Home Ingredients Progestive® (Bacillus coagulans Probiotic — Nutraceuticals International Group)
Gut Health

Progestive® (Bacillus coagulans Probiotic — Nutraceuticals International Group)

Bacillus coagulans
Evidence Level
Limited
0 Clinical Trials
3 Documented Benefits
2/5 Evidence Score

Progestive® is a probiotic ingredient from Nutraceuticals International Group built on Bacillus coagulans, a spore-forming beneficial bacterium that survives stomach acid well. It supports a balanced gut microbiome and digestive health. The specific benefit depends on the strain and dose a finished product uses.

Studied Dose No Progestive-strain trial has fixed a dose. In the cited Bacillus coagulans IBS trials, participants took about 1 to 6 billion CFU per day.
Active Compound Bacillus coagulans (reclassified in 2020 as Weizmannia coagulans), a spore-forming probiotic bacterium. The manufacturer does not disclose a specific strain designation, so the ingredient cannot be matched to any published clinical trial.

Benefits

Digestive support

Bacillus coagulans supports a balanced gut microbiome and healthy digestion, and is studied for easing occasional bloating and irregularity.

Survives to the gut

As a spore-forming probiotic, Bacillus coagulans resists stomach acid and heat well, helping more live cells reach the intestines.

Immune and strain-dependent note

Because much immune tissue lines the gut, probiotics may support immune balance; the actual benefit depends on the specific strain and dose.

Mechanism of action

1

Microbiome balance

Bacillus coagulans helps maintain a healthy balance of gut bacteria and produces lactic acid that supports a favorable gut environment.

2

Spore-based resilience

Its protective spore form lets it survive stomach acid and storage, germinating in the intestine where it acts.

Clinical trials

Side effects and drug interactions

Common Potential side effects

Generally well-tolerated — mild gas or bloating can occur at first.
Choose a product listing the specific strain and CFU count.
Immunocompromised individuals should consult a doctor.

Important Drug interactions

No major drug interactions are established.
Separate from antibiotics by a couple of hours.
Tell your doctor if you are immunocompromised.

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Frequently asked questions about Progestive® (Bacillus coagulans Probiotic — Nutraceuticals International Group)

What is Progestive?

Progestive® is a probiotic ingredient from Nutraceuticals International Group built on Bacillus coagulans, a spore-forming beneficial bacterium that survives stomach acid well. It supports a balanced gut microbiome and digestive health. The specific benefit depends on the strain and dose a finished product uses.

What is Progestive used for?

Progestive is researched primarily for Gut Health. Bacillus coagulans supports a balanced gut microbiome and healthy digestion, and is studied for easing occasional bloating and irregularity.

What is the recommended dosage of Progestive?

The clinically studied dose is No Progestive-strain trial has fixed a dose. In the cited Bacillus coagulans IBS trials, participants took about 1 to 6 billion CFU per day. Always follow the product label and check with a healthcare provider for personal advice.

Is Progestive safe, and does it have side effects?

For most healthy adults, Progestive is well tolerated at studied doses. Reported effects can include: Generally well-tolerated — mild gas or bloating can occur at first. Choose a product listing the specific strain and CFU count. It may also interact with some medications. Progestive is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does Progestive interact with any medications?

Possible interactions include: No major drug interactions are established. Separate from antibiotics by a couple of hours. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for Progestive?

NutraSmarts rates the evidence for Progestive as Limited (2 out of 5). It is backed by 3 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(3 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Gupta AK, Maity C Efficacy and safety of Bacillus coagulans LBSC in irritable bowel syndrome: A prospective, interventional, randomized, double-blind, placebo-controlled clinical study Medicine (Baltimore). 2021;100(3):e23641. doi:10.1097/MD.0000000000023641.PubMedUsed to support: Human RCT (CONSORT-compliant) demonstrating that Bacillus coagulans LBSC significantly improved IBS symptom scores including bloating, abdominal pain, and stool consistency versus placebo. Supports digestive support benefit of Bacillus coagulans (genus/species data; not the Progestive® strain specifically).
  2. Majeed M, Nagabhushanam K, Natarajan S, Sivakumar A, Ali F, Pande A, Majeed S, Karri SK Bacillus coagulans MTCC 5856 supplementation in the management of diarrhea predominant Irritable Bowel Syndrome: a double blind, randomized, placebo controlled pilot clinical study Nutrition Journal. 2016;15:21. doi:10.1186/s12937-016-0140-6.PubMedUsed to support: Human double-blind RCT showing Bacillus coagulans MTCC 5856 significantly reduced IBS symptoms including diarrhea, pain, and bloating over 90 days. Supports digestive support and survives-to-the-gut claim for Bacillus coagulans; strain differs from Progestive®.
  3. Abhari K, Saadati S, Hosseini-Oskouiee F, Yari Z, Hosseini H, Sohrab G, Hejazi E, Agah S, Sadeghi A, Hekmatdoost A Is Bacillus coagulans supplementation plus low FODMAP diet superior to low FODMAP diet in irritable bowel syndrome management? European Journal of Nutrition. 2020;59(5):2111-2117. doi:10.1007/s00394-019-02060-y.PubMedUsed to support: Human RCT: a Bacillus coagulans spore capsule (about 1 billion CFU) plus 400 mg inulin was added to a low-FODMAP diet for 8 weeks in 50 IBS patients. Abdominal pain, distension, quality of life and stool consistency improved significantly in BOTH the probiotic and placebo groups; only the IBS symptom severity score improved significantly more with the probiotic than with diet alone. Because the active capsule also contained the prebiotic inulin, the effect cannot be attributed to the bacterium alone, and the strain used is not the Progestive strain (Progestive's strain is undisclosed).