Top 5 — Ranked by Evidence
Moderate
Setria® Glutathione
Increased blood and tissue glutathione levels
250–500 mg/day; 250 mg shown effective for increasing blood glutathione levels
Moderate
Milk Thistle
What About Detox?
The efficacy of these mechanisms depends on silymarin content (standardized extracts
Moderate
NAC (N-Acetylcysteine)
Liver Health and Detoxification
600–1,800 mg/day in divided doses; respiratory: 600 mg twice daily; liver support: 60
Moderate
Sulforaphane / Glucoraphanin
Detoxification enzyme support
Standard supplementation: 60-150 mg glucoraphanin with active myrosinase (provides 10
📈 Fastest Growing Detox & Cleanse Ingredients
Branded ingredients seeing rapid growth in formulator adoption and clinical research in 2024–2026.
Trending
Moderate
Sulforaphane / Glucoraphanin
Detoxification enzyme support
60-150 mg glucoraphanin (with active myrosinase) = 10-40 mg sulforaphane equivalent; direct…
Trending
Moderate
Setria® Glutathione
Increased blood and tissue glutathione levels
250–500 mg/day; 250 mg shown effective for increasing blood glutathione levels
Trending
Limited
Broccoli Extract (Glucoraphanin)
Airborne pollutant detoxication — measured benzene and acrolein excretion
Glucoraphanin 30-100 mg/day with myrosinase; sulforaphane 10-50 mg/day; ASD trials 50-150…
🔬 Future Detox & Cleanse Ingredients to Watch
Lower current evidence but active research underway — these may become top picks within 2–3 years.
Watch
Limited
Hepure™ (Clove + Immortelle Liver Detox)
Liver detox claim rests on cell-model data only
~300-500 mg/day in finished products (no published human clinical dose for Hepure…
Watch
Preliminary
Calcium D-Glucarate
Toxin / Xenobiotic Clearance
1,000-3,000 mg/day is the range used in practice; no human dosing study is cited, so this…
Watch
Moderate
NAC (N-Acetylcysteine)
Liver Health and Detoxification
600–1,800 mg/day in divided doses; 600 mg twice daily; 600 mg three times daily.
Recommended Detox & Cleanse Products
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Real products featuring the best-evidenced detox & cleanse ingredients ranked above - chosen for clinically-studied forms and doses, third-party testing, and value. Match the supplement to your specific need.
Best for glutathione & antioxidant support
Amazon →
NOW Foods NAC 600 mg with Selenium & Molybdenum
600 mg veg capsules, 250 ct
NAC is a precursor to glutathione, paired with selenium and molybdenum; non-GMO, vegan, large 250-count.
Best for liver & antioxidant support
Amazon →
Jarrow Formulas Milk Thistle
150 mg 30:1 extract (80% silymarin), 200 ct
Standardized 30:1 extract delivering 80% silymarin flavonoids; non-GMO, vegan, up to a 200-day supply.
Best for phase-1 detox & cellular support
Amazon →
Jarrow Formulas BroccoMax
35 mg SGS delayed-release veg caps, 120 ct
Broccoli seed extract with active myrosinase to convert glucoraphanin into sulforaphane; delayed-release, non-GMO, vegan.
Best for antioxidant recycling & metabolic support
Amazon →
Doctor's Best Alpha-Lipoic Acid 600 mg
600 mg veg capsules, 60 ct
ALA is a versatile antioxidant that helps regenerate other antioxidants and supports glucose metabolism; non-GMO, vegan.
All Detox & Cleanse Ingredients (14)
Moderate
Setria® Glutathione
Increased blood and tissue glutathione levels
250–500 mg/day; 250 mg shown effective for increasing blood glutathione levels
Moderate
Milk Thistle
What About Detox?
The efficacy of these mechanisms depends on silymarin content (standardized extracts
Moderate
NAC (N-Acetylcysteine)
Liver Health and Detoxification
600–1,800 mg/day in divided doses; respiratory: 600 mg twice daily; liver support: 60
Moderate
Sulforaphane / Glucoraphanin
Detoxification enzyme support
Standard supplementation: 60-150 mg glucoraphanin with active myrosinase (provides 10
Limited
Chlorophyll / Chlorophyllin
Reduction of aflatoxin-DNA adducts (high-risk populations)
AFLATOXIN PROTECTION: 100 mg sodium copper chlorophyllin 3×/day (300 mg/day total). D
Limited
4Liver™ (Liver Health Botanical Blend)
Liver enzyme normalization
Per Saanroo product specification
Limited
Broccoli Extract (Glucoraphanin)
Airborne pollutant detoxication — measured benzene and acrolein excretion
Glucoraphanin: 30-100 mg/day with myrosinase. Sulforaphane: 10-50 mg/day. ASD trials:
Limited
FenuKale™ Nu
Nrf2-pathway antioxidant / pollution-detox support
350 mg/day for 56 days
Limited
Hepure™ (Clove + Immortelle Liver Detox)
Liver detox claim rests on cell-model data only
No published human clinical dose for Hepure™ specifically. Per Nexira product literat
Limited
Polyporus umbellatus (Zhu Ling / Chu Ling)
Traditional diuretic used for fluid balance and urinary support
TCM DECOCTION: 10-15 g/day raw herb. SEVERE EDEMA: 20-30 g short-term under TCM pract
Preliminary
L-Methionine
SAMe synthesis and methylation support
About 500 to 1,000 mg per day on supplement labels; no cited study tested a dose for general health in healthy people, and excess methionine may be harmful.
Moderate
Truebroc® (Glucoraphanin Broccoli Seed Extract — Brassica Protection Products)
NRF2 activation and detoxification enzyme upregulation
30-150 mg/day (providing 4-20 mg glucoraphanin) is the usual supplement range; the cited studies used other broccoli sprout preparations, so their doses do not map onto these numbers.
Preliminary
Calcium D-Glucarate
Toxin / Xenobiotic Clearance
1,000-3,000 mg/day is the range used in practice; no human dosing study is cited, so this reflects practice convention rather than a studied dose.
Preliminary
Champex® (Champignon Mushroom Extract — Agaricus bisporus)
Breath freshness
Commonly around 200 to 400 mg per day.