EnduBerry™ Nu (Haskap / Blue Honeysuckle Berry)

Lonicera caerulea
Evidence Level
Limited
1 Clinical Trial
3 Documented Benefits
2/5 Evidence Score

EnduBerry™ Nu is Mibelle Biochemistry's oral haskap (blue honeysuckle berry, Lonicera caerulea) extract, standardized for anthocyanins (notably cyanidin-3-O-glucoside) and positioned for endurance and exercise performance. The one trial usually cited for it was randomized, double-blind and placebo-controlled, but it used separate groups of people rather than a crossover, and it tested a different company's haskap powder (Haskapa, Oxford, UK), not EnduBerry Nu. Thirty male recreational runners aged 18 to 45 were randomized to 6 g a day of freeze-dried haskap powder for 6 days plus a dose about an hour before testing, or to placebo; the haskap group ran a 5 km time trial about 21 seconds faster (roughly 2%) and lasted about 20 seconds longer to exhaustion. The study was co-funded by Haskapa, whose powder was tested, and by Mibelle, which makes EnduBerry Nu. Honest framing: one small trial in men only, of a related product rather than this brand.

Studied Dose The trial used 6 g a day of freeze-dried haskap berry powder (about 150 mg anthocyanins) for 6 days, plus a further dose about an hour before exercise. That was a different company's powder, so no dose has been established for EnduBerry Nu itself. Note that 6 g a day is a lot more than a single pre-workout capsule.
Active Compound Anthocyanin-rich haskap berry (Lonicera caerulea) powder, with cyanidin-3-O-glucoside as the key marker; EnduBerry™ Nu (Mibelle Biochemistry).

Benefits

Faster 5 km run in one trial, using a different haskap powder

In a randomized, double-blind, placebo-controlled trial in 30 non-smoking male recreational runners aged 18 to 45, 6 g a day of haskap berry powder for 6 days (plus a dose about an hour before testing) beat placebo: the 5 km time trial was about 21 seconds faster (P = 0.016, roughly a 2% improvement) and time to exhaustion was about 20 seconds longer (P = 0.031). Important caveats: this was a parallel-group study, not a crossover; no women were included; and the powder was a commercial Haskapa product, not EnduBerry Nu. The study was co-funded by Haskapa and by Mibelle, the maker of EnduBerry Nu.

Antioxidant rationale is a theory here, not a measured result

Haskap berries are rich in anthocyanins, and one popular idea is that these help the body handle exercise-related oxidative stress and support blood flow. That remains a proposed explanation, not something shown here. The running trial measured only performance, heart rate, oxygen use, blood lactate and perceived effort; it did not measure a single marker of oxidative stress, antioxidant capacity or inflammation.

Background reading: a review of related berries and blood vessels

The only other source on this page is a 2025 review article about blueberry and honeysuckle anthocyanins and blood vessel health. A review summarizes other people's work; it is not a test of this ingredient, and results seen with other dark berries are not evidence for this one.

Mechanism of action

1

Anthocyanin antioxidant activity

In laboratory testing, cyanidin-based anthocyanins can neutralize reactive molecules, and berry polyphenols may help blood vessels relax. Whether this is what improved running times is unknown: the trial did not measure oxidative stress or antioxidant capacity, so the link to better oxygen delivery is an idea rather than a demonstrated chain of events.

2

Polyphenol vascular signaling

Berry polyphenols modulate endothelial function and blood flow, a plausible route to improved endurance performance.

Clinical trials

1
Haskap Berry Endurance Running Trial (separate groups, not a crossover)

Randomized, double-blind, placebo-controlled trial using two separate groups of people, not a crossover (Nutrients, 2022; PMID 35215430). The product tested was a commercially available Haskapa haskap powder, not EnduBerry Nu.

30 non-smoking male recreational runners aged 18 to 45; no women were studied

The haskap group took 6 g a day of freeze-dried haskap powder (about 150 mg anthocyanins) for 6 days plus a dose about an hour before testing. Against placebo, the 5 km time trial was about 21 seconds faster (P = 0.016, roughly 2%) and time to exhaustion was about 20 seconds longer (P = 0.031), with modest changes in heart rate and oxygen use at easier paces. Limitations: 30 participants in total, men only, separate groups rather than a crossover, and the study was co-funded by Haskapa, whose powder was tested, and by Mibelle, which makes EnduBerry Nu.

Side effects and drug interactions

Common Potential side effects

Generally very well tolerated; haskap is an edible berry.
Mild gastrointestinal upset possible with concentrated anthocyanin intake.
Harmless reddish tint to stool/urine can occur with high anthocyanin intake.
Allergy to berries is rare but possible.

Important Drug interactions

Anticoagulants/antiplatelets: high-dose anthocyanins carry a theoretical mild bleeding-risk interaction.
Generally a low-interaction, food-derived profile.

Frequently asked questions about EnduBerry™ Nu (Haskap / Blue Honeysuckle Berry)

What is EnduBerry Nu?

EnduBerry Nu is an oral haskap (blue honeysuckle berry) extract from Mibelle, rich in anthocyanins and taken to support endurance and exercise performance. One placebo-controlled trial in 30 male runners found faster 5 km times, but it used separate groups rather than a crossover and it tested a different company's haskap powder, not EnduBerry Nu.

How strong is the evidence?

Promising but early. There is one small trial: 30 men, separate groups rather than a crossover, and it used a different company's haskap powder while being co-funded by that company and by Mibelle. It found small but real performance gains, roughly 2% on a 5 km run. No published trial on this page tested EnduBerry Nu itself, and none measured antioxidant activity in people, so the antioxidant angle stays a theory.

What is EnduBerry Nu used for?

EnduBerry Nu is researched primarily for Athletic Performance. In a randomized, double-blind, placebo-controlled trial in 30 non-smoking male recreational runners aged 18 to 45, 6 g a day of haskap berry powder for 6 days (plus a dose about an hour before testing) beat placebo: the 5 km time trial was…

What is the recommended dosage of EnduBerry Nu?

The clinically studied dose is The trial used 6 g a day of freeze-dried haskap berry powder (about 150 mg anthocyanins) for 6 days, plus a further dose about an hour before exercise. That was a different company's powder, so no dose has been established for EnduBerry Nu itself. Always follow the product label and check with a healthcare provider for personal advice.

Is EnduBerry Nu safe, and does it have side effects?

For most healthy adults, EnduBerry Nu is well tolerated at studied doses. Reported effects can include: Generally very well tolerated; haskap is an edible berry. Mild gastrointestinal upset possible with concentrated anthocyanin intake. It may also interact with some medications. EnduBerry Nu is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does EnduBerry Nu interact with any medications?

Possible interactions include: Anticoagulants/antiplatelets: high-dose anthocyanins carry a theoretical mild bleeding-risk interaction. Generally a low-interaction, food-derived profile. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for EnduBerry Nu?

NutraSmarts rates the evidence for EnduBerry Nu as Limited (2 out of 5). It is backed by 1 clinical trial and 2 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(2 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Howatson G, Snaith GC, Kimble R, Cowper G, Keane KM Improved Endurance Running Performance Following Haskap Berry (Lonicera caerulea L.) Ingestion. Nutrients. 2022;14(4). doi: 10.3390/nu14040780.PubMedUsed to support: A randomized, double-blind, placebo-controlled trial in 30 male recreational runners aged 18 to 45, using two separate groups (the paper explicitly says independent groups, not a crossover). 6 g a day of a commercially available Haskapa haskap powder for 6 days, plus a pre-exercise dose, made the 5 km time trial about 21 seconds faster (P = 0.016) and time to exhaustion about 20 seconds longer (P = 0.031). This was not EnduBerry Nu; the study was co-funded by Haskapa and by Mibelle. No oxidative stress or antioxidant markers were measured.
  2. Jurja S, Negreanu-Pirjol T, Mehedinti MC, Hincu MA, Negreanu-Pirjol BS, Roncea FN, et al. Blueberries and Honeysuckle Berries: Anthocyanin-Rich Polyphenols for Vascular Endothelial Health and Cardiovascular Disease Prevention. Nutrients. 2025;17(24). doi: 10.3390/nu17243888.PubMedUsed to support: A 2025 review article (not a study, and not about exercise) summarizing research on blueberry and honeysuckle anthocyanins in relation to blood vessel health. It is background reading only and does not test EnduBerry Nu or any performance outcome.