Home Ingredients Curcuwin Ultra+® (144× Bioavailable Curcumin — OmniActive)
Joint HealthAnti-InflammatoryCardiovascular

Curcuwin Ultra+® (144× Bioavailable Curcumin — OmniActive)

Curcuma longa
Evidence Level
Very Strong
2 Clinical Trials
7 Documented Benefits
5/5 Evidence Score

Curcuwin Ultra+® is OmniActive's highly bioavailable curcumin — distinguished by 144× greater bioavailability vs standard curcumin and 40% faster absorption. One capsule (250/500 mg) equals 30 capsules of standard curcumin. Made using OmniActive's Ultrasol technology with bioenhancers. Used for: joint health, knee osteoarthritis support (5-day onset), heart health, sports nutrition, healthy aging.

Studied Dose 250 mg or 500 mg/day Curcuwin Ultra+ (each providing 50 mg or 100 mg curcuminoids)
Active Compound Curcuminoids in OmniActive Ultrasol technology with bioenhancers

Benefits

144× Bioavailability vs Standard Curcumin

Curcuwin Ultra+ is 144× more bioavailable compared to standard curcumin — one capsule (250/500 mg) equivalent to 30 capsules of standard curcumin/turmeric powder.

Supported by Trial 2

40% Faster Absorption

Curcuwin Ultra+ absorbed 40% faster than standard curcumin — supports rapid clinical effects.

Supported by Trial 2

Joint Health for Knee OA (5-Day Onset)

Multi-centric RCT of 134 adults with mild knee OA showed Curcuwin Ultra+ provides improvements in joint comfort, function, range of motion, knee muscle strength, and quality of life — with effects appearing in as early as 5 days.

Supported by Trial 1

Reduced Rescue Medication Use

Same trial: significant reduction in frequency of rescue medication use compared to placebo — practical clinical benefit.

Supported by Trial 1

Heart Health and Sports Nutrition

Curcuwin Ultra+ inherits clinically supported heart health and sports nutrition benefits from original Curcuwin (same Ultrasol foundational technology).

Supported by Trial 1, Trial 2

Convenient Low-Dose

One capsule daily provides effects requiring 30 capsules of standard curcumin — convenience advantage.

Supported by Trial 2

Versatile Formulation

Excellent organoleptic profile allows incorporation into challenging applications including gummies and beverages.

Mechanism of action

1

Ultrasol Technology with Bioenhancers

Curcuwin Ultra+ formulated using specialized process incorporating bioenhancers to better protect and deliver more curcuminoids than standard curcumin.

2

144× Bioavailability Enhancement

Multi-component approach addresses curcumin's primary clinical limitation (poor absorption); delivers significantly more active curcuminoids to systemic circulation.

3

NF-kB and Multiple Inflammatory Pathway Modulation

Same fundamental anti-inflammatory mechanism as other curcumin; bioavailability advantage delivers more active to inflammation sites.

4

Cartilage and Joint Tissue Effects

Effects on inflammation, oxidative stress, and matrix metalloproteinases relevant to cartilage health.

5

Sustained 84-Day Efficacy

Joint health benefits continue and build through 84-day supplementation period.

Clinical trials

1
Curcuwin Ultra+ for Knee OA — 134 Adults, 84 Days
PubMed

Multi-centric, randomized, double-blind, parallel, placebo-controlled study of Curcuwin Ultra+ at 250 mg (50 mg curcuminoids) or 500 mg (100 mg curcuminoids) vs placebo for 84 days in 134 adults with mild knee OA.

134 adults with mild knee osteoarthritis.

Both doses significantly reduced discomfort scores and rescue medication frequency vs placebo; improved knee muscle strength, range of motion, quality of life. Effects appeared as early as 5 days. Published in Journal of Orthopedic Research and Therapy.

2
Curcuwin Ultra+ Bioavailability Studies — OmniActive
PubMed

PK studies comparing Curcuwin Ultra+ vs standard curcumin.

Healthy adults.

144× greater bioavailability; 40% faster absorption.

Side effects and drug interactions

Common Potential side effects

Generally extremely well-tolerated.
Mild GI distress (rare).
Yellow staining (mouth, urine) — harmless.
Allergic reactions rare.
Theoretical bleeding at high doses.

Important Drug interactions

Anticoagulants — modest antiplatelet effects from curcumin.
Antiplatelets — additive bleeding risk.
Diabetes medications — modest hypoglycemic effects.
Pre-surgery — discontinue 1-2 weeks before.
Gallstones — curcumin cholagogue; avoid.
Pregnancy — culinary turmeric safe; concentrated supplementation limited safety data; avoid high-dose during pregnancy.
Iron absorption — modest reduction at high doses.
Hepatically-metabolized medications — modest CYP interactions.

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Frequently asked questions about Curcuwin Ultra+® (144× Bioavailable Curcumin — OmniActive)

What is Curcuwin Ultra+?

Curcuwin Ultra+® is OmniActive's highly bioavailable curcumin — distinguished by 144× greater bioavailability vs standard curcumin and 40% faster absorption. One capsule (250/500 mg) equals 30 capsules of standard curcumin. Made using OmniActive's Ultrasol technology with bioenhancers.

What is Curcuwin Ultra+ used for?

Curcuwin Ultra+ is researched primarily for Joint Health, Anti-Inflammatory, and Cardiovascular. Curcuwin Ultra+ is 144× more bioavailable compared to standard curcumin — one capsule (250/500 mg) equivalent to 30 capsules of standard curcumin/turmeric powder.

What is the recommended dosage of Curcuwin Ultra+?

The clinically studied dose is 250 mg or 500 mg/day Curcuwin Ultra+ (each providing 50 mg or 100 mg curcuminoids) Always follow the product label and check with a healthcare provider for personal advice.

Is Curcuwin Ultra+ safe, and does it have side effects?

For most healthy adults, Curcuwin Ultra+ is well tolerated at studied doses. Reported effects can include: Generally extremely well-tolerated. Mild GI distress (rare). It may also interact with some medications. Curcuwin Ultra+ is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does Curcuwin Ultra+ interact with any medications?

Possible interactions include: Anticoagulants — modest antiplatelet effects from curcumin. Antiplatelets — additive bleeding risk. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for Curcuwin Ultra+?

NutraSmarts rates the evidence for Curcuwin Ultra+ as Very Strong (5 out of 5). It is backed by 2 clinical trials and 3 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(3 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Jäger R, Lowery RP, Calvanese AV, Joy JM, Purpura M, Wilson JM. Comparative absorption of curcumin formulations. Nutr J. 2014;13:11. doi: 10.1186/1475-2891-13-11.PubMedUsed to support: Brand-specific bioavailability RCT (crossover, healthy volunteers): the hydrophilic-carrier formulation (CurcuWIN) showed 45.9-fold higher absorption of total curcuminoids vs standard curcumin, exceeding phytosome (5.8x) and volatile-oil (34.9x) formulations. Small crossover; manufacturer-funded.
  2. Briskey D, Sax AT, Mallard AR, Rao A. Superior bioavailability of a novel curcumin formulation in healthy humans under fasting conditions. Adv Ther. 2022;39(6):2752-2762. doi: 10.1007/s12325-022-02081-w.PubMedUsed to support: Brand-specific to CurcuWIN Ultra+ (CU+): crossover PK study in 24 fasting healthy adults. CU+ 250 mg and 500 mg gave 144x and 149x higher relative absorption of total curcuminoids vs 1900 mg of 95% turmeric extract. Small sample; manufacturer-funded.
  3. Oliver JM, Stoner L, Rowlands DS, Caldwell AR, Sanders E, Kreutzer A, Mitchell JB, Purpura M, Jäger R. Novel form of curcumin improves endothelial function in young, healthy individuals: a double-blind placebo controlled study. J Nutr Metab. 2016;2016:1089653. doi: 10.1155/2016/1089653.PubMedUsed to support: Brand-specific (CurcuWIN, 250/1000 mg) 8-week RCT in 60 healthy adults 19-29. The 1000 mg dose (200 mg curcumin) improved flow-mediated dilation by ~3 percentage points vs placebo (an endothelial marker). Small sample; manufacturer-affiliated authors.