Home Ingredients Vitaflavan® (Grape Seed Extract)
AntioxidantCardiovascular

Vitaflavan® (Grape Seed Extract)

Vitis vinifera
Evidence Level
Moderate
1 Clinical Trial
3 Documented Benefits
3/5 Evidence Score

Vitaflavan® is a French grape seed (Vitis vinifera) extract standardized for oligomeric proanthocyanidins (OPCs), among the most powerful plant antioxidants. Grape seed OPCs are studied for supporting blood-vessel health, antioxidant defense, and, in women, menopause-related comfort and body composition.

Studied Dose Commonly 100 to 300 mg per day.
Active Compound Grape seed extract standardized for oligomeric proanthocyanidins (OPCs / procyanidins).

Benefits

Antioxidant defense

Grape seed OPCs are highly potent antioxidants that help protect cells and blood vessels from oxidative stress.

Supported by Trial 1

Vascular and cardiovascular support

OPCs support healthy blood-vessel function and circulation, contributing to cardiovascular health.

Supported by Trial 1

Menopausal support

In a randomized controlled trial, grape seed proanthocyanidin extract supported improvements in menopausal symptoms and body composition in middle-aged women.

Supported by Trial 1

Mechanism of action

1

Proanthocyanidin antioxidant action

OPCs neutralize free radicals and support the body's antioxidant enzymes, protecting blood vessels and tissues.

2

Endothelial support

Grape seed polyphenols support nitric-oxide-mediated blood-vessel relaxation and healthy circulation.

Clinical trials

1
Grape Seed OPCs and Menopause — RCT
PubMed

Randomized, double-blind, placebo-controlled pilot trial of grape seed proanthocyanidin extract on menopausal symptoms and body composition. (Terauchi et al. 2014, Menopause)

Middle-aged women.

Grape seed extract supported improvements in menopausal symptoms, body composition, and cardiovascular measures.

Side effects and drug interactions

Common Potential side effects

Generally well-tolerated — adverse effects are uncommon at normal doses.
Mild digestive upset is occasionally reported.
Discontinue if any unusual reaction occurs.

Important Drug interactions

Anticoagulants — grape seed may have a mild blood-thinning effect; monitor.
Blood pressure medication — possible additive effect; monitor.
Tell your doctor before surgery.

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Frequently asked questions about Vitaflavan® (Grape Seed Extract)

What is Vitaflavan?

Vitaflavan® is a French grape seed (Vitis vinifera) extract standardized for oligomeric proanthocyanidins (OPCs), among the most powerful plant antioxidants. Grape seed OPCs are studied for supporting blood-vessel health, antioxidant defense, and, in women, menopause-related comfort and body composition.

What is Vitaflavan used for?

Vitaflavan is researched primarily for Antioxidant and Cardiovascular. Grape seed OPCs are highly potent antioxidants that help protect cells and blood vessels from oxidative stress.

What is the recommended dosage of Vitaflavan?

The clinically studied dose is Commonly 100 to 300 mg per day. Always follow the product label and check with a healthcare provider for personal advice.

Is Vitaflavan safe, and does it have side effects?

For most healthy adults, Vitaflavan is well tolerated at studied doses. Reported effects can include: Generally well-tolerated — adverse effects are uncommon at normal doses. Mild digestive upset is occasionally reported. It may also interact with some medications. Vitaflavan is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does Vitaflavan interact with any medications?

Possible interactions include: Anticoagulants — grape seed may have a mild blood-thinning effect; monitor. Blood pressure medication — possible additive effect; monitor. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for Vitaflavan?

NutraSmarts rates the evidence for Vitaflavan as Moderate (3 out of 5). It is backed by 1 clinical trial and 1 cited reference summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(1 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Terauchi M, Horiguchi N, Kajiyama A, et al. Effects of grape seed proanthocyanidin extract on menopausal symptoms, body composition, and cardiovascular parameters in middle-aged women: a randomized, double-blind, placebo-controlled pilot study. Menopause. 2014;21(9):990-6..PubMedUsed to support: RCT supporting menopausal and body-composition benefit of grape seed OPCs.