Benefits
Male sexual function
No trial of Virilast has been published, so the maker's own results cannot be checked. The evidence is for single herbs from the blend, tested alone. Tribulus terrestris sold as Tribestan (1,500 mg a day for 12 weeks) improved erectile function scores versus placebo in 180 men with mild to moderate erectile dysfunction. Ongoing erection problems deserve a doctor's check.
Stress and morning cortisol
One cited study tested an ashwagandha extract alone (Shoden, 240 mg a day for 60 days) in 60 stressed but healthy adults: anxiety scores and morning cortisol fell versus placebo. Testosterone rose in the men over time, but not significantly versus placebo. The extract and amount in Virilast differ, and no cited study measured energy or vitality.
Mechanism of action
Hormonal and dopaminergic support
This describes how the individual herbs are thought to work, not anything measured for the blend. Tribulus terrestris raised total testosterone in men diagnosed with late-onset low testosterone, and Mucuna pruriens raised testosterone, LH, and dopamine in men being screened for infertility. In the one study done in healthy people, the testosterone change was not significant versus placebo, and no cited study measured DHEA.
Nitric oxide and circulation
Nitric oxide is often offered as an explanation for herbs of this kind, but none of the studies cited on this page measured nitric oxide or blood flow, so this remains an idea rather than a finding.