VitaCurrant® (blackcurrant anthocyanin extract — FutureCeuticals)

Ribes nigrum
Evidence Level
Limited
4 Clinical Trials
4 Documented Benefits
2/5 Evidence Score

VitaCurrant is a blackcurrant (Ribes nigrum) fruit extract from FutureCeuticals, standardized for anthocyanins, the deep-purple pigments (mainly delphinidin and cyanidin glycosides) that give the berry its color. Blackcurrant is one of the richest dietary sources of these compounds. In supplements it is used for eye comfort and low-light vision. The human studies behind that use were all done with generic blackcurrant anthocyanin extracts, not with VitaCurrant itself, and they are small: a short crossover study in healthy adults on dark adaptation and screen-related eye strain, a small study of eye pressure, a two-year study in 38 people with glaucoma who were already using prescription eye drops, and a single-dose study of forearm blood flow during typing. None of the cited human studies measured antioxidant levels or oxidative stress in people. Note this is different from blackcurrant seed oil, which supplies the fatty acid GLA rather than anthocyanins.

Studied Dose Blackcurrant anthocyanins ~50 mg/day (the dose used in the eye studies, which were run mainly in people with glaucoma already using prescription eye drops, plus a small group of healthy volunteers); 12.5-50 mg as a single dose in the dark-adaptation study. There is no published dosing study on VitaCurrant itself.
Active Compound Blackcurrant anthocyanins (delphinidin & cyanidin glycosides); typically std. ~25%

Benefits

Supports low-light vision and dark adaptation

Blackcurrant anthocyanins are traditionally used to support the eye's ability to adjust to dim light. In a small crossover study in healthy adults, single doses of 12.5, 20 and 50 mg lowered the dark-adaptation threshold in a dose-dependent way, with the clearest effect at 50 mg. That study was published in 2000 in Alternative Medicine Review, a low-tier journal that no longer publishes. It tested generic blackcurrant anthocyanins, not VitaCurrant.

Helps ease screen-related eye fatigue

Long hours at a computer or phone can leave eyes tired and strained. In that same small 2000 crossover study, blackcurrant anthocyanins reduced the temporary shift in focus measured right after a stretch of intensive computer screen work. It is one small short-term study in healthy adults, published in a low-tier journal, using generic blackcurrant anthocyanins rather than VitaCurrant. Whether that translates into feeling less eye strain day to day was not measured.

Short-term effects on blood flow in small studies

Two small studies looked at blood flow. In healthy young men, a single dose raised forearm blood flow about two hours later during a typing task. In the two-year trial in 38 people with glaucoma who were also using prescription eye drops, eye blood flow increased compared with placebo. Neither study measured heart or artery health, so this is not evidence of a benefit for the heart or blood vessels.

Antioxidant activity shown in the lab

Blackcurrant anthocyanins act as antioxidants in laboratory tests, meaning they can neutralize reactive molecules in a test tube. None of the human studies cited on this page measured antioxidant status, oxidative stress markers or any aging-related outcome, so this is chemistry rather than a proven benefit in people.

Mechanism of action

1

Rhodopsin regeneration in the retina

In laboratory experiments, cyanidin-based anthocyanins from blackcurrant speed up the regeneration of rhodopsin, the light-sensitive pigment in retinal rod cells. Faster rhodopsin turnover is a proposed explanation for the dark-adaptation findings, but it has not been confirmed in people.

2

Ciliary muscle relaxation and focusing

Delphinidin-3-rutinoside, a major blackcurrant anthocyanin, relaxes ciliary smooth muscle in laboratory models. Because the ciliary muscle controls the lens's focusing power, this relaxation is a proposed mechanism for reduced eye strain during sustained near work.

3

Vasomodulation and blood flow

Anthocyanins are thought to influence vascular tone, in part through nitric oxide and endothelin-1 signaling, but that pathway comes from laboratory work. In people, the only related findings on this page are a short-term rise in forearm blood flow in healthy young men and an increase in eye blood flow in the small two-year trial in glaucoma patients who were on prescription drops.

4

Free-radical scavenging

The polyphenol structure of anthocyanins lets them donate electrons and neutralize reactive oxygen species in laboratory tests. No human study cited here measured oxidative stress, so any reduction in oxidative burden in the body is unproven.

Clinical trials

1
Dark adaptation and screen-induced eye fatigue

Double-blind, placebo-controlled crossover trial of blackcurrant anthocyanosides at 12.5, 20 and 50 mg (Nakaishi et al., 2000, Alternative Medicine Review). Component/class evidence on blackcurrant anthocyanins, not on the finished VitaCurrant product.

Healthy adult volunteers

Blackcurrant anthocyanoside intake produced a dose-dependent lowering of the dark-adaptation threshold, significant at 50 mg, and blunted the temporary shift in focus measured after intensive computer screen work compared with placebo. Limitations: small, short-term and single-dose, and published in Alternative Medicine Review, a low-tier journal that has since ceased publication.

2
Intraocular pressure in healthy adults and glaucoma patients

Placebo-controlled, double-masked crossover study, blackcurrant anthocyanins 50 mg/day for 4 weeks (Ohguro, Ohguro & Yagi, 2013, Journal of Ocular Pharmacology and Therapeutics). Component/class evidence on blackcurrant anthocyanins, not the finished VitaCurrant product.

12 healthy volunteers and 21 glaucoma patients on standard therapy

This small pilot study measured eye pressure in healthy volunteers and in glaucoma patients who were already on standard treatment, and reported lower eye pressure readings. It is very small, and the larger two-year trial by the same group found no significant change in eye pressure, so this should not be treated as an established effect. Glaucoma is a leading cause of irreversible blindness: nothing here replaces prescribed glaucoma treatment, and anyone with eye-pressure concerns needs an ophthalmologist.

3
Two-year study of visual field in open-angle glaucoma

Randomized, placebo-controlled, double-masked trial, blackcurrant anthocyanins 50 mg/day for 24 months (Ohguro et al., 2012, Ophthalmologica). Component/class evidence, not on the finished VitaCurrant product.

38 people with open-angle glaucoma, 19 per group, who were already using prescription antiglaucoma eye drops

Over two years, the anthocyanin group showed less visual-field deterioration than placebo, but the difference was marginal (p=0.039) in a trial of only 38 people, 19 per group. Eye blood flow increased. There was no significant change in eye pressure. The supplement was given in addition to prescribed antiglaucoma medication, never instead of it. This is a report of a trial in people with an eye disease, not a benefit a healthy person should expect, and no one should change glaucoma treatment because of it.

4
Peripheral muscle circulation during typing

Double-blind, placebo-controlled crossover study, blackcurrant anthocyanin ~17 mg/kg body weight (Matsumoto et al., 2005, European Journal of Applied Physiology). Component/class evidence on blackcurrant anthocyanins, not the finished VitaCurrant product.

Healthy young men

A single dose increased forearm blood flow about 2 hours after swallowing it during a typing task, and was linked with less typing-related muscle stiffness. Very small sample of healthy young men, one measurement session, and blood flow in a forearm muscle during typing says nothing about heart or artery health.

Side effects and drug interactions

Common Potential side effects

Generally well tolerated in the small studies done so far; blackcurrant has a long history of food use, but the trials were small and short, so uncommon side effects may not have shown up
Mild digestive upset such as gas or loose stools is possible, especially at higher doses
Temporary harmless discoloration of urine or stool from the purple pigments can occur
Allergic reactions are uncommon but possible in people sensitive to berries

Important Drug interactions

Blood thinners and antiplatelet drugs (e.g., warfarin, aspirin, clopidogrel): anthocyanins may modestly affect blood flow, so tell your doctor before combining.
Blood pressure medications: possible additive effect on circulation; discuss with your doctor if you take antihypertensives.
Glaucoma medications: do not replace prescribed eye-pressure treatment; tell your ophthalmologist before adding any anthocyanin supplement.
If you are pregnant, nursing, or taking any prescription medication, talk to your healthcare provider before use.

Frequently asked questions about VitaCurrant® (blackcurrant anthocyanin extract — FutureCeuticals)

What is VitaCurrant?

VitaCurrant is a blackcurrant (Ribes nigrum) fruit extract from FutureCeuticals, standardized for anthocyanins, the deep-purple pigments (mainly delphinidin and cyanidin glycosides) that give the berry its color. Blackcurrant is one of the richest dietary sources of these compounds.

What is VitaCurrant used for?

VitaCurrant is researched primarily for Eye Health. Blackcurrant anthocyanins are traditionally used to support the eye's ability to adjust to dim light. In a small crossover study in healthy adults, single doses of 12.

What is the recommended dosage of VitaCurrant?

The clinically studied dose is Blackcurrant anthocyanins ~50 mg/day (the dose used in the eye studies, which were run mainly in people with glaucoma already using prescription eye drops, plus a small group of healthy volunteers); 12.5-50 mg as a single dose in the dark-adaptation study. Always follow the product label and check with a healthcare provider for personal advice.

Is VitaCurrant safe, and does it have side effects?

For most healthy adults, VitaCurrant is well tolerated at studied doses. Reported effects can include: Generally well tolerated in the small studies done so far; blackcurrant has a long history of food use, but the trials were small and short, so uncommon side effects may not have shown up Mild digestive upset such as gas or loose stools is possible, especially at higher doses It may also interact with some medications. VitaCurrant is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does VitaCurrant interact with any medications?

Possible interactions include: Blood thinners and antiplatelet drugs (e.g., warfarin, aspirin, clopidogrel): anthocyanins may modestly affect blood flow, so tell your doctor before combining. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for VitaCurrant?

NutraSmarts rates the evidence for VitaCurrant as Limited (2 out of 5). It is backed by 4 clinical trials and 4 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(4 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Nakaishi H, Matsumoto H, Tominaga S, Hirayama M Effects of black current anthocyanoside intake on dark adaptation and VDT work-induced transient refractive alteration in healthy humans Alternative Medicine Review. 2000;Altern Med Rev. 2000;5(6):553-562.PubMedUsed to support: Dark adaptation and post-screen-work refractive shift in healthy adults; small 2000 crossover study in a low-tier, now-defunct journal. Does not test rhodopsin or ciliary mechanisms in people.
  2. Ohguro H, Ohguro I, Yagi S Effects of black currant anthocyanins on intraocular pressure in healthy volunteers and patients with glaucoma Journal of Ocular Pharmacology and Therapeutics. 2013;J Ocul Pharmacol Ther. 2013;29(1):61-67.PubMedUsed to support: Eye health / intraocular pressure clinical trial (component evidence)
  3. Ohguro H, Ohguro I, Katai M, Tanaka S Two-year randomized, placebo-controlled study of black currant anthocyanins on visual field in glaucoma Ophthalmologica. 2012;Ophthalmologica. 2012;228(1):26-35.PubMedUsed to support: Two-year add-on trial in 38 glaucoma patients already on prescription drops: marginal visual-field difference (p=0.039), increased ocular blood flow, no significant change in eye pressure (component evidence, not VitaCurrant)
  4. Matsumoto H, Takenami E, Iwasaki-Kurashige K, Osada T, Katsumura T, Hamaoka T Effects of blackcurrant anthocyanin intake on peripheral muscle circulation during typing work in humans European Journal of Applied Physiology. 2005;Eur J Appl Physiol. 2005;94(1-2):36-45.PubMedUsed to support: Short-term forearm muscle blood flow during typing in a small group of healthy young men; does not support a heart, artery or general circulation claim