Home Ingredients Alliàge™ (Aged Garlic Extract — S-Allylcysteine)

Alliàge™ (Aged Garlic Extract — S-Allylcysteine)

Allium sativum
Evidence Level
Preliminary
0 Clinical Trials
3 Documented Benefits
1/5 Evidence Score

Alliàge™ is a branded aged garlic (Allium sativum) extract from Vidya Herbs, which the maker says is processed to convert allicin into S-allylcysteine (SAC). It is marketed for men's hormonal and sexual wellbeing. No published or registered human trial of Alliàge was found in PubMed or ClinicalTrials.gov. A paid partner feature from the maker describes a 60-day placebo-controlled trial in 52 men taking 200 mg a day, with better symptom, erectile function and testosterone measures, but it gives no journal or registry entry, so the results cannot be checked. Most aged garlic extract trials used Kyolic, a different extract: systolic blood pressure fell a few mmHg more than placebo, and cholesterol results differ by trial. Garlic supplements may increase bleeding risk.

Studied Dose No published trial has tested Alliàge. The maker describes 200 mg a day for 60 days in an unpublished trial. Blood pressure trials of a different aged garlic extract used 240 mg to 1.2 g a day for 12 weeks.
Active Compound Aged garlic (Allium sativum) extract; the maker says its process converts allicin into S-allylcysteine (SAC) but publishes no SAC content or aging time. Alliàge™ is manufactured by Vidya Herbs.

Benefits

Blood pressure research on other aged garlic extracts

In a 12-week trial of a different aged garlic extract, 1.2 g a day lowered systolic pressure 5.0 mmHg more than placebo in 88 adults with uncontrolled high blood pressure; in a dose trial only the 480 mg dose beat placebo. Pooled across 19 aged garlic trials, systolic fell about 2.5 mmHg and diastolic did not change. None tested Alliàge.

Cholesterol research on other garlic products

Results differ by trial. In a six-month government-funded trial, aged garlic extract at about one clove's equivalent did not lower LDL compared with placebo, while pooled aged garlic trials found LDL about 4.4 mg/dL lower. These studies used other products, not Alliàge.

Maker-reported men's wellbeing trial

In a paid partner feature, the maker describes a 60-day placebo-controlled trial in 52 men aged 25 to 60 taking 200 mg a day, with better symptom, erectile function, fatigue and quality of life scores and higher testosterone. No journal publication, registry entry or full data are given, so these results cannot be checked.

Mechanism of action

1

S-allylcysteine and the aging process

A review by a Wakunaga scientist explains that the odorous allicin-type compounds of crushed garlic break down during processing and that long-term extraction forms S-allylcysteine and related compounds. Vidya says its process converts allicin into S-allylcysteine but gives no aging time or SAC percentage.

2

Platelet aggregation and adhesion

In a randomized double-blind dose-finding study in 34 healthy adults taking 2.4 to 7.2 g a day of a different aged garlic extract, platelet aggregation thresholds rose moderately and platelet adhesion to fibrinogen fell. These are laboratory measures of platelet function, not bleeding events.

Clinical trials

Side effects and drug interactions

Common Potential side effects

Breath and body odor, abdominal pain, gas and nausea are listed by NCCIH for garlic taken by mouth.
Some people have allergic reactions to garlic.
Garlic supplements may increase the risk of bleeding; tell your surgeon about them before any operation.
Garlic in amounts greater than those in foods may not be safe during pregnancy or breastfeeding, according to NCCIH.
In a 12-week trial in people taking warfarin, headache, fatigue, colds and dizziness occurred at similar rates on aged garlic extract and placebo.

Important Drug interactions

Anticoagulants and aspirin: NCCIH says garlic supplements may increase bleeding risk and advises talking with your health care provider. In a 12-week pilot trial of 48 closely monitored people on warfarin, there was no evidence of increased bleeding on aged garlic extract or placebo; one small trial cannot rule out a risk.
Saquinavir (HIV protease inhibitor): in 10 healthy volunteers, three weeks of twice-daily garlic caplets (not aged garlic extract) lowered saquinavir exposure by 51%, and levels were still 60% to 70% of baseline 10 days after stopping. The authors advise caution when combining them.
Blood pressure medicines: aged garlic extract lowered systolic pressure more than placebo when added to existing blood pressure medication, so the effects may add together; monitor blood pressure.

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Frequently asked questions about Alliàge™ (Aged Garlic Extract — S-Allylcysteine)

What is Alliàge used for?

Alliàge is a branded aged garlic extract from Vidya Herbs, processed to form S-allylcysteine and marketed for men's hormonal and sexual wellbeing. It has no published human trial. Trials of other aged garlic extracts found small systolic blood pressure falls compared with placebo, and cholesterol results differ by trial; those results do not show what Alliàge does.

Has Alliàge been tested in published clinical trials?

No published or registered trial of Alliàge was found in PubMed or ClinicalTrials.gov. A paid partner feature from the maker describes a 60-day placebo-controlled trial in 52 men taking 200 mg a day with better symptom and testosterone measures, but it gives no journal, registry number or full data, so the results cannot be checked.

Does aged garlic boost testosterone?

That has not been shown in a published human trial. The only human data for Alliàge come from the maker's unpublished trial described in a paid partner feature. Erectile difficulty can be a sign of a medical problem, so it is worth seeing a doctor rather than relying on a supplement.

Is Alliàge safe, and does it have side effects?

There are no published safety data for Alliàge itself; the maker reports no adverse events in its unpublished trial. NCCIH lists breath and body odor, abdominal pain, gas and nausea for garlic taken by mouth, and says garlic supplements may increase bleeding risk, so tell your doctor if you take anticoagulants or aspirin or are scheduled for surgery.

What is Alliàge?

Alliàge™ is a branded aged garlic (Allium sativum) extract from Vidya Herbs, which the maker says is processed to convert allicin into S-allylcysteine (SAC). It is marketed for men's hormonal and sexual wellbeing. No published or registered human trial of Alliàge was found in PubMed or ClinicalTrials.gov.

What is the recommended dosage of Alliàge?

No published trial has tested Alliàge. The maker describes 200 mg a day for 60 days in an unpublished trial. Blood pressure trials of a different aged garlic extract used 240 mg to 1.2 g a day for 12 weeks. Always follow the product label and check with a healthcare provider for personal advice.

Does Alliàge interact with any medications?

Possible interactions include: Anticoagulants and aspirin: NCCIH says garlic supplements may increase bleeding risk and advises talking with your health care provider. In a 12-week pilot trial of 48 closely monitored people on warfarin, there was no evidence of increased bleeding on aged garlic extract or plac… If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for Alliàge?

NutraSmarts rates the evidence for Alliàge as Preliminary (1 out of 5). It is backed by 11 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(11 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Vidya Herbs (paid partner feature). Aged garlic extract shows promise for men's testosterone support in new findings. NutraIngredients (Partner Feature, paid for by Vidya). 2026;Published 16 March 2026; accessed October 2026..SourceUsed to support: Not PubMed-indexed; advertiser-written content paid for by the maker, read. Says Alliàge is made by a process that converts allicin into S-allylcysteine, and describes a just-completed double-blind placebo-controlled trial in 52 men aged 25 to 60 with reduced-testosterone symptoms and suboptimal erectile function who took 200 mg of Alliàge or maltodextrin after dinner for 60 days. It reports better AMS, IIEF, fatigue and SF-36 scores and higher free and total testosterone than placebo, no change in DHEA and no adverse events, but gives no journal, registry number or full data, so the results cannot be checked.
  2. Ried K, Frank OR, Stocks NP. Aged garlic extract reduces blood pressure in hypertensives: a dose-response trial. Eur J Clin Nutr. 2013;67(1):64-70. doi: 10.1038/ejcn.2012.178.PubMedUsed to support: Randomized, double-blind, placebo-controlled dose-response trial in 79 general practice patients with uncontrolled systolic hypertension, most already on medication, taking 240, 480 or 960 mg/day of aged garlic extract (0.6, 1.2 or 2.4 mg S-allylcysteine) or placebo for 12 weeks. Only the 480 mg dose lowered systolic blood pressure significantly more than placebo, by 11.8 mmHg; the 960 mg dose reached P=0.07 at 8 weeks, and the 240 mg dose and diastolic pressure did not differ from placebo. Supported by a Royal Adelaide Hospital research grant; Kyolic capsules were provided by the distributor Vitaco Health, which was not involved in the study.
  3. Ried K, Travica N, Sali A. The effect of aged garlic extract on blood pressure and other cardiovascular risk factors in uncontrolled hypertensives: the AGE at Heart trial. Integr Blood Press Control. 2016;9:9-21. doi: 10.2147/IBPC.S93335.PubMedUsed to support: Twelve-week double-blind randomized trial in 88 adults with uncontrolled hypertension, most already on medication, taking 1.2 g/day of aged garlic extract or placebo. Systolic blood pressure fell 5.0 mmHg more than placebo; the overall diastolic difference was not significant. A post-hoc subgroup defined as responders showed larger falls of 11.5 and 6.3 mmHg. Central pressure, arterial stiffness, cholesterol and inflammatory markers only trended in garlic's favor and did not reach significance. Funded by a grant from Wakunaga of America, which makes the extract and supplied the capsules. Dropout was 22% on placebo and 9% on garlic; 25% of participants were on blood-thinning medication, and the authors report that the extract did not increase bleeding risk in them.
  4. Bashiri S, TaghipourSheshdeh F, Foshati S, Askarpour M, Ahmadi A, Babajafari S. The Effect of Aged Garlic Supplementation on Blood Pressure and Lipid Profile: A Dose-Response Grade-Assessed Systematic Review and Meta-Analysis of Randomized Controlled Trials. Phytother Res. 2025;39(12):5669-5694. doi: 10.1002/ptr.70032.PubMedUsed to support: Meta-analysis of 19 trials of aged garlic. Systolic blood pressure fell 2.49 mmHg and LDL 4.41 mg/dL; diastolic pressure and HDL did not change, and the total cholesterol change (-4.74 mg/dL) fell just short of significance. The authors call for further high-quality trials.
  5. Behrouz V, Zahroodi M, Clark CCT, Mir E, Atashi N, Rivaz R. Effects of Garlic Supplementation on Cardiovascular Risk Factors in Adults: A Comprehensive Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutr Rev. 2026;84(1):1-35. doi: 10.1093/nutrit/nuaf090.PubMedUsed to support: Meta-analysis of 108 randomized trials in 7,137 adults of garlic in many forms. Garlic lowered systolic blood pressure by 3.71 mmHg, diastolic by 1.97 mmHg, total cholesterol by 10.21 mg/dL and LDL by 5.90 mg/dL, with effects largest in adults with unfavorable baseline risk; the authors call for larger, longer and more rigorous trials. These are risk markers for garlic in general, not results for Alliàge.
  6. Gardner CD, Lawson LD, Block E, Chatterjee LM, Kiazand A, Balise RR, Kraemer HC. Effect of raw garlic vs commercial garlic supplements on plasma lipid concentrations in adults with moderate hypercholesterolemia: a randomized clinical trial. Arch Intern Med. 2007;167(4):346-53. doi: 10.1001/archinte.167.4.346.PubMedUsed to support: NIH-funded six-month trial in 192 adults with LDL cholesterol of 130 to 190 mg/dL, randomized to raw garlic, a powdered garlic supplement, an aged garlic extract supplement or placebo at about one 4 g clove equivalent 6 days a week. None of the three garlic forms had a statistically or clinically significant effect on LDL or on other blood lipids.
  7. Amagase H. Clarifying the real bioactive constituents of garlic. J Nutr. 2006;136(3 Suppl):716S-725S. doi: 10.1093/jn/136.3.716S.PubMedUsed to support: Review by an author affiliated with Wakunaga, which makes Kyolic. States that odorous thiosulfinates such as allicin decompose during processing, that long-term extraction forms S-allylcysteine, S-allylmercaptocysteine, saponins and N-alpha-fructosyl arginine, and that processing methods yield garlic preparations with differing effects.
  8. Steiner M, Li W. Aged garlic extract, a modulator of cardiovascular risk factors: a dose-finding study on the effects of AGE on platelet functions. J Nutr. 2001;131(3s):980S-4S. doi: 10.1093/jn/131.3.980S.PubMedUsed to support: Randomized double-blind study in 34 healthy adults taking 2.4 to 7.2 g/day of aged garlic extract or placebo. Platelet aggregation thresholds for epinephrine and collagen rose moderately, and platelet adhesion to fibrinogen was inhibited at all doses; adhesion to von Willebrand factor fell only at 7.2 g/day.
  9. Macan H, Uykimpang R, Alconcel M, Takasu J, Razon R, Amagase H, Niihara Y. Aged garlic extract may be safe for patients on warfarin therapy. J Nutr. 2006;136(3 Suppl):793S-795S. doi: 10.1093/jn/136.3.793S.PubMedUsed to support: Double-blind randomized placebo-controlled pilot study: 52 patients on warfarin were randomized and 48 completed 12 weeks of aged garlic extract 5 mL twice daily or placebo. There was no evidence of increased bleeding in either group, and minor adverse events (headache, fatigue, colds, dizziness) did not differ between groups. The authors limit their conclusion to closely monitored patients.
  10. Piscitelli SC, Burstein AH, Welden N, Gallicano KD, Falloon J. The effect of garlic supplements on the pharmacokinetics of saquinavir. Clin Infect Dis. 2002;34(2):234-8. doi: 10.1086/324351.PubMedUsed to support: In 10 healthy volunteers, garlic caplets taken twice daily for about three weeks lowered saquinavir AUC by 51%, trough levels by 49% and peak levels by 54%; after a 10-day washout, values had recovered only to 60% to 70% of baseline. The product was a garlic caplet, not aged garlic extract. The authors advise caution when combining garlic supplements with saquinavir.
  11. National Center for Complementary and Integrative Health. Garlic. NCCIH, National Institutes of Health. 2025;Fact sheet, updated February 2025; accessed 2026. Not PubMed-indexed..SourceUsed to support: Not PubMed-indexed: US government fact sheet on garlic in general. Lists oral side effects as breath and body odor, abdominal pain, flatulence and nausea, and notes allergic reactions in some people; says garlic supplements may increase the risk of bleeding, which matters before surgery or with anticoagulants or aspirin; and says garlic taken orally in amounts greater than those in foods may not be safe in pregnancy or breastfeeding.