (Theacrine)
TeaCrine® is Compound Solutions' patented theacrine — a purine alkaloid structurally related to caffeine but w…
Moderate
2 trials
Metabolic Health
Coconut Oil
Coconut oil is a dietary supplement derived from the meat of mature coconuts, rich in medium-chain triglycerid…
Limited
4 trials
Energy
Guayusa (AMATEA® Organic Guayusa)
Guayusa (Ilex guayusa) is a caffeinated holly tree native to the upper Amazon basin, traditionally consumed as…
Limited
2 trials