Benefits
Nitric oxide and circulation support
Arginine is the substrate the body converts into nitric oxide, which relaxes and widens blood vessels, supporting healthy circulation and blood flow.
Blood pressure support
Umbrella reviews of meta-analyses report L-arginine can modestly support healthy blood pressure, consistent with its nitric-oxide mechanism.
Exercise blood flow and men's health
Arginine is used for exercise 'pump' and for erectile and circulatory support, though oral citrulline often raises arginine levels more reliably.
Mechanism of action
Nitric oxide synthesis
Arginine is converted by nitric oxide synthase into nitric oxide, a vasodilator that improves endothelial function and blood flow.
Peptide-bound delivery
Carrying arginine on whey peptides improves solubility and taste and, per the manufacturer, absorption versus the free amino acid.
Clinical trials
Umbrella review of meta-analyses (Journal of Chiropractic Medicine, 2016).
Pooled cardiovascular and clinical populations
Across meta-analyses, L-arginine showed benefits for blood pressure and endothelial/circulatory measures, with effect sizes varying by population.
Systematic review (BJOG, 2025).
Blood-pressure-related populations
L-arginine and L-citrulline supplementation supported blood-pressure outcomes via nitric-oxide signaling.