SelectSIEVE® Apple PCQ (Apple Polyphenols)

Malus domestica
Evidence Level
Preliminary
1 Clinical Trial
2 Documented Benefits
1/5 Evidence Score

SelectSIEVE® Apple PCQ is an apple (Malus domestica) polyphenol ingredient isolated from apple juice. Its distributor describes it as built around three polyphenols, phlorizin, chlorogenic acid and quercetin, rather than as a procyanidin concentrate. No published human trial has tested SelectSIEVE Apple PCQ itself. The one human study cited here tested Applephenon, a procyanidin rich apple extract from Asahi Breweries with a different composition. In that 12 week trial in 65 healthy Japanese women aged 20 to 39, 300 or 600 mg a day reduced the rise in redness and darkening of upper arm skin after UV exposure compared with placebo, measured as change from baseline. The raw readings did not differ between groups, the higher dose was no better than the lower one, and facial moisture and water loss did not improve. Asahi Breweries funded the study, and two of the five authors declared that they worked for the company.

Studied Dose No dose of SelectSIEVE Apple PCQ has been studied. The one cited trial gave 300 or 600 mg a day of a different apple extract (Applephenon) for 12 weeks, and the higher dose was not better than the lower one.
Active Compound Apple polyphenols isolated from apple juice, described by the distributor as centred on phlorizin, chlorogenic acid and quercetin in glycoside form.

Benefits

Skin color after UV exposure in a trial of another apple extract

In a 12 week double blind trial in 65 healthy women aged 20 to 39, 300 or 600 mg a day of a procyanidin rich apple extract reduced the rise in redness and melanin after UV exposure versus placebo, measured as change from baseline. Raw readings did not differ, and skin moisture did not improve. The extract tested was Applephenon, not this ingredient.

Antioxidant activity in lab tests

Apple polyphenols, including procyanidins and quercetin, scavenge free radicals in lab assays. No human study has measured antioxidant activity or tissue protection in people taking this ingredient, so this is a lab finding rather than a demonstrated effect in the body.

Mechanism of action

1

Polyphenol antioxidants

In lab studies apple polyphenols neutralize free radicals. This is a proposed explanation for the reduced UV related skin darkening seen in one trial of a different apple extract, not something that trial measured in the skin.

2

Hydration and skin barrier

Skin water content and water loss through the skin were measured in the one trial and did not differ from placebo, so hydration and barrier claims are not supported.

Clinical trials

1
Applephenon (Different Apple Extract) and UV Related Skin Color, 65 Women
PubMed

Randomized, double blind, placebo controlled 12 week trial of 300 or 600 mg a day of Applephenon, a procyanidin rich apple extract from Asahi Breweries, not this ingredient. Asahi funded the study; all five authors were listed at Asahi research laboratories and two declared they worked for the company. (Shoji et al. 2020, Nutrients)

65 healthy Japanese women aged 20 to 39; 59 analysed.

The change from baseline in UV induced redness, melanin and lightness was significantly smaller with apple polyphenols than placebo, but the raw readings did not differ between groups at any point and there was no clear dose response. Facial water content and water loss did not differ from placebo. No supplement related adverse events.

Side effects and drug interactions

Common Potential side effects

No supplement related adverse events were reported in the one 12 week trial of a related apple extract; there is no safety data for this ingredient itself.
Mild digestive upset is occasionally reported.
Discontinue if any unusual reaction occurs.

Important Drug interactions

No major drug interactions are established for this ingredient.
Tell your doctor about all supplements if you take prescription medication.
Use caution if pregnant, breastfeeding, or managing a health condition.

Frequently asked questions about SelectSIEVE® Apple PCQ (Apple Polyphenols)

What is SelectSIEVE Apple PCQ?

SelectSIEVE® Apple PCQ is an apple (Malus domestica) polyphenol ingredient isolated from apple juice. Its distributor describes it as built around three polyphenols, phlorizin, chlorogenic acid and quercetin, rather than as a procyanidin concentrate. No published human trial has tested SelectSIEVE Apple PCQ itself.

What is SelectSIEVE Apple PCQ used for?

SelectSIEVE Apple PCQ is researched primarily for Hair, Skin & Nails. In a 12 week double blind trial in 65 healthy women aged 20 to 39, 300 or 600 mg a day of a procyanidin rich apple extract reduced the rise in redness and melanin after UV exposure versus placebo, measured as change from baseline.

What is the recommended dosage of SelectSIEVE Apple PCQ?

No dose of SelectSIEVE Apple PCQ has been studied. The one cited trial gave 300 or 600 mg a day of a different apple extract (Applephenon) for 12 weeks, and the higher dose was not better than the lower one. Always follow the product label and check with a healthcare provider for personal advice.

Is SelectSIEVE Apple PCQ safe, and does it have side effects?

Side effects and cautions reported for SelectSIEVE Apple PCQ include: No supplement related adverse events were reported in the one 12 week trial of a related apple extract; there is no safety data for this ingredient itself. Mild digestive upset is occasionally reported. It may also interact with some medications. SelectSIEVE Apple PCQ is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does SelectSIEVE Apple PCQ interact with any medications?

Possible interactions include: No major drug interactions are established for this ingredient. Tell your doctor about all supplements if you take prescription medication. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for SelectSIEVE Apple PCQ?

NutraSmarts rates the evidence for SelectSIEVE Apple PCQ as Preliminary (1 out of 5). It is backed by 1 study summary and 1 cited reference summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(1 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Shoji T, Masumoto S, Moriichi N, Ohtake Y, Kanda T. Administration of Apple Polyphenol Supplements for Skin Conditions in Healthy Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Nutrients. 2020;12(4):1071. doi: 10.3390/nu12041071.PubMedUsed to support: Randomized, double blind, placebo controlled trial in 65 healthy women for 12 weeks at 300 or 600 mg a day: smaller UV induced change in redness, melanin and lightness than placebo, but no difference in raw readings, no effect on skin hydration or water loss and no dose response. The material was Applephenon from Asahi Breweries, not SelectSIEVE Apple PCQ; Asahi funded the study and two authors declared they worked for it.