Benefits
Centuries of traditional use in European herbal medicine
Sundew herb has been taken as a traditional airway remedy since at least the seventeenth century and appears in a few hundred medicines registered in Europe, many of them syrups and drops. This is a record of use, not proof of effect: no EU herbal monograph exists for sundew, and no trial of sundew on its own in people appears in PubMed.
Honey and four-herb syrup with sundew compared with placebo in children
In a small placebo-controlled pilot trial in 56 children aged 5 to 11 with a cough during a cold, a syrup of eucalyptus honey with horehound, sundew flower, ivy leaf and plantain extracts lowered day-time cough scores more than placebo from day 3 and night-time scores from day 4 through day 7. Honey and ivy are active ingredients too, so sundew's share is unknown.
Homeopathic syrups listing sundew compared with placebo
Two placebo-controlled trials of homeopathic syrups that list Drosera among four or ten ingredients reported lower cough scores than placebo, one in 180 children over 7 days and one in 80 adults with a respiratory infection. These homeopathic dilutions hold little or no measurable sundew, so the results say nothing about sundew herb at supplement doses.
Airway muscle relaxation and cilia activity in lab studies
In slices of mouse windpipe, a round-leaved sundew extract eased acetylcholine-triggered muscle tightening and sped up the beating of the cilia that sweep mucus out of the airways. Its flavonoids, mainly quercetin and a galloyl form of hyperoside, carried these effects. This is tissue work, not a test in living animals or people.
Calming of inflammatory enzymes and cells in lab studies
In test tubes, sundew extracts blocked human neutrophil elastase, an enzyme released by white blood cells, and the flavonoids rather than the naphthoquinones were responsible. In guinea-pig gut tissue the extracts also relaxed muscle through acetylcholine and histamine receptors. None of this has been measured in people.
Bacterial biofilm effects of sundew compounds in the lab
Flavonoid and naphthoquinone fractions from cultivated round-leaved sundew reduced biofilm formation by drug-resistant E. coli in culture, with the flavonoids appearing to act partly by binding iron. These are laboratory results with no human data, and sundew is not a substitute for medical treatment of an infection.
Mechanism of action
Flavonoids inhibit PDE1 and PDE4 in airway tissue
Quercetin and 2″-O-galloylhyperoside inhibited the phosphodiesterases PDE1A and PDE4D in enzyme assays, and a PDE4 inhibitor mimicked the rise in ciliary beat in mouse windpipe slices. Shown only in isolated tissue and enzyme assays.
Muscarinic M3 receptor antagonism
Sundew extracts and quercetin blocked acetylcholine-type (carbachol) contractions of guinea-pig gut tissue, an effect traced to muscarinic M3 receptors, with a histamine H1 component in one study. In mouse windpipe slices, sundew extract also relaxed acetylcholine-induced contractions. Tissue findings only.
Neutrophil elastase inhibition by flavonols
Hyperoside, quercetin and isoquercitrin inhibited human neutrophil elastase at low microgram per ml concentrations, while the sundew naphthoquinones were inactive in the same assay.
Naphthoquinones carry the toxicity concern
Sundew species make mainly plumbagin or mainly ramentaceone (7-methyljuglone), reactive naphthoquinones that are cytotoxic in cell studies. In a 3D human mucosa model a naphthoquinone-rich fraction cut cell viability while a whole extract with about 0.02% naphthoquinones did not; content varies by species.
Clinical trials
Pilot, randomized, double-blind, placebo-controlled multicenter trial of Sediflù, a medical-device syrup of eucalyptus honey with dry extracts of horehound, sundew flower, ivy leaf and plantain leaf, 10 ml twice daily for 7 days; sponsored by Cinfa. (Núñez et al. 2024, Clin Pediatr (Phila))
56 children aged 5 to 11 with a dry or productive cough of 3 to 7 days during a cold (27 syrup, 29 placebo).
Night-time cough scores were lower than with placebo from day 4 and day-time scores from day 3, and the gap grew through day 7. No adverse effects occurred in either group. The trial was small and the syrup has five active ingredients, including honey, so the result cannot be credited to sundew. The authors note milder coughs than usual during the 2020 to 2021 mask period and slightly higher baseline scores in the syrup group.
Randomized, double-blind, placebo-controlled trial of Monapax, a homeopathic syrup combining Drosera, Coccus cacti, Cuprum sulfuricum and Ipecacuanha, for 7 days; one author is employed by the license holder, Cassella-med. (Voß et al. 2018, Drug Res (Stuttg))
180 children aged 6 months to 12 years with acute dry cough (89 syrup, 91 placebo).
The cough score improved by 5.2 points on the syrup and 3.2 on placebo (p < 0.0001); secondary measures also favored the syrup. Mild or moderate adverse reactions were seen in 6 children on the syrup and 9 on placebo. This is a homeopathic product: its current German product information lists only 0.02 g of Drosera mother tincture per 100 g of syrup beside three other ingredients, so the result says nothing about sundew herb at supplement doses.
Randomized, double-blind, placebo-controlled trial of a homeopathic cough syrup (Stodal), which the authors' later paper lists as nine homeopathic dilutions (3 CH to 6 CH) plus an unstated amount of Drosera mother tincture, taken for one week. (Zanasi et al. 2014, Pulm Pharmacol Ther)
80 patients with acute cough from an upper respiratory infection or acute bronchitis (40 syrup, 40 placebo).
Cough scores fell in both groups, but severity was lower on the syrup at day 4 (p < 0.001) and day 7 (p = 0.023). Measured sputum viscosity was lower on the syrup in the 53 who gave samples, while patients' own rating of viscosity did not differ (p = 0.059). No treatment-related adverse events. Sundew is one of ten ingredients and its amount is not stated, so the result says nothing about sundew herb at supplement doses.