Benefits
Sexual desire and function
There is no published trial of Virilast itself, and a PubMed search for the brand returns nothing, so the company's own sponsored results cannot be checked. What has been published involves single herbs from the blend, tested alone and in men with a diagnosed problem. Tribulus terrestris sold under a different brand name, at 1,500 mg a day for 12 weeks, improved sexual function scores versus placebo in 180 men with mild to moderate erectile dysfunction. A smaller study of 70 men tested Tribulus in men diagnosed with late-onset low testosterone. Ongoing trouble with erections is a medical issue worth raising with a doctor, since it can be an early sign of heart or blood vessel disease.
Male vitality and stress
One cited study tested ashwagandha on its own, not Virilast: a branded extract (Shoden) at 240 mg a day in 60 stressed but otherwise healthy adults for 60 days, which lowered morning cortisol and anxiety scores versus placebo. Testosterone rose over time in the men in that study, but the change was not statistically significant compared with placebo, and there was no change in women. The extract and dose used there are not the same as what this blend provides, and no cited study measured energy.
Antioxidant and circulation claims: not tested
None of the four studies cited on this page measured nitric oxide, blood flow, or antioxidant activity, in the blend or in its individual herbs. This is a marketing claim rather than a tested effect.
Mechanism of action
Hormonal and dopaminergic support
This describes how the individual herbs are thought to work, not anything measured for the blend. Tribulus terrestris raised total testosterone in men diagnosed with late-onset low testosterone, and Mucuna pruriens raised testosterone, LH, and dopamine in men being screened for infertility. In the one study done in healthy people, the testosterone change was not significant versus placebo, and no cited study measured DHEA.
Nitric oxide and circulation
Nitric oxide is often offered as an explanation for herbs of this kind, but none of the studies cited on this page measured nitric oxide or blood flow, so this remains an idea rather than a finding.