Home Ingredients Brox-25® (Bromelain)
Anti-InflammatoryJoint HealthGut Health

Brox-25® (Bromelain)

Ananas comosus
Evidence Level
Moderate
1 Clinical Trial
3 Documented Benefits
3/5 Evidence Score

Brox-25® is a bromelain ingredient, the protein-digesting enzyme complex from pineapple (Ananas comosus) stems. Bromelain is studied for supporting a healthy inflammatory response, easing post-procedure swelling, and aiding protein digestion, making it a versatile enzyme supplement.

Studied Dose Commonly 200 to 500 mg (or defined enzyme-activity units) per day.
Active Compound Bromelain, a mixture of proteolytic (protein-digesting) enzymes from pineapple stem, measured in GDU or FIP activity units.

Benefits

Inflammation and swelling

In a randomized controlled trial, bromelain reduced post-surgical inflammation and improved recovery, supporting its use for swelling and a healthy inflammatory response.

Supported by Trial 1

Joint comfort

By calming inflammation, bromelain is used to support joint comfort, often alongside other joint ingredients.

Supported by Trial 1

Digestive enzyme support

As a proteolytic enzyme, bromelain helps break down dietary protein and supports comfortable digestion.

Supported by Trial 1

Mechanism of action

1

Proteolytic activity

Bromelain's enzymes break down proteins, aiding digestion and breaking down inflammatory and clot-related proteins in tissue.

2

Anti-inflammatory modulation

Bromelain influences inflammatory mediators and helps clear swelling-related fluid and proteins after injury or surgery.

Clinical trials

1
Bromelain and Post-Surgical Inflammation — RCT
PubMed

Double-blind randomized placebo-controlled trial of bromelain in periodontal surgery. (Babazade et al. 2023, BMC Oral Health)

Adults undergoing periodontal surgery.

Bromelain reduced post-surgical inflammation and supported recovery versus placebo.

Side effects and drug interactions

Common Potential side effects

GENERALLY WELL-TOLERATED — digestive symptoms are most common.
Mild stomach upset or diarrhea can occur.
Avoid if you have a pineapple allergy.

Important Drug interactions

Anticoagulants — bromelain may increase bleeding risk; monitor.
Antibiotics (amoxicillin, tetracycline) — bromelain may increase their absorption.
Stop before surgery and tell your doctor.

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Frequently asked questions about Brox-25® (Bromelain)

What is Brox-25® (Bromelain)?

Brox-25® is a bromelain ingredient, the protein-digesting enzyme complex from pineapple (Ananas comosus) stems. Bromelain is studied for supporting a healthy inflammatory response, easing post-procedure swelling, and aiding protein digestion, making it a versatile enzyme supplement.

What is the recommended dosage of Brox-25® (Bromelain)?

The clinically studied dose for Brox-25® (Bromelain) is Commonly 200 to 500 mg (or defined enzyme-activity units) per day.. Always follow product labeling and consult a healthcare provider for personalized dosing recommendations.

What is Brox-25® (Bromelain) used for?

Brox-25® (Bromelain) is studied for inflammation and swelling, joint comfort, digestive enzyme support. In a randomized controlled trial, bromelain reduced post-surgical inflammation and improved recovery, supporting its use for swelling and a healthy inflammatory response.

Are there side effects from taking Brox-25® (Bromelain)?

Reported potential side effects may include: GENERALLY WELL-TOLERATED — digestive symptoms are most common. Mild stomach upset or diarrhea can occur. Always consult a healthcare provider before starting any new supplement, especially if you have underlying conditions or take medications.

Is Brox-25® (Bromelain) safe to take?

Whether Brox-25® (Bromelain) is safe depends on the dose, your overall health, and any medications you take. At studied doses, reported side effects can include: GENERALLY WELL-TOLERATED — digestive symptoms are most common. It may also interact with certain medications. Brox-25® (Bromelain) is not suitable for everyone — consult a healthcare provider before use if you are pregnant or breastfeeding, have a medical condition, or take prescription medications.

References(1 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Babazade H, Mirzaagha A, Konarizadeh S. The effect of bromelain in periodontal surgery: a double-blind randomized placebo-controlled trial. BMC Oral Health. 2023;23(1):286..PubMedUsed to support: RCT supporting anti-inflammatory benefit of bromelain.