Home Ingredients Xorialyc® (Olive Leaf Extract for Skin Inflammation)
Hair, Skin & NailsAnti-Inflammatory

Xorialyc® (Olive Leaf Extract for Skin Inflammation)

Olea europaea
Evidence Level
Moderate
2 Clinical Trials
6 Documented Benefits
3/5 Evidence Score

Xorialyc® is a next-generation olive leaf extract developed by Pharmactive Biotech Products (Spain) — designed for skin inflammation and skin quality applications. Distinguished by activity from luteolin, quercetin, and ortho-diphenols — inhibits NF-κB, COX-2, and PGE₂ inflammatory pathways while providing antioxidant protection. 60-day consumer study (n=50, ages 40-60) at 300 mg/day showed: 74% reduction in redness, 76% reduction in itching, 72% reduction in tightness, ~72% improvement in skin hydration and quality. 80% noticed visible effects. Used for: skin redness, itching, inflammatory skin conditions, beauty-from-within.

Studied Dose 300 mg/day (research-validated dose)
Active Compound Olive leaf polyphenols (luteolin, quercetin, ortho-diphenols, oleuropein)

Benefits

Skin Redness Reduction

Pharmactive 60-day consumer study (50 adults aged 40-60) at 300 mg/day showed 74% reduction in skin redness. Useful for inflammatory skin conditions, sensitivity, rosacea-adjacent concerns.

Supported by Trial 1

Itching Reduction

Same study: 76% reduction in itching. Relevant for: eczema-adjacent conditions, dry skin itching, sensitive skin.

Supported by Trial 1, Trial 2

Skin Tightness Reduction

72% reduction in skin tightness sensation. Improves overall skin comfort.

Supported by Trial 1, Trial 2

Hydration and Skin Quality (~72% improvement)

Improvements in skin hydration and overall quality. Beauty-from-within mechanism complementing topical interventions.

Supported by Trial 1, Trial 2

Strong User Satisfaction (80% Visible Effects)

80% noticed visible effects; 78% said it worked fast and would recommend it. Clinically meaningful real-world satisfaction.

Supported by Trial 1

Multiple Inflammatory Pathway Inhibition

Activity via inhibition of NF-κB, COX-2, and PGE₂ — foundational anti-inflammatory pathways. Strong antioxidant protection from polyphenol fraction.

Supported by Trial 2

Mechanism of action

1

NF-κB Pathway Inhibition

NF-κB is master inflammatory transcription factor; Xorialyc compounds inhibit NF-κB activation — reduces downstream inflammatory gene expression in skin cells.

2

COX-2 Inhibition

COX-2 produces inflammatory prostaglandins; Xorialyc compounds inhibit COX-2 — reduces inflammatory prostaglandin synthesis. Same target as NSAIDs.

3

PGE₂ Reduction

Prostaglandin E2 (PGE₂) drives inflammatory skin reactions; Xorialyc reduces PGE₂ formation.

4

Luteolin and Quercetin Bioactivity

Luteolin is potent anti-inflammatory flavonoid; quercetin has documented anti-inflammatory/antioxidant effects; Xorialyc concentrates these compounds for skin applications.

5

Ortho-Diphenol Antioxidant Activity

Ortho-diphenols (catechol-type structures including hydroxytyrosol-related compounds) provide potent antioxidant activity protecting skin from oxidative damage.

Clinical trials

1
Xorialyc 60-Day Consumer Study — Pharmactive

60-day consumer study of Xorialyc 300 mg/day in 50 adults aged 40-60.

50 adults aged 40-60.

74% redness reduction, 76% itching reduction, 72% tightness reduction, ~72% hydration/skin quality improvement; 80% noticed visible effects; 78% would recommend.

2
Olive Polyphenol Anti-Inflammatory Mechanism

Multiple studies of olive polyphenols on inflammatory pathways including NF-κB, COX-2, PGE₂.

Cell, animal, and human studies.

Confirmed inhibition of NF-κB, COX-2, PGE₂; established anti-inflammatory mechanism for skin and other inflammatory applications.

Side effects and drug interactions

Common Potential side effects

Generally well-tolerated.
Mild GI distress.
Allergic reactions to olive rare.
Bitter taste characteristic of olive polyphenols (minimal in capsule).

Important Drug interactions

Antihypertensives — modest additive BP effects.
Anticoagulants — modest effects.
Diabetes medications — modest hypoglycemic effects.
Pregnancy/lactation — culinary olive use safe; concentrated extract supplementation limited safety data; consult.
Photosensitizing medications — generally non-interactive.

Featured in these supplement guides

Acne→Eczema & Skin Inflammation→

More Hair, Skin & Nails Ingredients

Hair, Skin & Nails
Bovine Collagen
Bovine collagen is hydrolyzed collagen sourced from cow hide, bone, and cartilage — the mo…
Hair, Skin & Nails
Marine Collagen
Marine collagen is hydrolyzed collagen sourced from fish skin and scales — predominantly T…
Hair, Skin & Nails
ceratiq® (Wheat-Derived Phytoceramides — PLT Health)
ceratiq® is PLT Health Solutions' patented, clinically-studied phytoceramide ingredient —…
Hair, Skin & Nails
DermaNiA® (Niacinamide for Skin Health — Sabinsa)
DermaNiA® is Sabinsa's branded niacinamide (nicotinamide, vitamin B3) for skin health appl…

Explore Other Ingredients

Antioxidant
Setria® Glutathione
Setria® is Kyowa Hakko's patented reduced L-glutathione (GSH) produced via fermentation —…
Bone Health
Collagen
Collagen is the most abundant structural protein in the human body — making up roughly 30%…
Hair, Skin & Nails
Hyaluronic Acid
Hyaluronic acid is a naturally occurring substance in the body, primarily found in connect…

Frequently asked questions about Xorialyc® (Olive Leaf Extract for Skin Inflammation)

What is Xorialyc?

Xorialyc® is a next-generation olive leaf extract developed by Pharmactive Biotech Products (Spain) — designed for skin inflammation and skin quality applications.

What is Xorialyc used for?

Xorialyc is researched primarily for Hair, Skin & Nails and Anti-Inflammatory. Pharmactive 60-day consumer study (50 adults aged 40-60) at 300 mg/day showed 74% reduction in skin redness. Useful for inflammatory skin conditions, sensitivity, rosacea-adjacent concerns.

What is the recommended dosage of Xorialyc?

The clinically studied dose is 300 mg/day (research-validated dose) Always follow the product label and check with a healthcare provider for personal advice.

Is Xorialyc safe, and does it have side effects?

For most healthy adults, Xorialyc is well tolerated at studied doses. Reported effects can include: Generally well-tolerated. Mild GI distress. It may also interact with some medications. Xorialyc is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does Xorialyc interact with any medications?

Possible interactions include: Antihypertensives — modest additive BP effects. Anticoagulants — modest effects. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for Xorialyc?

NutraSmarts rates the evidence for Xorialyc as Moderate (3 out of 5). It is backed by 2 clinical trials and 3 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(3 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Torrecillas-Baena B, Camacho-Cardenosa M, Carmona-Luque MD, Dorado G, Berenguer-Pérez M, Quesada-Gómez JM, Gálvez-Moreno MÁ, Casado-Díaz A Comparative Study of the Efficacy of EHO-85, a Hydrogel Containing Olive Tree (Olea europaea) Leaf Extract, in Skin Wound Healing International Journal of Molecular Sciences. 2023;24(17):13328. doi: 10.3390/ijms241713328.PubMedUsed to support: Demonstrates that olive leaf extract (Olea europaea) hydrogel reduces skin inflammation and promotes collagen matrix organisation in a wound-healing model, with wounds showing less inflammation and higher collagen content versus controls. Supports the skin-redness/inflammation reduction and skin-quality claims for olive leaf extract at the compound level; this is an animal (rat) study, not a human trial of the Xorialyc brand.
  2. Weng Z, Patel AB, Vasiadi M, Therianou A, Theoharides TC Luteolin inhibits human keratinocyte activation and decreases NF-κB induction that is increased in psoriatic skin PLoS ONE. 2014;9(2):e90739. doi: 10.1371/journal.pone.0090739.PubMedUsed to support: Shows that luteolin — a key flavonoid in Xorialyc's olive leaf standardisation — significantly inhibits TNF-stimulated NF-κB nuclear translocation, IL-6, IL-8, and VEGF release in human keratinocytes, and reduces RELA gene expression that is elevated in psoriatic skin. Provides mechanistic basis for the Skin Redness Reduction and Itching Reduction benefits via the NF-κB pathway; this is an in-vitro study in human cells, not a clinical trial.
  3. Wang J, Yuan M, Li Q, Shen C, Zhang X, Zhu C, Cen Q Combined protection against UVB-induced photoaging by oleuropein, hydroxytyrosol, and verbascoside through modulation of inflammation, oxidative stress, and collagen homeostasis Scientific Reports. 2025;15(1):41008. doi: 10.1038/s41598-025-24845-4.PubMedUsed to support: Demonstrates that the combination of oleuropein, hydroxytyrosol, and verbascoside — all present in Olea europaea extracts — suppresses UVB-induced inflammation, oxidative stress, collagen degradation, and MMP expression in human dermal fibroblasts and keratinocytes via Nrf2 upregulation. Supports Skin Tightness Reduction and Hydration/Skin Quality claims via the COX-2/PGE₂/NF-κB anti-inflammatory axis; this is an in-vitro study, not a branded Xorialyc clinical trial.