Cyperus rotundus (Nutgrass / Musta)

Cyperus rotundus L.
Evidence Level
Preliminary
5 Clinical Trials
5 Documented Benefits
1/5 Evidence Score

Cyperus rotundus, known as nutgrass or purple nutsedge and called musta or nagarmotha in Ayurveda, is a common sedge whose underground rhizome, or tuber, has a long history of traditional use across India, China and other regions, mostly for digestive complaints and menstrual discomfort. Most of what is known about it comes from traditional practice, laboratory work and animal studies rather than from human trials. The small amount of human research that exists tested a standardized rhizome extract for body weight in people who were already following a diet and exercise plan, and those studies were funded by the company that makes the extract. Traditional use is background, not proof that the herb does anything in particular. It is not a treatment for any disease, and pregnant women should avoid it because of its traditional use for the menstrual cycle and the lack of safety data.

Studied Dose 1,000 mg/day of a standardized rhizome extract (500 mg plus 5 mg piperine, twice daily) for 90 days in the weight trials; traditional use is as a dried-rhizome powder or decoction, not a standardized dose.
Active Compound Sesquiterpenes (cyperene, alpha-cyperone), stilbenes (piceatannol, scirpusin A and B) and flavonoids.

Benefits

Traditional use as a digestive and carminative herb

In Ayurvedic, Siddha and other folk systems the dried rhizome has long been used to ease everyday digestive complaints such as an upset stomach, cramping and loose stools, usually as a powder or a simple decoction. This is a record of traditional practice and laboratory signals, not evidence from human trials, so it is best read as background rather than proof.

Relaxes isolated intestinal muscle in laboratory tests

In test-tube work using isolated animal intestine, a crude rhizome extract reduced spontaneous and triggered contractions in a pattern similar to a known antispasmodic, appearing to act through calcium channels. This fits the herb's folk use for cramping and loose stools but has not been confirmed in people.

Fiber-rich tuber traditionally eaten as a food

Food-science analysis of the tuber found it is high in dietary fiber, mostly the insoluble kind, along with starch and smaller amounts of protein and minerals. The tuber has been eaten as a famine food in several regions. Fiber from whole foods supports normal bowel regularity, though this analysis measured composition rather than any effect in people.

Body weight and waist measures in two maker-funded trials

Two small placebo-controlled studies in adults with a high body mass index, both paid for by the extract's maker, tested a standardized rhizome extract alongside diet and exercise for 90 days. The groups taking the extract showed larger reductions in body weight, waist size and blood fats than placebo. The trials were short and industry funded.

Protected the stomach lining in animal studies

In rats given a painkiller known to irritate the stomach, an oral rhizome extract lowered the amount of visible stomach-lining damage and raised the animals' natural antioxidant defenses in the tissue. These are animal findings that match the herb's traditional use for the stomach; they do not show the same effect in people.

Mechanism of action

1

May calm gut muscle through calcium channels

Laboratory studies on isolated animal intestine suggest a crude extract blocks the calcium entry that drives smooth-muscle contraction, which would relax the gut wall. This is one proposed explanation for the traditional antispasmodic use and comes from test-tube work, not from people.

2

Stilbenes may limit fat-cell formation

The standardized extract is concentrated in stilbenes such as piceatannol and the scirpusins. In cultured fat cells and in diet-fed mice these compounds reduced the build-up of new fat cells and lowered markers tied to fat storage. These are cell and animal findings, not human mechanisms.

3

Slows digestive enzymes in the test tube

Extracts of the rhizome inhibited digestive enzymes including pancreatic lipase and alpha-amylase, and the enzyme DPP-4, in laboratory assays. Slowing these enzymes could in theory reduce how quickly fat and starch are absorbed, but this has been shown only in test tubes and animals.

Clinical trials

1
90-Day Weight Trial of a Standardized Extract With Piperine
PubMed

Randomized, double-blind, placebo-controlled trial of 1,000 mg/day of a standardized Cyperus rotundus extract with piperine, added to diet and exercise, funded by the extract's maker. (Majeed et al. 2025, Medicine)

96 adults with obesity in India, taking 500 mg extract plus 5 mg piperine twice daily or placebo for 90 days.

The extract group had significantly greater reductions in body weight, body mass index, waist and hip circumference than placebo, along with improvements in blood fats and apolipoprotein B. No adverse events were reported. The trial was short and funded by the extract's manufacturer, and all participants also dieted and exercised.

2
Pilot Weight Study Plus Cell and Mouse Experiments
PubMed

Randomized, double-blind, placebo-controlled pilot in overweight adults of a stilbene-standardized rhizome extract, with supporting fat-cell and mouse work, funded by the extract's maker. (Majeed et al. 2022, Diabetes Metab Syndr Obes)

30 adults with a body mass index of 30 to 40 took the extract or placebo for 90 days; the rest of the paper used cultured fat cells and high-fat-diet mice.

The small human group lost more weight and showed lower waist size, body mass index and blood fats than placebo, with no reported side effects. In the laboratory the extract reduced fat-cell build-up, and in mice it lowered weight gain, leptin and blood fats. The human part was a pilot and was manufacturer funded.

3
Antispasmodic Activity on Isolated Animal Tissue
PubMed

Laboratory and animal study of a crude rhizome extract on isolated gut, airway and blood-vessel tissue to probe its folk uses. (Hussain et al. 2018, Pak J Pharm Sci)

Isolated rabbit intestine and other animal tissue preparations; no human participants.

The extract relaxed spontaneous and triggered contractions of isolated intestine in a way similar to a reference antispasmodic, appearing to act through calcium-channel blockade, and also relaxed airway and vessel tissue. The authors read this as support for traditional use in cramping and loose stools. These are tissue and animal results only.

4
Stomach-Lining Protection in Painkiller-Treated Rats
PubMed

Animal study of an oral rhizome extract against aspirin-induced stomach-lining damage in rats. (Thomas et al. 2015, J Basic Clin Physiol Pharmacol)

Rats given aspirin to injure the stomach lining, pretreated with 250 or 500 mg/kg of a rhizome extract; no human participants.

The extract lowered the visible stomach-lining damage score by about half in a dose-related way, comparable to a standard ulcer drug tested in the same experiment, and raised antioxidant enzyme and glutathione levels in the stomach tissue. This is an animal model of stomach injury, not a study in people.

5
Digestive-Enzyme and Antidiabetes Effects in Rats
PubMed

Laboratory and animal study of a rhizome extract on digestive enzymes and on diabetic rats. (Abdella et al. 2024, Heliyon)

Enzyme assays in the test tube plus diabetic rats given the extract; no human participants.

In test tubes the extract inhibited the digestive enzymes lipase and alpha-amylase and the enzyme DPP-4, and in diabetic rats it lowered inflammation and oxidative markers while supporting antioxidant defenses. These are laboratory and animal findings and were not tested in people.

Side effects and drug interactions

Common Potential side effects

Human safety data are limited to two short, manufacturer-funded weight trials, which reported no adverse events; longer-term safety in people is not well studied.
As with any fibrous plant material, the powdered rhizome or a decoction may cause mild gas, bloating or stomach upset in some people, especially at first.
Traditional preparations are not standardized, so the amount of active compounds can vary a lot between products and batches.
Nutgrass tubers gathered from the wild can take up trace metals from soil; choose products that test for heavy metals.

Important Drug interactions

Diabetes medicines: laboratory work shows the extract can slow carbohydrate-digesting enzymes, so in theory it could add to blood-sugar-lowering drugs; monitor if you take them.
The standardized extract is sold with piperine (black pepper extract), which can raise blood levels of many medicines by slowing how the liver clears them; separate it from prescription drugs and ask your doctor.
Because human data are so limited, treat any combination with prescription medicines cautiously and check with a pharmacist or doctor.

Frequently asked questions about Cyperus rotundus (Nutgrass / Musta)

Is Cyperus rotundus proven to work for digestion?

No. Its digestive reputation comes from centuries of traditional use plus laboratory and animal studies, not from human trials. Those sources are useful background, but they do not prove the herb settles digestion in people. The only human trials so far looked at body weight, not digestion, and were funded by the extract's maker.

What does the human research actually show?

Two small, short, manufacturer-funded studies tested a standardized rhizome extract in adults with a high body mass index who were also dieting and exercising. The extract groups lost somewhat more weight and waist size and had better blood fats than placebo. That is a narrow and early body of evidence, not a general endorsement.

How is it taken?

Traditionally the dried rhizome is used as a powder or a decoction, with no standardized amount. The weight trials used 1,000 mg a day of a standardized extract, split into two doses with piperine, for 90 days. Follow the product label and talk to your doctor before starting.

Is it safe during pregnancy?

Avoid it in pregnancy. The herb has a long traditional use for the menstrual cycle, and there is not enough safety research in pregnant women to consider it safe. If you are pregnant or breastfeeding, do not use it without medical advice.

What is Cyperus rotundus?

Cyperus rotundus, known as nutgrass or purple nutsedge and called musta or nagarmotha in Ayurveda, is a common sedge whose underground rhizome, or tuber, has a long history of traditional use across India, China and other regions, mostly for digestive complaints and menstrual discomfort.

What is Cyperus rotundus used for?

Cyperus rotundus is researched primarily for Gut Health. In Ayurvedic, Siddha and other folk systems the dried rhizome has long been used to ease everyday digestive complaints such as an upset stomach, cramping and loose stools, usually as a powder or a simple decoction.

What is the recommended dosage of Cyperus rotundus?

The clinically studied dose is 1,000 mg/day of a standardized rhizome extract (500 mg plus 5 mg piperine, twice daily) for 90 days in the weight trials; traditional use is as a dried-rhizome powder or decoction, not a standardized dose. Always follow the product label and check with a healthcare provider for personal advice.

Is Cyperus rotundus safe, and does it have side effects?

For most healthy adults, Cyperus rotundus is well tolerated at studied doses. Reported effects can include: Human safety data are limited to two short, manufacturer-funded weight trials, which reported no adverse events; longer-term safety in people is not well studied. It may also interact with some medications. Cyperus rotundus is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does Cyperus rotundus interact with any medications?

Possible interactions include: Diabetes medicines: laboratory work shows the extract can slow carbohydrate-digesting enzymes, so in theory it could add to blood-sugar-lowering drugs; monitor if you take them. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for Cyperus rotundus?

NutraSmarts rates the evidence for Cyperus rotundus as Preliminary (1 out of 5). It is backed by 5 clinical trials and 8 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(8 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Majeed A, Majeed S, Devarajan TV, Narasinga Rao SSVV, Gudimallam S, Ramanujappa M, Thazhathidath S, Mundkur L. Efficacy and safety of Cyperus rotundus extract on weight management in obese individuals: A randomized, double-blind, placebo-controlled study. Medicine (Baltimore). 2025;104(47):e45666. doi: 10.1097/MD.0000000000045666.PubMedUsed to support: Randomized, double-blind, placebo-controlled trial in 96 adults with obesity (90 days, 500 mg standardized extract plus 5 mg piperine twice daily, with diet and exercise), funded by the extract's maker: the extract group had greater reductions in body weight, body mass index, waist and hip circumference and in blood fats and apolipoprotein B than placebo, with no reported adverse events.
  2. Majeed M, Nagabhushanam K, Bhat B, Ansari M, Pandey A, Bani S, Mundkur L. The Anti-Obesity Potential of Cyperus rotundus Extract Containing Piceatannol, Scirpusin A and Scirpusin B from Rhizomes: Preclinical and Clinical Evaluations. Diabetes Metab Syndr Obes. 2022;15:369-382. doi: 10.2147/DMSO.S348412.PubMedUsed to support: Manufacturer-funded study: a randomized, double-blind, placebo-controlled pilot in 30 adults with a body mass index of 30 to 40 (90 days) found greater reductions in body weight, waist size, body mass index and blood fats with the stilbene-standardized extract than placebo, with no reported side effects; cultured fat cells and high-fat-diet mice showed reduced fat-cell build-up and weight gain.
  3. Hussain M, Waqas HM, Hussain I, Majeed A, Raza SM, Janbaz KH. Pharmacological validation of the folkloric uses of Cyperus rotundus L. in different ailments: An in vivo and in vitro research. Pak J Pharm Sci. 2018;31(1):95-102..PubMedUsed to support: Tissue and animal study: a crude rhizome extract relaxed spontaneous and triggered contractions of isolated rabbit intestine (and airway and vessel tissue) in a pattern consistent with calcium-channel blockade, which the authors read as support for traditional use in diarrhea and dyspepsia. No human participants.
  4. Thomas D, Govindhan S, Baiju EC, Padmavathi G, Kunnumakkara AB, Padikkala J. Cyperus rotundus L. prevents non-steroidal anti-inflammatory drug-induced gastric mucosal damage by inhibiting oxidative stress. J Basic Clin Physiol Pharmacol. 2015;26(5):485-90. doi: 10.1515/jbcpp-2014-0093.PubMedUsed to support: Animal study: an oral methanolic rhizome extract (250 and 500 mg/kg) reduced aspirin-induced stomach-lining damage in rats by about half in a dose-dependent way, comparable to ranitidine, and raised gastric antioxidant enzymes and glutathione. An animal model of stomach injury, not evidence in people.
  5. Abdella FIA, Toumi A, Boudriga S, Alanazi TYA, Alshamari AK, Alrashdi AA, Hamden K. Antiobesity and antidiabetes effects of Cyperus rotundus rhizomes presenting protein tyrosine phosphatase, dipeptidyl peptidase 4, metabolic enzymes, stress oxidant and inflammation inhibitory potential. Heliyon. 2024;10(5):e27598. doi: 10.1016/j.heliyon.2024.e27598.PubMedUsed to support: Laboratory and animal study: a rhizome extract inhibited the digestive enzymes lipase and alpha-amylase and the enzyme DPP-4 in vitro, and in diabetic rats reduced inflammatory and oxidative markers while supporting antioxidant defenses. Test-tube and animal findings only.
  6. Xue BX, He RS, Lai JX, Mireku-Gyimah NA, Zhang LH, Wu HH. Phytochemistry, data mining, pharmacology, toxicology and the analytical methods of Cyperus rotundus L. (Cyperaceae): a comprehensive review. Phytochem Rev. 2023;1-46. doi: 10.1007/s11101-023-09870-3.PubMedUsed to support: Comprehensive review: summarizes the rhizome's traditional use for digestive, nervous and gynecological complaints across Chinese, Ayurvedic and other systems, catalogs its chemistry including sesquiterpenes and flavonoids, and reviews toxicology pointing to a generally low-toxicity profile. Used for traditional-use context and chemistry, not as efficacy evidence.
  7. Giorgi G, Sahin AW, Patriarca A, Sciubba F, Massimi L, Zannini E, Miccheli A, Tomassini A, Brasili E. Novel food ingredients from Cyperus rotundus L.: an ancient famine food and the world's pernicious weed coming back on the table. Food Res Int. 2026;241:119741. doi: 10.1016/j.foodres.2026.119741.PubMedUsed to support: Food-science characterization of the tuber: high total dietary fiber (about 39 g per 100 g, mostly insoluble) plus starch, moderate protein and minerals such as calcium, potassium and magnesium, with only low levels of toxic trace elements. Used for the tuber's food composition and traditional food use.
  8. Taheri Y, Herrera-Bravo J, Huala L, Salazar LA, Sharifi-Rad J, Akram M, Shahzad K, Melgar-Lalanne G, Baghalpour N, Tamimi K, Mahroo-Bakhtiyari J, Kregiel D, Dey A, Kumar M, Suleria HAR, Cruz-Martins N, Cho WC. Cyperus spp.: A Review on Phytochemical Composition, Biological Activity, and Health-Promoting Effects. Oxid Med Cell Longev. 2021;2021:4014867. doi: 10.1155/2021/4014867.PubMedUsed to support: Review of the Cyperus genus summarizing phytochemistry and reported biological activities, including antioxidant and anti-inflammatory signals from laboratory studies. Used for background on the plant's chemistry and preclinical activity, not as human efficacy evidence.