Home Ingredients KiOtransine® (Chitin-Glucan Prebiotic Fiber — KitoZyme)
Gut HealthMetabolic Health

KiOtransine® (Chitin-Glucan Prebiotic Fiber — KitoZyme)

Evidence Level
Limited
0 Clinical Trials
3 Documented Benefits
2/5 Evidence Score

KiOtransine® is a chitin-glucan prebiotic fiber from KitoZyme, a non-animal biopolymer purified from the fungus Aspergillus niger. This insoluble fiber is slowly fermented along the whole colon, feeding beneficial bacteria and supporting healthy digestion and transit.

Studied Dose Commonly a few grams per day.
Active Compound Chitin-glucan, a non-animal insoluble prebiotic fiber from Aspergillus niger.

Benefits

Gut microbiome support

KiOtransine shows bifidogenic (Bifidobacteria-promoting) prebiotic activity, supporting a healthier balance of gut bacteria.

Digestive comfort and transit

The fiber is studied for supporting comfortable digestion and healthy transit, with a product developed for IBS-like symptoms.

Cardiometabolic interest

Chitin-glucan has been studied for supporting cardiometabolic markers, an area of ongoing research.

Mechanism of action

1

Slow colonic fermentation

The insoluble chitin-glucan is fermented gradually along the colon, producing short-chain fatty acids and butyrate that nourish the gut lining.

2

Bifidogenic activity

KiOtransine selectively encourages the growth of beneficial Bifidobacteria.

Clinical trials

Side effects and drug interactions

Common Potential side effects

Generally well-tolerated as a fiber.
Mild gas or bloating can occur as intake rises.
Increase the dose gradually and drink plenty of water.

Important Drug interactions

No major drug interactions are established for this ingredient.
Tell your doctor about all supplements if you take prescription medication.
Use caution if pregnant, breastfeeding, or managing a health condition.

Featured in these supplement guides

Bloating→

More Gut Health Ingredients

Gut Health
Pancrelipase / Pancreatin
Pancrelipase (also called pancreatin) is a standardized blend of three primary pancreatic…
Gut Health
Sunfiber® (Partially Hydrolyzed Guar Gum)
Sunfiber® is the original and most extensively clinically-studied partially hydrolyzed gua…
Gut Health
Peppermint (Mentha × piperita)
Peppermint is a hybrid mint (Mentha aquatica × Mentha spicata) whose leaves and extracted…
Gut Health
PepZinGI® (Zinc-Carnosine for Gut Lining)
PepZinGI® (NutriScience Innovations) is a unique chelate of zinc and L-carnosine in a 1:1…

Explore Other Ingredients

Muscle & Recovery
L-Glutamine
L-glutamine is the most abundant amino acid in the body and the primary metabolic fuel for…
Immune Support
Probiotics (Multi-strain Blends)
Multi-strain probiotic blends are the most common form of probiotic supplements — typicall…
Antioxidant
Chlorella
Chlorella is a single-celled freshwater green algae rich in chlorophyll, complete protein…

Frequently asked questions about KiOtransine® (Chitin-Glucan Prebiotic Fiber — KitoZyme)

What is KiOtransine?

KiOtransine® is a chitin-glucan prebiotic fiber from KitoZyme, a non-animal biopolymer purified from the fungus Aspergillus niger. This insoluble fiber is slowly fermented along the whole colon, feeding beneficial bacteria and supporting healthy digestion and transit.

What is KiOtransine used for?

KiOtransine is researched primarily for Gut Health and Metabolic Health. KiOtransine shows bifidogenic (Bifidobacteria-promoting) prebiotic activity, supporting a healthier balance of gut bacteria.

What is the recommended dosage of KiOtransine?

The clinically studied dose is Commonly a few grams per day. Always follow the product label and check with a healthcare provider for personal advice.

Is KiOtransine safe, and does it have side effects?

For most healthy adults, KiOtransine is well tolerated at studied doses. Reported effects can include: Generally well-tolerated as a fiber. Mild gas or bloating can occur as intake rises. It may also interact with some medications. KiOtransine is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does KiOtransine interact with any medications?

Possible interactions include: No major drug interactions are established for this ingredient. Tell your doctor about all supplements if you take prescription medication. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for KiOtransine?

NutraSmarts rates the evidence for KiOtransine as Limited (2 out of 5). It is backed by 3 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(3 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Neyrinck AM, Rodriguez J, Zhang Z, Seethaler B, Mailleux F, Vercammen J, Bindels LB, Cani PD, Nazare JA, Maquet V, Laville M, Bischoff SC, Walter J, Delzenne NM Noninvasive monitoring of fibre fermentation in healthy volunteers by analyzing breath volatile metabolites: lessons from the FiberTAG intervention study Gut Microbes. 2021;13(1):1-16. doi:10.1080/19490976.2020.1862028.PubMedUsed to support: Human crossover intervention with 15 healthy volunteers showing a single 4.5 g dose of chitin-glucan (the active fiber in KiOtransine) was well tolerated and produced detectable colonic fermentation metabolites (including butyrate) in breath, supporting gut microbiome and digestive comfort claims. Note: evidence is for the chitin-glucan active; KiOtransine brand not named.
  2. Calatayud M, Verstrepen L, Ghyselinck J, Van den Abbeele P, Marzorati M, Modica S, Ranjanoro T, Maquet V Chitin Glucan Shifts Luminal and Mucosal Microbial Communities, Improve Epithelial Barrier and Modulates Cytokine Production In Vitro Nutrients. 2021;13(9):3249. doi:10.3390/nu13093249.PubMedUsed to support: In vitro human fecal fermentation/colonic model study showing chitin-glucan (the KiOtransine active) shifted microbial communities, improved epithelial barrier integrity, and modulated cytokines (increased IL-10), supporting gut microbiome and digestive comfort claims. Note: in vitro study; not a clinical trial in living human subjects.
  3. Santisteban V, Muñoz-García N, López-Yerena A, Puntes M, Badimon L, Padró T Efficacy of Food Industry By-Product β-Glucan/Chitin-Chitosan on Lipid Profile of Overweight and Obese Individuals: Sustainability and Nutraceuticals Nutrients. 2024;16(19):3420. doi:10.3390/nu16193420.PubMedUsed to support: Human RCT showing β-glucan/chitin-chitosan supplementation significantly raised HDL cholesterol and reduced ApoB in overweight/obese adults, providing mechanistic support for the cardiometabolic interest claim. Note: this used a chitosan-containing blend; chitin-glucan is the related but distinct KiOtransine active.