NUTRALYS® Pea Protein (Roquette)

Pisum sativum
Evidence Level
Limited
5 Clinical Trials
5 Documented Benefits
2/5 Evidence Score

NUTRALYS is Roquette's line of pea protein isolates made from yellow peas (Pisum sativum). In one trial report, the peas were milled, the starch and fiber separated, and the protein purified and spray dried, giving an isolate of 85% protein on a dry basis. In a 12-week resistance-training trial funded by Roquette, biceps thickness gains versus a maltodextrin placebo were only a non-significant trend overall; a significant advantage appeared in a sensitivity analysis of the weakest participants, and pea did not differ from whey. Other Roquette-funded trials found it similar to whey for strength and muscle protein synthesis, but versus water it did not significantly lower blood markers of exercise muscle damage. In a single-meal test, adding it to a glucose drink blunted the blood sugar rise versus glucose alone. No trial has tested it for weight loss.

Studied Dose 25 g twice daily for 12 weeks with resistance training; 50 g/day (25 g at breakfast and lunch) for 8 days in older men; one 20 to 22.5 g serving daily for 84 days with training; 0.9 g/kg/day for 5 days after eccentric exercise; 25 g or 50 g with a 50 g glucose drink in a single-meal test.
Active Compound Pea protein isolate (the NUTRALYS isolate in one trial: 85% protein, 7% fat, 3% carbohydrate and 5% ash on a dry basis). Per 100 g of that isolate: leucine 6.4 g, isoleucine 3.7 g, valine 4.0 g, lysine 5.7 g, arginine 6.6 g, methionine 0.8 g.

Benefits

Biceps Thickness in a 12-Week Resistance Training Trial

In a 12-week upper-body training trial in 161 young men, 25 g of NUTRALYS pea protein twice daily gave biceps thickness gains that were only a non-significant trend versus a maltodextrin placebo overall; in a sensitivity analysis of the weakest participants, gains with pea were significantly larger than placebo. Roquette funded the trial, and strength did not differ between groups.

Muscle Protein Synthesis Above a Baseline Protein Intake

In older men eating a controlled diet at the protein RDA, adding 25 g of NUTRALYS pea protein at breakfast and lunch for 8 days raised integrated myofibrillar protein synthesis compared with their own RDA-only phase, matching whey, while collagen produced no change. This was a short within-person comparison funded by Roquette, not a training study.

Similar Strength and Muscle Results to Whey With Training

In an 84-day trial in sedentary adults doing weekly resistance training, a daily NUTRALYS pea protein serving and whey showed no significant differences in changes in strength, muscle mass or body composition. Whey was an active comparator and there was no placebo group, so this shows similarity to whey, not an effect versus no supplement; Roquette funded the trial.

Smaller Blood Sugar Rise When Added to a Glucose Drink

In a single-meal crossover test in 31 healthy adults, adding 25 g or 50 g of NUTRALYS pea protein to a 50 g glucose drink lowered the 3-hour glucose response by 31% and 53% versus glucose alone and raised the insulin response; two authors worked for Roquette. Single-meal results do not show effects of regular use.

Milk-Free and Soy-Free Protein Option

Pea protein contains no milk or soy protein, so it can suit people who avoid those foods. Pea itself is a legume allergen: a scoping review notes that allergies to pea, chickpea, lentil and lupine are frequently implicated in severe allergic reactions, so people with legume allergies should take care.

Mechanism of action

1

Muscle Protein Synthesis Stimulation

Pea protein supplies the essential amino acids that drive muscle protein synthesis; in older men, adding NUTRALYS pea protein above the protein RDA raised integrated myofibrillar protein synthesis, and supplemental protein (pea, whey or collagen) raised mTORC1 and rpS6 signaling with no difference between proteins. Per 100 g it has less leucine than whey (6.4 vs 8.6 g) but more arginine (6.6 vs 2.1 g).

2

Amino Acid Profile and Digestibility

In a human study using ileal sampling, with Roquette coauthors, a pea protein isolate had 93.6% real ileal amino acid digestibility, not different from casein, and a DIAAS of 1.00, though leucine, valine, lysine and phenylalanine were less digestible than in casein. Methionine in the NUTRALYS isolate is about half that of whey per 100 g.

3

Insulin Response With Carbohydrate

Taken with a glucose drink, NUTRALYS pea protein raised the 3-hour insulin response by 28% at 25 g and 40% at 50 g alongside the lower glucose response, while the gut hormones GIP and GLP-1 showed no clear difference from glucose alone.

4

Stomach Digestion and Gut Hormones in Lab and Animal Tests

In a simulated stomach model, NUTRALYS pea protein formed temporary particles while whey stayed dissolved, suggesting digestion between that of whey and casein; in rats, pea and whey meals gave comparable CCK, GLP-1 and PYY responses. These are lab and animal findings, not human results, from a study with Roquette coauthors.

Clinical trials

1
Pea Protein vs Whey vs Placebo with Resistance Training
PubMed

Double-blind randomized trial of NUTRALYS pea protein isolate (25 g twice daily) versus whey concentrate versus a maltodextrin placebo for 12 weeks; Roquette, the pea-protein maker, funded the study and three authors were Roquette employees. (Babault et al. 2015, J Int Soc Sports Nutr)

161 men aged 18 to 35 doing 12 weeks of upper-limb resistance training.

Biceps thickness rose in all groups, with only a non-significant trend between groups overall (P = 0.09). In a sensitivity analysis of the weakest participants at baseline, gains were 20.2% with pea, 15.6% with whey and 8.6% with placebo, and pea was significantly greater than placebo; whey did not differ from either. Strength gains did not differ between groups.

2
Pea, Whey or Collagen Added Above the Protein RDA in Older Men
PubMed

Double-blind randomized trial: after 7 days on a controlled diet at the protein RDA, men added 25 g of whey, pea (NUTRALYS S85 Plus N) or collagen protein at breakfast and lunch (50 g/day) for 8 days; synthesis was measured with deuterated water and biopsies and compared with each man's RDA phase. Funded by a research contract from Roquette Freres, the pea-protein maker. (McKendry et al. 2024, Am J Clin Nutr)

31 healthy older men (mean age 72), 11 of them in the pea group.

Integrated myofibrillar (muscle) protein synthesis rose from 1.46 to 1.59 %/day with pea versus the RDA phase, the same rise as with whey, while collagen produced no change. Anabolic signaling (mTORC1, rpS6) rose with supplemental protein, with no difference between the three proteins.

3
Pea Protein vs Whey With Resistance Training in Sedentary Adults
PubMed

Randomized comparator-controlled parallel trial of pea protein versus whey for 84 days with a weekly resistance training program; no placebo group. Funded by Roquette Canada, with three Roquette employees among the authors. (Singh et al. 2024, Nutrients)

Healthy sedentary adults.

Changes in a composite score of handgrip, upper-body and lower-body tests, body composition and product liking did not differ between pea and whey. Within groups, the composite score rose 16.1% with pea (p = 0.01) and 11.1% with whey (p = 0.06).

4
Pea Protein vs Whey vs Water After Eccentric Exercise
PubMed

Randomized trial of 0.9 g protein/kg/day in three doses for 5 days after a 90-minute eccentric exercise bout, with the two proteins given double-blind and a water-only arm; Roquette funded it and its scientists helped design the study and write the paper. (Nieman et al. 2020, Nutrients)

92 non-athletic, non-obese men aged 18 to 55.

Whey significantly lowered blood creatine kinase and myoglobin versus water on days 4 and 5; pea protein had an intermediate effect that was not significant versus water, and pea and whey did not differ. Neither protein changed delayed-onset pain ratings, bench press or Wingate results versus water.

5
Pea Protein Added to a Glucose Drink
PubMed

Single-blind randomized crossover single-meal test of 50 g glucose alone or with 25 g or 50 g NUTRALYS pea protein; two authors were Roquette employees. (Thondre et al. 2021, Eur J Nutr)

31 healthy adults.

The 180-minute glucose iAUC was 31% lower with 25 g and 53% lower with 50 g pea protein than with glucose alone (p < 0.001), and insulin iAUC was 28% and 40% higher. GIP and GLP-1 showed no clear difference from control.

Side effects and drug interactions

Common Potential side effects

In a 12-week trial, adverse events were reported by one participant in the NUTRALYS pea group versus four on placebo and three on whey; the only digestive events (diarrhea) were in the placebo group.
In an 84-day trial in sedentary adults, the authors reported that both pea protein and whey were "safe and well-tolerated in the enrolled population"; adverse events were reported by 7 participants in each group, none rated as possibly, probably or most probably related to the products.
Pea is a legume allergen: a scoping review notes that allergies to pea, chickpea, lentil and lupine are frequently implicated in severe allergic reactions. People with legume allergies should check with an allergist.
Some people with chronic kidney disease may need moderate protein amounts; NIDDK advises working with a dietitian or health care professional to find the right balance of protein.

Important Drug interactions

Levodopa (with carbidopa): MedlinePlus advises talking to your doctor before changing to a high-protein diet; regular protein powder use adds to dietary protein.
Glucose-lowering medicines: in a single-meal test in healthy adults, NUTRALYS pea protein taken with a glucose drink lowered the blood sugar rise and increased insulin release; discuss regular use with your clinician.

Frequently asked questions about NUTRALYS® Pea Protein (Roquette)

What is NUTRALYS Pea Protein used for?

NUTRALYS is a range of pea protein isolates from Roquette, taken in trials as a protein drink. Studies funded by Roquette or with Roquette coauthors have tested it with resistance training, for muscle protein synthesis in older men, after hard exercise, and added to a glucose drink in a single-meal test.

What is the recommended dosage of NUTRALYS Pea Protein?

There is no official recommended dose. Trials used 25 g twice daily alongside resistance training, 50 g a day split between breakfast and lunch in older men, one 20 to 22.5 g serving a day for 84 days, and 25 to 50 g with a glucose drink in a single-meal test. Total daily protein intake matters more than any single serving.

Is NUTRALYS pea protein as good as whey for muscle?

In Roquette-funded trials with training, NUTRALYS pea protein and whey showed no significant differences in muscle size, strength or body composition, and both raised muscle protein synthesis equally in older men. These trials were not built to prove equivalence. After eccentric exercise, whey lowered blood markers of muscle damage versus water while pea did not reach significance.

Does NUTRALYS pea protein help with recovery after hard exercise?

Not clearly. After eccentric exercise, NUTRALYS pea protein had an intermediate effect on creatine kinase and myoglobin that was not significant versus water and did not change soreness. In a separate trial of a different pea protein product in older adults, pea did not lower creatine kinase after a long walk versus placebo.

Does NUTRALYS pea protein help with weight loss?

No trial has tested NUTRALYS pea protein for weight or fat loss. A study with Roquette coauthors found that pea and whey meals gave comparable gut fullness hormone responses, but that was in rats, not people.

What is NUTRALYS Pea Protein?

Nutralys is Roquette's line of pea protein isolates made from yellow peas (Pisum sativum). In one trial report, the peas were milled, the starch and fiber separated, and the protein purified and spray dried, giving an isolate of 85% protein on a dry basis.

Is NUTRALYS Pea Protein safe, and does it have side effects?

Side effects and cautions reported for NUTRALYS Pea Protein include: In a 12-week trial, adverse events were reported by one participant in the Nutralys pea group versus four on placebo and three on whey; the only digestive events (diarrhea) were in the placebo group. It may also interact with some medications. NUTRALYS Pea Protein is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does NUTRALYS Pea Protein interact with any medications?

Possible interactions include: Levodopa (with carbidopa): MedlinePlus advises talking to your doctor before changing to a high-protein diet; regular protein powder use adds to dietary protein. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for NUTRALYS Pea Protein?

NutraSmarts rates the evidence for NUTRALYS Pea Protein as Limited (2 out of 5). It is backed by 5 study summaries and 11 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(11 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Babault N, Païzis C, Deley G, Guérin-Deremaux L, Saniez MH, Lefranc-Millot C, Allaert FA. Pea proteins oral supplementation promotes muscle thickness gains during resistance training: a double-blind, randomized, Placebo-controlled clinical trial vs. Whey protein. J Int Soc Sports Nutr. 2015;12(1):3. doi: 10.1186/s12970-014-0064-5.PubMedUsed to support: Roquette-funded double-blind trial of NUTRALYS pea protein isolate (25 g twice daily) vs whey vs maltodextrin placebo in 161 men over 12 weeks of resistance training. Overall between-group biceps thickness difference was a non-significant trend (P = 0.09); in a sensitivity analysis of the weakest participants pea exceeded placebo and did not differ from whey; strength did not differ between groups. Full text gives the isolate's production steps, composition (85% protein) and amino acid table, and adverse events (1 in the pea group, 4 placebo, 3 whey).
  2. McKendry J, Lowisz CV, Nanthakumar A, MacDonald M, Lim C, Currier BS, Phillips SM. The effects of whey, pea, and collagen protein supplementation beyond the recommended dietary allowance on integrated myofibrillar protein synthetic rates in older males: a randomized controlled trial. Am J Clin Nutr. 2024;120(1):34-46. doi: 10.1016/j.ajcnut.2024.05.009.PubMedUsed to support: Double-blind randomized trial in 31 older men, funded by a Roquette Freres research contract (pea arm used NUTRALYS S85 Plus N): adding 50 g/day of whey or pea protein above the RDA for 8 days raised integrated myofibrillar protein synthesis vs each man's RDA phase (1.46 to 1.59 %/day for pea), while collagen did not; mTORC1 and rpS6 signaling rose with supplemental protein with no difference between proteins.
  3. Singh RG, Guérin-Deremaux L, Lefranc-Millot C, Perreau C, Crowley DC, Lewis ED, Evans M, Moulin M. Efficacy of Pea Protein Supplementation in Combination with a Resistance Training Program on Muscle Performance in a Sedentary Adult Population: A Randomized, Comparator-Controlled, Parallel Clinical Trial. Nutrients. 2024;16(13):2017. doi: 10.3390/nu16132017.PubMedUsed to support: Roquette Canada-funded triple-blind comparator trial in sedentary adults aged 30 to 59 (pea arm used NUTRALYS S85 Plus; three Roquette employees among the authors): 84 days of pea protein vs whey with weekly resistance training; no between-group differences in whole-body strength, muscle mass or product liking; strength rose 16.1% within the pea group. No placebo arm reported (other plant-protein arms of the study were not reported in this paper). The authors reported both products were "safe and well-tolerated in the enrolled population".
  4. Nieman DC, Zwetsloot KA, Simonson AJ, Hoyle AT, Wang X, Nelson HK, Lefranc-Millot C, Guérin-Deremaux L. Effects of Whey and Pea Protein Supplementation on Post-Eccentric Exercise Muscle Damage: A Randomized Trial. Nutrients. 2020;12(8):2382. doi: 10.3390/nu12082382.PubMedUsed to support: Randomized trial in 92 men after eccentric exercise, funded by Roquette with Roquette coauthors (pea arm used NUTRALYS S85 Plus): whey lowered creatine kinase and myoglobin vs water; pea had an intermediate, non-significant effect vs water and did not differ from whey; neither changed soreness or fitness tests.
  5. Thondre PS, Achebe I, Sampson A, Maher T, Guérin-Deremaux L, Lefranc-Millot C, Ahlström E, Lightowler H. Co-ingestion of NUTRALYS(®) pea protein and a high-carbohydrate beverage influences the glycaemic, insulinaemic, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) responses: preliminary results of a randomised controlled trial. Eur J Nutr. 2021;60(6):3085-3093. doi: 10.1007/s00394-021-02481-8.PubMedUsed to support: Single-blind randomized crossover single-meal test in 31 healthy adults (two Roquette coauthors): adding 25 g or 50 g NUTRALYS pea protein to 50 g glucose lowered 180-minute glucose iAUC by 31% and 53% vs glucose alone and raised insulin iAUC by 28% and 40%; GIP and GLP-1 showed no clear difference.
  6. Guillin FM, Gaudichon C, Guérin-Deremaux L, Lefranc-Millot C, Airinei G, Khodorova N, Benamouzig R, Pomport PH, Martin J, Calvez J. Real ileal amino acid digestibility of pea protein compared to casein in healthy humans: a randomized trial. Am J Clin Nutr. 2022;115(2):353-363. doi: 10.1093/ajcn/nqab354.PubMedUsed to support: Randomized human trial with naso-ileal sampling in 15 adults (Roquette coauthors; pea protein isolate not named as NUTRALYS in the abstract): real ileal amino acid digestibility 93.6% for pea protein isolate vs 96.8% for casein (not different); leucine, valine, lysine and phenylalanine less digestible in pea; DIAAS 1.00 for pea.
  7. Overduin J, Guérin-Deremaux L, Wils D, Lambers TT. NUTRALYS(®) pea protein: characterization of in vitro gastric digestion and in vivo gastrointestinal peptide responses relevant to satiety. Food Nutr Res. 2015;59:25622. doi: 10.3402/fnr.v59.25622.PubMedUsed to support: Lab and animal study, not a human trial (two Roquette authors): in a simulated stomach model NUTRALYS pea protein transiently aggregated into particles while whey stayed dissolved; in nine rats, pea and whey meals gave comparable CCK, GLP-1 and PYY responses, with weaker early ghrelin and insulin responses for pea. Supports the digestion mechanism only, not any human appetite or weight claim.
  8. Spoelder M, Koopmans L, Hartman YAW, Bongers CCWG, Schoofs MCA, Eijsvogels TMH, Hopman MTE. Supplementation with Whey Protein, but Not Pea Protein, Reduces Muscle Damage Following Long-Distance Walking in Older Adults. Nutrients. 2023;15(2):342. doi: 10.3390/nu15020342.PubMedUsed to support: Other product, not NUTRALYS (supplements from NewCare, which funded the study): randomized trial in 47 active adults aged 60 and over; 13 days of 25 g/day pea protein did not lower creatine kinase after a 20 to 30 km walk vs placebo, while whey did; no group differences in LDH, strength, muscle mass or soreness.
  9. Hildebrand HV, Arias A, Simons E, Gerdts J, Povolo B, Rothney J, Protudjer JLP. Adult and Pediatric Food Allergy to Chickpea, Pea, Lentil, and Lupine: A Scoping Review. J Allergy Clin Immunol Pract. 2021;9(1):290-301.e2. doi: 10.1016/j.jaip.2020.10.046.PubMedUsed to support: Scoping review of 47 studies: pea, chickpea, lentil and lupine allergies are frequently implicated in severe allergic reactions; research focused mainly on prevalence.
  10. National Institute of Diabetes and Digestive and Kidney Diseases. Healthy Eating for Adults with Chronic Kidney Disease NIDDK Health Information. 2026;Web page, accessed 2026..SourceUsed to support: Not PubMed-indexed (NIH web page, accessed 2026). States that some people with chronic kidney disease may need moderate amounts of protein and should work with a dietitian or health care professional to find the right balance of protein.
  11. U.S. National Library of Medicine. Levodopa and Carbidopa: MedlinePlus Drug Information MedlinePlus. 2026;Web page, accessed 2026..SourceUsed to support: Not PubMed-indexed (NIH web page, accessed 2026). Advises patients to talk to their doctor if they plan to change to a diet high in protein while taking levodopa and carbidopa.