Home Ingredients SOD B Dimpless® (Melon Superoxide Dismutase)
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SOD B Dimpless® (Melon Superoxide Dismutase)

Cucumis melo
Evidence Level
Limited
2 Clinical Trials
3 Documented Benefits
2/5 Evidence Score

SOD B Dimpless® is a melon (Cucumis melo) concentrate naturally rich in superoxide dismutase (SOD), one of the body's master antioxidant enzymes. The melon SOD concentrate is studied as the Extramel version for reducing perceived stress and fatigue, and the Dimpless version reduced the visible appearance of thigh cellulite in one small trial.

Studied Dose 10 mg/day (about 140 IU SOD) in the stress and fatigue trial (Extramel version); 40 mg/day (about 480 IU SOD) in the cellulite trial (SOD B Dimpless version).
Active Compound Melon (Cucumis melo) concentrate standardized for superoxide dismutase (SOD) antioxidant enzyme activity, protected for oral delivery.

Benefits

Antioxidant defense

Melon SOD is an antioxidant enzyme, and oral intake is proposed to raise the body's own antioxidant enzyme activity. This antioxidant effect has not been directly measured in the human trials of this ingredient.

Supported by Trial 1, Trial 2

Stress and fatigue

In a placebo-controlled clinical trial, a melon SOD concentrate reduced perceived stress and fatigue in healthy people.

Supported by Trial 1, Trial 2

Skin smoothness

In a small placebo-controlled trial in 41 women, SOD B Dimpless at 40 mg/day reduced the visible appearance of thigh cellulite over 8 weeks (about 9.5 percent at 4 weeks, 11.3 percent at 8 weeks). This is one small industry-funded study, and abdominal cellulite did not improve significantly.

Supported by Trial 2

Mechanism of action

1

Superoxide dismutase activity

SOD converts damaging superoxide radicals into less harmful molecules, the first line of the body's antioxidant enzyme defense.

2

Induction of internal antioxidants

Oral melon SOD is thought to prompt the body to raise its own antioxidant enzyme activity, extending protection against oxidative stress.

Clinical trials

1
Melon SOD Concentrate and Stress/Fatigue — RCT
PubMed

Pilot double-blind placebo-controlled trial of a proprietary melon juice concentrate (melon SOD) on stress and fatigue in healthy people. (Milesi et al. 2009, Nutrition Journal)

Healthy adults.

The melon SOD concentrate reduced measures of stress and fatigue versus placebo.

2
Melon SOD (SOD B Dimpless) and Cellulite Appearance, small RCT
PubMed

Randomized double-blind placebo-controlled trial: 41 women, 21 given SOD B Dimpless at 40 mg/day (480 IU SOD) for 56 days. (Lemaire et al. 2016, Phytotherapie 14(1):23-28)

Women aged 31 to 50 with cellulite.

Visible thigh cellulite reduced about 9.5 percent at 28 days and 11.3 percent at 56 days versus placebo; abdominal cellulite did not change significantly. Single small industry-funded trial.

Side effects and drug interactions

Common Potential side effects

Generally well-tolerated — adverse effects are uncommon at normal doses.
Mild digestive upset is occasionally reported.
Discontinue if any unusual reaction occurs.

Important Drug interactions

No major drug interactions are established for this ingredient.
Tell your doctor about all supplements if you take prescription medication.
Use caution if pregnant, breastfeeding, or managing a health condition.

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Frequently asked questions about SOD B Dimpless® (Melon Superoxide Dismutase)

What is SOD B Dimpless?

SOD B Dimpless® is a melon (Cucumis melo) concentrate naturally rich in superoxide dismutase (SOD), one of the body's master antioxidant enzymes. The melon SOD concentrate is studied as the Extramel version for reducing perceived stress and fatigue, and the Dimpless version reduced the visible appearance of thigh cellu…

What is SOD B Dimpless used for?

SOD B Dimpless is researched primarily for Hair, Skin & Nails and Stress & Anxiety. Melon SOD is an antioxidant enzyme, and oral intake is proposed to raise the body's own antioxidant enzyme activity. This antioxidant effect has not been directly measured in the human trials of this ingredient.

What is the recommended dosage of SOD B Dimpless?

The clinically studied dose is 10 mg/day (about 140 IU SOD) in the stress and fatigue trial (Extramel version); 40 mg/day (about 480 IU SOD) in the cellulite trial (SOD B Dimpless version). Always follow the product label and check with a healthcare provider for personal advice.

Is SOD B Dimpless safe, and does it have side effects?

For most healthy adults, SOD B Dimpless is well tolerated at studied doses. Reported effects can include: Generally well-tolerated — adverse effects are uncommon at normal doses. Mild digestive upset is occasionally reported. It may also interact with some medications. SOD B Dimpless is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does SOD B Dimpless interact with any medications?

Possible interactions include: No major drug interactions are established for this ingredient. Tell your doctor about all supplements if you take prescription medication. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for SOD B Dimpless?

NutraSmarts rates the evidence for SOD B Dimpless as Limited (2 out of 5). It is backed by 2 clinical trials and 2 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(2 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Milesi MA, Lacan D, Brosse H, et al. Effect of an oral supplementation with a proprietary melon juice concentrate (Extramel) on stress and fatigue in healthy people: a pilot, double-blind, placebo-controlled clinical trial. Nutr J. 2009;8:40..PubMedUsed to support: Pilot double-blind placebo-controlled RCT in 70 healthy adults aged 30 to 55: 10 mg/day of the melon SOD concentrate (branded Extramel, the stress/fatigue version, not the Dimpless skin version) improved subjective stress and fatigue scores versus placebo over 4 weeks. Outcomes were psychometric scales; antioxidant status itself was not measured, and no skin or cellulite outcome was assessed.
  2. Lemaire B, Le Quere S, Simoneau G, Lacan D. Etude clinique d'une superoxyde dismutase de melon naturelle et bioactive (SOD B Dimpless) sur la cellulite (clinical trial of a natural bioactive melon superoxide dismutase on cellulite). Phytotherapie. 2016;14(1):23-28. doi: 10.1007/s10298-015-0977-4.SourceUsed to support: Randomized, double-blind, placebo-controlled trial in 41 women aged 31 to 50 with cellulite (21 given SOD B Dimpless at 40 mg/day, 480 IU SOD, for 56 days). Visible thigh cellulite fell about 9.5 percent at 28 days and 11.3 percent at 56 days versus placebo. A single small industry-funded trial; abdominal cellulite did not improve significantly.