Home Ingredients GutGard® (Deglycyrrhizinated Licorice — Natural Remedies)
Gut Health

GutGard® (Deglycyrrhizinated Licorice — Natural Remedies)

Glycyrrhiza glabra
Evidence Level
Moderate
1 Clinical Trial
3 Documented Benefits
3/5 Evidence Score

GutGard® is a flavonoid-rich licorice (Glycyrrhiza glabra) root extract from Natural Remedies, processed to remove most glycyrrhizin (the compound that can raise blood pressure). This makes it a gentler licorice for digestive use, and it is studied for easing reflux, indigestion, and supporting the stomach lining.

Studied Dose Around 150 mg per day.
Active Compound Glycyrrhiza glabra root extract standardized to licorice flavonoids and largely free of glycyrrhizin.

Benefits

Reflux and indigestion

In a clinical study, GutGard supported relief of gastroesophageal reflux and indigestion symptoms, easing heartburn and upper-digestive discomfort.

Supported by Trial 1

Stomach lining support

Licorice flavonoids support the protective mucus lining of the stomach, helping defend it against irritation.

H. pylori balance

Licorice extracts are studied for discouraging the H. pylori bacteria linked to gastritis and ulcers, supporting a healthier stomach environment.

Mechanism of action

1

Mucosal protection

Licorice flavonoids stimulate protective mucus and support the integrity of the stomach and esophageal lining.

2

Glycyrrhizin removed

Removing glycyrrhizin keeps the digestive benefits while avoiding the blood-pressure and potassium effects of whole licorice.

Clinical trials

1
GutGard and Reflux Symptoms — Clinical Study
PubMed

Clinical study of GutGard in managing gastroesophageal reflux symptoms. (Raj et al. 2025, Complementary Medicine Research)

Adults with reflux symptoms.

GutGard supported relief of reflux and indigestion symptoms with a good safety profile, consistent with its mucosal-protective actions.

Side effects and drug interactions

Common Potential side effects

Generally well-tolerated — deglycyrrhizinated licorice avoids the blood-pressure effects of whole licorice.
Mild digestive upset is occasionally reported.
Much safer than whole licorice for regular use.

Important Drug interactions

Blood pressure medication — DGL minimizes the usual licorice effect, but monitor if sensitive.
Diuretics — whole licorice affects potassium; DGL much less so.
Tell your doctor if you take medication for reflux or ulcers.

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Frequently asked questions about GutGard® (Deglycyrrhizinated Licorice — Natural Remedies)

What is GutGard?

GutGard® is a flavonoid-rich licorice (Glycyrrhiza glabra) root extract from Natural Remedies, processed to remove most glycyrrhizin (the compound that can raise blood pressure). This makes it a gentler licorice for digestive use, and it is studied for easing reflux, indigestion, and supporting the stomach lining.

What is GutGard used for?

GutGard is researched primarily for Gut Health. In a clinical study, GutGard supported relief of gastroesophageal reflux and indigestion symptoms, easing heartburn and upper-digestive discomfort.

What is the recommended dosage of GutGard?

The clinically studied dose is Around 150 mg per day. Always follow the product label and check with a healthcare provider for personal advice.

Is GutGard safe, and does it have side effects?

For most healthy adults, GutGard is well tolerated at studied doses. Reported effects can include: Generally well-tolerated — deglycyrrhizinated licorice avoids the blood-pressure effects of whole licorice. Mild digestive upset is occasionally reported. It may also interact with some medications. GutGard is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does GutGard interact with any medications?

Possible interactions include: Blood pressure medication — DGL minimizes the usual licorice effect, but monitor if sensitive. Diuretics — whole licorice affects potassium; DGL much less so. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for GutGard?

NutraSmarts rates the evidence for GutGard as Moderate (3 out of 5). It is backed by 1 clinical trial and 1 cited reference summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(1 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Raj JP, Saxena U, Belhekar MN, et al. Efficacy and Safety of GutGard in Managing Gastroesophageal Reflux Disease. Complement Med Res. 2025;32(1):26-36..PubMedUsed to support: Clinical study supporting reflux symptom relief.