Home Ingredients Ginginoll® (Ginger Extract — Akay)
Gut HealthAnti-Inflammatory

Ginginoll® (Ginger Extract — Akay)

Zingiber officinale
Evidence Level
Moderate
1 Clinical Trial
3 Documented Benefits
3/5 Evidence Score

Ginginoll® is a ginger (Zingiber officinale) extract from Akay, standardized for gingerols, the warming compounds behind ginger's benefits. Ginger is one of the best-studied natural remedies for nausea and is also used to support digestion and a healthy inflammatory response. That evidence reflects ginger the ingredient generally — there is no published human trial on Ginginoll® itself.

Studied Dose Commonly around 1 gram of ginger per day.
Active Compound Ginger (Zingiber officinale) extract standardized for gingerols.

Benefits

Nausea relief

Ginger is well studied for easing nausea; a meta-analysis of ginger (the ingredient generally, not Ginginoll® specifically) found it helpful for nausea and vomiting, including in pregnancy — pregnant women should check with a clinician before using ginger.

Supported by Trial 1

Digestive support

Ginger supports stomach emptying and comfortable digestion, easing bloating and queasiness.

Supported by Trial 1

Anti-inflammatory support

Ginger's gingerols may influence inflammatory signaling in lab studies; the human evidence for joint and muscle comfort is weaker and borrowed from ginger research broadly, not from Ginginoll® itself.

Supported by Trial 1

Mechanism of action

1

Gut-motility support

Ginger promotes stomach emptying and gut motility and calms the nausea signals sent from the gut to the brain.

2

Anti-inflammatory action

Gingerols inhibit inflammatory enzymes (COX and LOX), lowering the body's inflammatory load.

Clinical trials

1
Ginger and Nausea — Meta-Analysis
PubMed

Meta-analysis of ginger for nausea and vomiting in pregnancy. (Hu et al. 2022, Journal of Maternal-Fetal and Neonatal Medicine)

Pregnant women across trials.

In this meta-analysis of ginger (the ingredient generally, not Ginginoll® specifically), ginger was at least as effective as vitamin B6 for pregnancy nausea and vomiting, though the difference was not statistically significant — supporting ginger's long-standing anti-nausea use. Pregnant women should talk to a clinician before using ginger.

Side effects and drug interactions

Common Potential side effects

Generally well-tolerated — mild heartburn or a warming sensation can occur.
High doses may cause mild digestive upset.
Take with food if it bothers your stomach.

Important Drug interactions

Anticoagulants — high-dose ginger may have a mild additive effect; monitor.
Diabetes and blood pressure medication — monitor, as ginger may modestly affect both.
Tell your doctor before surgery if taking high doses.

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Frequently asked questions about Ginginoll® (Ginger Extract — Akay)

What is Ginginoll?

Ginginoll® is a ginger (Zingiber officinale) extract from Akay, standardized for gingerols, the warming compounds behind ginger's benefits. Ginger is one of the best-studied natural remedies for nausea and is also used to support digestion and a healthy inflammatory response.

What is Ginginoll used for?

Ginginoll is researched primarily for Gut Health and Anti-Inflammatory. Ginger is well studied for easing nausea; a meta-analysis of ginger (the ingredient generally, not Ginginoll® specifically) found it helpful for nausea and vomiting, including in pregnancy — pregnant women should check with a clinician befo…

What is the recommended dosage of Ginginoll?

The clinically studied dose is Commonly around 1 gram of ginger per day. Always follow the product label and check with a healthcare provider for personal advice.

Is Ginginoll safe, and does it have side effects?

For most healthy adults, Ginginoll is well tolerated at studied doses. Reported effects can include: Generally well-tolerated — mild heartburn or a warming sensation can occur. High doses may cause mild digestive upset. It may also interact with some medications. Ginginoll is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does Ginginoll interact with any medications?

Possible interactions include: Anticoagulants — high-dose ginger may have a mild additive effect; monitor. Diabetes and blood pressure medication — monitor, as ginger may modestly affect both. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for Ginginoll?

NutraSmarts rates the evidence for Ginginoll as Moderate (3 out of 5). It is backed by 1 clinical trial and 1 cited reference summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(1 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Hu Y, Amoah AN, Zhang H, et al. Effect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy: a meta-analysis. J Matern Fetal Neonatal Med. 2022;35(1):187-196..PubMedUsed to support: Meta-analysis supporting anti-nausea benefit of ginger (the active in Ginginoll).