Benefits
Liver Health and Hepatoprotection
Siliphos provides bioavailable silybin for liver protection — multiple clinical trials in liver applications including fatty liver, viral hepatitis adjunct, and hepatotoxic exposure protection.
Fatty Liver (NAFLD) Support
Multiple trials show Siliphos improves liver enzyme markers (ALT, AST) and steatosis markers in non-alcoholic fatty liver disease.
10× Bioavailability vs Standard Silymarin
Standard silymarin (containing silybin + other flavonolignans) has poor bioavailability; Siliphos addresses this. Critical for clinical efficacy.
Antioxidant Liver Cell Protection
Silybin protects hepatocytes from oxidative damage; supports glutathione regeneration; foundation of liver protective effects.
Hepatotoxic Exposure Adjunct
Used as adjunct for hepatotoxic medications, alcohol-related liver stress, environmental toxin exposure.
Mechanism of action
Silybin Most Active Component
Silymarin from milk thistle is mixture of flavonolignans — SILYBIN (silibinin) is the most active component; comprises ~50-60% of silymarin. Siliphos focuses on silybin specifically for higher activity.
Phytosome® Bioavailability Enhancement
Standard silymarin has poor bioavailability (~5-10%); Phytosome improves silybin absorption ~10×.
Hepatocyte Membrane Protection
Silybin stabilizes hepatocyte (liver cell) membranes; protects from toxin entry; foundation of antidote effect against amanita mushroom poisoning.
Antioxidant and Glutathione Support
Direct antioxidant + supports endogenous glutathione (master liver antioxidant) regeneration.
Anti-Inflammatory Liver Effects
Reduces inflammatory markers in liver tissue.
Clinical trials
Multiple Siliphos trials in NAFLD patients on liver enzymes, steatosis, fibrosis markers.
NAFLD patients.
Significant improvements in ALT, AST, steatosis markers vs placebo. Established Siliphos NAFLD evidence.
Meta-analyses of silymarin (including bioavailable forms like Siliphos) for various liver conditions.
Various liver disease populations.
Generally supportive evidence for liver enzyme improvements and protective effects; bioavailable forms more reliable.
About this ingredient
SILIPHOS® is a SILYBIN PHYTOSOME® formulation developed by INDENA (Italy) — using PHYTOSOME® technology applied to SILYBIN (most active component of milk thistle silymarin complex). MILK THISTLE BACKGROUND: Silybum marianum; traditional liver herb used for over 2,000 years; native to Mediterranean. SILYMARIN COMPLEX: mixture of flavonolignans — SILYBIN (silibinin), SILIDIANIN, SILICHRISTIN; SILYBIN is most active (~50-60% of silymarin); responsible for most clinical effects. SILIPHOS FOCUS: silybin specifically (not full silymarin complex).
KEY DISTINCTIONS: (1) PHYTOSOME® TECHNOLOGY for enhanced silybin bioavailability (~10× standard); (2) SILYBIN-FOCUSED (most active component); (3) Pharmaceutical-grade Indena quality; (4) Multiple liver health clinical trials.
EVIDENCE-BASED USES: (1) Liver health and hepatoprotection; (2) NAFLD (non-alcoholic fatty liver disease); (3) Hepatotoxic exposure adjunct; (4) Antioxidant liver cell protection; (5) Hepatic detoxification support.
CRITICAL CAUTIONS: (1) ACTIVE LIVER DISEASE — fatty liver, hepatitis, cirrhosis require medical evaluation; supplementation adjunctive; (2) HEPATICALLY-METABOLIZED MEDICATIONS — silymarin may modestly affect CYP enzymes; consult; (3) PREGNANCY/LACTATION — milk thistle traditionally considered safe; (4) DOSE — 120-360 mg/day silybin equivalent; per Indena specification; (5) SILIPHOS vs STANDARD SILYMARIN — Phytosome bioavailability advantage clinically meaningful; standard silymarin often underperforms; (6) SILIPHOS vs MILK THISTLE WHOLE EXTRACT — standardized 80% silymarin extracts are alternative; Siliphos provides more bioavailable focused silybin; (7) HEPATIC DETOX — comprehensive approach: limit alcohol, healthy weight, avoid hepatotoxic medications when possible, balanced diet foundational; supplements adjunct; (8) NAFLD MANAGEMENT — primary intervention is weight loss; supplements adjunctive; (9) AMANITA MUSHROOM POISONING — silibinin (IV form) is established antidote — different application than oral supplementation; (10) BRAND VERIFICATION — Siliphos® Phytosome® is Indena trademark; specific clinical evidence on this branded form; (11) For COMPREHENSIVE LIVER HEALTH — Siliphos reasonable alongside other approaches; multiple liver-supportive options available.