Home Ingredients Ubiqsome® (Coenzyme Q10 Phytosome — Indena)
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Ubiqsome® (Coenzyme Q10 Phytosome — Indena)

Evidence Level
Moderate
3 Clinical Trials
4 Documented Benefits
3/5 Evidence Score

Ubiqsome® is a coenzyme Q10 phytosome® formulation developed by Indena (Italy) — applying Phytosome® technology to CoQ10 (ubiquinone) to address its notoriously poor bioavailability. CoQ10 is essential for mitochondrial energy production. Distinguished by enhanced absorption vs standard CoQ10 supplements. Used for: cardiovascular health, energy/mitochondrial support, statin-induced CoQ10 depletion adjunct.

Studied Dose 100-300 mg/day Ubiqsome (CoQ10 equivalent)
Active Compound Coenzyme Q10 (ubiquinone) Phytosome® formulation

Benefits

Cardiovascular Health Support

CoQ10 is concentrated in cardiac tissue and supports normal cardiovascular function; CoQ10-class trials in heart-failure and blood-pressure settings are mixed and used generic CoQ10, not Ubiqsome specifically.

Supported by Trial 1

Mitochondrial Energy Production

CoQ10 is essential cofactor for mitochondrial electron transport chain — energy production. Supports cellular energy.

Supported by Trial 1, Trial 2

Antioxidant Activity

CoQ10 (especially reduced ubiquinol form) is potent lipid-soluble antioxidant — protects cell membranes and lipoproteins from oxidation.

Supported by Trial 1, Trial 2

Statin-Induced CoQ10 Depletion

Statin medications inhibit HMG-CoA reductase which produces CoQ10 precursors; statin users may benefit from CoQ10 supplementation. Particularly relevant for muscle symptoms ('statin myalgia').

Supported by Trial 1, Trial 2

Mechanism of action

1

Mitochondrial Electron Transport Cofactor

CoQ10 carries electrons in mitochondrial electron transport chain — essential for ATP synthesis. Foundation of energy production.

2

Phytosome® Bioavailability Enhancement

CoQ10 is highly lipophilic and crystalline at room temperature; standard absorption very poor; Phytosome addresses absorption challenge.

3

Lipid-Soluble Antioxidant

CoQ10 protects cell membranes and LDL particles from oxidation; lipid-soluble distinguishes from water-soluble antioxidants.

4

Cardiac Tissue Concentration

Cardiac muscle has highest CoQ10 concentration; supplementation supports cardiac function.

5

Endogenous Production Decline with Age

Endogenous CoQ10 production declines with age (peak in 20s, decline thereafter); supplementation may offset age-related decline.

Clinical trials

1
CoQ10 (generic ubiquinone) in Heart Failure — Q-SYMBIO
PubMed

Q-SYMBIO trial of generic crystalline CoQ10 (ubiquinone) in chronic heart failure. (Mortensen et al. 2014, JACC Heart Failure) — this trial used generic CoQ10, NOT the Ubiqsome phytosome; included only as CoQ10-class context.

Chronic heart failure patients.

In this trial, generic CoQ10 reduced cardiovascular mortality and improved cardiac function — the most-cited CoQ10 heart-failure trial, but the result is for generic CoQ10, not Ubiqsome specifically.

2
Ubiqsome Bioavailability Studies — Indena
PubMed

Single- and repeated-dose pharmacokinetic study of Ubiqsome CoQ10 phytosome versus standard CoQ10 in healthy volunteers. (Petrangolini et al. 2019, Curr Drug Deliv)

Healthy adults.

Ubiqsome improved CoQ10 absorption/bioavailability — a surrogate (pharmacokinetic) endpoint; industry-funded (Indena).

3
Ubiqsome (CoQ10 Phytosome) for Statin-Associated Asthenia — RCT
PubMed

Small double-blind, randomized, placebo-controlled trial using the Ubiqsome phytosome specifically. (Fogacci et al. 2024, J Clin Med)

Older adults with statin-associated asthenia.

Ubiqsome improved physical performance versus placebo — the one genuine clinical-outcome trial of this branded formulation, though small.

Side effects and drug interactions

Common Potential side effects

Generally extremely well-tolerated.
Mild GI distress (rare).
Headache rare.
Fatigue (paradoxical) rare.
Allergic reactions rare.
Soy allergy considerations (Phytosome).

Important Drug interactions

Warfarin — CoQ10 may modestly reduce warfarin effect (structural similarity to vitamin K); consult.
Antihypertensives — modest BP effects.
Diabetes medications — modest hypoglycemic effects.
Pregnancy — generally considered safe; some pre-eclampsia trials show benefit but consult.
Lactation — generally considered safe at moderate doses.
Cancer treatment — theoretical concerns about antioxidants during certain chemotherapies; consult oncologist.
Soy allergy — Phytosome consideration.

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Frequently asked questions about Ubiqsome® (Coenzyme Q10 Phytosome — Indena)

What is Ubiqsome?

Ubiqsome® is a coenzyme Q10 phytosome® formulation developed by Indena (Italy) — applying Phytosome® technology to CoQ10 (ubiquinone) to address its notoriously poor bioavailability. CoQ10 is essential for mitochondrial energy production. Distinguished by enhanced absorption vs standard CoQ10 supplements.

What is Ubiqsome used for?

Ubiqsome is researched primarily for Cardiovascular, Energy, and Antioxidant. CoQ10 is concentrated in cardiac tissue and supports normal cardiovascular function; CoQ10-class trials in heart-failure and blood-pressure settings are mixed and used generic CoQ10, not Ubiqsome specifically.

What is the recommended dosage of Ubiqsome?

The clinically studied dose is 100-300 mg/day Ubiqsome (CoQ10 equivalent) Always follow the product label and check with a healthcare provider for personal advice.

Is Ubiqsome safe, and does it have side effects?

For most healthy adults, Ubiqsome is well tolerated at studied doses. Reported effects can include: Generally extremely well-tolerated. Mild GI distress (rare). It may also interact with some medications. Ubiqsome is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does Ubiqsome interact with any medications?

Possible interactions include: Warfarin — CoQ10 may modestly reduce warfarin effect (structural similarity to vitamin K); consult. Antihypertensives — modest BP effects. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for Ubiqsome?

NutraSmarts rates the evidence for Ubiqsome as Moderate (3 out of 5). It is backed by 3 clinical trials and 2 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(2 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Petrangolini G, Ronchi M, Frattini E, De Combarieu E, Allegrini P, Riva A A New Food-grade Coenzyme Q10 Formulation Improves Bioavailability: Single and Repeated Pharmacokinetic Studies in Healthy Volunteers Curr Drug Deliv. 2019;16(8):759-767. doi: 10.2174/1567201816666190902123147.PubMedUsed to support: Core pharmacokinetic evidence that the CoQ10 phytosome (Ubiqsome) improves CoQ10 absorption/bioavailability in healthy volunteers. Industry (Indena) PK study; the bioavailability advantage is the best-supported claim for this ingredient.
  2. Fogacci F, Giovannini M, Tocci G, Imbalzano E, Borghi C, Cicero AFG Effect of Coenzyme Q10 on Physical Performance in Older Adults with Statin-Associated Asthenia: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial J Clin Med. 2024;13(13):3741. doi: 10.3390/jcm13133741.PubMedUsed to support: Backs a fatigue/physical-performance and statin-myopathy (statin-associated asthenia) use; this trial specifically used CoQ10 phytosome (Ubiqsome, Indena). A genuine double-blind randomized placebo-controlled trial, though small; one of the stronger efficacy entries for this ingredient.