Dihydromyricetin (DHM, from Hovenia dulcis)

Dihydromyricetin (DHM), a flavonoid from the Japanese raisin tree (Hovenia dulcis), is marketed mainly as a hangover and anti-alcohol supplement, to support the body's breakdown of alcohol and protect the liver. It is also studied for liver and metabolic health.

DHM is popular for hangover support, on the idea that it speeds alcohol metabolism and counters some of alcohol's effects on the brain and liver. Human evidence is limited and mostly anecdotal or preclinical, so results vary.

Products typically provide a few hundred milligrams, taken before, during, or after drinking; follow product labeling. It is not a license to drink more, and it does not prevent intoxication or impairment.

It is generally reported as well tolerated. Importantly, it does not make drinking safe or prevent impairment, so never use it to justify drinking more or driving. Those with liver conditions or on medication should check with a doctor.

Dihydromyricetin (DHM) is a flavonoid from the Japanese raisin tree (Hovenia dulcis), marketed mainly as a hangover and anti-alcohol supplement that may support the body's breakdown of alcohol and help protect the liver; it is also studied for liver and metabolic health.

Dihydromyricetin is researched primarily for Liver Health. DHM is studied for supporting the liver enzymes that break down alcohol and its toxic byproduct acetaldehyde, which is closely linked to hangover symptoms.

The clinically studied dose is Commonly 300 to 600 mg taken around alcohol intake. Always follow the product label and check with a healthcare provider for personal advice.

For most healthy adults, Dihydromyricetin is well tolerated at studied doses. Reported effects can include: Generally well-tolerated in studies. Does not make drinking safe and is not a reason to drink more or to drive. It may also interact with some medications. Dihydromyricetin is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Possible interactions include: Alcohol and sedatives — DHM acts on GABA-A pathways; never rely on it to counter impairment. May affect liver enzymes that process medications; ask your doctor. If you take prescription medication, check with a pharmacist or doctor before using it.

NutraSmarts rates the evidence for Dihydromyricetin as Limited (2 out of 5). It is backed by 1 clinical trial and 2 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.