Home Ingredients TraceReplace™ (plant-derived trace mineral complex — FutureCeuticals)
Antioxidant

TraceReplace™ (plant-derived trace mineral complex — FutureCeuticals)

Evidence Level
Preliminary
2 Clinical Trials
4 Documented Benefits
1/5 Evidence Score

TraceReplace is a branded, plant-derived trace mineral complex from FutureCeuticals. The maker says it is derived from ancient plant deposits buried beneath sandstone formations in the western United States and supplies more than 60 trace minerals and elements in a soluble form, sold as a powder or liquid concentrate for beverages, mineral supplements and multivitamins. The maker's product page does not list the amount of each element, and no human study of TraceReplace has been published.

Studied Dose No clinical dose has been established for TraceReplace; follow the amount stated on the finished product label.
Active Compound Plant-derived multi-trace-mineral complex; the maker states it supplies more than 60 trace minerals and elements in a soluble form but does not list the amount of each on its product page

Benefits

Broad-spectrum trace mineral source

The maker says TraceReplace supplies more than 60 trace minerals and elements from one plant-derived source, but its product page does not list amounts. Humans need about 20 essential elements, so not every element in the complex is a nutrient, and no study has tested whether it improves mineral status. It complements, not replaces, a balanced diet.

Supported by Trial 1

Minerals used by antioxidant enzymes (untested for TraceReplace)

Magnesium, zinc, iron, manganese and copper are among the metal ions many enzymes need to catalyze reactions, and zinc, copper, manganese and iron are parts of the antioxidant enzymes superoxide dismutase and catalase. These are general roles of the minerals, not effects measured for TraceReplace, which has no published human studies.

Supported by Trial 1, Trial 2

Bone-related minerals (untested for TraceReplace)

Calcium, magnesium, zinc, manganese and copper are among the nutrients that contribute to bone health, and zinc, manganese and copper are readily available in the average American diet. The maker does not list how much of each mineral TraceReplace supplies, and it has not been tested for bone health.

Supported by Trial 1, Trial 2

Water-soluble form (per the maker)

The maker describes TraceReplace as small, soluble, hydrophilic minerals, offered as a powder or liquid concentrate for hydration drinks, mineral supplements and multivitamins. Its claim that plant processing makes the minerals easier to absorb has not been tested in any published study.

Supported by Trial 1

Mechanism of action

1

Claimed plant processing of minerals

The maker states that ancient plants absorbed minerals and, through photosynthesis, converted large insoluble minerals into small soluble molecules, which were preserved in plant deposits beneath sandstone formations and are then extracted and dried. No published analysis has confirmed the chemical forms of the minerals in TraceReplace or compared their absorption with mineral salts.

2

Enzyme cofactor roles

Metal ions such as magnesium, zinc, iron, manganese and copper help many enzymes catalyze reactions, and selenium, manganese, copper, zinc and iron are components of antioxidant enzymes (glutathione peroxidase, superoxide dismutases, catalase). This is general mineral biology; whether TraceReplace changes mineral status or enzyme activity in people has not been studied.

3

Aqueous solubility

The maker describes TraceReplace as small, soluble, hydrophilic minerals that are extracted from the plant deposit and dried, and offers powder and liquid-concentrate forms for dry-mix and liquid products. Solubility is a formulation property and has not been shown to improve absorption in people.

Clinical trials

1
No published human trial on the finished TraceReplace ingredient

A PubMed search (September 2026) found no study of TraceReplace. The maker's product page describes its source and form but publishes no element-by-element analysis or efficacy data.

Not applicable: no human study of the branded ingredient has been published.

The rationale is compositional and class-based: the maker describes the extract as supplying a broad spectrum of plant-derived trace minerals. Any health benefit is inferred from the known roles of the constituent minerals, not from a trial of TraceReplace itself.

2
Dietary rationale: micronutrient intake in modern vs ancestral diets
PubMed

Class/rationale evidence, not a study of TraceReplace: review comparing ancestral (Paleolithic) and modern diets (Eaton & Eaton, 2000, European Journal of Nutrition).

Comparative dietary/nutritional analysis, not a clinical trial of any supplement.

Supports the general premise that modern diets can differ from ancestral patterns in micronutrient supply, which is the marketing rationale for broad trace-mineral supplementation. It does not demonstrate any benefit of TraceReplace specifically.

Side effects and drug interactions

Common Potential side effects

No human tolerance studies of TraceReplace have been published
Mineral concentrates can cause mild stomach upset or nausea in sensitive individuals
Excessive intake of trace minerals such as iron, zinc or copper over time may cause imbalances or toxicity, so do not exceed recommended amounts. TraceReplace's element profile is not published and may include non-essential elements such as aluminium or heavy metals, so choose a product with a recent third-party certificate of analysis; take extra care in pregnancy, for children, or with kidney disease, since aluminium toxicity occurs especially in chronic kidney disease
People who already take a multivitamin or mineral supplement should account for combined mineral intake

Important Drug interactions

Mineral-containing products can reduce absorption of certain antibiotics (tetracyclines, fluoroquinolones); separate dosing by a few hours and tell your doctor
Zinc and copper from trace-mineral blends may interfere with each other and with medications like penicillamine; discuss with your doctor or pharmacist
Any iron it contains can interact with thyroid medication (levothyroxine) and some other drugs; ask your doctor about timing
If you take any prescription medication or have a mineral-related condition such as hemochromatosis or Wilson's disease, tell your doctor before use

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Frequently asked questions about TraceReplace™ (plant-derived trace mineral complex — FutureCeuticals)

What is TraceReplace?

TraceReplace is a branded, plant-derived trace mineral complex from FutureCeuticals. The maker says it is derived from ancient plant deposits buried beneath sandstone formations in the western United States and supplies more than 60 trace minerals and elements in a soluble form, sold as a powder or liquid concentrate f…

What is TraceReplace used for?

TraceReplace is researched primarily for Antioxidant. The maker says TraceReplace supplies more than 60 trace minerals and elements from one plant-derived source, but its product page does not list amounts.

What is the recommended dosage of TraceReplace?

The clinically studied dose is No clinical dose has been established for TraceReplace; follow the amount stated on the finished product label. Always follow the product label and check with a healthcare provider for personal advice.

Is TraceReplace safe, and does it have side effects?

For most healthy adults, TraceReplace is well tolerated at studied doses. Reported effects can include: No human tolerance studies of TraceReplace have been published Mineral concentrates can cause mild stomach upset or nausea in sensitive individuals It may also interact with some medications. TraceReplace is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does TraceReplace interact with any medications?

Possible interactions include: Mineral-containing products can reduce absorption of certain antibiotics (tetracyclines, fluoroquinolones); separate dosing by a few hours and tell your doctor Zinc and copper from trace-mineral blends may interfere with each other and with medications like penicillamine; discuss… If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for TraceReplace?

NutraSmarts rates the evidence for TraceReplace as Preliminary (1 out of 5). It is backed by 2 clinical trials and 7 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(7 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Eaton SB, Eaton SB 3rd. Paleolithic vs. modern diets--selected pathophysiological implications European Journal of Nutrition. 2000;39(2):67-70..PubMedUsed to support: Review arguing that Paleolithic diets supplied high levels of micronutrients and differed from modern diets in ways with health implications; its abstract gives no soil or trace-mineral data, and it did not test TraceReplace.
  2. Andreini C, Bertini I, Cavallaro G, Holliday GL, Thornton JM. Metal ions in biological catalysis: from enzyme databases to general principles. J Biol Inorg Chem. 2008;13(8):1205-18..PubMedUsed to support: Database analysis showing magnesium and zinc are the most common redox-inert metal ions in enzyme catalysis, and iron, followed by manganese, cobalt, molybdenum, copper and nickel, the most common redox-active ones; class evidence for mineral cofactor roles, did not test TraceReplace.
  3. Zoroddu MA, Aaseth J, Crisponi G, Medici S, Peana M, Nurchi VM. The essential metals for humans: a brief overview. J Inorg Biochem. 2019;195:120-129..PubMedUsed to support: Review stating that humans need about 20 essential elements, including 10 metals (Na, K, Mg, Ca, Fe, Mn, Co, Cu, Zn, Mo), and that the body also contains metals it does not need; class evidence, did not test TraceReplace.
  4. Wołonciej M, Milewska E, Roszkowska-Jakimiec W. Trace elements as an activator of antioxidant enzymes. Postepy Hig Med Dosw (Online). 2016;70:1483-1498..PubMedUsed to support: Review describing selenium (glutathione peroxidase), manganese, copper and zinc (superoxide dismutases) and iron (catalase) as components of antioxidant enzymes; class evidence, did not test TraceReplace.
  5. Price CT, Langford JR, Liporace FA. Essential Nutrients for Bone Health and a Review of their Availability in the Average North American Diet. Open Orthop J. 2012;6:143-9..PubMedUsed to support: Review naming calcium, magnesium, silicon, boron, zinc, manganese and copper among nutrients that contribute to bone health, and noting zinc, manganese and copper are readily available in the average American diet and may have adverse effects at higher intakes; class evidence, did not test TraceReplace.
  6. Pitman SK, Hoang UTP, Wi CH, Alsheikh M, Hiner DA, Percival KM. Revisiting Oral Fluoroquinolone and Multivalent Cation Drug-Drug Interactions: Are They Still Relevant? Antibiotics (Basel). 2019;8(3):108..PubMedUsed to support: Review showing that oral preparations containing multivalent cations chelate fluoroquinolones in the gut, which can cause clinically significant decreases in fluoroquinolone absorption; class evidence, did not test TraceReplace.
  7. Coulson JM, Hughes BW. Dose-response relationships in aluminium toxicity in humans. Clin Toxicol (Phila). 2022;60(4):415-428..PubMedUsed to support: Systematic review of 179 human cases of aluminium exposure; toxic exposure caused neurotoxicity and bone disease, especially in people with chronic kidney disease; did not test TraceReplace.