Home Ingredients ChitoClear® (Chitosan — Primex)
Weight ManagementCardiovascular

ChitoClear® (Chitosan — Primex)

Evidence Level
Moderate
1 Clinical Trial
3 Documented Benefits
3/5 Evidence Score

ChitoClear® is a high-purity chitosan from Primex, a fiber-like compound derived from the shells of cold-water shrimp. Chitosan carries a positive charge that lets it bind dietary fat and bile in the gut, and it is studied for supporting modest weight management and healthy cholesterol.

Studied Dose Commonly 1 to 3 grams per day with meals.
Active Compound Chitosan, a deacetylated chitin biopolymer derived from shellfish shells.

Benefits

Weight management

A systematic review and meta-analysis of randomized trials found chitosan supplementation supported modest reductions in body weight and body composition.

Supported by Trial 1

Fat binding

Chitosan binds some dietary fat in the digestive tract, reducing the amount absorbed from a meal.

Supported by Trial 1

Cholesterol support

By binding bile acids and fat, chitosan is studied for supporting healthy cholesterol levels.

Supported by Trial 1

Mechanism of action

1

Electrostatic fat binding

Positively charged chitosan binds negatively charged fatty acids and bile acids in the gut, forming complexes that are excreted rather than absorbed.

2

Bile-acid sequestration

Removing bile acids prompts the body to use cholesterol to make more, supporting lower circulating cholesterol.

Clinical trials

1
Chitosan and Body Weight — Meta-Analysis
PubMed

Systematic review and meta-analysis of randomized controlled trials of chitosan on body weight and composition. (Huang et al. 2020, Critical Reviews in Food Science and Nutrition)

Adults across multiple RCTs.

Chitosan supplementation supported modest reductions in body weight and body composition versus control.

Side effects and drug interactions

Common Potential side effects

GENERALLY WELL-TOLERATED — digestive symptoms are most common.
Mild constipation, gas, or nausea can occur.
Derived from shellfish; avoid if you have a shellfish allergy.

Important Drug interactions

May reduce absorption of fat-soluble vitamins (A, D, E, K); separate dosing.
Take medications and chitosan at least 2 hours apart.
Warfarin — possible interaction; monitor.

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Frequently asked questions about ChitoClear® (Chitosan — Primex)

What is ChitoClear® (Chitosan — Primex)?

ChitoClear® is a high-purity chitosan from Primex, a fiber-like compound derived from the shells of cold-water shrimp. Chitosan carries a positive charge that lets it bind dietary fat and bile in the gut, and it is studied for supporting modest weight management and healthy cholesterol.

What is the recommended dosage of ChitoClear® (Chitosan — Primex)?

The clinically studied dose for ChitoClear® (Chitosan — Primex) is Commonly 1 to 3 grams per day with meals.. Always follow product labeling and consult a healthcare provider for personalized dosing recommendations.

What is ChitoClear® (Chitosan — Primex) used for?

ChitoClear® (Chitosan — Primex) is studied for weight management, fat binding, cholesterol support. A systematic review and meta-analysis of randomized trials found chitosan supplementation supported modest reductions in body weight and body composition.

Are there side effects from taking ChitoClear® (Chitosan — Primex)?

Reported potential side effects may include: GENERALLY WELL-TOLERATED — digestive symptoms are most common. Mild constipation, gas, or nausea can occur. Always consult a healthcare provider before starting any new supplement, especially if you have underlying conditions or take medications.

Is ChitoClear® (Chitosan — Primex) safe to take?

Whether ChitoClear® (Chitosan — Primex) is safe depends on the dose, your overall health, and any medications you take. At studied doses, reported side effects can include: GENERALLY WELL-TOLERATED — digestive symptoms are most common. It may also interact with certain medications. ChitoClear® (Chitosan — Primex) is not suitable for everyone — consult a healthcare provider before use if you are pregnant or breastfeeding, have a medical condition, or take prescription medications.

References(1 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Huang H, Liao D, Zou Y, et al. The effects of chitosan supplementation on body weight and body composition: a systematic review and meta-analysis of randomized controlled trials. Crit Rev Food Sci Nutr. 2020;60(11):1815-1825..PubMedUsed to support: Meta-analysis supporting weight-management benefit of chitosan.