Home Ingredients ResVinol® (Japanese Knotweed and Red Wine Resveratrol Extract — Ethical Naturals)
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ResVinol® (Japanese Knotweed and Red Wine Resveratrol Extract — Ethical Naturals)

Polygonum cuspidatum
Evidence Level
Limited
4 Clinical Trials
3 Documented Benefits
2/5 Evidence Score

ResVinol® is a branded extract from Ethical Naturals that supplies trans-resveratrol and other polyphenols from the root of Japanese knotweed (Polygonum cuspidatum) and a red wine matrix. No published trial has tested ResVinol itself, so the evidence on this page comes from studies of other resveratrol supplements. A meta-analysis of 17 small randomized trials found lower insulin resistance scores overall and, in people with metabolic syndrome, lower glucose and cholesterol readings. Studies of antioxidant blood markers disagree with each other. Resveratrol's reputation for switching on SIRT1, an enzyme linked to calorie restriction, rests partly on a laboratory test artifact, and no longevity effect has been shown in people. At high doses resveratrol can change how the liver processes some medicines.

Studied Dose Trials in the cardiometabolic meta-analysis used 10 to 3,000 mg of resveratrol a day for 14 days to one year; the metabolic trial in men used 150 mg a day for 30 days. No dose of ResVinol itself has been tested in a published trial.
Active Compound Trans-resveratrol plus other polyphenols, from Japanese knotweed root and a red wine matrix.

Benefits

Insulin resistance and cholesterol markers

A meta-analysis of 17 randomized trials (651 people) found resveratrol lowered an insulin resistance score overall, and in people with metabolic syndrome it lowered glucose, LDL cholesterol and total cholesterol. Doses varied widely, results differed between groups, and none of the trials used ResVinol.

Supported by Trial 1

Antioxidant blood markers

Two meta-analyses of randomized trials disagree. One (12 trials) found no significant change in the antioxidant enzymes SOD, catalase or glutathione peroxidase and a borderline rise in total antioxidant capacity. The other (16 trials) found higher glutathione peroxidase but no change in SOD, MDA or total antioxidant capacity.

Supported by Trial 2, Trial 3

Sirtuin levels and calorie restriction-like effects

In a small trial of 11 men with obesity, 150 mg a day of a different resveratrol ingredient for 30 days raised muscle SIRT1 protein and caused some metabolic changes resembling calorie restriction. A laboratory study found resveratrol does not directly activate SIRT1, and no longevity benefit has been shown in people.

Supported by Trial 4

Mechanism of action

1

SIRT1 activation (disputed)

Resveratrol was proposed to activate SIRT1 directly. A laboratory study found it activated SIRT1 only when the test substrate carried a fluorescent tag, not with natural substrates. In a small human trial, muscle SIRT1 protein levels rose after 30 days of resveratrol.

2

AMPK activation

In the 30-day trial in men with obesity, resveratrol activated AMPK, a cellular energy sensor, in muscle and improved muscle mitochondrial respiration on a fat-derived fuel.

Clinical trials

1
Resveratrol and Cardiometabolic Markers: Meta-Analysis of 17 Trials
PubMed

Meta-analysis of 17 randomized controlled trials comparing people with metabolic syndrome with healthy people with or without obesity. (Sergi et al. 2020, Arch Med Sci Atheroscler Dis)

651 participants across 17 trials; trial sizes ranged from 16 to 90 people.

Resveratrol significantly lowered HOMA insulin resistance overall. In people with metabolic syndrome it significantly lowered glucose, LDL cholesterol and total cholesterol. The authors noted heterogeneity between the populations studied. No trial used ResVinol.

2
Resveratrol and Oxidative Stress Enzymes: Meta-Analysis of 12 Trials
PubMed

Systematic review and meta-analysis of randomized controlled trials published up to December 2018. (Koushki et al. 2020, Postgrad Med J)

Participants in 12 randomized controlled trials.

Resveratrol did not significantly change blood SOD, catalase or glutathione peroxidase. Total antioxidant capacity rose with borderline significance (p = 0.05), and heterogeneity between studies was severe.

3
Resveratrol and Oxidative Stress Markers: Meta-Analysis of 16 Trials
PubMed

Systematic review and meta-analysis of clinical trials published up to December 2018. (Omidian et al. 2020, Endocr Metab Immune Disord Drug Targets)

Participants in 16 clinical trials.

Resveratrol raised blood glutathione peroxidase but had no significant effect on SOD, MDA or total antioxidant capacity. The authors concluded it may not have a clinically significant effect on oxidative stress.

4
Resveratrol and Metabolism in Men With Obesity (30 Days)
PubMed

Randomized, double-blind, placebo-controlled crossover trial of 150 mg a day of resveratrol (resVida) for 30 days. (Timmers et al. 2011, Cell Metab)

11 healthy men with obesity.

Resveratrol lowered sleeping and resting metabolic rate, activated AMPK and raised SIRT1 and PGC-1 alpha protein in muscle, and lowered liver fat, blood glucose, triglycerides and inflammation markers. The trial was very small and short, and no longevity outcome was measured.

Side effects and drug interactions

Common Potential side effects

In a 4-week study of 1 g a day in 42 healthy volunteers, all reported side effects were mild to moderate.
Digestive effects were the most common: diarrhea in 4 people and heartburn in 3, and one person stopped after the first dose because of diarrhea.
Stop taking it and talk to a doctor if you notice an unusual reaction.

Important Drug interactions

Medicines processed by the liver enzymes CYP3A4, CYP2D6 or CYP2C9: in healthy volunteers, 1 g a day of resveratrol for 4 weeks reduced these enzymes' activity, which could raise levels of some drugs. Ask a pharmacist before combining.
Medicines processed by CYP1A2: the same study found this enzyme's activity increased, which could lower levels of some drugs.
The studies cited here did not test safety in pregnancy or breastfeeding, so ask a doctor first.

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Frequently asked questions about ResVinol® (Japanese Knotweed and Red Wine Resveratrol Extract — Ethical Naturals)

What is ResVinol?

ResVinol® is a branded extract from Ethical Naturals that supplies trans-resveratrol and other polyphenols from the root of Japanese knotweed (Polygonum cuspidatum) and a red wine matrix. No published trial has tested ResVinol itself, so the evidence on this page comes from studies of other resveratrol supplements.

What is ResVinol used for?

ResVinol is researched primarily for Longevity, Cardiovascular, and Antioxidant. A meta-analysis of 17 randomized trials (651 people) found resveratrol lowered an insulin resistance score overall, and in people with metabolic syndrome it lowered glucose, LDL cholesterol and total cholesterol.

What is the recommended dosage of ResVinol?

The clinically studied dose is Trials in the cardiometabolic meta-analysis used 10 to 3,000 mg of resveratrol a day for 14 days to one year; the metabolic trial in men used 150 mg a day for 30 days. No dose of ResVinol itself has been tested in a published trial. Always follow the product label and check with a healthcare provider for personal advice.

Is ResVinol safe, and does it have side effects?

Side effects and cautions reported for ResVinol include: In a 4-week study of 1 g a day in 42 healthy volunteers, all reported side effects were mild to moderate. Digestive effects were the most common: diarrhea in 4 people and heartburn in 3, and one person stopped after the first dose because of diarrhea. It may also interact with some medications. ResVinol is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does ResVinol interact with any medications?

Possible interactions include: Medicines processed by the liver enzymes CYP3A4, CYP2D6 or CYP2C9: in healthy volunteers, 1 g a day of resveratrol for 4 weeks reduced these enzymes' activity, which could raise levels of some drugs. Ask a pharmacist before combining. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for ResVinol?

NutraSmarts rates the evidence for ResVinol as Limited (2 out of 5). It is backed by 4 study summaries and 7 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(7 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Sergi C, Chiu B, Feulefack J, Shen F, Chiu B. Usefulness of resveratrol supplementation in decreasing cardiometabolic risk factors comparing subjects with metabolic syndrome and healthy subjects with or without obesity: meta-analysis using multinational, randomised, controlled trials. Arch Med Sci Atheroscler Dis. 2020;5:e98-e111. doi: 10.5114/amsad.2020.95884.PubMedUsed to support: Meta-analysis of 17 randomized trials (651 people; doses 10 to 3,000 mg, 14 to 365 days). Resveratrol lowered HOMA insulin resistance overall, and in people with metabolic syndrome it lowered glucose, LDL cholesterol and total cholesterol.
  2. Koushki M, Lakzaei M, Khodabandehloo H, Hosseini H, Meshkani R, Panahi G. Therapeutic effect of resveratrol supplementation on oxidative stress: a systematic review and meta-analysis of randomised controlled trials. Postgrad Med J. 2020;96(1134):197-205. doi: 10.1136/postgradmedj-2019-136415.PubMedUsed to support: Meta-analysis of 12 randomized trials: no significant effect on SOD, catalase or glutathione peroxidase, with a borderline rise in total antioxidant capacity (p = 0.05) and severe heterogeneity.
  3. Omidian M, Abdolahi M, Daneshzad E, Sedighiyan M, Aghasi M, Abdollahi H, Omidian P, Dabiri S, Mahmoudi M. The Effects of Resveratrol on Oxidative Stress Markers: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Endocr Metab Immune Disord Drug Targets. 2020;20(5):718-727. doi: 10.2174/1871530319666191116112950.PubMedUsed to support: Meta-analysis of 16 clinical trials: resveratrol raised glutathione peroxidase but had no significant effect on SOD, MDA or total antioxidant capacity; the authors judged the effect on oxidative stress may not be clinically significant.
  4. Timmers S, Konings E, Bilet L, Houtkooper RH, van de Weijer T, Goossens GH, Hoeks J, van der Krieken S, Ryu D, Kersten S, Moonen-Kornips E, Hesselink MKC, Kunz I, Schrauwen-Hinderling VB, Blaak E, Auwerx J, Schrauwen P. Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab. 2011;14(5):612-22. doi: 10.1016/j.cmet.2011.10.002.PubMedUsed to support: Randomized double-blind crossover trial in 11 healthy men with obesity: 150 mg a day of resveratrol (resVida) for 30 days lowered metabolic rate, activated muscle AMPK, raised SIRT1 and PGC-1 alpha protein, and lowered liver fat, glucose, triglycerides and inflammation markers.
  5. Pacholec M, Bleasdale JE, Chrunyk B, Cunningham D, Flynn D, Garofalo RS, Griffith D, Griffor M, Loulakis P, Pabst B, Qiu X, Stockman B, Thanabal V, Varghese A, Ward J, Withka J, Ahn K. SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1. J Biol Chem. 2010;285(11):8340-51. doi: 10.1074/jbc.M109.088682.PubMedUsed to support: Laboratory study: resveratrol activated SIRT1 only with a fluorophore-tagged peptide substrate, not with native peptide or full-length protein substrates.
  6. Chow HH, Garland LL, Hsu CH, Vining DR, Chew WM, Miller JA, Perloff M, Crowell JA, Alberts DS. Resveratrol modulates drug- and carcinogen-metabolizing enzymes in a healthy volunteer study. Cancer Prev Res (Phila). 2010;3(9):1168-75. doi: 10.1158/1940-6207.CAPR-09-0155.PubMedUsed to support: 42 healthy volunteers took 1 g of resveratrol daily for 4 weeks: CYP3A4, CYP2D6 and CYP2C9 activity fell and CYP1A2 activity rose. The full text reports mild to moderate side effects, most often diarrhea (4 people) and heartburn (3 people).
  7. Swanson Health Products Doctor's Best Trans-Resveratrol 200 with ResVinol product listing Swanson Health Products (retailer product page). 2026;Accessed October 2026..SourceUsed to support: Not PubMed-indexed; retailer product listing. Describes ResVinol-25 as a proprietary extract with polyphenols and trans-resveratrol from the red wine matrix and Japanese knotweed root, lists 200 mg trans-resveratrol and 80 mg polyphenols per serving, and states ResVinol is a registered trademark of Ethical Naturals, Inc.