Home Ingredients Myoceram® (oral rice/corn ceramides — InnoVactiv)
Hair, Skin & Nails

Myoceram® (oral rice/corn ceramides — InnoVactiv)

Oryza sativa (rice) or Zea mays (corn)-derived glucosylceramides
Evidence Level
Limited
3 Clinical Trials
4 Documented Benefits
2/5 Evidence Score

Myoceram is a branded, allergen-free ceramide ingredient sourced from non-GMO rice or corn and taken by mouth at a low daily dose to support the skin barrier from within. Rather than sitting on the surface like a cream, dietary glucosylceramides are thought to supply building blocks and signals that help skin make its own ceramides, the lipids that hold moisture in and keep the barrier intact. Honest evidence note: there is no published trial on Myoceram itself; its support comes from the maker's unpublished dossier plus independent human and lab studies on dietary glucosylceramide from rice and other plants. Evidence is limited.

Studied Dose 20 to 40 mg/day (rice-derived label dose ~30 mg/day)
Active Compound Plant (rice/corn) glucosylceramides; sphingoid bases including 4,8-sphingadienine

Benefits

Helps support the skin barrier

Taken daily, plant ceramides are used to help maintain a healthy, intact skin barrier, the outer layer that keeps moisture in and irritants out.

Supported by Trial 3, Trial 1

Helps maintain skin hydration

By supporting the skin's own moisture-retaining lipids, oral ceramides are used to help keep skin feeling hydrated and comfortable across the body, not just where a cream is applied.

Supported by Trial 1, Trial 3

Helps reduce moisture loss through skin

Class research on dietary glucosylceramide associates supplementation with lower transepidermal water loss, a marker of how much water escapes through a compromised barrier.

Supported by Trial 3, Trial 1

Supports healthy-looking skin

A better-supported barrier is associated with smoother-feeling, healthier-looking skin texture; allergen-free, gluten-free sourcing makes it a convenient daily option.

Supported by Trial 1, Trial 3

Mechanism of action

1

Supplies sphingoid building blocks

After digestion, plant glucosylceramides release sphingoid bases such as 4,8-sphingadienine that serve as raw material and signals for the skin's own ceramide synthesis.

2

Upregulates ceramide-making enzymes

Laboratory and animal work suggests oral glucosylceramide can increase expression of ceramide synthase enzymes (e.g., CerS3/CerS4) and raise epidermal ceramide levels.

3

Reinforces the stratum corneum lipid matrix

Ceramides are a core component of the lipid 'mortar' between skin cells; supporting their production helps maintain the barrier that limits water loss.

Clinical trials

1
Rice ceramide supplementation and skin barrier (class evidence; not Myoceram-branded)

Open-label, single-arm prospective study of oral rice (Oryza sativa) ceramides over 12 weeks; a different rice-ceramide brand, not Myoceram, but the closest published human study on the same source material (Leo 2022, Nutrients).

50 healthy adults (ages ~21 to 40+), no chronic skin disease; 40 mg/day.

Reported improvements in skin hydration, firmness/elasticity and wrinkle severity, with reductions in transepidermal water loss, melanin index and erythema index. Uncontrolled (no placebo), so results are suggestive rather than definitive.

2
Oral glucosylceramide and transepidermal water loss in humans (class evidence; konjac source)

Randomized, double-blind, placebo-controlled human study of dietary glucosylceramide (konjac source) over 12 weeks; class/mechanistic evidence for dietary glucosylceramide, not a Myoceram trial (Uchiyama 2008, Journal of Health Science).

100 healthy subjects selected for relatively high cheek transepidermal water loss.

Cheek transepidermal water loss was significantly lower in the test group versus placebo at weeks 8 and 12 (p=0.023 and p=0.002).

3
Plant ceramides/glucosylceramides and skin barrier (class evidence; wine lees source)

Randomized, double-blind, placebo-controlled study of ceramides plus glucosylceramides from wine lees extract over 12 weeks; class evidence for dietary ceramides, not a Myoceram trial (Sanjaya 2024, Nutrients).

30 healthy Japanese adults (ages 20 to 64); supplement standardized to at least 2 mg ceramides/glucosylceramides per day.

Transepidermal water loss was significantly lower in the test group than placebo at 12 weeks (p=0.04); skin water content did not differ significantly.

Side effects and drug interactions

Common Potential side effects

Generally well tolerated in studies of dietary glucosylceramide; no serious adverse events reported.
Mild, occasional digestive upset is possible with any oral supplement.
Rice- and corn-derived Myoceram is marketed as gluten- and allergen-free, but anyone with specific food sensitivities should check the finished product label.

Important Drug interactions

No clinically significant drug interactions have been established for dietary plant ceramides/glucosylceramides.
As with any supplement, people who are pregnant or breastfeeding, or who take prescription medications, should consult a healthcare provider before use.

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Frequently asked questions about Myoceram® (oral rice/corn ceramides — InnoVactiv)

What is Myoceram?

Myoceram is a branded, allergen-free ceramide ingredient sourced from non-GMO rice or corn and taken by mouth at a low daily dose to support the skin barrier from within.

What is Myoceram used for?

Myoceram is researched primarily for Hair, Skin & Nails. Taken daily, plant ceramides are used to help maintain a healthy, intact skin barrier, the outer layer that keeps moisture in and irritants out.

What is the recommended dosage of Myoceram?

The clinically studied dose is 20 to 40 mg/day (rice-derived label dose ~30 mg/day) Always follow the product label and check with a healthcare provider for personal advice.

Is Myoceram safe, and does it have side effects?

For most healthy adults, Myoceram is well tolerated at studied doses. Reported effects can include: Generally well tolerated in studies of dietary glucosylceramide; no serious adverse events reported. Mild, occasional digestive upset is possible with any oral supplement. It may also interact with some medications. Myoceram is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does Myoceram interact with any medications?

Possible interactions include: No clinically significant drug interactions have been established for dietary plant ceramides/glucosylceramides. As with any supplement, people who are pregnant or breastfeeding, or who take prescription medications, should consult a healthcare provider before use. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for Myoceram?

NutraSmarts rates the evidence for Myoceram as Limited (2 out of 5). It is backed by 3 clinical trials and 6 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(6 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Leo TK, Tan ESS, Amini F, Rehman N, Ng ESC, Tan CK Effect of Rice (Oryza sativa L.) Ceramides Supplementation on Improving Skin Barrier Functions and Depigmentation: An Open-Label Prospective Study Nutrients. 2022;Nutrients. 2022;14(13):2737. doi:10.3390/nu14132737. Open-label, single-arm study; rice-ceramide brand (not Myoceram), 40 mg/day for 12 weeks in 50 healthy adults..PubMedUsed to support: Closest published human study on the same source material (oral rice ceramides), supporting reduced transepidermal water loss and improved hydration; class evidence, not Myoceram-specific.
  2. Uchiyama T, Nakano Y, Ueda O, Mori H, Nakashima M, Noda A, Ishizaki C, Mizoguchi M Oral Intake of Glucosylceramide Improves Relatively Higher Level of Transepidermal Water Loss in Mice and Healthy Human Subjects Journal of Health Science. 2008;J Health Sci. 2008;54(5):559-566. doi:10.1248/jhs.54.559. Randomized, double-blind, placebo-controlled human study (konjac glucosylceramide), n=100, 12 weeks. Not indexed in PubMed (no PMID)..SourceUsed to support: Human RCT showing dietary glucosylceramide significantly lowers cheek transepidermal water loss; class evidence for the ingredient mechanism, not Myoceram-specific.
  3. Sanjaya A, Ishida A, Li X, Kim Y, Yamada H, Kometani T, Yamashita Y, Kim YI Efficacy and Safety of Oral Administration of Wine Lees Extract (WLE)-Derived Ceramides and Glucosylceramides in Enhancing Skin Barrier Function: A Randomized, Double-Blind, Placebo-Controlled Study Nutrients. 2024;Nutrients. 2024;16(13):2100. doi:10.3390/nu16132100. RCT, n=30 healthy adults, 12 weeks; plant ceramides/glucosylceramides from wine lees..PubMedUsed to support: Placebo-controlled human evidence that dietary ceramides/glucosylceramides reduce transepidermal water loss; class evidence, not Myoceram-specific.
  4. Venkataramana SH, Puttaswamy N, Kodimule S Potential benefits of oral administration of Amorphophallus konjac glycosylceramides on skin health - a randomized clinical study BMC Complementary Medicine and Therapies. 2020;BMC Complement Med Ther. 2020;20:26. doi:10.1186/s12906-019-2721-3. Randomized, placebo-controlled, single-blind study; konjac glycosylceramides, n=51, 6 weeks..PubMedUsed to support: Randomized human evidence that dietary glycosylceramide improves signs of skin dryness and hyperpigmentation; class evidence, not Myoceram-specific.
  5. Shimoda H, Terazawa S, Hitoe S, Tanaka J, Nakamura S, Matsuda H, Yoshikawa M Changes in ceramides and glucosylceramides in mouse skin and human epidermal equivalents by rice-derived glucosylceramide Journal of Medicinal Food. 2012;J Med Food. 2012;15(12):1064-1072. doi:10.1089/jmf.2011.2137. Mechanistic study in mice and human epidermal equivalents; rice-derived glucosylceramide..PubMedUsed to support: Mechanistic evidence that rice-derived glucosylceramide raises epidermal ceramide levels and may improve barrier function; supports proposed mechanism, not a human Myoceram trial.
  6. Shirakura Y, Kikuchi K, Matsumura K, Mukai K, Mitsutake S, Igarashi Y 4,8-Sphingadienine and 4-hydroxy-8-sphingenine activate ceramide production in the skin Lipids in Health and Disease. 2012;Lipids Health Dis. 2012;11:108. doi:10.1186/1476-511X-11-108. Mechanistic study of sphingoid bases derived from dietary glucosylceramide..PubMedUsed to support: Mechanistic evidence that sphingoid bases from dietary glucosylceramide activate ceramide production in skin cells; supports the 'ceramides from within' mechanism, not a Myoceram trial.