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Top Picks — Liver Health

🫀 Best Liver Health Supplements

Hepatoprotective compounds, glutathione precursors, and liver-supporting nutrients ranked by clinical evidence for liver function and protection.

35 ingredients reviewed Ranked by clinical evidence

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Top 5 — Ranked by Evidence

PhosphatidylCholine

Liver fat on FibroScan in a placebo-controlled trial

NAFLD/MASLD: 1.5-2.1 g/day standardized PC × 6 months. General choline/cognitive: 500

Liver fat export and normal liver function

425 mg/day (women AI); 550 mg/day (men AI); 930 mg/day (pregnant); up to 3,500 mg/day

Liver enzyme levels (ALT and AST)

420 mg per day of silymarin (140 mg three times daily) in cirrhosis and diabetes

Siliphos® (Silybin Phytosome — Indena)

Liver enzymes and liver health

120-360 mg/day Siliphos (silybin equivalent)

Omega-3 Fatty Acids

Liver fat and liver enzyme support

1–3 g/day combined EPA+DHA for general health; 2–4 g/day for triglyceride reduction (

📈 Fastest Growing Liver Health Ingredients

Branded ingredients seeing rapid growth in formulator adoption and clinical research in 2024–2026.

CurQfen® (Curcumin-Fenugreek FenuMat — Akay Bioactives)

Healthy liver enzyme levels

400 to 1,000 mg/day of CurQfen in trials: 400 mg once daily (knee comfort), 250 mg twice daily…

Siliphos® (Silybin Phytosome — Indena)

Liver enzymes and liver health

Indena suggests starting from 80 mg a day of Siliphos. Studies dosed by silybin content: 120…

NAC (N-Acetylcysteine)

Antioxidant Support

600 to 1,200 mg per day (600 mg once or twice daily) in lung and fertility trials; 2,000 to…

🔬 Future Liver Health Ingredients to Watch

Lower current evidence but active research underway — these may become top picks within 2–3 years.

Cinaran® (Artichoke Leaf Extract)

Commonly 600 mg to 1.8 g of extract per day.

Omega-3 Fatty Acids

Liver fat and liver enzyme support

At least 250 mg/day EPA+DHA for the general population; about 1 g/day EPA in EPA-rich mood…

Betaine / TMG (Trimethylglycine)

Methylation support and fatty-liver evidence (mixed)

1.5 to 6 g/day; athletic performance: 2.5 g/day (most studied dose); homocysteine reduction:…

Recommended Liver Health Products

Heads up: NutraSmarts may earn a commission from purchases made through these links, at no extra cost to you. We curate these picks based on the same evidence we cite throughout the page. Full disclosure.

Real products featuring the best-evidenced liver health ingredients ranked above - chosen for clinically-studied forms and doses, third-party testing, and value. Match the supplement to your specific need.

Best for premium milk thistle support Amazon →

Thorne S.A.T. (Milk Thistle Complex)

Milk thistle + artichoke + turmeric capsules, 60 ct

Pairs standardized silymarin with artichoke and turmeric from a four-times-tested, third-party-certified brand.

Best value NAC for glutathione support Amazon →

NOW Foods NAC 600 mg with Selenium

600 mg veg capsules, 250 ct

NAC is a precursor to glutathione, with added selenium and molybdenum; non-GMO, GMP-made, economical large count.

Best for a clean, single-ingredient TUDCA Amazon →

Double Wood Supplements TUDCA

250 mg/capsule (500 mg serving), 60 ct

Pure tauroursodeoxycholic acid with no fillers, third-party tested with published COAs; transparent, label-clear dose.

Best for high-absorption curcumin Amazon →

Doctor's Best High Absorption Curcumin (C3 Complex + BioPerine)

1000 mg curcuminoids/serving capsules, 120 ct

Pairs the well-studied C3 Complex curcuminoids with BioPerine black pepper to aid absorption; vegan, non-GMO.

All Liver Health Ingredients (35)

PhosphatidylCholine

Liver fat on FibroScan in a placebo-controlled trial

NAFLD/MASLD: 1.5-2.1 g/day standardized PC × 6 months. General choline/cognitive: 500

Liver fat export and normal liver function

425 mg/day (women AI); 550 mg/day (men AI); 930 mg/day (pregnant); up to 3,500 mg/day

Liver enzyme levels (ALT and AST)

420 mg per day of silymarin (140 mg three times daily) in cirrhosis and diabetes

Siliphos® (Silybin Phytosome — Indena)

Liver enzymes and liver health

120-360 mg/day Siliphos (silybin equivalent)

Omega-3 Fatty Acids

Liver fat and liver enzyme support

1–3 g/day combined EPA+DHA for general health; 2–4 g/day for triglyceride reduction (

4Liver™ (Liver Health Botanical Blend)

Supports healthy liver fat markers in overweight adults

Per Saanroo product specification

Agrimony (Agrimonia eupatoria)

Liver enzymes and triglycerides in adults with raised ALT

Two 200 ml cups of tea a day for 30 days in the tea study; capsules of a water

EVNol® (Palm Tocotrienol and Tocopherol Complex — ExcelVite)

Liver ultrasound appearance in a 1-year trial

The trials used 200 mg of mixed tocotrienols twice a day, 400 mg/day total, for 1 to 2 years, delivered as a self-emulsifying softgel rather than plain tocotrienol oil.

Liver fat reduction and metabolic health

2.4-12 mg/day fucoxanthin in human trials, up to 12 mg/day alone for 12 weeks; trials at 1-2 mg/day found no change in body fat.

Green Cardamom (Elettaria cardamomum)

Liver enzyme ALT and ultrasound liver fat grade

3 g/day of ground whole green cardamom in capsules (1 g or 0.5 g each, split across

Robuvit® (French Oak Wood Extract — Horphag Research)

Healthy liver enzyme levels

300 mg/day Robuvit®; fatigue studies use 300 mg/day; a small fatty-liver study used

Sumac (Rhus coriaria)

Liver enzyme levels in placebo-controlled diet trials

1 to 3 g/day of sumac fruit powder in capsules: 500 mg twice daily for 6 weeks, 500 mg

TUDCA (Tauroursodeoxycholic Acid)

Cholestasis / Liver Support

250-1,750 mg/day; ALS research used up to 2 g/day combined with sodium phenylbutyrate

Xanthigen® (Fucoxanthin + Pomegranate Seed Oil)

Liver fat measured in women who already had fatty liver disease

PIVOTAL: 600 mg Xanthigen®/day × 16 weeks (300 mg PSO + 300 mg brown seaweed extract

FucoVital® (Microalgae Fucoxanthin — Algatech)

Liver fat: studied only in women with diagnosed fatty liver disease

No established dose for FucoVital itself, as no trial of it is cited; in the Xanthigen trial, energy expenditure rose at fucoxanthin above 2.4 mg per day, a product also containing pomegranate seed oil.

Phosphocomplex® (Silybin Phytosome — Indena)

A standardized daily dose providing bioavailable silybin.

VitaCholine® (Choline Bitartrate — Balchem)

Liver fat export: a required nutrient

Commonly 300 to 550 mg of choline per day.

Purslane (Portulaca oleracea)

Liver enzyme and liver stiffness readings

Seeds: 10 g/day for 5 to 8 weeks (with yogurt or as sachets); 1 g/day of seed powder

Liver enzyme levels

General use: 3-6 g/day. NAFLD studies: 1.2-1.5 g/day × 3 months. Metabolic syndrome:

CurQfen® (Curcumin-Fenugreek FenuMat — Akay Bioactives)

Healthy liver enzyme levels

400-500 mg/day CurQfen (research-validated; some applications use higher)

DeltaGold® (Annatto Tocotrienols — American River Nutrition)

Lower liver enzymes and liver fat index versus placebo

DeltaGold 70 at 430 or 860 mg/day (300 or 600 mg tocotrienol) for 12 weeks; annatto

Liver Enzyme Levels (GGT, AST and ALT)

Human trials used 1,000 mg a day of a Japanese oyster extract (three tablets) for 12

Punarnava (Boerhavia diffusa)

Liver-protective effects in rats and mice (no human data)

Traditional amounts, not tested in people: 1 to 3 g whole plant powder, or 250 to 500 mg standardized extract two to three times a day; tea 5 to 10 g dried herb. No human trial has set a dose.

Cinaran® (Artichoke Leaf Extract)

Commonly 600 mg to 1.8 g of extract per day.

Antrodia cinnamomea (Niu-Chang-Chih / Stout Camphor Fungus)

Liver fat and liver inflammation test scores

NASH RCT: 3 capsules/day = 420 mg ACM × 6 months (n=28). SUBHEALTH ALT RCT: 250 mg AC

BroccoRaphanin® (Broccoli Seed Glucoraphanin)

Commonly providing tens of milligrams of glucoraphanin per day.

D-Pinitol (3-O-Methyl-D-chiro-Inositol)

Liver fat and liver enzyme levels

1.2 g/day (600 mg twice daily) for 13 weeks; 2 g/day for 6 weeks; 20 mg/kg/day for 4

Kutki (Picrorhiza kurroa)

Liver function markers (bilirubin and liver enzymes)

Traditional powder 0.5-1 g; the only controlled trial used 375 mg three times a day; note 3-6 g is used deliberately to cause purging, so more is not better.

Licorice Root (Glycyrrhiza glabra)

Lower liver enzyme ALT, studied in adults with fatty liver

75 mg twice daily of a deglycyrrhizinated extract in the dyspepsia trial. The EU advises no more than 100 mg glycyrrhizin a day.

Asteracantha longifolia (Hygrophila spinosa)

Hepatoprotective Activity (Animal Evidence)

No human trial has established a dose; traditional Ayurvedic use is about 3 to 6 g of whole plant powder per day, or 250 to 500 mg of extract once or twice a day.

Betaine / TMG (Trimethylglycine)

Methylation support and fatty-liver evidence (mixed)

2–6 g/day; athletic performance: 2.5 g/day (most studied dose); homocysteine reductio

Polyporus umbellatus (Zhu Ling / Chu Ling)

Renal fibrosis protection

TCM DECOCTION: 10-15 g/day raw herb. SEVERE EDEMA: 20-30 g short-term under TCM pract

Alcolec® (Phosphatidylcholine / Lecithin — American Lecithin)

Commonly a few hundred milligrams to grams per day.

AuroraGreen® (Wild Alaska Dandelion — Denali BioTechnologies)

Traditional use for digestion, and preclinical liver research

Per the product specification.

The liver's use of methionine (not a detox or liver treatment)

About 500 to 1,000 mg per day on supplement labels; no cited study tested a dose for general health in healthy people, and excess methionine may be harmful.