Home Ingredients Exceptionhyal® (Full-Spectrum Hyaluronic Acid — Roelmi)
Hair, Skin & Nails

Exceptionhyal® (Full-Spectrum Hyaluronic Acid — Roelmi)

Evidence Level
Limited
1 Clinical Trial
3 Documented Benefits
2/5 Evidence Score

Exceptionhyal® is an oral hyaluronic acid from Roelmi HPC that provides a full spectrum of molecular weights rather than a single size. Different-sized hyaluronan fragments act in different ways in the skin, and the full-spectrum approach is designed to support hydration, elasticity, and a smoother complexion from within, as shown in a single 28-day, manufacturer-sponsored, placebo-controlled trial in 60 women.

Studied Dose Around 200 mg per day.
Active Compound Full-spectrum hyaluronic acid (sodium hyaluronate) spanning a range of molecular weights, produced by biofermentation.

Benefits

Skin hydration

Oral hyaluronic acid supports the skin's ability to hold moisture, improving hydration and a plump, healthy appearance from the inside.

Supported by Trial 1

Elasticity and smoothness

In a clinical study, the full-spectrum hyaluronan improved skin elasticity and profile measures, supporting firmness and a smoother surface.

Supported by Trial 1

Joint fluid role (not measured in the cited study)

Hyaluronic acid is a natural component of joint fluid, and oral hyaluronic acid is sometimes taken for joint comfort. This was not measured in the ExceptionHYAL skin study cited on this page, and no joint trial of this product is cited.

Supported by Trial 1

Mechanism of action

1

Water-binding matrix

Hyaluronic acid holds many times its weight in water, supporting the moisture content and volume of the skin's extracellular matrix.

2

Multi-weight signaling

Different molecular weights of hyaluronan signal differently to skin cells, and the full spectrum is intended to support both hydration and renewal.

Clinical trials

1
Full-Spectrum Hyaluronan and Skin — Clinical Study
PubMed

Randomized, double-blind, placebo-controlled trial of 200 mg/day oral full-spectrum hyaluronan on skin parameters. (Michelotti et al. 2021, European Journal of Dermatology)

60 adult women with mild-to-moderate skin ageing signs; 28 days.

In a randomized, double-blind, placebo-controlled trial of 60 women over 28 days, the active arm showed improved skin hydration (+10.6%), reduced wrinkle depth (-18.8%) and volume (-17.6%), and increased elasticity and firmness (+5.1%).

Side effects and drug interactions

Common Potential side effects

Generally well-tolerated — oral hyaluronic acid is well tolerated.
Side effects are rare.
No major safety concerns at supplemental doses.

Important Drug interactions

No significant drug interactions are established.
Generally compatible with collagen and other skin supplements.
Tell your doctor if pregnant or breastfeeding.

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Frequently asked questions about Exceptionhyal® (Full-Spectrum Hyaluronic Acid — Roelmi)

What is Exceptionhyal?

Exceptionhyal® is an oral hyaluronic acid from Roelmi HPC that provides a full spectrum of molecular weights rather than a single size. Different-sized hyaluronan fragments act in different ways in the skin, and the full-spectrum approach is designed to support hydration, elasticity, and a smoother complexion from with…

What is Exceptionhyal used for?

Exceptionhyal is researched primarily for Hair, Skin & Nails. Oral hyaluronic acid supports the skin's ability to hold moisture, improving hydration and a plump, healthy appearance from the inside.

What is the recommended dosage of Exceptionhyal?

The clinically studied dose is Around 200 mg per day. Always follow the product label and check with a healthcare provider for personal advice.

Is Exceptionhyal safe, and does it have side effects?

For most healthy adults, Exceptionhyal is well tolerated at studied doses. Reported effects can include: Generally well-tolerated — oral hyaluronic acid is well tolerated. Side effects are rare. It may also interact with some medications. Exceptionhyal is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does Exceptionhyal interact with any medications?

Possible interactions include: No significant drug interactions are established. Generally compatible with collagen and other skin supplements. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for Exceptionhyal?

NutraSmarts rates the evidence for Exceptionhyal as Limited (2 out of 5). It is backed by 1 clinical trial and 1 cited reference summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(1 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Michelotti A, Cestone E, De Ponti I, et al. Oral intake of a new full-spectrum hyaluronan improves skin profilometry and ageing. Eur J Dermatol. 2021;31(6):798-805..PubMedUsed to support: Single randomized, double-blind, placebo-controlled trial (60 women, 200 mg/day, 28 days) reporting improved skin hydration, reduced wrinkle depth and volume, and increased elasticity in the active arm.