Home Ingredients GliSODin® (Vegetal SOD with Gliadin — Isocell)
Anti-Inflammatory

GliSODin® (Vegetal SOD with Gliadin — Isocell)

Cucumis melo
Evidence Level
Limited
1 Clinical Trial
3 Documented Benefits
2/5 Evidence Score

GliSODin® is a plant-derived superoxide dismutase (SOD) from a special melon (Cucumis melo), combined with a wheat gliadin carrier that protects the enzyme through digestion. SOD is one of the body's own antioxidant enzymes. Human testing of GliSODin is very limited: a 6 week trial in 19 competitive rowers taking 500 mg a day found higher SOD activity in red blood cells and lower C-reactive protein, while a 12 week trial in 38 women aged 50 to 65 with self-reported fatigue found no significant benefit over placebo. The airway and immune research cited on this page was done in mice, and no cited study measured skin.

Studied Dose Both published human trials used 500 mg per day: for 6 weeks in competitive rowers, and for 12 weeks in women aged 50 to 65.
Active Compound Vegetal superoxide dismutase (SOD) from melon, bound to a wheat gliadin biopolymer intended to protect the enzyme as it passes through digestion. The carrier is a wheat protein, so anyone with celiac disease or a wheat allergy should avoid this ingredient.

Benefits

Antioxidant blood markers in a 19-person athlete trial

In the one positive human trial, 19 rowers from the Polish national team took 500 mg a day for 6 weeks (10 on GliSODin, 9 on placebo). The supplemented group ended with higher SOD activity in their red blood cells and lower C-reactive protein, a marker of inflammation. Those are blood measurements in a very small group of elite athletes, not a health outcome for an everyday user. A second trial in 38 women aged 50 to 65 with self-reported fatigue found no significant difference from placebo after 12 weeks, and the placebo group actually improved slightly more (fatigue fell 1.6% on GliSODin versus 4.1% on placebo).

Supported by Trial 1

Airway effects seen only in mice

The airway research behind this claim was done in mice with experimentally induced asthma, not in people. No human study has tested whether GliSODin affects immune function or breathing, and results in mice frequently do not carry over to humans.

Supported by Trial 1

Skin: not shown for the supplement on its own

Nothing cited here measured skin. The one published human skin study of a GliSODin formula also had participants use prescription tazarotene 0.1% cream, so any skin change in that study cannot be credited to the oral supplement.

Supported by Trial 1

Mechanism of action

1

SOD induction

The proposed idea is that the gliadin-protected SOD prompts the body to make more of its own antioxidant enzymes rather than acting as a direct antioxidant itself. The only human support for this is the rise in red blood cell SOD activity measured in 19 rowers over 6 weeks.

2

Anti-inflammatory signaling

In mice with induced asthma, the melon SOD complex reduced airway inflammation and shifted T-cell activity. This chain of events has not been tested in people.

Clinical trials

1
GliSODin and Airway Inflammation (Mouse Study)
PubMed

Laboratory study in a mouse model of asthma, looking at airway inflammation and T-cell differentiation. (Klein et al. 2023, Frontiers in Allergy)

Mice with experimentally induced asthma. No people took part.

In these mice, GliSODin prevented airway inflammation and altered T-cell differentiation. Findings in mice often do not repeat in humans, and no human trial has tested GliSODin for airway or immune outcomes. Asthma is a medical condition that needs a doctor's care; this is not a treatment for it.

Side effects and drug interactions

Common Potential side effects

Generally well tolerated in the human trials published so far, but those trials were small and short, together covering fewer than 60 people for 6 to 12 weeks.
Contains wheat gliadin; people with wheat allergy or celiac disease should avoid it.
Mild digestive upset has rarely been reported, though the published trials were too small to detect uncommon side effects.

Important Drug interactions

No drug interactions have been reported, but the supplement has only been studied in a few dozen people, so interactions may simply not have been looked for.
Avoid if you have celiac disease or wheat allergy due to the gliadin carrier.
Tell your doctor if you manage an autoimmune condition.

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Frequently asked questions about GliSODin® (Vegetal SOD with Gliadin — Isocell)

What is GliSODin?

GliSODin® is a plant-derived superoxide dismutase (SOD) from a special melon (Cucumis melo), combined with a wheat gliadin carrier that protects the enzyme through digestion. SOD is one of the body's own antioxidant enzymes.

What is GliSODin used for?

GliSODin is researched primarily for Anti-Inflammatory. In the one positive human trial, 19 rowers from the Polish national team took 500 mg a day for 6 weeks (10 on GliSODin, 9 on placebo).

What is the recommended dosage of GliSODin?

The clinically studied dose is Both published human trials used 500 mg per day: for 6 weeks in competitive rowers, and for 12 weeks in women aged 50 to 65. Always follow the product label and check with a healthcare provider for personal advice.

Is GliSODin safe, and does it have side effects?

For most healthy adults, GliSODin is well tolerated at studied doses. Reported effects can include: Generally well tolerated in the human trials published so far, but those trials were small and short, together covering fewer than 60 people for 6 to 12 weeks. Contains wheat gliadin; people with wheat allergy or celiac disease should avoid it. It may also interact with some medications. GliSODin is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does GliSODin interact with any medications?

Possible interactions include: No drug interactions have been reported, but the supplement has only been studied in a few dozen people, so interactions may simply not have been looked for. Avoid if you have celiac disease or wheat allergy due to the gliadin carrier. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for GliSODin?

NutraSmarts rates the evidence for GliSODin as Limited (2 out of 5). It is backed by 1 clinical trial and 3 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(3 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Klein M, Dijoux E, Cheminant MA, et al. GliSODin prevents airway inflammation by inhibiting T-cell differentiation. Front Allergy. 2023;4:1199355..PubMedUsed to support: Mouse model of asthma. Brand-named, but animal evidence, not human evidence.
  2. Skarpanska-Stejnborn A, Pilaczynska-Szczesniak L, Basta P, Deskur-Smielecka E, Woitas-Slubowska D, Adach Z. Effects of oral supplementation with plant superoxide dismutase extract on selected redox parameters and an inflammatory marker in a 2,000-m rowing-ergometer test. Int J Sport Nutr Exerc Metab. 2011;21(2):124-34..PubMedUsed to support: Double-blind randomised trial in 19 competitive rowers (10 supplemented, 9 placebo), 500 mg daily for 6 weeks; erythrocyte superoxide dismutase activity rose and C-reactive protein fell. Biomarkers in elite athletes, not a consumer health outcome.
  3. Houghton CA, Steels EL, Fassett RG, Coombes JS. Effects of a gliadin-combined plant superoxide dismutase extract on self-perceived fatigue in women aged 50-65 years. Phytomedicine. 2011;18(6):521-6..PubMedUsed to support: Randomised, double-blind, placebo-controlled trial in 38 women aged 50 to 65, 500 mg daily for 12 weeks. NEGATIVE RESULT: no significant difference in general fatigue between or within groups, with the placebo group improving numerically more.