Home Ingredients Actiful® (Orange and Pomegranate Complex — Solabia)
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Actiful® (Orange and Pomegranate Complex — Solabia)

Evidence Level
Preliminary
0 Clinical Trials
3 Documented Benefits
1/5 Evidence Score

Actiful® is a polyphenol complex of sweet orange (Citrus sinensis) and pomegranate (Punica granatum) developed for energy and vitality, especially in healthy aging. It is positioned to support blood flow and mitochondrial energy production. Independent published clinical data are limited, so benefits should be viewed with realistic expectations.

Studied Dose Around 600 to 700 mg per day.
Active Compound Polyphenol complex of sweet orange (Citrus sinensis) and pomegranate (Punica granatum) extracts.

Benefits

Energy and vitality

Actiful is positioned to support immediate and sustained energy and vitality, of particular interest for healthy aging; independent published evidence is still limited.

Blood flow support

The orange and pomegranate polyphenols are studied for supporting nitric-oxide production and healthy blood flow.

Limited-evidence note

Most data for Actiful come from supplier-sponsored research; large independent published trials are not yet available.

Mechanism of action

1

Nitric-oxide support

The polyphenols are studied for supporting nitric-oxide synthesis, which relaxes blood vessels and improves blood flow.

2

Mitochondrial energy

Actiful is positioned to support more efficient mitochondrial energy (ATP) production at the cellular level.

Clinical trials

Side effects and drug interactions

Common Potential side effects

Generally well-tolerated — adverse effects are uncommon at normal doses.
Mild digestive upset is occasionally reported.
Discontinue if any unusual reaction occurs.

Important Drug interactions

Blood pressure medication — citrus and pomegranate may have additive effects; monitor.
Drugs affected by grapefruit-type fruits — consult a doctor.
Tell your doctor if pregnant or breastfeeding.

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Frequently asked questions about Actiful® (Orange and Pomegranate Complex — Solabia)

What is Actiful?

Actiful® is a polyphenol complex of sweet orange (Citrus sinensis) and pomegranate (Punica granatum) developed for energy and vitality, especially in healthy aging. It is positioned to support blood flow and mitochondrial energy production.

What is Actiful used for?

Actiful is researched primarily for Energy, Cardiovascular, and Longevity. Actiful is positioned to support immediate and sustained energy and vitality, of particular interest for healthy aging; independent published evidence is still limited.

What is the recommended dosage of Actiful?

The clinically studied dose is Around 600 to 700 mg per day. Always follow the product label and check with a healthcare provider for personal advice.

Is Actiful safe, and does it have side effects?

For most healthy adults, Actiful is well tolerated at studied doses. Reported effects can include: Generally well-tolerated — adverse effects are uncommon at normal doses. Mild digestive upset is occasionally reported. It may also interact with some medications. Actiful is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does Actiful interact with any medications?

Possible interactions include: Blood pressure medication — citrus and pomegranate may have additive effects; monitor. Drugs affected by grapefruit-type fruits — consult a doctor. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for Actiful?

NutraSmarts rates the evidence for Actiful as Preliminary (1 out of 5). It is backed by 2 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(2 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Trexler ET, Smith-Ryan AE, Melvin MN, Roelofs EJ, Wingfield HL Effects of pomegranate extract on blood flow and running time to exhaustion Applied Physiology, Nutrition, and Metabolism. 2014;39(9):1038-42. doi:10.1139/apnm-2014-0137.PubMedUsed to support: Human study showing pomegranate extract (Punica granatum component of Actiful) improves blood flow and exercise time to exhaustion; supports the blood flow and energy/vitality benefit claims (component literature)
  2. Pranskuniene Z, Belousoviene E, Baranauskiene N, Eimantas N, Vaitkaitiene E, Bernatoniene J, Brazaitis M, Pranskunas A Modulation of Endothelial Glycocalyx and Microcirculation in Healthy Young Men during High-Intensity Sprint Interval Cycling-Exercise by Supplementation with Pomegranate Extract: A Randomized Controlled Trial International Journal of Environmental Research and Public Health. 2020;17(12):4405. doi:10.3390/ijerph17124405.PubMedUsed to support: Human RCT showing pomegranate extract modulates endothelial glycocalyx and microcirculation during exercise in healthy men; supports the blood flow support claim (component literature — pomegranate is one of the two Actiful ingredients)