Home Ingredients Cinaran® (Artichoke Leaf Extract)
Liver HealthCardiovascularGut Health

Cinaran® (Artichoke Leaf Extract)

Cynara scolymus
Evidence Level
Moderate
1 Clinical Trial
3 Documented Benefits
3/5 Evidence Score

Cinaran® is a standardized artichoke (Cynara scolymus) leaf extract concentrated for cynarin and chlorogenic acid. Artichoke has a long history as a digestive and liver tonic, and modern trials study it for supporting liver health, healthy cholesterol, and comfortable digestion by stimulating bile flow.

Studied Dose Commonly 600 mg to 1.8 g of extract per day.
Active Compound Standardized artichoke leaf extract concentrated for cynarin (caffeoylquinic acids) and chlorogenic acid.

Benefits

Liver support

In a randomized controlled trial in non-alcoholic fatty liver disease, artichoke leaf extract supported improvements in liver measures, reflecting its traditional liver-tonic use.

Supported by Trial 1

Healthy cholesterol

Artichoke leaf extract is studied for supporting healthy total and LDL cholesterol, in part by promoting bile-driven cholesterol clearance.

Supported by Trial 1

Digestive comfort

By stimulating bile flow, artichoke supports the digestion of fats and eases bloating and fullness after meals.

Supported by Trial 1

Mechanism of action

1

Bile stimulation

Artichoke's caffeoylquinic acids increase bile production and flow (a choleretic effect), aiding fat digestion and cholesterol elimination.

2

Antioxidant liver protection

Cynarin and chlorogenic acid are antioxidants that help protect liver cells from oxidative stress.

Clinical trials

1
Artichoke Leaf Extract and Fatty Liver — RCT
PubMed

Pilot double-blind randomized controlled trial of artichoke leaf extract in non-alcoholic fatty liver disease. (Panahi et al. 2018, Phytotherapy Research)

Adults with non-alcoholic fatty liver disease.

Artichoke leaf extract supported improvements in liver measures versus placebo.

Side effects and drug interactions

Common Potential side effects

GENERALLY WELL-TOLERATED — digestive effects are most common.
Mild gas or cramping can occur from increased bile flow.
Avoid if you have bile-duct obstruction or gallstones.

Important Drug interactions

Bile-duct or gallbladder conditions — consult a doctor before use.
Cholesterol medication — may have additive effects; monitor.
Tell your doctor if you have liver or gallbladder disease.

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Frequently asked questions about Cinaran® (Artichoke Leaf Extract)

What is Cinaran® (Artichoke Leaf Extract)?

Cinaran® is a standardized artichoke (Cynara scolymus) leaf extract concentrated for cynarin and chlorogenic acid. Artichoke has a long history as a digestive and liver tonic, and modern trials study it for supporting liver health, healthy cholesterol, and comfortable digestion by stimulating bile flow.

What is the recommended dosage of Cinaran® (Artichoke Leaf Extract)?

The clinically studied dose for Cinaran® (Artichoke Leaf Extract) is Commonly 600 mg to 1.8 g of extract per day.. Always follow product labeling and consult a healthcare provider for personalized dosing recommendations.

What is Cinaran® (Artichoke Leaf Extract) used for?

Cinaran® (Artichoke Leaf Extract) is studied for liver support, healthy cholesterol, digestive comfort. In a randomized controlled trial in non-alcoholic fatty liver disease, artichoke leaf extract supported improvements in liver measures, reflecting its traditional liver-tonic use.

Are there side effects from taking Cinaran® (Artichoke Leaf Extract)?

Reported potential side effects may include: GENERALLY WELL-TOLERATED — digestive effects are most common. Mild gas or cramping can occur from increased bile flow. Always consult a healthcare provider before starting any new supplement, especially if you have underlying conditions or take medications.

Is Cinaran® (Artichoke Leaf Extract) safe to take?

Whether Cinaran® (Artichoke Leaf Extract) is safe depends on the dose, your overall health, and any medications you take. At studied doses, reported side effects can include: GENERALLY WELL-TOLERATED — digestive effects are most common. It may also interact with certain medications. Cinaran® (Artichoke Leaf Extract) is not suitable for everyone — consult a healthcare provider before use if you are pregnant or breastfeeding, have a medical condition, or take prescription medications.

References(1 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Panahi Y, Kianpour P, Mohtashami R, et al. Efficacy of artichoke leaf extract in non-alcoholic fatty liver disease: A pilot double-blind randomized controlled trial. Phytother Res. 2018;32(7):1382-1387..PubMedUsed to support: RCT supporting liver benefit of artichoke leaf extract.