Home Ingredients Hepure™ (Clove & Immortelle Extract — Nexira)
Antioxidant

Hepure™ (Clove & Immortelle Extract — Nexira)

Evidence Level
Preliminary
2 Clinical Trials
3 Documented Benefits
1/5 Evidence Score

Hepure™ is an organic blend of clove (Syzygium aromaticum) and immortelle (Helichrysum italicum) extracts from Nexira in France, marketed for liver support, with the immortelle sourced from Corsica. Nexira says it compared more than 100 botanical sources in liver cell tests before choosing this pair. A Nexira-sponsored cell study of 28 plant and algal extracts found clove and immortelle among the strongest antioxidants, found that combining them worked better than either alone, and found that both still switched on antioxidant defense signaling in liver cells after passing through a layer of intestinal cells. No human trial of Hepure has been published. Small human studies of a different clove extract and of immortelle tea measured blood antioxidant markers, but they did not test this blend or liver function.

Studied Dose No human dose of Hepure has been tested. Related human studies used 250 mg a day of a different clove bud polyphenol extract and a daily immortelle herbal tea.
Active Compound Clove extract (eugenol and other phenolic compounds, flavonoids) and immortelle extract (arzanol and related phloroglucinols, hydroxycinnamic acids, flavonoids).

Benefits

Antioxidant activity of the clove and immortelle pair

In a Nexira-sponsored in vitro study, clove and immortelle extracts neutralized free radicals inside cells at low concentrations, and combinations of the strongest extracts worked better than single extracts. These are lab results; the blend has not been tested in people.

Supported by Trial 2, Trial 1

Liver cell antioxidant defense signaling

After passing through a layer of intestinal cells, clove and immortelle extracts still switched on the Nrf2 antioxidant defense pathway in HepG2 liver cells in vitro. Whether this happens in people has not been tested.

Supported by Trial 1, Trial 2

Blood antioxidant markers with related clove and immortelle preparations

In a crossover trial in 16 men given alcohol, 250 mg of a different clove bud polyphenol extract raised blood glutathione and superoxide dismutase and lowered lipid peroxidation versus placebo. A 28-day immortelle tea trial reported better serum antioxidant capacity. Neither tested Hepure.

Supported by Trial 1

Mechanism of action

1

Direct antioxidant activity from phenolic compounds

Clove contains eugenol and phenolic acids, and immortelle contains arzanol, a compound that blocked lipid oxidation and protected cells from oxidative stress in lab tests. A clove extract also protected rat liver slices from chemical damage in vitro.

2

Nrf2 antioxidant defense signaling

In cell studies, clove and immortelle extracts activated the ARE/Nrf2 pathway in liver cells, and an immortelle tea extract raised activity of genes for superoxide dismutase, catalase and glutathione reductase.

Clinical trials

1
Clove Bud Polyphenols and Oxidative Stress After Alcohol (Crossover RCT)
PubMed

Randomized, double-blind, placebo-controlled crossover trial of 250 mg/day of a clove bud polyphenol extract (Clovinol, not Hepure) with alcohol at 1 g/kg body weight. (Mammen et al. 2018, J Med Food)

16 male social drinkers.

Compared with placebo, the clove extract sped blood acetaldehyde clearance, lowered oxidative stress, lipid peroxidation, C-reactive protein and interleukin-6, and raised glutathione and superoxide dismutase. Hangover scores fell 55 percent. This tested a different clove extract, not the Hepure blend.

2
Immortelle Tea in Adults With Metabolic Syndrome Traits (Randomized Comparative Trial)
PubMed

Double-blind randomized comparative trial of a daily Helichrysum italicum or Helichrysum arenarium herbal tea for 28 days, with no placebo group. (Kenig et al. 2022, Food Funct)

27 adults with at least two traits of metabolic syndrome (14 drank immortelle tea).

The immortelle tea group lost body weight and body fat, both groups showed improved serum antioxidant properties, and both showed a fall in HDL cholesterol. This tested immortelle tea, not the Hepure blend.

Side effects and drug interactions

Common Potential side effects

No human safety data exist for Hepure itself.
People allergic to plants in the daisy family (Asteraceae), which includes immortelle, may react.
Clove allergy is possible.
Clove has a strong aromatic taste.

Important Drug interactions

Blood thinners: clove contains eugenol, which is often flagged for possible effects on clotting; ask a doctor before combining.
Diabetes medicines and medicines processed by the liver: no interaction data exist for this blend; ask a doctor first.
Surgery: stop in advance and tell your doctor.
Pregnancy and breastfeeding: no safety data; avoid.

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Frequently asked questions about Hepure™ (Clove & Immortelle Extract — Nexira)

What is Hepure?

Hepure™ is an organic blend of clove (Syzygium aromaticum) and immortelle (Helichrysum italicum) extracts from Nexira in France, marketed for liver support, with the immortelle sourced from Corsica. Nexira says it compared more than 100 botanical sources in liver cell tests before choosing this pair.

What is Hepure used for?

Hepure is researched primarily for Antioxidant. In a Nexira-sponsored in vitro study, clove and immortelle extracts neutralized free radicals inside cells at low concentrations, and combinations of the strongest extracts worked better than single extracts.

What is the recommended dosage of Hepure?

No human dose of Hepure has been tested. Related human studies used 250 mg a day of a different clove bud polyphenol extract and a daily immortelle herbal tea. Always follow the product label and check with a healthcare provider for personal advice.

Is Hepure safe, and does it have side effects?

Side effects and cautions reported for Hepure include: No human safety data exist for Hepure itself. People allergic to plants in the daisy family (Asteraceae), which includes immortelle, may react. It may also interact with some medications. Hepure is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does Hepure interact with any medications?

Possible interactions include: Blood thinners: clove contains eugenol, which is often flagged for possible effects on clotting; ask a doctor before combining. Diabetes medicines and medicines processed by the liver: no interaction data exist for this blend; ask a doctor first. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for Hepure?

NutraSmarts rates the evidence for Hepure as Preliminary (1 out of 5). It is backed by 2 study summaries and 7 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(7 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Furger C, Gironde C, Rigal M, Dufour C, Guillemet D. Cell-Based Antioxidant Properties and Synergistic Effects of Natural Plant and Algal Extracts Pre and Post Intestinal Barrier Transport. Antioxidants (Basel). 2022;11(3):565. doi: 10.3390/antiox11030565.PubMedUsed to support: Nexira-sponsored cell study of 27 plant extracts and 1 algal extract: clove and immortelle extracts were among the strongest intracellular antioxidants, combinations of the strongest extracts were synergistic, and clove and immortelle kept their ability to activate ARE/Nrf2 antioxidant signaling in HepG2 liver cells after an intestinal cell barrier. In vitro only.
  2. Mammen RR, Natinga Mulakal J, Mohanan R, Maliakel B, Illathu Madhavamenon K. Clove Bud Polyphenols Alleviate Alterations in Inflammation and Oxidative Stress Markers Associated with Binge Drinking: A Randomized Double-Blinded Placebo-Controlled Crossover Study. J Med Food. 2018;21(11):1188-1196. doi: 10.1089/jmf.2017.4177.PubMedUsed to support: Randomized double-blind crossover trial in 16 male social drinkers: 250 mg/day of a clove bud polyphenol extract (Clovinol) with alcohol lowered oxidative stress, lipid peroxidation and inflammatory markers and raised glutathione and superoxide dismutase versus placebo. Different clove extract, not Hepure.
  3. Kenig S, Kramberger K, Šik Novak K, Karnjuš I, Bandelj D, Petelin A, Jenko Pražnikar Z. Helichrysum italicum (Roth) G. Don and Helichrysum arenarium (L.) Moench infusions in reversing the traits of metabolic syndrome: a double-blind randomized comparative trial. Food Funct. 2022;13(14):7697-7706. doi: 10.1039/d2fo00880g.PubMedUsed to support: Randomized comparative trial in 27 adults with metabolic syndrome traits: 28 days of Helichrysum italicum or H. arenarium tea improved serum antioxidant properties and lowered HDL; the immortelle group lost weight and body fat. No placebo group; not Hepure.
  4. Rosa A, Deiana M, Atzeri A, Corona G, Incani A, Melis MP, Appendino G, Dessì MA. Evaluation of the antioxidant and cytotoxic activity of arzanol, a prenylated alpha-pyrone-phloroglucinol etherodimer from Helichrysum italicum subsp.microphyllum. Chem Biol Interact. 2007;165(2):117-26. doi: 10.1016/j.cbi.2006.11.006.PubMedUsed to support: In vitro study: arzanol and other compounds from Helichrysum italicum inhibited lipid peroxidation, and arzanol protected monkey kidney (VERO) cells from induced oxidative stress. Component chemistry, not the Hepure blend.
  5. Kramberger K, Jenko Pražnikar Z, Baruca Arbeiter A, Petelin A, Bandelj D, Kenig S. A Comparative Study of the Antioxidative Effects of Helichrysum italicum and Helichrysum arenarium Infusions. Antioxidants (Basel). 2021;10(3):380. doi: 10.3390/antiox10030380.PubMedUsed to support: In vitro comparison of Helichrysum infusions: one H. italicum type, richest in hydroxycinnamic acids and arzanol derivatives, had the highest radical scavenging activity, protected cell lines from oxidative stress and raised superoxide dismutase 1, catalase and glutathione reductase 1 gene activity. Component data, not Hepure.
  6. Hina S, Rehman K, Shahid M, Jahan N. In vitro antioxidant, hepatoprotective potential and chemical profiling of Syzygium aromaticum using HPLC and GC-MS. Pak J Pharm Sci. 2017;30(3(Suppl.)):1031-1039..PubMedUsed to support: Lab study of clove extract: radical scavenging and reducing power in chemical assays, DNA protection, and protection of rat liver slices from carbon tetrachloride toxicity. Component data, not Hepure.
  7. Nexira. HEPURE™ brand page. Nexira (manufacturer website). 2026;Accessed 2026-10-05..SourceUsed to support: Manufacturer page, not PubMed-indexed: describes Hepure as an organic clove and immortelle formulation with immortelle from Corsica, and states that Nexira compared more than 100 botanical sources in liver cells. Lists no human clinical study or dose.