Benefits
Vitamin A status in children eating orange-fleshed sweet potato
In a randomized trial in 180 South African children aged 5 to 10, 125 g a day of boiled, mashed orange-fleshed sweet potato on school days improved a liver vitamin A store marker compared with white-fleshed sweet potato, which has no beta-carotene. The share of children with normal status rose from 78% to 87%, a trend that was not formally tested.
Vitamin A intake in households growing orange-fleshed sweet potato
In randomized programs in rural Uganda and Mozambique that promoted growing and eating orange-fleshed sweet potato, vitamin A intake rose in young children and women compared with control areas. In Uganda, low blood retinol fell by 9.5 percentage points in children. In Bangladeshi women, 60 days of the root raised blood beta-carotene but not total body vitamin A.
Blood sugar markers with white-skinned sweet potato extract (Caiapo)
In a Cochrane review, 4 g a day of Caiapo for 3 to 5 months lowered HbA1c by about 0.3 percentage points versus placebo in two pooled trials of 122 adults with type 2 diabetes managed by diet. The review's three small trials all came from one research group and were judged very low quality. This extract is not a substitute for medical care.
Glycemic response to boiled versus baked or roasted sweet potato
In a glycemic index test of ten Jamaican sweet potato varieties in ten healthy adults, boiled sweet potato had a glycemic index of 41 to 50, while baked (82 to 94) and roasted (79 to 93) sweet potato were much higher. Cooking method mattered more than variety. This was a single-meal test, not a long-term trial.
Liver enzyme levels with a purple sweet potato beverage
In two placebo-controlled trials of a purple sweet potato beverage rich in anthocyanins, 8 weeks lowered the liver enzyme GGT in 38 Japanese men, and GGT, AST and ALT at some time points in 37 Europeans, compared with a low-anthocyanin placebo drink. Participants had mildly raised liver enzymes. The second, a pilot trial, included authors from Yakult, which supplied the beverage in a related study.
Oxidative stress markers after exercise with purple sweet potato leaves
In a crossover trial in 15 untrained young men, 7 days of a diet including purple sweet potato leaves, compared with a low-polyphenol diet, raised plasma polyphenols and antioxidant power and lowered oxidative damage markers and the inflammatory signal IL-6 after an hour of running. Heat shock protein 72 did not differ. These are blood markers, not performance.
Mechanism of action
Beta-carotene converted to vitamin A as needed
Orange flesh owes its color to beta-carotene, which the gut converts to vitamin A. NIH counts 12 mcg of dietary beta-carotene as 1 mcg RAE, and conversion falls when vitamin A stores are adequate. Plasma beta-carotene rose in women eating the root even when body vitamin A stores did not, so higher blood carotene does not by itself show better status.
Cooking changes how fast the starch is digested
Boiled sweet potato produced a much lower blood sugar rise than baked or roasted sweet potato of the same varieties in a glycemic index test. The study measured blood glucose responses only and did not test why cooking method mattered; within each method, variety made a smaller difference.
Anthocyanins absorbed from purple-fleshed roots and leaves
Purple-fleshed sweet potato is rich in acylated anthocyanins, and purple sweet potato leaves were used as a high-polyphenol food in trials. In the leaf trial, a diet with the leaves raised plasma polyphenols compared with a low-polyphenol diet. How these compounds might act on liver enzymes is not established in people; that work is mainly in cells and animals.
Clinical trials
Randomized controlled feeding trial: 125 g of boiled, mashed orange-fleshed sweet potato (1031 mcg RAE a day as beta-carotene) or the same amount of white-fleshed sweet potato with no beta-carotene, on 53 school days. All children were dewormed. Vitamin A stores were assessed with the modified relative dose response test. Funding is not detailed in the abstract (van Jaarsveld et al. 2005, Am J Clin Nutr)
180 primary school children aged 5 to 10 in South Africa (90 per group).
The vitamin A store marker (DR:R ratio) improved more with orange-fleshed sweet potato than control (intervention effect -0.008, 95% CI -0.015 to -0.001, P = 0.02). Children with normal vitamin A status rose from 78% to 87% in the treatment group (P = 0.096) and changed from 86% to 82% in controls; these proportions were not used to test the effect.
Randomized controlled effectiveness study of two 2-year programs (intensive and reduced) promoting household growing and eating of orange sweet potato, compared with control areas, by a HarvestPlus team at the International Food Policy Research Institute (Hotz et al. 2012, J Nutr)
Farming households in Uganda: intake measured in children aged 6 to 35 months (265) and 3 to 5 years (578) and women (573); vitamin A status measured in children aged 3 to 5 and women with low serum retinol at baseline.
Orange sweet potato intake rose in both program groups (P < 0.01) and supplied 44 to 60% of vitamin A intake at follow-up. Inadequate vitamin A intake fell by more than 30 percentage points in young children and more than 25 points in women versus control. Low serum retinol fell by 9.5 percentage points in children with complete data (396, P < 0.05); the abstract reports a status result for children only.
Randomized controlled trial, 6 days a week for 10 weeks: boiled white-fleshed sweet potato (0 RAE), boiled orange-fleshed sweet potato (600 mcg RAE a day), fried orange-fleshed sweet potato, or white-fleshed sweet potato plus a retinyl palmitate capsule, added to home diets (Jamil et al. 2012, J Nutr)
Women with low initial vitamin A status in a resource-poor community in Bangladesh (30 per group).
Final plasma beta-carotene was higher in the orange-fleshed groups (P < 0.0001), and marginally higher with fried than boiled (P = 0.07). Plasma retinol and total body vitamin A pool size did not differ by group, including the retinyl palmitate group. The authors concluded the impact on vitamin A status appeared limited in this population.
Randomized, placebo-controlled multicenter trial: 4 g Caiapo (an extract of white sweet potato) or placebo once daily for 12 weeks, with oral glucose tolerance tests monthly. The abstract does not state funding or who supplied the extract (Ludvik et al. 2004, Diabetes Care)
61 adults with type 2 diabetes treated by diet alone (30 Caiapo, 31 placebo), mean age about 55.
HbA1c fell from 7.21% to 6.68% with Caiapo (P < 0.001) and was unchanged with placebo (7.04% to 7.10%). Two-hour glucose fell more with Caiapo than placebo (P < 0.001), and end-of-study cholesterol was lower than placebo (P < 0.05). Body weight fell in both groups. Triglycerides and blood pressure did not change, and no significant adverse effects were reported.
Randomized, placebo-controlled multicenter trial: 4 g Caiapo daily or placebo for 5 months. The abstract does not state funding or who supplied the extract (Ludvik et al. 2008, Diabetes Obes Metab)
61 adults with type 2 diabetes on diet only (27 Caiapo, 34 placebo).
With Caiapo, insulin sensitivity (OGIS, P = 0.0072) and adiponectin rose, and fibrinogen, HbA1c (6.46% to 6.25%), fasting glucose and triglycerides fell compared with baseline; in the placebo group HbA1c rose from 6.25% to 6.50%. Body weight, cholesterol and the inflammation marker hs-CRP did not change. The abstract reports mainly within-group changes.
Randomized, double-blind, placebo-controlled parallel trial for 8 weeks: two 125 mL bottles a day of a purple sweet potato beverage (200.3 mg anthocyanins per bottle) or a placebo drink (1.7 mg). Funding is not stated in the abstract (Suda et al. 2008, Eur J Clin Nutr)
Healthy men aged 30 to 60 in Kumamoto, Japan, with one or more liver enzymes (GGT, AST, ALT) above normal and no viral hepatitis; 38 of 48 enrolled completed.
GGT, AST and ALT showed group by time interactions (P < 0.05). GGT was lower than placebo at 2 weeks (-14.1 IU/L, P = 0.017), 6 weeks and 8 weeks (-27.9 IU/L, P = 0.014), but not significantly at 4 weeks (P = 0.081). Other measures were not affected.
Double-blind, placebo-controlled pilot trial for 8 weeks: three 125 mL bottles a day of a purple sweet potato beverage (177 mg anthocyanins per bottle) or placebo (1.3 mg). Three authors were affiliated with Yakult, which supplied the beverage in this group's 2016 study (Oki et al. 2017, Eur J Clin Nutr)
40 healthy Caucasian adults aged 41 to 69 with mildly raised liver enzymes; 39 completed and 37 were analyzed.
Compared with placebo, GGT was lower on day 43 (P = 0.038; day 15 P = 0.077), AST was lower on days 29 and 43, and ALT was lower on day 43 (P = 0.037). Results were reported by time point; other blood and clinical chemistry values showed no clinically relevant changes.
Controlled crossover trial: 7 days of a high-polyphenol diet with purple sweet potato leaves or a low-polyphenol control diet, 14-day washout, then 1 hour of treadmill running at 70% of VO2max. Funding is not stated in the abstract (Chang et al. 2010, J Appl Physiol (1985))
15 healthy, untrained young men in Taiwan.
Compared with the control diet, the leaf diet raised plasma total polyphenols and antioxidant power (FRAP) and lowered the oxidative damage markers TBARS and protein carbonyl and plasma IL-6 around exercise. Heat shock protein 72 did not differ between diets. Exercise performance was not an outcome.