Home Ingredients Rējen™ (Fulvic and Humic Acid Trace Minerals — Compound Solutions)
Gut HealthEnergy

Rējen™ (Fulvic and Humic Acid Trace Minerals — Compound Solutions)

Evidence Level
Preliminary
1 Clinical Trial
2 Documented Benefits
1/5 Evidence Score

Rējen™ is a branded fulvic and humic acid ingredient from Compound Solutions that the maker says carries 70+ trace minerals, is separated without the usual chemical (base-acid) extraction and has low heavy metal content. It is marketed for trace mineral replenishment, energy, metabolism and gut health. The maker makes no senolytic, autophagy or cellular rejuvenation claims for it, and no human trial of Rējen™ is indexed in PubMed.

Studied Dose Not established: Compound Solutions publishes no serving size, and no human study of Rējen™ is indexed in PubMed (checked September 2026)
Active Compound Fulvic and humic acids with 70+ trace minerals (Rējen™ by Compound Solutions); fulvic/humic percentages and the mineral profile are not published

Benefits

Trace mineral source (fulvic and humic acids)

Compound Solutions describes Rējen™ as trace minerals with fulvic and humic acids (70+ minerals) meant to help replenish minerals in the diet. It has not published amounts per serving or any human data showing these minerals are absorbed or improve mineral status. The maker makes no senolytic, autophagy or cellular rejuvenation claims for it.

Supported by Trial 1

Gut health, energy and metabolism (maker's stated uses)

Compound Solutions markets Rējen™ for gut health, energy and metabolism but has published no human results; its announced human studies have not appeared. The nearest evidence is an uncontrolled 45 day study in which a different humic acid product raised total colonic bacteria in 14 healthy volunteers; no digestive or energy outcomes were measured.

Supported by Trial 1

Mechanism of action

1

Proposed actions of fulvic and humic acids

Fulvic acid is a humic substance produced by soil microorganisms. A review notes claims that it can modulate the immune system, influence the oxidative state of cells and improve gastrointestinal function, but found the available research minimal while arguing it merits further study. None of these actions has been tested for Rējen™, and the maker offers its in vitro data only on request.

Clinical trials

1
Rējen™: no PubMed-indexed human trial of the branded ingredient

Per Compound Solutions, in vitro studies are available on request and human studies were to complete in 2025. No Rējen™ study, in vitro or human, was found in PubMed as of September 2026.

Rējen™ is a fulvic and humic acid ingredient with 70+ trace minerals from Compound Solutions, not a senolytic or NAD+ blend. No human trial of this branded ingredient is indexed in PubMed.

No Rējen™ results have been published, so the maker's claims are unverified in people. Evidence on related materials is thin: an uncontrolled 45 day study of a different humic acid product (Swidsinski et al., 2017; 14 healthy volunteers) found higher colonic bacterial concentrations, and a phase 1 trial of oral carbohydrate-derived fulvic acid in 30 men (Gandy et al., 2012) found stable safety measures over one week. Neither tested Rējen™.

Side effects and drug interactions

Common Potential side effects

No human safety data have been published for Rējen™; the maker reports low heavy metal content
Studies of other humic or fulvic acid products reported loose stools and bloating, and mild, transient diarrhea, headache and sore throat

Important Drug interactions

No interaction studies exist for Rējen™; ask a clinician before use if you take medications

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Frequently asked questions about Rējen™ (Fulvic and Humic Acid Trace Minerals — Compound Solutions)

What is Rējen?

Rējen™ is a branded fulvic and humic acid ingredient from Compound Solutions that the maker says carries 70+ trace minerals, is separated without the usual chemical (base-acid) extraction and has low heavy metal content. It is marketed for trace mineral replenishment, energy, metabolism and gut health.

What is Rējen used for?

Rējen is researched primarily for Gut Health and Energy. Compound Solutions describes Rējen™ as trace minerals with fulvic and humic acids (70+ minerals) meant to help replenish minerals in the diet.

What is the recommended dosage of Rējen?

Not established: Compound Solutions publishes no serving size, and no human study of Rējen™ is indexed in PubMed (checked September 2026) Always follow the product label and check with a healthcare provider for personal advice.

Is Rējen safe, and does it have side effects?

Side effects and cautions reported for Rējen include: No human safety data have been published for Rējen™; the maker reports low heavy metal content Studies of other humic or fulvic acid products reported loose stools and bloating, and mild, transient diarrhea, headache and sore throat It may also interact with some medications. Rējen is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does Rējen interact with any medications?

Possible interactions include: No interaction studies exist for Rējen™; ask a clinician before use if you take medications If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for Rējen?

NutraSmarts rates the evidence for Rējen as Preliminary (1 out of 5). It is backed by 1 study summary and 3 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(3 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Swidsinski A, Dörffel Y, Loening-Baucke V, Gille C, Reißhauer A, Göktas O, Krüger M, Neuhaus J, Schrödl W. Impact of humic acids on the colonic microbiome in healthy volunteers. World J Gastroenterol. 2017;23(5):885-890. doi: 10.3748/wjg.v23.i5.885.PubMedUsed to support: Uncontrolled study in 14 healthy volunteers: a different humic acid product (Activomin, 800 mg three times daily for 10 days, then 400 mg three times daily) raised total colonic bacterial concentrations over 45 days while individual profiles and diversity stayed stable; one man had loose stools and bloating. It measured no clinical outcomes and did not test Rējen™.
  2. Gandy JJ, Meeding JP, Snyman JR, van Rensburg CE. Phase 1 clinical study of the acute and subacute safety and proof-of-concept efficacy of carbohydrate-derived fulvic acid. Clin Pharmacol. 2012;4:7-11. doi: 10.2147/CPAA.S25784.PubMedUsed to support: Double-blind phase 1 study in 30 men with atopy: oral carbohydrate-derived fulvic acid (up to 40 mL of a 3.8% solution twice daily for a week) left safety measures unchanged and reduced skin prick test responses; mild, transient diarrhea, headache and sore throat were reported. It tested a different fulvic acid material, not Rējen™.
  3. Winkler J, Ghosh S. Therapeutic Potential of Fulvic Acid in Chronic Inflammatory Diseases and Diabetes. J Diabetes Res. 2018;2018:5391014. doi: 10.1155/2018/5391014.PubMedUsed to support: Minireview of fulvic acid research: describes claims that it modulates immune function, cellular oxidative state and gastrointestinal function, and concludes the available research is minimal but worth pursuing. Background on the ingredient class only; it did not test Rējen™.