Restorative sleep improvement
The clinical trial showed a 64% greater improvement in restorative sleep quality in the Serezin group vs. placebo at 4 weeks. Unlike melatonin or sedatives, Serezin works by reducing pain that disrupts sleep rather than directly inducing sedation.
Nighttime and daytime pain reduction
By Day 7, significant improvements in pain scores were observed. By Day 28, subjects experienced a 2.6x greater reduction in nighttime discomfort and a 75% greater reduction in daytime discomfort vs. placebo — addressing a root cause of poor sleep in aging adults.
Sleep onset and quality
By Day 14, subjects showed 85% greater improvement in ease of falling asleep and 93% greater improvements in sleep quality vs. placebo (Leeds Sleep Evaluation Questionnaire). Benefits were consistent across both male and female participants, including a women-only analysis presented at SLEEP 2025.
Mood and morning alertness
Serezin subjects reported a 2.2x improvement in overall mood scores and significantly easier time waking, with greater morning alertness — addressing the full sleep experience rather than just sleep onset.
Boswellic acid anti-inflammatory activity
Boswellia serrata extract inhibits 5-lipoxygenase (5-LOX), the enzyme that produces pro-inflammatory leukotrienes responsible for joint and soft tissue inflammation. This targeted anti-inflammatory action reduces the chronic low-grade pain that disrupts sleep quality in aging adults.
Ginger COX inhibition and analgesic activity
Zingiber officinale constituents (gingerols, shogaols) inhibit cyclooxygenase (COX-1 and COX-2) enzymes, reducing prostaglandin-mediated pain signaling. The synergistic combination of 5-LOX inhibition (Boswellia) and COX inhibition (ginger) provides broader pain pathway coverage than either alone.
Circadian rhythm preservation
By addressing pain as the root cause of sleep disruption rather than forcing sedation, Serezin preserves natural sleep architecture and circadian rhythm integrity — allowing deeper, more restorative sleep stages to occur naturally.
4-week randomized, double-blind, placebo-controlled study in 60 healthy adults aged 50–70 with disturbed sleep due to everyday aches and pains. Results presented at SLEEP 2025 (American Academy of Sleep Medicine Conference).
60 healthy men and women aged 50–70 with sleep-disrupting pain. 4-week intervention.
By week 1: improved restorative sleep. By week 2: 85% greater improvement in sleep onset, 93% greater sleep quality improvement vs. placebo. By week 4: 2.6x less nighttime discomfort, 75% less daytime pain, 2.2x better mood scores. No serious adverse events.