Home Ingredients Hepure™ (Clove + Immortelle Liver Detox)
Liver HealthDetox & Cleanse

Hepure™ (Clove + Immortelle Liver Detox)

Evidence Level
Limited
2 Clinical Trials
4 Documented Benefits
2/5 Evidence Score

Hepure™ is an organic clove (Syzygium aromaticum) + immortelle/helichrysum (Helichrysum italicum) extract from Nexira (France), positioned for liver health and detoxification. Evidence is primarily in vitro liver-cell antioxidant and nutrigenomic data; human clinical trials on the finished ingredient have not been published.

Studied Dose No published human clinical dose for Hepure™ specifically. Per Nexira product literature, finished products typically use ~300-500 mg/day. Mechanistic evidence is from in vitro liver cell studies only — human trial data pending.
Active Compound Clove polyphenols (eugenol, flavonoids) + Helichrysum compounds (italidiones, flavonoids)

Benefits

In vitro hepatoprotective antioxidant activity

Nexira screened 100+ botanical extracts for liver-cell antioxidant potency before selecting the clove + immortelle combination as the strongest performer. In their cell models, the combination outperformed either ingredient alone in direct antioxidant activity against oxidative stress markers.

Supported by Trial 1

Nutrigenomic activation of liver antioxidant genes

In vitro studies reported upregulation of gene expression coding for endogenous liver antioxidant defenses — the basis of the 'nutrigenomic mechanism' positioning. The proposed model is dual: direct antioxidant activity from phenolic compounds plus induction of cellular defense pathways.

Supported by Trial 1, Trial 2

EFSA pending claim on Helichrysum italicum

Nexira lists a pending EFSA claim on the Helichrysum italicum component: "Helps to maintain a healthy liver function, supporting the digestion and the body purification." Pending status means this claim is not yet authorized — products cannot use it on labels in the EU until/unless approved.

Supported by Trial 2, Trial 1

Clean-label and organic positioning

Helichrysum italicum is sourced from the Corsican maquis; clove is sourced traditionally. Both extracts are certified organic. The water-extraction process uses no added carrier — a positioning advantage for clean-label, organic-certified finished products.

Supported by Trial 2, Trial 1

Mechanism of action

1

Direct antioxidant activity from phenolic compounds

Eugenol is the dominant compound in clove (~70-90% of clove essential oil); helichrysum contains arzanol, gnaphaliin, and italipyrone among other italoid compounds. Both have demonstrated radical-scavenging activity in cell-based assays.

2

Nutrigenomic induction of liver defense genes

In hepatocyte cell models, the combination upregulates expression of antioxidant defense genes (specific genes/pathways not detailed in publicly available Nexira literature). This is the mechanistic basis for the 'detoxification pathway activation' positioning.

3

Anti-inflammatory marker modulation

Helichrysum italicum has documented anti-inflammatory activity in published literature, primarily from in vitro and small clinical studies on the plant rather than the Hepure™ finished ingredient specifically.

Clinical trials

1
Nexira In Vitro Hepatocyte Screening Study

Nexira screened 100+ botanical extracts for antioxidant activity in liver cell lines and selected clove + immortelle as the best-performing combination.

Clinical population described in trial publication.

Nexira screened 100+ botanical extracts for antioxidant activity in liver cell lines and selected clove + immortelle as the best-performing combination. The screening reported direct antioxidant activity plus upregulation of gene expression coding for endogenous antioxidant defenses. This is in vitro evidence — not a human clinical trial.

2
Helichrysum italicum Anti-Inflammatory Literature

Independent published literature on Helichrysum italicum (the immortelle component) supports anti-inflammatory and antioxidant activity in cellular models and small in vivo studies.

Clinical population described in trial publication.

Independent published literature on Helichrysum italicum (the immortelle component) supports anti-inflammatory and antioxidant activity in cellular models and small in vivo studies. None of these were conducted on the Hepure™ finished ingredient. The basis for the proposed mechanism rather than for clinical efficacy claims.

Side effects and drug interactions

Common Potential side effects

Generally well-tolerated.
Mild GI distress.
Allergic reactions to Asteraceae family rare (Helichrysum is in Asteraceae).
Allergic reactions to Myrtaceae family rare (Clove is in Myrtaceae).
Theoretical bleeding risk at high doses (eugenol effects on platelets) — minor.
Taste: aromatic clove notes; pleasant or strong depending on user preference.

Important Drug interactions

Anticoagulants — theoretical bleeding risk from clove eugenol; modest at typical doses.
Diabetes medications — modest hypoglycemic effects.
Hepatotoxic medications — theoretical interactions; consult.
Anesthesia — clove may potentiate some anesthetic effects; discontinue 1-2 weeks pre-surgery.
Pregnancy — both Clove and Helichrysum traditionally cautioned in pregnancy; avoid supplementation.
Lactation — limited safety data; avoid.

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Frequently asked questions about Hepure™ (Clove + Immortelle Liver Detox)

What is Hepure?

Hepure™ is an organic clove (Syzygium aromaticum) + immortelle/helichrysum (Helichrysum italicum) extract from Nexira (France), positioned for liver health and detoxification.

What is Hepure used for?

Hepure is researched primarily for Liver Health and Detox & Cleanse. Nexira screened 100+ botanical extracts for liver-cell antioxidant potency before selecting the clove + immortelle combination as the strongest performer.

What is the recommended dosage of Hepure?

The clinically studied dose is No published human clinical dose for Hepure™ specifically. Per Nexira product literature, finished products typically use ~300-500 mg/day. Mechanistic evidence is from in vitro liver cell studies only — human trial data pending. Always follow the product label and check with a healthcare provider for personal advice.

Is Hepure safe, and does it have side effects?

For most healthy adults, Hepure is well tolerated at studied doses. Reported effects can include: Generally well-tolerated. Mild GI distress. It may also interact with some medications. Hepure is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does Hepure interact with any medications?

Possible interactions include: Anticoagulants — theoretical bleeding risk from clove eugenol; modest at typical doses. Diabetes medications — modest hypoglycemic effects. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for Hepure?

NutraSmarts rates the evidence for Hepure as Limited (2 out of 5). It is backed by 2 clinical trials and 3 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(3 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Antonella Rosa, Monica Deiana, Angela Atzeri, Giulia Corona, Alessandra Incani, M Paola Melis, Giovanni Appendino, M Assunta Dessì Evaluation of the antioxidant and cytotoxic activity of arzanol, a prenylated alpha-pyrone-phloroglucinol etherodimer from Helichrysum italicum subsp. microphyllum Chemico-Biological Interactions. 2007;165(2):117-26. doi:10.1016/j.cbi.2006.11.006.PubMedUsed to support: Demonstrates in vitro antioxidant activity of arzanol — the signature phloroglucinol compound of Helichrysum italicum (immortelle), one of the two botanical components of Hepure™ — showing strong inhibition of lipid peroxidation and protection of fibroblast cells from oxidative stress. Supports the in vitro hepatoprotective antioxidant and antioxidant gene activation claims (component literature, not the Hepure™ blend itself).
  2. Katja Kramberger, Zala Jenko Pražnikar, Alenka Baruca Arbeiter, Ana Petelin, Dunja Bandelj, Saša Kenig A Comparative Study of the Antioxidative Effects of Helichrysum italicum and Helichrysum arenarium Infusions Antioxidants (Basel). 2021;10(3):380. doi:10.3390/antiox10030380.PubMedUsed to support: Confirms that Helichrysum italicum (immortelle) exhibits the highest radical scavenging activity among tested Helichrysum species, with antioxidant activity outperforming related species across multiple assays. Highest activity correlated with hydroxycinnamic acids and arzanol derivatives. Supports the in vitro antioxidant activity benefit of the immortelle component in Hepure™ (component literature, not the finished Hepure™ blend).
  3. Saman Hina, Khalilur Rehman, Muhammad Shahid, Nazish Jahan In vitro antioxidant, hepatoprotective potential and chemical profiling of Syzygium aromaticum using HPLC and GC-MS Pakistan Journal of Pharmaceutical Sciences. 2017;30(3 Suppl.):1031-1039.PubMedUsed to support: In vitro study demonstrating that Syzygium aromaticum (clove) extract shows strong DPPH radical scavenging activity and hepatoprotective effects against CCl4-induced cytotoxicity in liver cells, with identified phenolic acids as active constituents. Supports the hepatoprotective antioxidant benefit of the clove component in Hepure™ (component literature, animal/in vitro; not the finished Hepure™ blend).