Home Ingredients VitaMK7® (Vitamin K2 as MK-7 — Gnosis)
Bone HealthCardiovascular

VitaMK7® (Vitamin K2 as MK-7 — Gnosis)

Evidence Level
Moderate
1 Clinical Trial
3 Documented Benefits
3/5 Evidence Score

VitaMK7® is a natural vitamin K2 in the menaquinone-7 (MK-7) form from Gnosis, produced by fermentation of Bacillus subtilis natto and standardized to over 99% of the active all-trans isomer. Vitamin K2 directs calcium into bones and away from arteries, supporting both bone strength and cardiovascular health.

Studied Dose Commonly 90 to 180 mcg of MK-7 per day.
Active Compound Vitamin K2 as menaquinone-7 (MK-7), greater than 99% all-trans isomer, from natto fermentation.

Benefits

Bone strength

In a 3-year randomized trial in postmenopausal women, low-dose MK-7 helped decrease age-related bone loss, supporting bone mineral density.

Supported by Trial 1

Arterial flexibility

Vitamin K2 activates a protein that keeps calcium out of artery walls, supporting flexible, healthy arteries.

Calcium routing

MK-7 helps direct dietary calcium into bone rather than soft tissue, complementing calcium and vitamin D.

Supported by Trial 1

Mechanism of action

1

Osteocalcin activation

MK-7 carboxylates (activates) osteocalcin, the protein that binds calcium into the bone matrix, strengthening bone.

2

Matrix Gla protein activation

MK-7 activates matrix Gla protein, which inhibits calcium deposition in artery walls, protecting cardiovascular tissue.

Clinical trials

1
MK-7 and Bone Loss — 3-Year RCT
PubMed

Three-year randomized trial of low-dose menaquinone-7 (MK-7) supplementation in healthy postmenopausal women. (Knapen et al. 2013, Osteoporosis International)

Healthy postmenopausal women.

Low-dose MK-7 helped decrease bone loss at the spine and femoral neck versus placebo.

Side effects and drug interactions

Common Potential side effects

Generally well-tolerated at recommended doses.
Vitamin K2 interferes with warfarin-type blood thinners; do not use without medical supervision.
Mild digestive upset is occasionally reported.

Important Drug interactions

Warfarin / vitamin-K-antagonists — directly opposes these blood thinners; medical supervision required.
Generally compatible with other medications.
Tell your doctor if you take anticoagulants.

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Frequently asked questions about VitaMK7® (Vitamin K2 as MK-7 — Gnosis)

What is VitaMK7?

VitaMK7® is a natural vitamin K2 in the menaquinone-7 (MK-7) form from Gnosis, produced by fermentation of Bacillus subtilis natto and standardized to over 99% of the active all-trans isomer. Vitamin K2 directs calcium into bones and away from arteries, supporting both bone strength and cardiovascular health.

What is VitaMK7 used for?

VitaMK7 is researched primarily for Bone Health and Cardiovascular. In a 3-year randomized trial in postmenopausal women, low-dose MK-7 helped decrease age-related bone loss, supporting bone mineral density.

What is the recommended dosage of VitaMK7?

The clinically studied dose is Commonly 90 to 180 mcg of MK-7 per day. Always follow the product label and check with a healthcare provider for personal advice.

Is VitaMK7 safe, and does it have side effects?

For most healthy adults, VitaMK7 is well tolerated at studied doses. Reported effects can include: Generally well-tolerated at recommended doses. Vitamin K2 interferes with warfarin-type blood thinners; do not use without medical supervision. It may also interact with some medications. VitaMK7 is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does VitaMK7 interact with any medications?

Possible interactions include: Warfarin / vitamin-K-antagonists — directly opposes these blood thinners; medical supervision required. Generally compatible with other medications. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for VitaMK7?

NutraSmarts rates the evidence for VitaMK7 as Moderate (3 out of 5). It is backed by 1 clinical trial and 1 cited reference summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(1 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Knapen MH, Drummen NE, Smit E, et al. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women. Osteoporos Int. 2013;24(9):2499-507..PubMedUsed to support: RCT supporting bone-density benefit of MK-7.