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Men's HealthProstate Health

NaturSYN® PowerUp (Maca and Rye for Men's Health)

Evidence Level
Preliminary
0 Clinical Trials
3 Documented Benefits
1/5 Evidence Score

NaturSYN® PowerUp is a men's-health blend of maca (Lepidium meyenii) and rye (Secale cereale) extracts from Nutraceuticals International Group. It is marketed for prostate, urinary flow, and sexual-function support. Published clinical data for the specific blend are limited: no published study has tested NaturSYN PowerUp itself. All three references on this page examined single components or a different branded extract, and none of them measured testosterone or any other hormone.

Studied Dose Not established. The product specification sets the dose, and no dose of the finished blend has been tested in a published clinical trial. The rye evidence comes from a specific branded rye pollen extract taken for 12 to 24 weeks, and the maca evidence comes from maca extract taken on its own.
Active Compound Blend of maca (Lepidium meyenii) and rye (Secale cereale) pollen/grain extracts.

Benefits

Prostate and urinary support

The rye evidence on this page is a systematic review of 4 randomized trials of Cernilton, a specific branded rye pollen (Secale cereale) extract, in 444 men with diagnosed benign prostatic hyperplasia treated for 12 to 24 weeks. Self-rated urinary symptoms improved versus placebo (relative risk 2.40) and nocturia was reduced (relative risk 2.05). This product contains rye extract, so the plant matches, but the trials used that branded extract rather than this blend, and the men enrolled had a diagnosed condition. No cited maca reference measured prostate or urinary outcomes. Nothing here shows that this blend treats benign prostatic hyperplasia or any other prostate condition.

Sexual performance

The maca evidence is two publications. One is a randomized, double-blind trial in men with mild erectile dysfunction, a diagnosed condition, reporting improved self-rated sexual well-being and performance versus placebo. The other is a systematic review of maca trials for sexual function rather than a new trial. Both looked at maca on its own rather than this blend, and neither measured testosterone or any other hormone.

Vitality support

This is a compositional statement rather than a clinical finding, and it is uncited. The blend's maca and rye extracts are described as supplying vitamins, flavonoids, sterols, and fatty acids, but no reference on this page measured vitality, energy, or any related outcome, and no published study has tested what this blend does.

Mechanism of action

1

Proposed anti-inflammatory and vascular actions

No published study has tested this blend, and no cited reference measured prostate inflammation or blood flow. Anti-inflammatory and vascular actions are proposed mechanisms rather than measured results here. The cited work reported urinary symptoms, nocturia, and self-rated sexual function only.

2

Maca adaptogenic action

Maca is described as an adaptogen, and the cited maca work reports improvements in self-rated sexual desire and well-being without any hormone being measured. Energy was not an outcome in the cited studies, and the mechanism behind the reported sexual-function effects has not been established.

Clinical trials

Side effects and drug interactions

Common Potential side effects

Generally well-tolerated in the studies of the individual components. The finished blend has no published safety or tolerability data of its own.
Mild digestive upset is occasionally reported.
Anyone with a grass-pollen allergy should check the rye component. Rye (Secale cereale) is a grass, and pollen extracts can trigger reactions in people sensitized to grass pollen. Because the rye material includes grain extract, people with celiac disease or gluten sensitivity should also confirm the gluten status with the manufacturer.

Important Drug interactions

No cited study measured testosterone or any other hormone, so no hormonal effect should be assumed. For hormone-related conditions — consult a doctor.
Persistent urinary or prostate symptoms need a medical evaluation. Difficulty urinating, a weak stream, or waking repeatedly at night can come from benign prostatic hyperplasia, infection, or prostate cancer, and no supplement substitutes for that assessment.
Maca and rye pollen extract have not been tested together in a published trial, so the combined effects and any drug interactions of this blend are unknown. Use caution if you are managing a health condition, and tell your doctor and pharmacist what you are taking.

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Frequently asked questions about NaturSYN® PowerUp (Maca and Rye for Men's Health)

What is NaturSYN PowerUp?

NaturSYN® PowerUp is a men's-health blend of maca (Lepidium meyenii) and rye (Secale cereale) extracts from Nutraceuticals International Group. It is marketed for prostate, urinary flow, and sexual-function support.

What is NaturSYN PowerUp used for?

NaturSYN PowerUp is researched primarily for Men's Health and Prostate Health. The rye evidence on this page is a systematic review of 4 randomized trials of Cernilton, a specific branded rye pollen (Secale cereale) extract, in 444 men with diagnosed benign prostatic hyperplasia treated for 12 to 24 weeks.

What is the recommended dosage of NaturSYN PowerUp?

The clinically studied dose is Not established. The product specification sets the dose, and no dose of the finished blend has been tested in a published clinical trial. Always follow the product label and check with a healthcare provider for personal advice.

Is NaturSYN PowerUp safe, and does it have side effects?

For most healthy adults, NaturSYN PowerUp is well tolerated at studied doses. Reported effects can include: Generally well-tolerated in the studies of the individual components. The finished blend has no published safety or tolerability data of its own. Mild digestive upset is occasionally reported. It may also interact with some medications. NaturSYN PowerUp is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does NaturSYN PowerUp interact with any medications?

Possible interactions include: No cited study measured testosterone or any other hormone, so no hormonal effect should be assumed. For hormone-related conditions — consult a doctor. Persistent urinary or prostate symptoms need a medical evaluation. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for NaturSYN PowerUp?

NutraSmarts rates the evidence for NaturSYN PowerUp as Preliminary (1 out of 5). It is backed by 3 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(3 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Shin BC, Lee MS, Yang EJ, Lim HS, Ernst E Maca (L. meyenii) for improving sexual function: a systematic review BMC Complement Altern Med. 2010;10:44. doi:10.1186/1472-6882-10-44.PubMedUsed to support: Systematic review of 4 RCTs concluding that maca (Lepidium meyenii) may improve sexual dysfunction or sexual desire; supports the Sexual performance benefit of NaturSYN® PowerUp. This is a review of earlier trials rather than a new trial, it evaluated maca on its own, and it did not measure vitality, testosterone, or any other hormone — evidence is for maca as a component herb, not the NaturSYN® blend specifically
  2. Zenico T, Cicero AFG, Valmorri L, Mercuriali M, Bercovich E Subjective effects of Lepidium meyenii (Maca) extract on well-being and sexual performances in patients with mild erectile dysfunction: a randomised, double-blind clinical trial Andrologia. 2009;41(2):95-99. doi:10.1111/j.1439-0272.2008.00892.x.PubMedUsed to support: Randomized double-blind trial showing maca extract significantly improved subjective sexual well-being and performance in men with mild erectile dysfunction versus placebo; supports the Sexual performance benefit of NaturSYN® PowerUp. Mild erectile dysfunction is a diagnosed condition, the treatment was maca extract on its own rather than this blend, and no hormone or vitality outcome was measured — evidence is for maca as a component herb, not the NaturSYN® blend specifically
  3. MacDonald R, Ishani A, Rutks I, Wilt TJ A systematic review of Cernilton for the treatment of benign prostatic hyperplasia BJU Int. 2000;85(7):836-841. doi:10.1046/j.1464-410x.2000.00365.x.PubMedUsed to support: Systematic review of 4 RCTs (n=444) showing that Cernilton, a standardized rye pollen (Secale cereale) extract, modestly improved overall urinary symptoms and nocturia in men with BPH and was well tolerated; supports Prostate and urinary support benefit of NaturSYN® PowerUp (which contains rye extract) — evidence is for rye pollen extract as a component herb, not the NaturSYN® blend specifically