Home Ingredients Calcium D-Glucarate
Detox & CleanseWomen's Health

Calcium D-Glucarate

Evidence Level
Limited
1 Clinical Trial
3 Documented Benefits
2/5 Evidence Score

Calcium D-glucarate is the calcium salt of D-glucaric acid, a compound found in fruits and vegetables. It is popular as a detoxification support because it inhibits an enzyme called beta-glucuronidase, which can help the body clear out hormones and toxins through a process called glucuronidation. Human outcome data are still limited.

Studied Dose Commonly 500 to 1500 mg per day.
Active Compound Calcium D-glucarate (calcium salt of D-glucaric acid), a beta-glucuronidase inhibitor.

Benefits

Detoxification support

By inhibiting beta-glucuronidase, calcium D-glucarate supports the body's glucuronidation pathway, which packages and eliminates used hormones and toxins.

Supported by Trial 1

Hormone metabolism support

The same pathway helps clear excess estrogen, the basis for calcium D-glucarate's use for hormone-balance support, though human evidence is preliminary.

Supported by Trial 1

Antioxidant interest

D-glucarate compounds show antioxidant activity in laboratory research.

Supported by Trial 1

Mechanism of action

1

Beta-glucuronidase inhibition

Calcium D-glucarate releases D-glucaro-1,4-lactone, which inhibits beta-glucuronidase, preventing toxins and hormones from being un-packaged and reabsorbed.

2

Enhanced glucuronidation clearance

With the enzyme inhibited, more glucuronide-bound compounds are excreted in bile and urine rather than recirculated.

Clinical trials

1
Calcium Glucarate and Beta-Glucuronidase — Mechanistic Study
PubMed

Study of the effect of calcium glucarate on beta-glucuronidase activity. (Dwivedi et al. 1990, Biochemical Medicine and Metabolic Biology). Mechanistic research.

Laboratory and animal models.

Calcium glucarate inhibited beta-glucuronidase activity, the mechanism behind its detoxification positioning; human outcome data remain limited.

Side effects and drug interactions

Common Potential side effects

GENERALLY WELL-TOLERATED — adverse effects are uncommon at normal doses.
Mild digestive upset is occasionally reported.
Discontinue if any unusual reaction occurs.

Important Drug interactions

May speed clearance of some medications via glucuronidation; consult a doctor.
Hormone therapy or birth control — possible interaction; consult a doctor.
Tell your doctor about all medications before use.

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Frequently asked questions about Calcium D-Glucarate

What is Calcium D-Glucarate?

Calcium D-glucarate is the calcium salt of D-glucaric acid, a compound found in fruits and vegetables. It is popular as a detoxification support because it inhibits an enzyme called beta-glucuronidase, which can help the body clear out hormones and toxins through a process called glucuronidation.

What is the recommended dosage of Calcium D-Glucarate?

The clinically studied dose for Calcium D-Glucarate is Commonly 500 to 1500 mg per day.. Always follow product labeling and consult a healthcare provider for personalized dosing recommendations.

What is Calcium D-Glucarate used for?

Calcium D-Glucarate is studied for detoxification support, hormone metabolism support, antioxidant interest. By inhibiting beta-glucuronidase, calcium D-glucarate supports the body's glucuronidation pathway, which packages and eliminates used hormones and toxins.

Are there side effects from taking Calcium D-Glucarate?

Reported potential side effects may include: GENERALLY WELL-TOLERATED — adverse effects are uncommon at normal doses. Mild digestive upset is occasionally reported. Always consult a healthcare provider before starting any new supplement, especially if you have underlying conditions or take medications.

Is Calcium D-Glucarate safe to take?

Whether Calcium D-Glucarate is safe depends on the dose, your overall health, and any medications you take. At studied doses, reported side effects can include: GENERALLY WELL-TOLERATED — adverse effects are uncommon at normal doses. It may also interact with certain medications. Calcium D-Glucarate is not suitable for everyone — consult a healthcare provider before use if you are pregnant or breastfeeding, have a medical condition, or take prescription medications.

References(1 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Dwivedi C, Heck WJ, Downie AA, et al. Effect of calcium glucarate on beta-glucuronidase activity and glucarate content of certain vegetables and fruits. Biochem Med Metab Biol. 1990;43(2):83-92..PubMedUsed to support: Mechanistic study supporting beta-glucuronidase inhibition by calcium D-glucarate.